Incidental Mutation 'R7062:Parp4'
| ID |
548363 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Parp4
|
| Ensembl Gene |
ENSMUSG00000054509 |
| Gene Name |
poly (ADP-ribose) polymerase family, member 4 |
| Synonyms |
VPARP, Adprtl1, C030027K23Rik, VAULT3, p193, PH5P, E230037B21Rik |
| MMRRC Submission |
045158-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.146)
|
| Stock # |
R7062 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
14 |
| Chromosomal Location |
56813076-56897251 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 56852216 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Serine
at position 799
(R799S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124258
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000161553]
|
| AlphaFold |
E9PYK3 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000161553
AA Change: R799S
PolyPhen 2
Score 0.478 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000124258
Gene: ENSMUSG00000054509
AA Change: R799S
| Domain | Start | End | E-Value | Type |
|---|
|
BRCT
|
3 |
84 |
4.32e-9 |
SMART |
|
low complexity region
|
97 |
104 |
N/A |
INTRINSIC |
|
SCOP:d1a26_1
|
252 |
352 |
2e-19 |
SMART |
|
Pfam:PARP
|
371 |
559 |
1.8e-50 |
PFAM |
|
VIT
|
600 |
728 |
1.5e-57 |
SMART |
|
VWA
|
867 |
1030 |
6.08e-13 |
SMART |
|
Blast:14_3_3
|
1149 |
1205 |
5e-10 |
BLAST |
|
low complexity region
|
1255 |
1264 |
N/A |
INTRINSIC |
|
low complexity region
|
1348 |
1362 |
N/A |
INTRINSIC |
|
low complexity region
|
1371 |
1394 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1395 |
1416 |
4.48e-6 |
PROSPERO |
|
Pfam:Drf_FH1
|
1443 |
1542 |
3.3e-15 |
PFAM |
|
low complexity region
|
1553 |
1587 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1588 |
1608 |
2.45e-5 |
PROSPERO |
|
low complexity region
|
1695 |
1708 |
N/A |
INTRINSIC |
|
low complexity region
|
1739 |
1750 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
99% (86/87) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mutants are helathy and fertile. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc9 |
T |
A |
6: 142,544,872 (GRCm39) |
D1370V |
probably damaging |
Het |
| Ackr1 |
A |
T |
1: 173,159,682 (GRCm39) |
I279N |
possibly damaging |
Het |
| Adcy10 |
A |
G |
1: 165,366,091 (GRCm39) |
H536R |
probably benign |
Het |
| Adgrb3 |
T |
C |
1: 25,865,166 (GRCm39) |
T226A |
possibly damaging |
Het |
| Apol10b |
T |
A |
15: 77,469,473 (GRCm39) |
M235L |
probably benign |
Het |
| Arhgap44 |
T |
C |
11: 64,902,758 (GRCm39) |
T570A |
probably benign |
Het |
| Astn1 |
A |
G |
1: 158,516,081 (GRCm39) |
|
probably null |
Het |
| Camsap3 |
A |
G |
8: 3,657,834 (GRCm39) |
|
probably benign |
Het |
| Ccdc73 |
C |
T |
2: 104,782,223 (GRCm39) |
A193V |
probably damaging |
Het |
| Ccl20 |
G |
A |
1: 83,095,535 (GRCm39) |
C32Y |
probably damaging |
Het |
| Cdk11b |
A |
G |
4: 155,711,268 (GRCm39) |
E16G |
probably damaging |
Het |
| Celsr2 |
T |
A |
3: 108,309,826 (GRCm39) |
N1591I |
possibly damaging |
Het |
| Col5a2 |
T |
C |
1: 45,456,785 (GRCm39) |
E306G |
probably benign |
Het |
| Cpa1 |
C |
T |
6: 30,640,676 (GRCm39) |
A106V |
probably benign |
Het |
| Ctdspl |
G |
A |
9: 118,866,538 (GRCm39) |
R199H |
probably damaging |
Het |
| Cyfip2 |
G |
A |
11: 46,151,659 (GRCm39) |
P547S |
probably damaging |
Het |
| Cyp2c37 |
A |
T |
19: 39,983,990 (GRCm39) |
|
probably null |
Het |
| Dnajc16 |
A |
G |
