Incidental Mutation 'R7051:Lcor'
ID 547631
Institutional Source Beutler Lab
Gene Symbol Lcor
Ensembl Gene ENSMUSG00000025019
Gene Name ligand dependent nuclear receptor corepressor
Synonyms LOC381224, A630025C20Rik, Gm340, 3110023F06Rik, Mlr2
MMRRC Submission 045148-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.560) question?
Stock # R7051 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 41471076-41574975 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 41574191 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 982 (D982G)
Ref Sequence ENSEMBL: ENSMUSP00000128083 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172371]
AlphaFold Q6ZPI3
Predicted Effect probably benign
Transcript: ENSMUST00000172371
AA Change: D982G

PolyPhen 2 Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000128083
Gene: ENSMUSG00000090673
AA Change: D982G

DomainStartEndE-ValueType
low complexity region 10 17 N/A INTRINSIC
low complexity region 438 450 N/A INTRINSIC
low complexity region 710 724 N/A INTRINSIC
low complexity region 768 779 N/A INTRINSIC
Pfam:DUF4553 787 1241 9.7e-179 PFAM
Meta Mutation Damage Score 0.0619 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 95% (80/84)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 81 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5930422O12Rik C T 8: 33,919,201 (GRCm39) S7L unknown Het
Aggf1 T C 13: 95,488,125 (GRCm39) K674R possibly damaging Het
Ampd1 T C 3: 102,997,389 (GRCm39) F264L probably damaging Het
Ankle1 A T 8: 71,860,387 (GRCm39) S302C probably damaging Het
Ankrd17 G A 5: 90,514,310 (GRCm39) probably benign Het
Arhgap18 T A 10: 26,725,917 (GRCm39) N47K possibly damaging Het
Atp5pb T C 3: 105,851,083 (GRCm39) N205D probably benign Het
Atp8b3 C T 10: 80,355,858 (GRCm39) E1285K probably benign Het
Atp8b3 C A 10: 80,365,552 (GRCm39) V401L probably damaging Het
Cacna1a G A 8: 85,356,544 (GRCm39) R1929Q possibly damaging Het
Cadm2 C T 16: 66,679,767 (GRCm39) S22N possibly damaging Het
Ccdc177 C T 12: 80,805,927 (GRCm39) V116M probably damaging Het
Cdhr18 A G 14: 13,828,486 (GRCm38) V758A Het
Cdkl2 A T 5: 92,181,084 (GRCm39) I185N probably damaging Het
Cfhr2 T A 1: 139,738,716 (GRCm39) I282L probably benign Het
Clns1a T A 7: 97,361,824 (GRCm39) probably null Het
Commd2 A T 3: 57,554,107 (GRCm39) I198N probably damaging Het
Creb3l2 C T 6: 37,313,200 (GRCm39) V365I possibly damaging Het
Dcaf6 A T 1: 165,251,886 (GRCm39) N79K possibly damaging Het
Dlg5 T C 14: 24,196,263 (GRCm39) N1622D possibly damaging Het
Dock7 C T 4: 98,834,969 (GRCm39) R1802H probably damaging Het
Dpy19l2 T C 9: 24,495,789 (GRCm39) K643R probably benign Het
Dscam G A 16: 96,620,986 (GRCm39) T574M probably benign Het
Fam209 A G 2: 172,315,969 (GRCm39) T115A probably damaging Het
Fastkd5 C T 2: 130,456,337 (GRCm39) C751Y probably damaging Het
Fat3 C A 9: 16,289,123 (GRCm39) L133F probably damaging Het
