Incidental Mutation 'R7061:Vmn2r16'
| ID |
548256 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r16
|
| Ensembl Gene |
ENSMUSG00000092080 |
| Gene Name |
vomeronasal 2, receptor 16 |
| Synonyms |
EG384220 |
| MMRRC Submission |
045384-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.170)
|
| Stock # |
R7061 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
109478247-109512347 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 109511620 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Phenylalanine
at position 609
(Y609F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127838
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165180]
|
| AlphaFold |
A0A3B2WCY4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000165180
AA Change: Y609F
PolyPhen 2
Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000127838
Gene: ENSMUSG00000092080
AA Change: Y609F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
76 |
425 |
2.3e-28 |
PFAM |
|
Pfam:NCD3G
|
509 |
563 |
8.2e-19 |
PFAM |
|
Pfam:7tm_3
|
596 |
831 |
3.5e-56 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
99% (68/69) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 66 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aard |
G |
A |
15: 51,903,617 (GRCm39) |
M13I |
probably benign |
Het |
| Abcb5 |
A |
C |
12: 118,841,509 (GRCm39) |
Y979D |
probably damaging |
Het |
| Adgrb1 |
G |
C |
15: 74,441,730 (GRCm39) |
V4L |
probably benign |
Het |
| Ap3b2 |
C |
T |
7: 81,110,757 (GRCm39) |
R1006Q |
unknown |
Het |
| Bpifa6 |
A |
T |
2: 153,834,236 (GRCm39) |
T343S |
probably benign |
Het |
| Celsr3 |
T |
A |
9: 108,724,793 (GRCm39) |
C2957* |
probably null |
Het |
| Chd6 |
G |
A |
2: 160,867,885 (GRCm39) |
Q428* |
probably null |
Het |
| Col5a1 |
C |
A |
2: 27,915,690 (GRCm39) |
C191* |
probably null |
Het |
| Cpox |
A |
G |
16: 58,491,223 (GRCm39) |
I145V |
possibly damaging |
Het |
| Csnk2a1 |
C |
T |
2: 152,116,091 (GRCm39) |
R268C |
probably benign |
Het |
| Dclk2 |
A |
G |
3: 86,739,038 (GRCm39) |
|
probably null |
Het |
| Dennd5a |
T |
C |
7: 109,504,386 (GRCm39) |
E909G |
probably benign |
Het |
| Depdc1a |
T |
A |
3: 159,228,489 (GRCm39) |
S414T |
possibly damaging |
Het |
| Dock5 |
A |
G |
14: 68,007,703 (GRCm39) |
F1502S |
probably damaging |
Het |
| Dop1b |
G |
T |
16: 93,558,951 (GRCm39) |
A448S |
probably benign |
Het |
| Dsg1c |
C |
A |
18: 20,410,066 (GRCm39) |
N511K |
probably benign |
Het |
| Epc2 |
G |
T |
2: 49,425,334 (GRCm39) |
R108L |
probably damaging |
Het |
| Erp44 |
T |
A |
4: 48,219,375 (GRCm39) |
I147F |
probably benign |
Het |
| Evc |
T |
C |
5: 37,476,446 (GRCm39) |
T368A |
possibly damaging |
Het |
| Fbxo41 |
G |
T |
6: 85,452,448 (GRCm39) |
R738S |
probably benign |
Het |
| Fli1 |
T |
C |
9: 32,335,518 (GRCm39) |
T305A |
probably damaging |
Het |
| Grk5 |
A |
G |
19: 61,034,530 (GRCm39) |
T93A |
probably benign |
Het |
| Grm2 |
A |
T |
9: 106,528,424 (GRCm39) |
N153K |
probably damaging |
Het |
| Helz |
A |
G |
11: 107,540,003 (GRCm39) |
T1007A |
possibly damaging |
Het |
| Helz2 |
A |
G |
2: 180,882,307 (GRCm39) |
L162P |
probably damaging |
Het |
| Hmgcr |
T |
A |
13: 96,802,656 (GRCm39) |
Q81L |
possibly damaging |
Het |
| Hnrnpu |
T |
C |
1: 178,163,691 (GRCm39) |
K218E |
unknown |
Het |
| Hydin |
A |
T |
8: 111,329,920 (GRCm39) |
I4885F |
possibly damaging |
Het |
| Ibsp |
A |
G |
5: 104,457,768 (GRCm39) |
|
probably null |
Het |
| Igfals |
T |
C |
17: 25,099,281 (GRCm39) |
L124P |
probably damaging |
Het |
| Il24 |
T |
A |
1: 130,811,108 (GRCm39) |
H142L |
possibly damaging |
Het |
| Iqca1l |
A |
G |
5: 24,750,063 (GRCm39) |
M660T |
probably benign |
Het |
| Kcnh2 |
A |
T |
5: 24,536,920 (GRCm39) |
H221Q |
probably benign |
Het |
| Man1a |
A |
G |
10: 53,796,331 (GRCm39) |
S454P |
probably damaging |
Het |
| Meiosin |
A |
T |
7: 18,834,053 (GRCm39) |
|
probably benign |
Het |
| Mfsd4b1 |
C |
T |
10: 39,879,382 (GRCm39) |
V172M |
possibly damaging |
Het |
| Mical2 |
T |
A |
7: 111,946,008 (GRCm39) |
I763K |
probably benign |
Het |
| Mybpc3 |
A |
G |
2: 90,955,749 (GRCm39) |
I594M |
possibly damaging |
Het |
| Neo1 |
T |
A |
9: 58,897,724 (GRCm39) |
R77S |
possibly damaging |
Het |
| Nlrp6 |
A |
G |
7: 140,502,780 (GRCm39) |
I265M |
probably benign |
Het |
| Or52n5 |
T |
C |
7: 104,587,883 (GRCm39) |
L50P |
probably damaging |
Het |
| Or5bw2 |
A |
G |
7: 6,573,782 (GRCm39) |
Y264C |
probably damaging |