4: 141,494,001 (GRCm39) |
F549L |
probably damaging |
Het |
| Dnm3 |
T |
A |
1: 161,962,060 (GRCm39) |
K50* |
probably null |
Het |
| Eci1 |
C |
T |
17: 24,645,714 (GRCm39) |
|
probably benign |
Het |
| Eif2b4 |
C |
T |
5: 31,350,175 (GRCm39) |
C49Y |
probably benign |
Het |
| Emc3 |
A |
T |
6: 113,499,757 (GRCm39) |
I56N |
probably damaging |
Het |
| Enthd1 |
A |
G |
15: 80,336,745 (GRCm39) |
L563P |
probably damaging |
Het |
| Ercc4 |
T |
A |
16: 12,950,811 (GRCm39) |
I635K |
probably damaging |
Het |
| Espl1 |
A |
C |
15: 102,207,331 (GRCm39) |
N265T |
probably benign |
Het |
| Fads2 |
T |
C |
19: 10,042,962 (GRCm39) |
|
probably null |
Het |
| Fam186a |
G |
A |
15: 99,831,521 (GRCm39) |
|
probably benign |
Het |
| Fastkd1 |
A |
T |
2: 69,534,666 (GRCm39) |
I368K |
possibly damaging |
Het |
| Fat1 |
G |
A |
8: 45,403,253 (GRCm39) |
M1I |
probably null |
Het |
| Foxj1 |
T |
C |
11: 116,222,819 (GRCm39) |
E328G |
probably benign |
Het |
| Gfod2 |
T |
C |
8: 106,449,508 (GRCm39) |
|
probably benign |
Het |
| Gm6525 |
C |
T |
3: 84,082,198 (GRCm39) |
R40C |
probably benign |
Het |
| Gna12 |
G |
A |
5: 140,771,240 (GRCm39) |
T144I |
probably benign |
Het |
| Ighv9-3 |
T |
C |
12: 114,104,712 (GRCm39) |
M11V |
probably benign |
Het |
| Kcnj14 |
T |
C |
7: 45,467,314 (GRCm39) |
Y344C |
probably damaging |
Het |
| Lrrc63 |
A |
T |
14: 75,323,737 (GRCm39) |
S496T |
probably benign |
Het |
| Ltn1 |
T |
C |
16: 87,224,491 (GRCm39) |
T78A |
probably damaging |
Het |
| Matr3 |
T |
A |
18: 35,712,072 (GRCm39) |
|
probably null |
Het |
| Mcpt4 |
A |
G |
14: 56,298,125 (GRCm39) |
M142T |
probably benign |
Het |
| Mroh7 |
A |
G |
4: 106,541,177 (GRCm39) |
F1154S |
probably damaging |
Het |
| Mrpl1 |
G |
T |
5: 96,361,650 (GRCm39) |
L12F |
probably benign |
Het |
| Myo3b |
G |
A |
2: 70,047,501 (GRCm39) |
V308I |
probably benign |
Het |
| Nfasc |
A |
G |
1: 132,529,707 (GRCm39) |
|
probably null |
Het |
| Npc1l1 |
T |
A |
11: 6,167,807 (GRCm39) |
M995L |
probably benign |
Het |
| Nvl |
A |
G |
1: 180,939,899 (GRCm39) |
I617T |
probably benign |
Het |
| Oas1h |
C |
A |
5: 120,999,528 (GRCm39) |
|
probably benign |
Het |
| Oasl2 |
T |
A |
5: 115,049,152 (GRCm39) |
Y197* |
probably null |
Het |
| Or4k1 |
A |
G |
14: 50,377,907 (GRCm39) |
L63P |
probably damaging |
Het |
| Or52ab7 |
T |
C |
7: 102,978,293 (GRCm39) |
V200A |
probably benign |
Het |
| Or5an1c |
T |
C |
19: 12,218,089 (GRCm39) |
N312S |
probably benign |
Het |
| Or5l13 |
T |
C |
2: 87,780,568 (GRCm39) |
E3G |
probably benign |
Het |
| Or5p70 |
C |
T |
7: 107,995,037 (GRCm39) |
R237* |
probably null |
Het |
| Or8g35 |
A |
T |
9: 39,381,353 (GRCm39) |
I223N |
probably benign |
Het |
| Orc6 |
T |
C |
8: 86,029,537 (GRCm39) |
V27A |
probably damaging |
Het |
| Pcdhga1 |
C |
A |
18: 37,958,130 (GRCm39) |
S826R |
probably damaging |
Het |
| Phldb1 |
T |
C |
9: 44,607,432 (GRCm39) |
R1258G |
probably damaging |
Het |
| Ppfia1 |
T |
C |
7: 144,106,210 (GRCm39) |
S21G |
probably benign |
Het |
| Ppp1r18 |
C |
A |
17: 36,179,103 (GRCm39) |
T326K |
probably damaging |
Het |
| Psg26 |
A |
G |
7: 18,216,521 (GRCm39) |
L106P |
probably damaging |
Het |
| Rabgap1l |
A |
T |
1: 160,054,220 (GRCm39) |
D265E |
probably benign |
Het |
| Rasgrp4 |
T |
C |
7: 28,849,619 (GRCm39) |
L554P |
possibly damaging |
Het |
| Rnf17 |
G |
T |
14: 56,703,111 (GRCm39) |
V621L |
probably benign |
Het |
| Sart3 |
T |
C |
