Incidental Mutation 'R7061:Zfp608'
| ID |
548297 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp608
|
| Ensembl Gene |
ENSMUSG00000052713 |
| Gene Name |
zinc finger protein 608 |
| Synonyms |
4932417D18Rik |
| MMRRC Submission |
045384-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.908)
|
| Stock # |
R7061 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
18 |
| Chromosomal Location |
54888045-54990180 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 54987997 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 173
(T173A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000068192
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000064763]
|
| AlphaFold |
Q56A10 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000064763
AA Change: T173A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000068192
Gene: ENSMUSG00000052713
AA Change: T173A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
51 |
61 |
N/A |
INTRINSIC |
|
low complexity region
|
150 |
184 |
N/A |
INTRINSIC |
|
low complexity region
|
214 |
234 |
N/A |
INTRINSIC |
|
low complexity region
|
252 |
266 |
N/A |
INTRINSIC |
|
low complexity region
|
309 |
326 |
N/A |
INTRINSIC |
|
low complexity region
|
428 |
445 |
N/A |
INTRINSIC |
|
low complexity region
|
459 |
471 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
552 |
577 |
1.86e0 |
SMART |
|
low complexity region
|
624 |
636 |
N/A |
INTRINSIC |
|
low complexity region
|
706 |
718 |
N/A |
INTRINSIC |
|
low complexity region
|
734 |
773 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
822 |
N/A |
INTRINSIC |
|
low complexity region
|
833 |
846 |
N/A |
INTRINSIC |
|
low complexity region
|
934 |
956 |
N/A |
INTRINSIC |
|
coiled coil region
|
1028 |
1054 |
N/A |
INTRINSIC |
|
low complexity region
|
1182 |
1193 |
N/A |
INTRINSIC |
|
low complexity region
|
1255 |
1268 |
N/A |
INTRINSIC |
|
low complexity region
|
1439 |
1450 |
N/A |
INTRINSIC |
|
low complexity region
|
1458 |
1466 |
N/A |
INTRINSIC |
|
low complexity region
|
1486 |
1502 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
99% (68/69) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 66 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4931409K22Rik |
A |
G |
5: 24,545,065 (GRCm38) |
M660T |
probably benign |
Het |
| Aard |
G |
A |
15: 52,040,221 (GRCm38) |
M13I |
probably benign |
Het |
| Abcb5 |
A |
C |
12: 118,877,774 (GRCm38) |
Y979D |
probably damaging |
Het |
| Adgrb1 |
G |
C |
15: 74,569,881 (GRCm38) |
V4L |
probably benign |
Het |
| Ap3b2 |
C |
T |
7: 81,461,009 (GRCm38) |
R1006Q |
unknown |
Het |
| Bpifa6 |
A |
T |
2: 153,992,316 (GRCm38) |
T343S |
probably benign |
Het |
| Celsr3 |
T |
A |
9: 108,847,594 (GRCm38) |
C2957* |
probably null |
Het |
| Chd6 |
G |
A |
2: 161,025,965 (GRCm38) |
Q428* |
probably null |
Het |
| Col5a1 |
C |
A |
2: 28,025,678 (GRCm38) |
C191* |
probably null |
Het |
| Cpox |
A |
G |
16: 58,670,860 (GRCm38) |
I145V |
possibly damaging |
Het |
| Csnk2a1 |
C |
T |
2: 152,274,171 (GRCm38) |
R268C |
probably benign |
Het |
| Dclk2 |
A |
G |
3: 86,831,731 (GRCm38) |
|
probably null |
Het |
| Dennd5a |
T |
C |
7: 109,905,179 (GRCm38) |
E909G |
probably benign |
Het |
| Depdc1a |
T |
A |
3: 159,522,852 (GRCm38) |
S414T |
possibly damaging |
Het |
| Dock5 |
A |
G |
14: 67,770,254 (GRCm38) |
F1502S |
probably damaging |
Het |
| Dopey2 |
G |
T |
16: 93,762,063 (GRCm38) |
A448S |
probably benign |
Het |
| Dsg1c |
C |
A |
18: 20,277,009 (GRCm38) |
N511K |
probably benign |
Het |
| Epc2 |
G |
T |
2: 49,535,322 (GRCm38) |
R108L |
probably damaging |
Het |
| Erp44 |
T |
A |
4: 48,219,375 (GRCm38) |
I147F |
probably benign |
Het |
| Evc |
T |
C |
5: 37,319,102 (GRCm38) |
T368A |
possibly damaging |
Het |
