Incidental Mutation 'R7047:Wnt5b'
ID 547370
Institutional Source Beutler Lab
Gene Symbol Wnt5b
Ensembl Gene ENSMUSG00000030170
Gene Name wingless-type MMTV integration site family, member 5B
Synonyms Wnt-5b
MMRRC Submission 045145-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7047 (G1)
Quality Score 171.009
Status Validated
Chromosome 6
Chromosomal Location 119409492-119521308 bp(-) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) T to A at 119425217 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000137065 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000117171] [ENSMUST00000118120] [ENSMUST00000119369] [ENSMUST00000178696]
AlphaFold P22726
Predicted Effect probably benign
Transcript: ENSMUST00000117171
SMART Domains Protein: ENSMUSP00000113188
Gene: ENSMUSG00000030170

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
WNT1 50 359 3.47e-215 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000118120
SMART Domains Protein: ENSMUSP00000112819
Gene: ENSMUSG00000030170

DomainStartEndE-ValueType
WNT1 12 321 3.47e-215 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000119369
SMART Domains Protein: ENSMUSP00000112448
Gene: ENSMUSG00000030170

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
WNT1 63 372 3.47e-215 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000178696
SMART Domains Protein: ENSMUSP00000137065
Gene: ENSMUSG00000030170

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
WNT1 50 359 3.47e-215 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 98% (53/54)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal numbers of thoracic motor neurons and proportions of motor columnar subtypes. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik A T 14: 32,382,131 (GRCm39) I1278N possibly damaging Het
Adcy5 T A 16: 35,087,585 (GRCm39) L482Q probably damaging Het
Adora2a A G 10: 75,162,145 (GRCm39) I95V probably damaging Het
Anapc1 A C 2: 128,457,350 (GRCm39) C1887G probably damaging Het
Arfgef2 T A 2: 166,693,865 (GRCm39) probably null Het
Capn11 G T 17: 45,949,622 (GRCm39) S448* probably null Het
Capn7 C T 14: 31,058,642 (GRCm39) probably benign Het
Cep55 T A 19: 38,048,539 (GRCm39) V65D possibly damaging Het
Col5a1 A G 2: 27,818,096 (GRCm39) K107R unknown Het
Dbh T A 2: 27,055,622 (GRCm39) I32N possibly damaging Het
Disp1 C A 1: 182,869,030 (GRCm39) R1130L probably damaging Het
Dzip3 A T 16: 48,802,489 (GRCm39) N13K probably benign Het
Emilin1 A G 5: 31,074,422 (GRCm39) N221S probably benign Het
Ext2 A G 2: 93,570,002 (GRCm39) F470L probably damaging Het
Filip1 T A 9: 79,760,916 (GRCm39) Q206L probably damaging Het
Garin1b T A 6: 29,323,809 (GRCm39) L178H probably damaging Het
Gpr63 G T 4: 25,007,320 (GRCm39) A15S probably benign Het
Grhl3 T C 4: 135,276,551 (GRCm39) probably null Het
Hspa5 C T 2: 34,663,204 (GRCm39) P127L probably damaging Het
Ift172 G T 5: 31,433,238 (GRCm39) Y193* probably null Het
Ints1 A C 5: 139,744,226 (GRCm39) L1512* probably null Het
Kat2b A G 17: 53,970,597 (GRCm39) Q661R probably benign Het
Kat6a A G 8: 23,428,554 (GRCm39) N1303S possibly damaging Het
L3mbtl4 G T 17: 68,768,561 (GRCm39) R223L probably benign Het
Maml2 T C 9: 13,532,177 (GRCm39) probably benign Het
Mixl1 A G 1: 180,524,183 (GRCm39) probably null Het
Mocs1 T C 17: 49,759,887 (GRCm39) probably null Het
Ms4a15 T G 19: 10,962,236 (GRCm39) N36T probably damaging Het
Msr1 G A 8: 40,095,657 (GRCm39) T2I possibly damaging Het
Nlgn1 A C 3: 25,490,199 (GRCm39) Y509* probably null Het
