Incidental Mutation 'R7056:Zswim2'
ID 547899
Institutional Source Beutler Lab
Gene Symbol Zswim2
Ensembl Gene ENSMUSG00000034552
Gene Name zinc finger SWIM-type containing 2
Synonyms 4933437F18Rik, MEX, 1700025P14Rik
MMRRC Submission 045153-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R7056 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 83745423-83771572 bp(-) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) C to T at 83751092 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000119439 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038223] [ENSMUST00000152829]
AlphaFold Q9D9X6
Predicted Effect probably null
Transcript: ENSMUST00000038223
SMART Domains Protein: ENSMUSP00000044913
Gene: ENSMUSG00000034552

DomainStartEndE-ValueType
Pfam:SWIM 54 87 1.4e-7 PFAM
RING 147 198 8.3e-5 SMART
ZnF_ZZ 229 273 1.8e-5 SMART
RING 344 385 1.3e-7 SMART
Predicted Effect probably null
Transcript: ENSMUST00000152829
SMART Domains Protein: ENSMUSP00000119439
Gene: ENSMUSG00000034552

DomainStartEndE-ValueType
Pfam:SWIM 54 87 1.6e-10 PFAM
RING 147 198 1.69e-2 SMART
ZnF_ZZ 229 273 3.65e-3 SMART
Blast:RING 344 365 3e-6 BLAST
Meta Mutation Damage Score 0.9483 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (62/62)
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atr T A 9: 95,744,916 (GRCm39) S78T probably damaging Het
B2m T C 2: 121,981,465 (GRCm39) L60P probably damaging Het
C1ra G A 6: 124,494,684 (GRCm39) E316K probably benign Het
Cep350 A C 1: 155,724,373 (GRCm39) I3075S probably damaging Het
Cep97 A G 16: 55,725,935 (GRCm39) S651P probably damaging Het
Chrna5 C T 9: 54,888,985 (GRCm39) probably benign Het
Cog5 T C 12: 31,715,468 (GRCm39) V80A possibly damaging Het
Col9a2 G A 4: 120,906,913 (GRCm39) probably null Het
Cop1 C T 1: 159,077,647 (GRCm39) L161F probably damaging Het
Cyp4f17 A T 17: 32,746,846 (GRCm39) M383L possibly damaging Het
Dennd4a A G 9: 64,814,205 (GRCm39) D1474G possibly damaging Het
Dgkb A C 12: 38,150,492 (GRCm39) S100R probably benign Het
Dnah17 A G 11: 118,016,212 (GRCm39) V309A probably benign Het
Dner C A 1: 84,558,457 (GRCm39) R169L possibly damaging Het
Dus1l T C 11: 120,682,120 (GRCm39) E362G probably benign Het
Eed A T 7: 89,619,564 (GRCm39) S168T possibly damaging Het
Eif3a T A 19: 60,751,500 (GRCm39) probably null Het
Fam234b A G 6: 135,205,450 (GRCm39) S472G probably benign Het
Fbn2 T A 18: 58,209,798 (GRCm39) T1028S probably benign Het
Fbxw16 A G 9: 109,265,352 (GRCm39) V393A possibly damaging Het
Fig4 A T 10: 41,096,928 (GRCm39) L838Q probably benign Het
Gm13941 T G 2: 110,927,147 (GRCm39) S137R unknown Het
Gm9938 T G 19: 23,701,981 (GRCm39) probably benign Het
Igsf10 T G 3: 59,238,501 (GRCm39) D560A probably damaging Het
Lrrk2 T A 15: 91,659,198 (GRCm39) L1870* probably null Het