| Fbxo41 |
G |
T |
6: 85,475,466 (GRCm38) |
R738S |
probably benign |
Het |
| Fli1 |
T |
C |
9: 32,424,222 (GRCm38) |
T305A |
probably damaging |
Het |
| Gm4969 |
A |
T |
7: 19,100,128 (GRCm38) |
|
probably benign |
Het |
| Gm8897 |
T |
C |
5: 11,419,104 (GRCm38) |
V74A |
possibly damaging |
Het |
| Grk5 |
A |
G |
19: 61,046,092 (GRCm38) |
T93A |
probably benign |
Het |
| Grm2 |
A |
T |
9: 106,651,225 (GRCm38) |
N153K |
probably damaging |
Het |
| Helz |
A |
G |
11: 107,649,177 (GRCm38) |
T1007A |
possibly damaging |
Het |
| Helz2 |
A |
G |
2: 181,240,514 (GRCm38) |
L162P |
probably damaging |
Het |
| Hmgcr |
T |
A |
13: 96,666,148 (GRCm38) |
Q81L |
possibly damaging |
Het |
| Hnrnpu |
T |
C |
1: 178,336,126 (GRCm38) |
K218E |
unknown |
Het |
| Hydin |
A |
T |
8: 110,603,288 (GRCm38) |
I4885F |
possibly damaging |
Het |
| Ibsp |
A |
G |
5: 104,309,902 (GRCm38) |
|
probably null |
Het |
| Igfals |
T |
C |
17: 24,880,307 (GRCm38) |
L124P |
probably damaging |
Het |
| Il24 |
T |
A |
1: 130,883,371 (GRCm38) |
H142L |
possibly damaging |
Het |
| Kcnh2 |
A |
T |
5: 24,331,922 (GRCm38) |
H221Q |
probably benign |
Het |
| Man1a |
A |
G |
10: 53,920,235 (GRCm38) |
S454P |
probably damaging |
Het |
| Mfsd4b1 |
C |
T |
10: 40,003,386 (GRCm38) |
V172M |
possibly damaging |
Het |
| Mical2 |
T |
A |
7: 112,346,801 (GRCm38) |
I763K |
probably benign |
Het |
| Mybpc3 |
A |
G |
2: 91,125,404 (GRCm38) |
I594M |
possibly damaging |
Het |
| Neo1 |
T |
A |
9: 58,990,441 (GRCm38) |
R77S |
possibly damaging |
Het |
| Nlrp6 |
A |
G |
7: 140,922,867 (GRCm38) |
I265M |
probably benign |
Het |
| Olfr1350 |
A |
G |
7: 6,570,783 (GRCm38) |
Y264C |
probably damaging |
Het |
| Olfr669 |
T |
C |
7: 104,938,676 (GRCm38) |
L50P |
probably damaging |
Het |
| Olfr877 |
T |
A |
9: 37,855,646 (GRCm38) |
V276D |
possibly damaging |
Het |
| Pcdhgb5 |
C |
A |
18: 37,731,923 (GRCm38) |
P257Q |
probably benign |
Het |
| Phactr1 |
A |
G |
13: 43,132,981 (GRCm38) |
D586G |
probably damaging |
Het |
| Pkn3 |
T |
A |
2: 30,083,536 (GRCm38) |
|
probably null |
Het |
| Prob1 |
A |
T |
18: 35,654,500 (GRCm38) |
S234T |
probably benign |
Het |
| Rab14 |
A |
T |
2: 35,183,417 (GRCm38) |
L131* |
probably null |
Het |
| Rab5c |
G |
A |
11: 100,719,963 (GRCm38) |
R40C |
probably damaging |
Het |
| Rhebl1 |
A |
G |
15: 98,879,283 (GRCm38) |
L103P |
probably damaging |
Het |
| Rnf10 |
G |
T |
5: 115,257,090 (GRCm38) |
F146L |
probably damaging |
Het |
| Rrbp1 |
T |
C |
2: 143,989,167 (GRCm38) |
K360R |
possibly damaging |
Het |
| Slc6a9 |
C |
T |
4: 117,868,064 (GRCm38) |
T575I |
probably benign |
Het |
| Smo |
A |
G |
6: 29,760,230 (GRCm38) |
H776R |
probably damaging |
Het |
| Tns2 |
A |
G |
15: 102,104,479 (GRCm38) |
M1V |
probably null |
Het |
| Ttn |
C |
A |
2: 76,894,692 (GRCm38) |
|
probably benign |
Het |
| Ugt3a1 |
A |
T |
15: 9,306,154 (GRCm38) |
M130L |
probably benign |
Het |
| Urb2 |
C |
T |
8: 124,028,297 (GRCm38) |
H248Y |
probably benign |
Het |
| Vit |
A |
T |
17: 78,625,156 (GRCm38) |
N564I |
probably damaging |
Het |
| Vmn1r60 |
A |
T |
7: 5,544,311 (GRCm38) |
Y263* |
probably null |
Het |
| Vmn2r16 |
A |
T |
5: 109,363,754 (GRCm38) |
Y609F |
probably damaging |
Het |
| Xpo7 |
T |
C |
14: 70,671,072 (GRCm38) |
I876V |
probably benign |
Het |
| Zfp442 |
A |
G |
2: 150,408,017 (GRCm38) |
I655T |
probably benign |
Het |
| Zfp574 |
T |
A |
7: 25,080,197 (GRCm38) |
C215S |
possibly damaging |
Het |
| Zfp69 |
A |
T |
4: 120,931,401 (GRCm38) |
V239D |
possibly damaging |
Het |
|
| Other mutations in Zfp608 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00500:Zfp608
|
APN |
18 |
54,988,333 (GRCm38) |
missense |
probably benign |
|
|
IGL00920:Zfp608
|
APN |
18 |