5: 113,883,663 (GRCm39) |
K783R |
possibly damaging |
Het |
| Slc23a2 |
T |
A |
2: 131,933,189 (GRCm39) |
I90F |
probably damaging |
Het |
| Slc5a2 |
A |
T |
7: 127,869,212 (GRCm39) |
M331L |
probably damaging |
Het |
| Slc5a7 |
C |
G |
17: 54,600,029 (GRCm39) |
G128A |
probably damaging |
Het |
| Smcr8 |
A |
T |
11: 60,671,180 (GRCm39) |
Q776L |
probably damaging |
Het |
| Smpd4 |
T |
A |
16: 17,458,835 (GRCm39) |
D519E |
probably damaging |
Het |
| Smurf1 |
A |
T |
5: 144,830,356 (GRCm39) |
|
probably null |
Het |
| Spata18 |
T |
A |
5: 73,816,636 (GRCm39) |
N125K |
probably benign |
Het |
| Spice1 |
T |
A |
16: 44,178,259 (GRCm39) |
M94K |
probably damaging |
Het |
| Stard4 |
T |
C |
18: 33,338,587 (GRCm39) |
|
probably null |
Het |
| Stx17 |
A |
G |
4: 48,140,442 (GRCm39) |
D49G |
probably benign |
Het |
| Tbce |
T |
C |
13: 14,194,380 (GRCm39) |
D93G |
possibly damaging |
Het |
| Tbx21 |
T |
A |
11: 96,989,719 (GRCm39) |
D491V |
probably damaging |
Het |
| Tmbim4 |
G |
T |
10: 120,044,731 (GRCm39) |
|
probably benign |
Het |
| Tmem209 |
C |
T |
6: 30,502,016 (GRCm39) |
R62H |
probably damaging |
Het |
| Tmem237 |
A |
T |
1: 59,158,771 (GRCm39) |
|
probably null |
Het |
| Tmprss9 |
T |
C |
10: 80,730,883 (GRCm39) |
I803T |
probably benign |
Het |
| Trip4 |
C |
T |
9: 65,792,292 (GRCm39) |
A7T |
probably benign |
Het |
| Unc13a |
T |
C |
8: 72,115,881 (GRCm39) |
D107G |
probably benign |
Het |
| Uso1 |
C |
A |
5: 92,340,599 (GRCm39) |
Q672K |
possibly damaging |
Het |
| Washc2 |
T |
A |
6: 116,196,949 (GRCm39) |
N239K |
possibly damaging |
Het |
| Zfp661 |
A |
G |
2: 127,419,040 (GRCm39) |
C367R |
probably damaging |
Het |
| Znrf3 |
T |
A |
11: 5,231,550 (GRCm39) |
E558D |
probably damaging |
Het |
|
| Other mutations in Parp4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00479:Parp4
|
APN |
14 |
56,853,917 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL00571:Parp4
|
APN |
14 |
56,884,810 (GRCm39) |
missense |
unknown |
|
|
IGL00737:Parp4
|
APN |
14 |
56,821,620 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00793:Parp4
|
APN |
14 |
56,840,334 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL01108:Parp4
|
APN |
14 |
56,844,897 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01131:Parp4
|
APN |
14 |
56,823,217 (GRCm39) |
splice site |
probably benign |
|
|
IGL01485:Parp4
|
APN |
14 |
56,859,661 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL01704:Parp4
|
APN |
14 |
56,839,783 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01993:Parp4
|
APN |
14 |
56,848,245 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02125:Parp4
|
APN |
14 |
56,827,959 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL02851:Parp4
|
APN |
14 |
56,886,326 (GRCm39) |
missense |
unknown |
|
|
IGL02863:Parp4
|
APN |
14 |
56,886,243 (GRCm39) |
missense |
unknown |
|
|
IGL03065:Parp4
|
APN |
14 |
56,875,326 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL03117:Parp4
|
APN |
14 |
56,840,313 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL03271:Parp4
|
APN |
14 |
56,823,082 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03309:Parp4
|
APN |
14 |
56,825,265 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03408:Parp4
|
APN |
14 |
56,839,865 (GRCm39) |
missense |
probably damaging |
0.99 |
|
poisonous
|
UTSW |
14 |
56,873,205 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0515_Parp4_195
|