Fcsk A T 8: 111,616,971 (GRCm39) I393N probably damaging Het
Frmd6 T C 12: 70,944,170 (GRCm39) V516A possibly damaging Het
Fry G A 5: 150,318,634 (GRCm39) D955N possibly damaging Het
Gm7298 T C 6: 121,751,993 (GRCm39) probably null Het
Golga7b T A 19: 42,256,899 (GRCm39) *168R probably null Het
Golim4 T A 3: 75,800,309 (GRCm39) Q395L probably benign Het
Gxylt2 T A 6: 100,781,537 (GRCm39) L404* probably null Het
H1f4 A G 13: 23,806,422 (GRCm39) V20A probably benign Het
Ighmbp2 G T 19: 3,311,462 (GRCm39) S984R probably damaging Het
Irf8 C T 8: 121,466,581 (GRCm39) R9W probably damaging Het
Itga4 T C 2: 79,148,470 (GRCm39) V788A possibly damaging Het
Kifap3 G A 1: 163,621,649 (GRCm39) R99H probably damaging Het
Kiss1r T C 10: 79,754,688 (GRCm39) S61P probably damaging Het
Krtap6-1 A T 16: 88,828,606 (GRCm39) M1L unknown Het
Large2 A T 2: 92,197,367 (GRCm39) M411K probably damaging Het
Lingo1 A G 9: 56,527,467 (GRCm39) V374A probably benign Het
Lrch1 A G 14: 75,022,962 (GRCm39) V637A probably damaging Het
Lyar T C 5: 38,382,024 (GRCm39) V2A probably damaging Het
Nell1 C T 7: 50,098,592 (GRCm39) S298L unknown Het
Ogfod3 T A 11: 121,086,031 (GRCm39) I188F probably damaging Het
Opa3 C A 7: 18,978,961 (GRCm39) A142E possibly damaging Het
Or5b123 T A 19: 13,596,769 (GRCm39) M81K possibly damaging Het
Or5k1 T C 16: 58,617,538 (GRCm39) T224A probably benign Het
Pald1 T C 10: 61,159,125 (GRCm39) R769G probably benign Het
Pappa2 T A 1: 158,784,753 (GRCm39) T86S unknown Het
Papss1 T C 3: 131,307,811 (GRCm39) Y266H probably damaging Het
Pcdhga7 C A 18: 37,849,994 (GRCm39) A667D probably damaging Het
Pcsk5 T A 19: 17,411,095 (GRCm39) T1766S probably benign Het
Pds5b T A 5: 150,717,747 (GRCm39) N1129K possibly damaging Het
Pop7 T C 5: 137,499,952 (GRCm39) N127S probably damaging Het
Ppfibp2 A G 7: 107,316,925 (GRCm39) E300G probably damaging Het
Ppp4r3b A G 11: 29,132,507 (GRCm39) K87E probably damaging Het
Psmd3 T A 11: 98,573,659 (GRCm39) M35K possibly damaging Het
Pus7 A G 5: 23,980,677 (GRCm39) V191A probably damaging Het
Rptor C T 11: 119,765,012 (GRCm39) probably benign Het
Sacs A G 14: 61,446,377 (GRCm39) M2808V probably benign Het
Scube3 G A 17: 28,386,573 (GRCm39) V831I probably benign Het
Sin3a A T 9: 57,011,218 (GRCm39) N492Y probably damaging Het
Slc12a3 A G 8: 95,092,572 (GRCm39) T998A probably damaging Het
Slc4a1 T C 11: 102,247,084 (GRCm39) N501S probably benign Het
Sltm G A 9: 70,466,348 (GRCm39) G94R probably damaging Het
Smc4 T A 3: 68,934,835 (GRCm39) W650R probably damaging Het
Smg7 A G 1: 152,724,601 (GRCm39) S527P probably damaging Het
Tcf20 T C 15: 82,740,279 (GRCm39) N391D probably damaging Het
Tiam2 G A 17: 3,498,758 (GRCm39) V845M probably damaging Het
Tln2 A G 9: 67,253,699 (GRCm39) F793L probably benign Het
Uckl1 T C 2: 181,216,037 (GRCm39) I193V probably damaging Het
Ugt1a5 A G 1: 88,094,077 (GRCm39) M102V probably benign Het