54,889,831 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01088:Zfp608
|
APN |
18 |
54,898,087 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL01447:Zfp608
|
APN |
18 |
54,899,011 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
IGL01534:Zfp608
|
APN |
18 |
54,898,932 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01547:Zfp608
|
APN |
18 |
54,894,449 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL01933:Zfp608
|
APN |
18 |
54,987,799 (GRCm38) |
missense |
probably benign |
|
|
IGL01998:Zfp608
|
APN |
18 |
54,891,818 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02167:Zfp608
|
APN |
18 |
54,988,224 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02266:Zfp608
|
APN |
18 |
54,897,581 (GRCm38) |
missense |
probably benign |
0.08 |
|
IGL02335:Zfp608
|
APN |
18 |
54,897,437 (GRCm38) |
nonsense |
probably null |
|
|
IGL02455:Zfp608
|
APN |
18 |
54,899,333 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02612:Zfp608
|
APN |
18 |
54,898,201 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02900:Zfp608
|
APN |
18 |
54,946,793 (GRCm38) |
missense |
probably damaging |
1.00 |
|
PIT4243001:Zfp608
|
UTSW |
18 |
54,898,024 (GRCm38) |
missense |
probably damaging |
1.00 |
|
PIT4519001:Zfp608
|
UTSW |
18 |
54,946,711 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R0005:Zfp608
|
UTSW |
18 |
54,895,520 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R0010:Zfp608
|
UTSW |
18 |
54,895,214 (GRCm38) |
splice site |
probably benign |
|
|
R0010:Zfp608
|
UTSW |
18 |
54,895,214 (GRCm38) |
splice site |
probably benign |
|
|
R0064:Zfp608
|
UTSW |
18 |
54,898,816 (GRCm38) |
missense |
probably benign |
|
|
R0401:Zfp608
|
UTSW |
18 |
54,898,994 (GRCm38) |
missense |
probably benign |
|
|
R0722:Zfp608
|
UTSW |
18 |
54,900,234 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1351:Zfp608
|
UTSW |
18 |
54,898,391 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1512:Zfp608
|
UTSW |
18 |
54,946,666 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1554:Zfp608
|
UTSW |
18 |
54,898,054 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1622:Zfp608
|
UTSW |
18 |
54,988,294 (GRCm38) |
missense |
probably benign |
0.07 |
|
R1669:Zfp608
|
UTSW |
18 |
54,987,739 (GRCm38) |
missense |
probably benign |
0.09 |
|
R1690:Zfp608
|
UTSW |
18 |
54,987,634 (GRCm38) |
missense |
possibly damaging |
0.62 |
|
R1721:Zfp608
|
UTSW |
18 |
54,899,249 (GRCm38) |
missense |
probably benign |
|
|
R1826:Zfp608
|
UTSW |
18 |
54,898,576 (GRCm38) |
missense |
probably benign |
0.03 |
|
R1864:Zfp608
|
UTSW |
18 |
54,897,911 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1952:Zfp608
|
UTSW |
18 |
54,897,779 (GRCm38) |
nonsense |
probably null |
|
|
R2049:Zfp608
|
UTSW |
18 |
54,895,565 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2051:Zfp608
|
UTSW |
18 |
54,988,314 (GRCm38) |
missense |
probably benign |
|
|
R2168:Zfp608
|
UTSW |
18 |
54,898,053 (GRCm38) |
nonsense |
probably null |
|
|
R2218:Zfp608
|
UTSW |
18 |
54,987,684 (GRCm38) |
missense |
probably benign |
0.14 |
|
R2283:Zfp608
|
UTSW |
18 |
54,988,374 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2399:Zfp608
|
UTSW |
18 |
54,897,902 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2520:Zfp608
|
UTSW |
18 |
54,988,506 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R2961:Zfp608
|
UTSW |
18 |
54,898,472 (GRCm38) |
missense |
possibly damaging |
0.60 |
|
R4074:Zfp608
|
UTSW |
18 |
54,898,108 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4076:Zfp608
|
UTSW |
18 |
54,898,108 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4206:Zfp608
|
UTSW |
18 |
54,988,195 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4756:Zfp608
|
UTSW |
18 |