UTSW |
14 |
56,851,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
toxic
|
UTSW |
14 |
56,866,615 (GRCm39) |
missense |
probably benign |
0.28 |
|
venomous
|
UTSW |
14 |
56,827,355 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
virulent
|
UTSW |
14 |
56,825,235 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0278:Parp4
|
UTSW |
14 |
56,844,980 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0320:Parp4
|
UTSW |
14 |
56,825,953 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0445:Parp4
|
UTSW |
14 |
56,840,205 (GRCm39) |
splice site |
probably null |
|
|
R0452:Parp4
|
UTSW |
14 |
56,886,300 (GRCm39) |
missense |
unknown |
|
|
R0511:Parp4
|
UTSW |
14 |
56,873,172 (GRCm39) |
splice site |
probably benign |
|
|
R0515:Parp4
|
UTSW |
14 |
56,851,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0608:Parp4
|
UTSW |
14 |
56,839,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0800:Parp4
|
UTSW |
14 |
56,827,408 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0959:Parp4
|
UTSW |
14 |
56,885,576 (GRCm39) |
missense |
unknown |
|
|
R1207:Parp4
|
UTSW |
14 |
56,885,339 (GRCm39) |
missense |
unknown |
|
|
R1207:Parp4
|
UTSW |
14 |
56,885,339 (GRCm39) |
missense |
unknown |
|
|
R1342:Parp4
|
UTSW |
14 |
56,827,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1520:Parp4
|
UTSW |
14 |
56,835,863 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1565:Parp4
|
UTSW |
14 |
56,827,329 (GRCm39) |
splice site |
probably benign |
|
|
R1574:Parp4
|
UTSW |
14 |
56,839,752 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1574:Parp4
|
UTSW |
14 |
56,839,752 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1649:Parp4
|
UTSW |
14 |
56,827,885 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1666:Parp4
|
UTSW |
14 |
56,861,620 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1781:Parp4
|
UTSW |
14 |
56,864,838 (GRCm39) |
splice site |
probably null |
|
|
R1799:Parp4
|
UTSW |
14 |
56,885,589 (GRCm39) |
missense |
unknown |
|
|
R1823:Parp4
|
UTSW |
14 |
56,827,329 (GRCm39) |
splice site |
probably benign |
|
|
R1859:Parp4
|
UTSW |
14 |
56,886,372 (GRCm39) |
missense |
unknown |
|
|
R1919:Parp4
|
UTSW |
14 |
56,861,474 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2000:Parp4
|
UTSW |
14 |
56,851,181 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2032:Parp4
|
UTSW |
14 |
56,866,553 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R2034:Parp4
|
UTSW |
14 |
56,871,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2177:Parp4
|
UTSW |
14 |
56,896,746 (GRCm39) |
missense |
unknown |
|
|
R2291:Parp4
|
UTSW |
14 |
56,851,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2865:Parp4
|
UTSW |
14 |
56,851,181 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3012:Parp4
|
UTSW |
14 |
56,832,873 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3841:Parp4
|
UTSW |
14 |
56,825,235 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3913:Parp4
|
UTSW |
14 |
56,857,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4064:Parp4
|
UTSW |
14 |
56,861,597 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4201:Parp4
|
UTSW |
14 |
56,829,848 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4288:Parp4
|
UTSW |
14 |
56,844,951 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4360:Parp4
|
UTSW |
14 |
56,866,661 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4506:Parp4
|
UTSW |