Usp38 G A 8: 81,727,750 (GRCm39) P328S possibly damaging Het
Vmn1r189 A G 13: 22,286,285 (GRCm39) V184A possibly damaging Het
Vps13d C A 4: 144,889,914 (GRCm39) A597S probably benign Het
Wdr47 T A 3: 108,525,840 (GRCm39) L121Q probably damaging Het
Wiz A G 17: 32,580,507 (GRCm39) S315P probably damaging Het
Zc3h13 T C 14: 75,568,597 (GRCm39) S1297P probably damaging Het
Zfp27 AATCCGCTTGTGCA AA 7: 29,594,446 (GRCm39) probably benign Het
Other mutations in Lcor
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00737:Lcor APN 19 41,541,139 (GRCm39) missense probably damaging 0.97
IGL02079:Lcor APN 19 41,544,126 (GRCm39) missense probably benign 0.40
IGL02100:Lcor APN 19 41,547,193 (GRCm39) missense possibly damaging 0.93
IGL02444:Lcor APN 19 41,547,450 (GRCm39) missense probably damaging 0.99
IGL02578:Lcor APN 19 41,547,589 (GRCm39) missense probably damaging 1.00
IGL03072:Lcor APN 19 41,547,253 (GRCm39) missense possibly damaging 0.85
IGL03118:Lcor APN 19 41,546,808 (GRCm39) missense probably damaging 0.99
IGL03153:Lcor APN 19 41,546,795 (GRCm39) missense probably damaging 0.98
BB003:Lcor UTSW 19 41,571,008 (GRCm39) missense probably benign
BB013:Lcor UTSW 19 41,571,008 (GRCm39) missense probably benign
R0006:Lcor UTSW 19 41,573,338 (GRCm39) missense probably benign 0.00
R0686:Lcor UTSW 19 41,570,811 (GRCm39) missense possibly damaging 0.73
R1104:Lcor UTSW 19 41,574,502 (GRCm39) missense probably damaging 0.99
R1278:Lcor UTSW 19 41,573,122 (GRCm39) missense probably benign 0.07
R1606:Lcor UTSW 19 41,573,513 (GRCm39) missense probably benign 0.35
R1756:Lcor UTSW 19 41,547,705 (GRCm39) missense probably benign
R1833:Lcor UTSW 19 41,573,387 (GRCm39) missense probably benign 0.00
R1889:Lcor UTSW 19 41,547,567 (GRCm39) missense probably damaging 0.99
R1905:Lcor UTSW 19 41,572,013 (GRCm39) missense possibly damaging 0.73
R1913:Lcor UTSW 19 41,546,913 (GRCm39) missense probably benign 0.40
R1983:Lcor UTSW 19 41,546,806 (GRCm39) missense probably damaging 0.98
R2697:Lcor UTSW 19 41,572,466 (GRCm39) missense probably benign 0.43
R2881:Lcor UTSW 19 41,571,488 (GRCm39) missense probably damaging 1.00
R3885:Lcor UTSW 19 41,546,795 (GRCm39) missense probably damaging 0.98
R3886:Lcor UTSW 19 41,546,795 (GRCm39) missense probably damaging 0.98
R3888:Lcor UTSW 19 41,546,795 (GRCm39) missense probably damaging 0.98
R3889:Lcor UTSW 19 41,546,795 (GRCm39) missense probably damaging 0.98
R4720:Lcor UTSW 19 41,574,334 (GRCm39) missense probably benign 0.04
R4864:Lcor UTSW 19 41,573,803 (GRCm39) missense probably benign
R4908:Lcor UTSW 19 41,572,601 (GRCm39) missense probably benign 0.00
R5160:Lcor UTSW 19 41,544,053 (GRCm39) missense probably damaging 0.99
R5193:Lcor UTSW 19 41,570,969 (GRCm39) missense probably damaging 1.00
R5215:Lcor UTSW 19 41,574,371 (GRCm39) missense probably damaging 1.00
R5276:Lcor UTSW 19 41,573,478 (GRCm39) missense probably damaging 0.98