54,894,472 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4771:Zfp608
|
UTSW |
18 |
54,988,300 (GRCm38) |
missense |
probably benign |
|
|
R4820:Zfp608
|
UTSW |
18 |
54,987,684 (GRCm38) |
missense |
probably benign |
0.14 |
|
R4825:Zfp608
|
UTSW |
18 |
54,897,969 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4912:Zfp608
|
UTSW |
18 |
54,946,591 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4975:Zfp608
|
UTSW |
18 |
54,889,890 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5138:Zfp608
|
UTSW |
18 |
54,891,799 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5192:Zfp608
|
UTSW |
18 |
54,898,497 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5557:Zfp608
|
UTSW |
18 |
54,987,870 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R5624:Zfp608
|
UTSW |
18 |
54,898,272 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5818:Zfp608
|
UTSW |
18 |
54,895,396 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5840:Zfp608
|
UTSW |
18 |
54,898,906 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5992:Zfp608
|
UTSW |
18 |
54,899,248 (GRCm38) |
missense |
probably benign |
0.15 |
|
R6106:Zfp608
|
UTSW |
18 |
54,987,872 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R6174:Zfp608
|
UTSW |
18 |
54,988,544 (GRCm38) |
start gained |
probably benign |
|
|
R6181:Zfp608
|
UTSW |
18 |
54,895,628 (GRCm38) |
missense |
possibly damaging |
0.56 |
|
R6517:Zfp608
|
UTSW |
18 |
54,899,078 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R6567:Zfp608
|
UTSW |
18 |
54,897,556 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6668:Zfp608
|
UTSW |
18 |
54,898,019 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6920:Zfp608
|
UTSW |
18 |
54,988,265 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7074:Zfp608
|
UTSW |
18 |
54,897,382 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R7087:Zfp608
|
UTSW |
18 |
54,899,397 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7391:Zfp608
|
UTSW |
18 |
54,897,547 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
R7600:Zfp608
|
UTSW |
18 |
54,988,020 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7723:Zfp608
|
UTSW |
18 |
54,897,601 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8054:Zfp608
|
UTSW |
18 |
54,899,546 (GRCm38) |
missense |
probably benign |
0.28 |
|
R8236:Zfp608
|
UTSW |
18 |
54,899,209 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8260:Zfp608
|
UTSW |
18 |
54,897,749 (GRCm38) |
missense |
possibly damaging |
0.60 |
|
R8732:Zfp608
|
UTSW |
18 |
54,988,000 (GRCm38) |
missense |
probably benign |
0.06 |
|
R8781:Zfp608
|
UTSW |
18 |
54,898,729 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8851:Zfp608
|
UTSW |
18 |
54,899,122 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R8940:Zfp608
|
UTSW |
18 |
54,900,229 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R9051:Zfp608
|
UTSW |
18 |
54,899,194 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9091:Zfp608
|
UTSW |
18 |
54,899,118 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9092:Zfp608
|
UTSW |
18 |
54,898,576 (GRCm38) |
missense |
probably benign |
0.03 |
|
R9236:Zfp608
|
UTSW |
18 |
54,899,282 (GRCm38) |
missense |
probably benign |
0.39 |
|
R9270:Zfp608
|
UTSW |
18 |
54,899,118 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9283:Zfp608
|
UTSW |
18 |
54,897,841 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
R9288:Zfp608
|
UTSW |
18 |
54,900,269 (GRCm38) |
missense |
probably benign |
0.39 |
|
R9463:Zfp608
|
UTSW |
18 |
54,897,202 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTTGGTCCCAAAGCCATAGAGG -3'
(R):5'- GGGCTAAAACTTCTAAGGATGC -3'
Sequencing Primer
(F):5'- GTCCCAAAGCCATAGAGGTGACC -3'
(R):5'- GGATGCTAATAAATCTCTGCCTTCTG -3'
|
| Posted On |
2019-05-13 |
Incidental Mutation