Het |
| Or8b9 |
T |
A |
9: 37,766,942 (GRCm39) |
V276D |
possibly damaging |
Het |
| Pcdhgb5 |
C |
A |
18: 37,864,976 (GRCm39) |
P257Q |
probably benign |
Het |
| Phactr1 |
A |
G |
13: 43,286,457 (GRCm39) |
D586G |
probably damaging |
Het |
| Pkn3 |
T |
A |
2: 29,973,548 (GRCm39) |
|
probably null |
Het |
| Prob1 |
A |
T |
18: 35,787,553 (GRCm39) |
S234T |
probably benign |
Het |
| Rab14 |
A |
T |
2: 35,073,429 (GRCm39) |
L131* |
probably null |
Het |
| Rab5c |
G |
A |
11: 100,610,789 (GRCm39) |
R40C |
probably damaging |
Het |
| Rhebl1 |
A |
G |
15: 98,777,164 (GRCm39) |
L103P |
probably damaging |
Het |
| Rnf10 |
G |
T |
5: 115,395,149 (GRCm39) |
F146L |
probably damaging |
Het |
| Rrbp1 |
T |
C |
2: 143,831,087 (GRCm39) |
K360R |
possibly damaging |
Het |
| Slc6a9 |
C |
T |
4: 117,725,261 (GRCm39) |
T575I |
probably benign |
Het |
| Smo |
A |
G |
6: 29,760,229 (GRCm39) |
H776R |
probably damaging |
Het |
| Speer1f |
T |
C |
5: 11,469,071 (GRCm39) |
V74A |
possibly damaging |
Het |
| Tns2 |
A |
G |
15: 102,012,914 (GRCm39) |
M1V |
probably null |
Het |
| Ttn |
C |
A |
2: 76,725,036 (GRCm39) |
|
probably benign |
Het |
| Ugt3a1 |
A |
T |
15: 9,306,240 (GRCm39) |
M130L |
probably benign |
Het |
| Urb2 |
C |
T |
8: 124,755,036 (GRCm39) |
H248Y |
probably benign |
Het |
| Vit |
A |
T |
17: 78,932,585 (GRCm39) |
N564I |
probably damaging |
Het |
| Vmn1r60 |
A |
T |
7: 5,547,310 (GRCm39) |
Y263* |
probably null |
Het |
| Xpo7 |
T |
C |
14: 70,908,512 (GRCm39) |
I876V |
probably benign |
Het |
| Zfp442 |
A |
G |
2: 150,249,937 (GRCm39) |
I655T |
probably benign |
Het |
| Zfp574 |
T |
A |
7: 24,779,622 (GRCm39) |
C215S |
possibly damaging |
Het |
| Zfp608 |
T |
C |
18: 55,121,069 (GRCm39) |
T173A |
probably benign |
Het |
| Zfp69 |
A |
T |
4: 120,788,598 (GRCm39) |
V239D |
possibly damaging |
Het |
|
| Other mutations in Vmn2r16 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01116:Vmn2r16
|
APN |
5 |
109,488,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01374:Vmn2r16
|
APN |
5 |
109,478,283 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01391:Vmn2r16
|
APN |
5 |
109,511,627 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL01419:Vmn2r16
|
APN |
5 |
109,510,267 (GRCm39) |
splice site |
probably benign |
|
|
IGL01634:Vmn2r16
|
APN |
5 |
109,488,177 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01845:Vmn2r16
|
APN |
5 |
109,511,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01875:Vmn2r16
|
APN |
5 |
109,478,277 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01910:Vmn2r16
|
APN |
5 |
109,487,951 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02217:Vmn2r16
|
APN |
5 |
109,487,676 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02327:Vmn2r16
|
APN |
5 |
109,487,987 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02491:Vmn2r16
|
APN |
5 |
109,487,703 (GRCm39) |
nonsense |
probably null |
|
|
IGL02531:Vmn2r16
|
APN |
5 |
109,488,134 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02680:Vmn2r16
|
APN |
5 |
109,487,948 (GRCm39) |
missense |
probably benign |
0.44 |
|
IGL02884:Vmn2r16
|
APN |
5 |
109,508,757 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03084:Vmn2r16
|
APN |
5 |
109,478,292 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03096:Vmn2r16
|
APN |
5 |
109,487,751 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03355:Vmn2r16
|
APN |
5 |
109,511,580 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R0280:Vmn2r16
|
UTSW |
5 |
109,488,005 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0594:Vmn2r16
|
UTSW |
5 |
109,511,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1016:Vmn2r16
|
UTSW |
5 |
109,487,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1109:Vmn2r16
|
UTSW |
5 |
109,487,652 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1248:Vmn2r16
|
UTSW |
5 |
109,508,643 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1626:Vmn2r16
|
UTSW |
5 |
109,511,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1909:Vmn2r16
|
UTSW |
5 |
109,511,853 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1929:Vmn2r16
|
UTSW |
5 |
109,487,124 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1982:Vmn2r16
|
UTSW |
5 |
109,511,890 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3038:Vmn2r16
|
UTSW |
5 |
109,487,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3437:Vmn2r16
|
UTSW |
5 |