R5319:Lcor UTSW 19 41,574,791 (GRCm39) missense probably damaging 0.99
R5321:Lcor UTSW 19 41,573,643 (GRCm39) missense probably damaging 1.00
R5432:Lcor UTSW 19 41,573,042 (GRCm39) missense probably damaging 1.00
R5605:Lcor UTSW 19 41,571,302 (GRCm39) missense probably damaging 1.00
R5941:Lcor UTSW 19 41,574,839 (GRCm39) missense probably damaging 1.00
R6020:Lcor UTSW 19 41,571,986 (GRCm39) missense possibly damaging 0.88
R6024:Lcor UTSW 19 41,572,396 (GRCm39) missense possibly damaging 0.84
R6112:Lcor UTSW 19 41,547,520 (GRCm39) missense possibly damaging 0.92
R6149:Lcor UTSW 19 41,573,641 (GRCm39) missense probably damaging 1.00
R6260:Lcor UTSW 19 41,570,810 (GRCm39) missense possibly damaging 0.73
R6260:Lcor UTSW 19 41,570,809 (GRCm39) missense probably null 0.91
R6476:Lcor UTSW 19 41,571,518 (GRCm39) missense probably benign 0.04
R7285:Lcor UTSW 19 41,572,754 (GRCm39) missense possibly damaging 0.91
R7372:Lcor UTSW 19 41,573,945 (GRCm39) missense probably damaging 1.00
R7762:Lcor UTSW 19 41,572,106 (GRCm39) missense probably benign 0.02
R7777:Lcor UTSW 19 41,547,234 (GRCm39) missense probably benign 0.33
R7833:Lcor UTSW 19 41,573,024 (GRCm39) missense probably benign 0.02
R7926:Lcor UTSW 19 41,571,008 (GRCm39) missense probably benign
R8164:Lcor UTSW 19 41,573,849 (GRCm39) missense probably damaging 1.00
R8319:Lcor UTSW 19 41,571,343 (GRCm39) missense probably damaging 1.00
R8323:Lcor UTSW 19 41,572,036 (GRCm39) missense probably benign 0.01
R8327:Lcor UTSW 19 41,570,996 (GRCm39) missense probably damaging 1.00
R8423:Lcor UTSW 19 41,573,888 (GRCm39) missense possibly damaging 0.95
R8556:Lcor UTSW 19 41,546,863 (GRCm39) frame shift probably null
R8780:Lcor UTSW 19 41,573,698 (GRCm39) missense probably damaging 1.00
R8781:Lcor UTSW 19 41,573,698 (GRCm39) missense probably damaging 1.00
R8788:Lcor UTSW 19 41,573,698 (GRCm39) missense probably damaging 1.00
R8798:Lcor UTSW 19 41,573,698 (GRCm39) missense probably damaging 1.00
R9013:Lcor UTSW 19 41,573,189 (GRCm39) missense probably damaging 1.00
R9035:Lcor UTSW 19 41,573,399 (GRCm39) missense probably benign 0.00
R9065:Lcor UTSW 19 41,573,698 (GRCm39) missense probably damaging 1.00
R9067:Lcor UTSW 19 41,573,698 (GRCm39) missense probably damaging 1.00
R9083:Lcor UTSW 19 41,574,839 (GRCm39) missense probably damaging 0.99
R9105:Lcor UTSW 19 41,573,311 (GRCm39) missense possibly damaging 0.88
R9487:Lcor UTSW 19 41,573,685 (GRCm39) missense probably damaging 1.00
R9573:Lcor UTSW 19 41,573,471 (GRCm39) missense probably damaging 1.00
R9704:Lcor UTSW 19 41,572,498 (GRCm39) missense possibly damaging 0.61
X0013:Lcor UTSW 19 41,572,971 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- AACACCCTCTTCAGAAGTTTCC -3'
(R):5'- GACATGAGCGGGTTAATGCAC -3'

Sequencing Primer
(F):5'- ACCATGTACCCTAGTTCACTACAGG -3'
(R):5'- CGGGTTAATGCACACGCTCTTG -3'
Posted On 2019-05-13