Incidental Mutation 'R7053:Or5m11b'
ID 547695
Institutional Source Beutler Lab
Gene Symbol Or5m11b
Ensembl Gene ENSMUSG00000059873
Gene Name olfactory receptor family 5 subfamily M member 11B
Synonyms GA_x6K02T2Q125-47454152-47455126, Olfr1029, MOR198-1P
MMRRC Submission 045150-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R7053 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 85805557-85806617 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 85806358 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Phenylalanine at position 257 (C257F)
Ref Sequence ENSEMBL: ENSMUSP00000150637 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056849] [ENSMUST00000082191] [ENSMUST00000217244]
AlphaFold A2ATE0
Predicted Effect probably benign
Transcript: ENSMUST00000056849
SMART Domains Protein: ENSMUSP00000053309
Gene: ENSMUSG00000044923

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 2.4e-58 PFAM
Pfam:7tm_1 47 296 3.2e-27 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000082191
AA Change: C257F

PolyPhen 2 Score 0.641 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000080828
Gene: ENSMUSG00000059873
AA Change: C257F

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.2e-56 PFAM
Pfam:7tm_1 41 290 2.1e-25 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000217244
AA Change: C257F

PolyPhen 2 Score 0.641 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam26a A T 8: 44,021,836 (GRCm39) C551* probably null Het
Aldh1l1 C A 6: 90,540,420 (GRCm39) T235K possibly damaging Het
Atp6v0a2 A G 5: 124,783,923 (GRCm39) E257G probably damaging Het
AW146154 A G 7: 41,131,988 (GRCm39) probably null Het
BC048507 T C 13: 68,011,772 (GRCm39) Y50H probably benign Het
Brip1 T C 11: 86,083,791 (GRCm39) N77D possibly damaging Het
Ccdc13 T C 9: 121,662,904 (GRCm39) E37G probably damaging Het
Ccn6 A G 10: 39,034,297 (GRCm39) Y102H probably damaging Het
Col27a1 T A 4: 63,251,404 (GRCm39) probably benign Het
Corin T A 5: 72,458,870 (GRCm39) I960L probably benign Het
Csnk2b A G 17: 35,335,422 (GRCm39) probably benign Het
Cyp2d26 T C 15: 82,676,801 (GRCm39) S182G probably benign Het
Dennd1a A G 2: 37,851,666 (GRCm39) L74P probably damaging Het
Dip2c A G 13: 9,660,740 (GRCm39) D838G probably damaging Het
Dkkl1 G T 7: 44,857,022 (GRCm39) Q182K probably damaging Het
Dnai2 T C 11: 114,629,521 (GRCm39) S183P probably damaging Het
Dnhd1 T C 7: 105,344,161 (GRCm39) L1835P probably damaging Het
Espl1 T C 15: 102,225,328 (GRCm39) probably null Het
Fam174a C T 1: 95,252,953 (GRCm39) A185V probably damaging Het
Fhip1b C T 7: 105,033,779 (GRCm39) G479D probably damaging Het
Gm40460 CACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG CACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG 7: 141,794,554 (GRCm39) probably benign Het
Grid2 G T 6: 64,677,402 (GRCm39) A74S unknown Het
Gsdma3 T A 11: 98,520,621 (GRCm39) M84K possibly damaging Het
Hlcs A T 16: 94,068,874 (GRCm39) S262R possibly damaging Het
Lrp1 A G 10: 127,376,963 (GRCm39) C4205R probably damaging Het
Mdc1 C T 17: 36,157,218 (GRCm39) A181V probably benign Het
Mdga2 T A 12: 66,736,158 (GRCm39) I357F probably benign Het
Mfn1 A G 3: 32,586,114 (GRCm39) I21V probably benign Het
Mgat4b C T 11: 50,124,367 (GRCm39) T409M probably damaging Het
Mgat4d G T 8: 84,098,261 (GRCm39) K341N probably damaging Het
Mpo A T 11: 87,694,336 (GRCm39) N109Y probably damaging Het
Mvp T C 7: 126,586,776 (GRCm39) Q785R possibly damaging Het
Nim1k A G 13: 120,189,145 (GRCm39) V88A probably damaging Het
