|Institutional Source||Beutler Lab|
|Gene Name||ras homolog family member U|
|Synonyms||2310026M05Rik, WRCH-1, mG28K, CDC42L1, WRCH1, Arhu|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R7053 (G1)|
|Chromosomal Location||123653929-123663884 bp(+) (GRCm38)|
|Type of Mutation||intron|
|DNA Base Change (assembly)||A to G at 123654195 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000118564 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000045487] [ENSMUST00000127664]|
AA Change: T84A
|Predicted Effect||probably benign
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.[provided by RefSeq, Mar 2011]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Rhou||
(F):5'- CTGTGGTCTCGGATAGAAGAAG -3'
(R):5'- AAGGAACGTTCTCGCAAGCC -3'
(F):5'- TGTCGCAGGGAAGCCTG -3'
(R):5'- TTGCTCCAGGCGAAGATC -3'