Mutagenetix > Incidental Mutations

Incidental Mutation 'R7051:Olfr173'

547620

Institutional Source

Beutler Lab

Gene Symbol

Olfr173

Ensembl Gene

ENSMUSG00000049362

Gene Name

olfactory receptor 173

Synonyms

MOR184-3, GA_x54KRFPKG5P-54960233-54959268

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.072) question?

Stock #

R7051 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

58795207-58800268 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 58797175 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 224 (T224A)

Ref Sequence

ENSEMBL: ENSMUSP00000145946 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049940] [ENSMUST00000206205]

Predicted Effect

probably benign
Transcript: ENSMUST00000049940
AA Change: T224A

PolyPhen 2 Score 0.213 (Sensitivity: 0.92; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000052798
Gene: ENSMUSG00000049362
AA Change: T224A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	5.7e-52	PFAM
Pfam:7tm_1	41	290	9.7e-19	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000206205
AA Change: T224A

PolyPhen 2 Score 0.213 (Sensitivity: 0.92; Specificity: 0.88)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

95% (80/84)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 81 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5930422O12Rik	C	T	8: 33,429,173	S7L	unknown	Het
Aggf1	T	C	13: 95,351,617	K674R	possibly damaging	Het
Ampd1	T	C	3: 103,090,073	F264L	probably damaging	Het
Ankle1	A	T	8: 71,407,743	S302C	probably damaging	Het
Ankrd17	G	A	5: 90,366,451		probably benign	Het
Arhgap18	T	A	10: 26,849,921	N47K	possibly damaging	Het
Atp5f1	T	C	3: 105,943,767	N205D	probably benign	Het
Atp8b3	C	T	10: 80,520,024	E1285K	probably benign	Het
Atp8b3	C	A	10: 80,529,718	V401L	probably damaging	Het
Cacna1a	G	A	8: 84,629,915	R1929Q	possibly damaging	Het
Cadm2	C	T	16: 66,882,879	S22N	possibly damaging	Het
Ccdc177	C	T	12: 80,759,153	V116M	probably damaging	Het
Cdkl2	A	T	5: 92,033,225	I185N	probably damaging	Het
Cfhr2	T	A	1: 139,810,978	I282L	probably benign	Het
Clns1a	T	A	7: 97,712,617		probably null	Het
Commd2	A	T	3: 57,646,686	I198N	probably damaging	Het
Creb3l2	C	T	6: 37,336,265	V365I	possibly damaging	Het
Dcaf6	A	T	1: 165,424,317	N79K	possibly damaging	Het
Dlg5	T	C	14: 24,146,195	N1622D	possibly damaging	Het
Dock7	C	T	4: 98,946,732	R1802H	probably damaging	Het
Dpy19l2	T	C	9: 24,584,493	K643R	probably benign	Het
Dscam	G	A	16: 96,819,786	T574M	probably benign	Het
Fam209	A	G	2: 172,474,049	T115A	probably damaging	Het
Fastkd5	C	T	2: 130,614,417	C751Y	probably damaging	Het
Fat3	C	A	9: 16,377,827	L133F	probably damaging	Het
Frmd6	T	C	12: 70,897,396	V516A	possibly damaging	Het
Fry	G	A	5: 150,395,169	D955N	possibly damaging	Het
Fuk	A	T	8: 110,890,339	I393N	probably damaging	Het
Gm281	A	G	14: 13,828,486	V758A		Het
Gm340	A	G	19: 41,585,752	D982G	probably benign	Het
Gm7298	T	C	6: 121,775,034		probably null	Het
Golga7b	T	A	19: 42,268,460	*168R	probably null	Het
Golim4	T	A	3: 75,893,002	Q395L	probably benign	Het
Gxylt2	T	A	6: 100,804,576	L404*	probably null	Het
Hist1h1e	A	G	13: 23,622,439	V20A	probably benign	Het
Ighmbp2	G	T	19: 3,261,462	S984R	probably damaging	Het
Irf8	C	T	8: 120,739,842	R9W	probably damaging	Het
Itga4	T	C	2: 79,318,126	V788A	possibly damaging	Het
Kifap3	G	A	1: 163,794,080	R99H	probably damaging	Het
Kiss1r	T	C	10: 79,918,854	S61P	probably damaging	Het
Krtap6-1	A	T	16: 89,031,718	M1L	unknown	Het
Large2	A	T	2: 92,367,022	M411K	probably damaging	Het
Lingo1	A	G	9: 56,620,183	V374A	probably benign	Het
Lrch1	A	G	14: 74,785,522	V637A	probably damaging	Het
Lyar	T	C	5: 38,224,680	V2A	probably damaging	Het
Nell1	C	T	7: 50,448,844	S298L	unknown	Het
Ogfod3	T	A	11: 121,195,205	I188F	probably damaging	Het
Olfr1487	T	A	19: 13,619,405	M81K	possibly damaging	Het
Opa3	C	A	7: 19,245,036	A142E	possibly damaging	Het
Pald1	T	C	10: 61,323,346	R769G	probably benign	Het
Pappa2	T	A	1: 158,957,183	T86S	unknown	Het
Papss1	T	C	3: 131,602,050	Y266H	probably damaging	Het
Pcdhga7	C	A	18: 37,716,941	A667D	probably damaging	Het
Pcsk5	T	A	19: 17,433,731	T1766S	probably benign	Het
Pds5b	T	A	5: 150,794,282	N1129K	possibly damaging	Het
Pop7	T	C	5: 137,501,690	N127S	probably damaging	Het
Ppfibp2	A	G	7: 107,717,718	E300G	probably damaging	Het
Ppp4r3b	A	G	11: 29,182,507	K87E	probably damaging	Het
Psmd3	T	A	11: 98,682,833	M35K	possibly damaging	Het
Pus7	A	G	5: 23,775,679	V191A	probably damaging	Het
Rptor	C	T	11: 119,874,186		probably benign	Het
Sacs	A	G	14: 61,208,928	M2808V	probably benign	Het
Scube3	G	A	17: 28,167,599	V831I	probably benign	Het
Sin3a	A	T	9: 57,103,934	N492Y	probably damaging	Het
Slc12a3	A	G	8: 94,365,944	T998A	probably damaging	Het
Slc4a1	T	C	11: 102,356,258	N501S	probably benign	Het
Sltm	G	A	9: 70,559,066	G94R	probably damaging	Het
Smc4	T	A	3: 69,027,502	W650R	probably damaging	Het
Smg7	A	G	1: 152,848,850	S527P	probably damaging	Het
Tcf20	T	C	15: 82,856,078	N391D	probably damaging	Het
Tiam2	G	A	17: 3,448,483	V845M	probably damaging	Het
Tln2	A	G	9: 67,346,417	F793L	probably benign	Het
Uckl1	T	C	2: 181,574,244	I193V	probably damaging	Het
Ugt1a5	A	G	1: 88,166,355	M102V	probably benign	Het
Usp38	G	A	8: 81,001,121	P328S	possibly damaging	Het
Vmn1r189	A	G	13: 22,102,115	V184A	possibly damaging	Het
Vps13d	C	A	4: 145,163,344	A597S	probably benign	Het
Wdr47	T	A	3: 108,618,524	L121Q	probably damaging	Het
Wiz	A	G	17: 32,361,533	S315P	probably damaging	Het
Zc3h13	T	C	14: 75,331,157	S1297P	probably damaging	Het
Zfp27	AATCCGCTTGTGCA	AA	7: 29,895,021		probably benign	Het