Oasl2 A T 5: 115,049,291 (GRCm39) I464L possibly damaging Het
Pkd1l2 A G 8: 117,740,681 (GRCm39) F2139L probably damaging Het
Pop1 T G 15: 34,530,421 (GRCm39) S940A probably benign Het
Ppp1r9a T A 6: 4,905,670 (GRCm39) M75K probably damaging Het
Prdm15 G A 16: 97,595,742 (GRCm39) Q1029* probably null Het
Rffl T C 11: 82,703,497 (GRCm39) K142R probably null Het
Rhou A G 8: 124,380,934 (GRCm39) probably benign Het
Rp1l1 A T 14: 64,268,958 (GRCm39) T1515S possibly damaging Het
Serpina1b T A 12: 103,698,688 (GRCm39) S54C possibly damaging Het
Slc30a2 G A 4: 134,074,726 (GRCm39) R161Q probably damaging Het
Taok3 T A 5: 117,390,627 (GRCm39) D529E probably benign Het
Tmem18 T A 12: 30,634,506 (GRCm39) M1K probably null Het
Tmem269 T A 4: 119,066,464 (GRCm39) H198L probably damaging Het
Tnrc18 A G 5: 142,772,984 (GRCm39) V432A unknown Het
Ttc6 A T 12: 57,707,318 (GRCm39) T742S probably benign Het
Uhrf2 T A 19: 30,069,519 (GRCm39) C749S probably damaging Het
Unc13c G A 9: 73,839,579 (GRCm39) T424I probably damaging Het
Vmn2r111 T C 17: 22,778,032 (GRCm39) N549S possibly damaging Het
Vmn2r61 A C 7: 41,916,557 (GRCm39) D390A probably damaging Het
Xpo7 A G 14: 70,922,298 (GRCm39) probably null Het
Zfp948 T A 17: 21,805,121 (GRCm39) L37* probably null Het
Other mutations in Or5m11b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02020:Or5m11b APN 2 85,805,579 (GRCm39) utr 5 prime probably benign
IGL02126:Or5m11b APN 2 85,806,517 (GRCm39) missense probably benign 0.00
IGL02584:Or5m11b APN 2 85,806,219 (GRCm39) missense probably damaging 0.96
IGL03410:Or5m11b APN 2 85,805,764 (GRCm39) missense probably damaging 0.99
R1466:Or5m11b UTSW 2 85,806,339 (GRCm39) missense probably damaging 1.00
R1466:Or5m11b UTSW 2 85,806,339 (GRCm39) missense probably damaging 1.00
R1499:Or5m11b UTSW 2 85,806,372 (GRCm39) missense possibly damaging 0.62
R1584:Or5m11b UTSW 2 85,806,339 (GRCm39) missense probably damaging 1.00
R2925:Or5m11b UTSW 2 85,806,125 (GRCm39) nonsense probably null
R2970:Or5m11b UTSW 2 85,806,454 (GRCm39) missense possibly damaging 0.75
R4571:Or5m11b UTSW 2 85,806,175 (GRCm39) missense probably damaging 0.97
R5533:Or5m11b UTSW 2 85,805,797 (GRCm39) missense possibly damaging 0.78
R5654:Or5m11b UTSW 2 85,806,500 (GRCm39) missense probably benign 0.00
R5827:Or5m11b UTSW 2 85,805,650 (GRCm39) missense probably benign 0.00
R5967:Or5m11b UTSW 2 85,806,535 (GRCm39) missense probably benign 0.01
R6291:Or5m11b UTSW 2 85,805,926 (GRCm39) missense probably damaging 1.00
R6735:Or5m11b UTSW 2 85,805,778 (GRCm39) missense possibly damaging 0.81
R6897:Or5m11b UTSW 2 85,805,700 (GRCm39) missense possibly damaging 0.45
R7163:Or5m11b UTSW 2 85,805,932 (GRCm39) missense probably damaging 1.00
R7358:Or5m11b UTSW 2 85,805,780 (GRCm39) missense possibly damaging 0.81
R8047:Or5m11b UTSW 2 85,806,271 (GRCm39) missense possibly damaging 0.52
R8271:Or5m11b UTSW 2 85,806,085 (GRCm39) missense probably benign 0.40
R8271:Or5m11b UTSW 2 85,805,766 (GRCm39) missense probably damaging 1.00
R8364:Or5m11b UTSW 2 85,806,358 (GRCm39) missense possibly damaging 0.64
R9100:Or5m11b UTSW 2 85,806,096 (GRCm39) missense probably benign 0.00
R9190:Or5m11b UTSW 2 85,805,884 (GRCm39) missense possibly damaging 0.66
R9646:Or5m11b UTSW 2 85,806,446 (GRCm39) missense probably benign 0.18
Predicted Primers PCR Primer
(F):5'- ACCCACCACTTATTAAGCTATCTTG -3'
(R):5'- TGTTGGAAGGTGGACGCATC -3'

Sequencing Primer
(F):5'- CATGCCATGTTAATATCAGCTGG -3'
(R):5'- CATCAATGCTGTCCTGATGAC -3'
Posted On 2019-05-13