Nsmce1 C A 7: 125,090,606 (GRCm39) G4C probably benign Het
Or4c113 A T 2: 88,885,490 (GRCm39) F93L probably damaging Het
Or51v15-ps1 A G 7: 103,278,918 (GRCm39) V83A probably damaging Het
Pan3 G A 5: 147,483,175 (GRCm39) G452D probably damaging Het
Pcyox1 G T 6: 86,365,891 (GRCm39) P441H probably damaging Het
Phf12 T C 11: 77,904,099 (GRCm39) V273A probably damaging Het
Plcd4 A G 1: 74,591,148 (GRCm39) E181G possibly damaging Het
Ptgfr A T 3: 151,541,178 (GRCm39) I110N possibly damaging Het
Rab40c A C 17: 26,138,458 (GRCm39) V8G probably damaging Het
Rasal3 T A 17: 32,615,458 (GRCm39) Y460F probably damaging Het
Rhbdf2 A G 11: 116,494,477 (GRCm39) probably null Het
Ryr2 T A 13: 11,839,286 (GRCm39) N496Y possibly damaging Het
Sacs A T 14: 61,450,451 (GRCm39) I4166F probably damaging Het
Sh2d3c T C 2: 32,611,172 (GRCm39) M1T probably null Het
Smarca2 C T 19: 26,646,555 (GRCm39) S651L possibly damaging Het
Sned1 A T 1: 93,213,540 (GRCm39) R1204S possibly damaging Het
Spata31d1b T C 13: 59,860,249 (GRCm39) Y41H probably damaging Het
Stab2 C T 10: 86,694,016 (GRCm39) C2075Y probably damaging Het
Tcte1 A T 17: 45,844,294 (GRCm39) Q90L possibly damaging Het
Tll2 C T 19: 41,074,679 (GRCm39) G945S probably damaging Het
Tmbim7 A T 5: 3,720,112 (GRCm39) T116S probably benign Het
Tnfrsf19 A T 14: 61,242,667 (GRCm39) C72* probably null Het
Usp17le T A 7: 104,417,640 (GRCm39) T501S probably benign Het
Other mutations in Wnt5b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01590:Wnt5b APN 6 119,417,515 (GRCm39) missense possibly damaging 0.70
IGL01822:Wnt5b APN 6 119,410,433 (GRCm39) missense probably damaging 1.00
Blizzard UTSW 6 119,423,319 (GRCm39) missense probably damaging 1.00
Invierno UTSW 6 119,417,272 (GRCm39) missense probably damaging 1.00
luftmensch UTSW 6 119,410,813 (GRCm39) missense probably damaging 0.97
R0557:Wnt5b UTSW 6 119,410,779 (GRCm39) missense probably damaging 1.00
R0732:Wnt5b UTSW 6 119,423,543 (GRCm39) nonsense probably null
R1472:Wnt5b UTSW 6 119,410,442 (GRCm39) missense probably damaging 1.00
R1673:Wnt5b UTSW 6 119,423,315 (GRCm39) missense probably benign 0.19
R4202:Wnt5b UTSW 6 119,417,272 (GRCm39) missense probably damaging 1.00
R5100:Wnt5b UTSW 6 119,417,449 (GRCm39) missense probably benign 0.20
R5264:Wnt5b UTSW 6 119,410,813 (GRCm39) missense probably damaging 0.97
R5393:Wnt5b UTSW 6 119,417,394 (GRCm39) missense probably damaging 1.00
R5394:Wnt5b UTSW 6 119,417,283 (GRCm39) missense probably damaging 0.98
R5482:Wnt5b UTSW 6 119,423,392 (GRCm39) missense probably benign 0.19
R5741:Wnt5b UTSW 6 119,410,690 (GRCm39) missense probably damaging 1.00
R5902:Wnt5b UTSW 6 119,425,199 (GRCm39) missense probably benign 0.00
R6005:Wnt5b UTSW 6 119,410,615 (GRCm39) missense probably benign 0.04
R6061:Wnt5b UTSW 6 119,410,603 (GRCm39) missense probably damaging 0.98
R6208:Wnt5b UTSW 6 119,423,473 (GRCm39) missense probably damaging 1.00
R6405:Wnt5b UTSW 6 119,410,457 (GRCm39) missense probably benign 0.06
R6478:Wnt5b UTSW 6 119,410,751 (GRCm39) missense probably damaging 1.00
R6482:Wnt5b UTSW 6 119,410,573 (GRCm39) missense possibly damaging 0.88
R7338:Wnt5b UTSW 6 119,425,092 (GRCm39) splice site probably null
R8044:Wnt5b UTSW 6 119,423,319 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCTCACTCACCACCAGGATTTG -3'
(R):5'- AGTGCTGAATTCCTCTGGGG -3'

Sequencing Primer
(F):5'- CAGGATTTGGGTCCAGGCTAGAC -3'
(R):5'- GGGGACCGAATTTGCTTTCAG -3'
Posted On 2019-05-13