109,478,362 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3734:Vmn2r16
|
UTSW |
5 |
109,478,280 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3820:Vmn2r16
|
UTSW |
5 |
109,510,143 (GRCm39) |
missense |
probably benign |
0.36 |
|
R3873:Vmn2r16
|
UTSW |
5 |
109,488,177 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4165:Vmn2r16
|
UTSW |
5 |
109,478,427 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4373:Vmn2r16
|
UTSW |
5 |
109,511,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4575:Vmn2r16
|
UTSW |
5 |
109,511,665 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4576:Vmn2r16
|
UTSW |
5 |
109,511,665 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4578:Vmn2r16
|
UTSW |
5 |
109,511,665 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4637:Vmn2r16
|
UTSW |
5 |
109,478,280 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4696:Vmn2r16
|
UTSW |
5 |
109,487,168 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5026:Vmn2r16
|
UTSW |
5 |
109,508,722 (GRCm39) |
nonsense |
probably null |
|
|
R5180:Vmn2r16
|
UTSW |
5 |
109,478,391 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5433:Vmn2r16
|
UTSW |
5 |
109,511,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5955:Vmn2r16
|
UTSW |
5 |
109,511,613 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R5958:Vmn2r16
|
UTSW |
5 |
109,510,153 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6353:Vmn2r16
|
UTSW |
5 |
109,488,119 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6389:Vmn2r16
|
UTSW |
5 |
109,478,344 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6819:Vmn2r16
|
UTSW |
5 |
109,488,412 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6994:Vmn2r16
|
UTSW |
5 |
109,487,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7063:Vmn2r16
|
UTSW |
5 |
109,511,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7220:Vmn2r16
|
UTSW |
5 |
109,508,772 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7268:Vmn2r16
|
UTSW |
5 |
109,488,331 (GRCm39) |
nonsense |
probably null |
|
|
R7420:Vmn2r16
|
UTSW |
5 |
109,511,736 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7591:Vmn2r16
|
UTSW |
5 |
109,510,223 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7644:Vmn2r16
|
UTSW |
5 |
109,487,837 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7939:Vmn2r16
|
UTSW |
5 |
109,487,705 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R7977:Vmn2r16
|
UTSW |
5 |
109,488,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7987:Vmn2r16
|
UTSW |
5 |
109,488,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8023:Vmn2r16
|
UTSW |
5 |
109,488,272 (GRCm39) |
nonsense |
probably null |
|
|
R8427:Vmn2r16
|
UTSW |
5 |
109,488,138 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8436:Vmn2r16
|
UTSW |
5 |
109,511,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8475:Vmn2r16
|
UTSW |
5 |
109,487,073 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8554:Vmn2r16
|
UTSW |
5 |
109,511,997 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8771:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8774:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8774-TAIL:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8775:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8775-TAIL:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8777:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8777-TAIL:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8825:Vmn2r16
|
UTSW |
5 |
109,487,019 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8865:Vmn2r16
|
UTSW |
5 |
109,487,910 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8900:Vmn2r16
|
UTSW |
5 |
109,511,619 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9365:Vmn2r16
|
UTSW |
5 |
109,488,064 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9683:Vmn2r16
|
UTSW |
5 |
109,511,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0027:Vmn2r16
|
UTSW |
5 |
109,487,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r16
|
UTSW |
5 |
109,511,779 (GRCm39) |
frame shift |
probably null |
|
|
Z1088:Vmn2r16
|
UTSW |
5 |
109,488,381 (GRCm39) |
missense |
probably benign |
0.03 |
|
Z1177:Vmn2r16
|
UTSW |
5 |
109,487,864 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTTTATGAGCAGATATGGAGCAG -3'
(R):5'- GCTTGAAAGCCATGACCACAG -3'
Sequencing Primer
(F):5'- TATGAGCAGATATGGAGCAGTGTGTG -3'
(R):5'- TTTGGCCAACACTGTAGAAATGGC -3'
|
| Posted On |
2019-05-13 |
Incidental Mutation