Mep1b T A 18: 21,224,247 (GRCm39) Y347N probably damaging Het
Mepce T C 5: 137,780,968 (GRCm39) N613D probably damaging Het
Mgat3 T G 15: 80,096,097 (GRCm39) L308R probably damaging Het
Morc2a A G 11: 3,625,925 (GRCm39) Y175C probably damaging Het
Necab2 A G 8: 120,178,878 (GRCm39) N98S probably benign Het
Net1 T C 13: 3,934,845 (GRCm39) M394V probably benign Het
Nfat5 G A 8: 108,094,738 (GRCm39) G993D probably damaging Het
Obscn C A 11: 58,887,122 (GRCm39) probably benign Het
Olr1 T C 6: 129,465,904 (GRCm39) H34R probably damaging Het
Or2ab1 A G 11: 58,489,044 (GRCm39) Y274C probably damaging Het
Or4f60 T C 2: 111,902,662 (GRCm39) N89D probably benign Het
Pmm2 T A 16: 8,460,628 (GRCm39) F27L probably damaging Het
Ptpdc1 C A 13: 48,740,466 (GRCm39) V261F possibly damaging Het
Pyroxd1 G T 6: 142,304,808 (GRCm39) R345L probably benign Het
Radil A T 5: 142,480,109 (GRCm39) C670* probably null Het
Rasgrf2 C T 13: 92,167,203 (GRCm39) S290N probably damaging Het
Rbm33 T C 5: 28,599,001 (GRCm39) probably benign Het
Rnf111 A T 9: 70,360,957 (GRCm39) S501R possibly damaging Het
Sel1l2 T A 2: 140,087,334 (GRCm39) I446F probably benign Het
Sh3pxd2b T C 11: 32,372,737 (GRCm39) S635P probably benign Het
Slc30a2 G A 4: 134,074,726 (GRCm39) R161Q probably damaging Het
Smg1 T C 7: 117,745,623 (GRCm39) probably benign Het
Sorcs2 C A 5: 36,225,474 (GRCm39) D132Y probably damaging Het
Sox18 T C 2: 181,313,280 (GRCm39) D12G probably damaging Het
Srsf4 G T 4: 131,628,004 (GRCm39) probably benign Het
Susd4 C A 1: 182,660,721 (GRCm39) T81N probably benign Het
Tmem256 G T 11: 69,729,416 (GRCm39) probably benign Het
Tor4a T C 2: 25,084,853 (GRCm39) H350R probably benign Het
Ugt2a3 T A 5: 87,484,953 (GRCm39) S24C probably damaging Het
Vmn2r111 T C 17: 22,778,032 (GRCm39) N549S possibly damaging Het
Vmn2r77 C T 7: 86,451,023 (GRCm39) T303I probably benign Het
Wdr70 T A 15: 7,913,877 (GRCm39) I591F possibly damaging Het
Wdr93 T C 7: 79,399,088 (GRCm39) I74T probably damaging Het
Zfp292 A T 4: 34,809,784 (GRCm39) C1087S probably damaging Het
Zfp592 T A 7: 80,673,067 (GRCm39) D10E probably damaging Het
Zfp69 A G 4: 120,788,295 (GRCm39) V340A probably benign Het
Other mutations in Zswim2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00844:Zswim2 APN 2 83,754,115 (GRCm39) missense probably benign 0.00
IGL01140:Zswim2 APN 2 83,745,672 (GRCm39) missense probably benign 0.06
IGL01362:Zswim2 APN 2 83,745,690 (GRCm39) missense probably benign 0.09
IGL01768:Zswim2 APN 2 83,748,301 (GRCm39) missense probably benign 0.00
IGL02166:Zswim2 APN 2 83,745,750 (GRCm39) nonsense probably null
IGL02187:Zswim2 APN 2 83,753,982 (GRCm39) missense probably damaging 0.98
IGL02239:Zswim2 APN 2 83,769,107 (GRCm39) nonsense probably null
IGL02629:Zswim2 APN 2 83,755,553 (GRCm39) missense possibly damaging 0.94