Other mutations in Olfr173

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02649:Olfr173	APN	16	58797350	missense	probably damaging	1.00
IGL02728:Olfr173	APN	16	58797480	missense	probably benign	0.07
IGL02893:Olfr173	APN	16	58797657	missense	probably damaging	1.00
R0035:Olfr173	UTSW	16	58797122	nonsense	probably null
R0480:Olfr173	UTSW	16	58797321	missense	probably benign	0.05
R1101:Olfr173	UTSW	16	58797252	missense	probably benign	0.27
R1434:Olfr173	UTSW	16	58797448	missense	probably benign	0.06
R1992:Olfr173	UTSW	16	58796946	missense	probably benign
R2220:Olfr173	UTSW	16	58797624	missense	possibly damaging	0.69
R2436:Olfr173	UTSW	16	58797244	missense	probably benign	0.00
R4212:Olfr173	UTSW	16	58797369	missense	possibly damaging	0.67
R4910:Olfr173	UTSW	16	58797442	missense	probably benign	0.03
R5666:Olfr173	UTSW	16	58797061	missense	possibly damaging	0.75
R5670:Olfr173	UTSW	16	58797061	missense	possibly damaging	0.75
R5896:Olfr173	UTSW	16	58797732	missense	probably damaging	1.00
R6182:Olfr173	UTSW	16	58797292	missense	probably damaging	1.00
R6613:Olfr173	UTSW	16	58797531	missense	probably damaging	0.99
R6723:Olfr173	UTSW	16	58797432	missense	probably benign	0.06
R7141:Olfr173	UTSW	16	58797408	missense	probably benign	0.05
R7179:Olfr173	UTSW	16	58796887	missense	probably benign	0.00
R7602:Olfr173	UTSW	16	58796980	missense	possibly damaging	0.62
R8425:Olfr173	UTSW	16	58797603	missense	probably benign	0.11
Z1176:Olfr173	UTSW	16	58797423	missense	probably damaging	1.00
Z1176:Olfr173	UTSW	16	58797673	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- CACTCTGCCTCTTAAGAAAGCC -3'
(R):5'- GCATTCTGTGGGTCTAATCAAATC -3'

Sequencing Primer
(F):5'- CTGCCTCTTAAGAAAGCCTTATGGAC -3'
(R):5'- TCTGTGGGTCTAATCAAATCAACCAC -3'

Posted On

2019-05-13