R0609:Zswim2 UTSW 2 83,754,003 (GRCm39) missense probably benign 0.02
R0943:Zswim2 UTSW 2 83,748,342 (GRCm39) missense possibly damaging 0.88
R0946:Zswim2 UTSW 2 83,754,103 (GRCm39) missense probably benign 0.10
R1006:Zswim2 UTSW 2 83,745,737 (GRCm39) missense probably damaging 0.97
R1191:Zswim2 UTSW 2 83,754,039 (GRCm39) missense possibly damaging 0.60
R1309:Zswim2 UTSW 2 83,769,100 (GRCm39) missense probably damaging 1.00
R1549:Zswim2 UTSW 2 83,754,092 (GRCm39) missense probably benign 0.24
R1563:Zswim2 UTSW 2 83,745,626 (GRCm39) missense possibly damaging 0.71
R1739:Zswim2 UTSW 2 83,745,684 (GRCm39) nonsense probably null
R1994:Zswim2 UTSW 2 83,746,007 (GRCm39) missense possibly damaging 0.95
R4039:Zswim2 UTSW 2 83,746,338 (GRCm39) missense probably damaging 1.00
R4645:Zswim2 UTSW 2 83,745,891 (GRCm39) missense probably benign 0.00
R4738:Zswim2 UTSW 2 83,745,739 (GRCm39) missense probably benign 0.16
R4855:Zswim2 UTSW 2 83,747,187 (GRCm39) critical splice donor site probably null
R4933:Zswim2 UTSW 2 83,755,571 (GRCm39) missense probably damaging 1.00
R4963:Zswim2 UTSW 2 83,755,454 (GRCm39) missense probably damaging 1.00
R5153:Zswim2 UTSW 2 83,770,010 (GRCm39) missense possibly damaging 0.75
R5401:Zswim2 UTSW 2 83,755,589 (GRCm39) missense possibly damaging 0.94
R5698:Zswim2 UTSW 2 83,755,527 (GRCm39) missense possibly damaging 0.92
R6002:Zswim2 UTSW 2 83,746,032 (GRCm39) missense probably damaging 0.98
R6396:Zswim2 UTSW 2 83,754,062 (GRCm39) missense probably damaging 1.00
R6447:Zswim2 UTSW 2 83,745,457 (GRCm39) splice site probably null
R6646:Zswim2 UTSW 2 83,746,128 (GRCm39) nonsense probably null
R6717:Zswim2 UTSW 2 83,745,753 (GRCm39) missense probably benign 0.02
R6735:Zswim2 UTSW 2 83,754,105 (GRCm39) missense probably benign 0.04
R6830:Zswim2 UTSW 2 83,770,028 (GRCm39) missense probably damaging 1.00
R7088:Zswim2 UTSW 2 83,746,071 (GRCm39) nonsense probably null
R7383:Zswim2 UTSW 2 83,745,672 (GRCm39) missense possibly damaging 0.95
R7440:Zswim2 UTSW 2 83,751,063 (GRCm39) missense probably damaging 1.00
R7747:Zswim2 UTSW 2 83,745,951 (GRCm39) missense probably damaging 0.97
R7955:Zswim2 UTSW 2 83,747,227 (GRCm39) missense probably benign 0.00
R7983:Zswim2 UTSW 2 83,753,911 (GRCm39) critical splice donor site probably null
R8765:Zswim2 UTSW 2 83,771,431 (GRCm39) missense probably damaging 1.00
R9295:Zswim2 UTSW 2 83,748,304 (GRCm39) missense probably benign 0.00
R9465:Zswim2 UTSW 2 83,746,275 (GRCm39) missense probably benign 0.21
X0018:Zswim2 UTSW 2 83,771,438 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CAGAGTGTTCTGTACTTTTCATGC -3'
(R):5'- CTTCTAAACACTGTGGAAGAGAGACAG -3'

Sequencing Primer
(F):5'- CATGCTCTTAGATCTGCCGG -3'
(R):5'- GGACCCTCTGATAATCAATGGATGC -3'
Posted On 2019-05-13