14 |
56,889,761 (GRCm39) |
missense |
unknown |
|
|
R4577:Parp4
|
UTSW |
14 |
56,827,867 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4633:Parp4
|
UTSW |
14 |
56,885,048 (GRCm39) |
missense |
unknown |
|
|
R4762:Parp4
|
UTSW |
14 |
56,848,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4836:Parp4
|
UTSW |
14 |
56,823,195 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4974:Parp4
|
UTSW |
14 |
56,827,355 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5049:Parp4
|
UTSW |
14 |
56,873,188 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5479:Parp4
|
UTSW |
14 |
56,861,552 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5683:Parp4
|
UTSW |
14 |
56,884,886 (GRCm39) |
nonsense |
probably null |
|
|
R5884:Parp4
|
UTSW |
14 |
56,852,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5965:Parp4
|
UTSW |
14 |
56,861,489 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6001:Parp4
|
UTSW |
14 |
56,878,740 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6027:Parp4
|
UTSW |
14 |
56,866,615 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6230:Parp4
|
UTSW |
14 |
56,844,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6242:Parp4
|
UTSW |
14 |
56,832,856 (GRCm39) |
nonsense |
probably null |
|
|
R6355:Parp4
|
UTSW |
14 |
56,839,757 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R6414:Parp4
|
UTSW |
14 |
56,864,838 (GRCm39) |
splice site |
probably null |
|
|
R6418:Parp4
|
UTSW |
14 |
56,858,108 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6477:Parp4
|
UTSW |
14 |
56,884,694 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6542:Parp4
|
UTSW |
14 |
56,885,339 (GRCm39) |
missense |
unknown |
|
|
R6759:Parp4
|
UTSW |
14 |
56,857,947 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6995:Parp4
|
UTSW |
14 |
56,851,196 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7002:Parp4
|
UTSW |
14 |
56,839,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7026:Parp4
|
UTSW |
14 |
56,858,049 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7101:Parp4
|
UTSW |
14 |
56,827,430 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7124:Parp4
|
UTSW |
14 |
56,840,256 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7162:Parp4
|
UTSW |
14 |
56,886,333 (GRCm39) |
missense |
unknown |
|
|
R7293:Parp4
|
UTSW |
14 |
56,885,303 (GRCm39) |
small deletion |
probably benign |
|
|
R7297:Parp4
|
UTSW |
14 |
56,885,138 (GRCm39) |
missense |
not run |
|
|
R7337:Parp4
|
UTSW |
14 |
56,839,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7539:Parp4
|
UTSW |
14 |
56,873,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7575:Parp4
|
UTSW |
14 |
56,875,375 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7808:Parp4
|
UTSW |
14 |
56,873,205 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7854:Parp4
|
UTSW |
14 |
56,896,805 (GRCm39) |
missense |
unknown |
|
|
R7960:Parp4
|
UTSW |
14 |
56,832,708 (GRCm39) |
splice site |
probably null |
|
|
R8152:Parp4
|
UTSW |
14 |
56,884,703 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8344:Parp4
|
UTSW |
14 |
56,886,186 (GRCm39) |
missense |
unknown |
|
|
R8416:Parp4
|
UTSW |
14 |
56,825,271 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8726:Parp4
|
UTSW |
14 |
56,866,556 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8752:Parp4
|
UTSW |
14 |
56,886,073 (GRCm39) |
missense |
unknown |
|
|
R8804:Parp4
|
UTSW |
14 |
56,853,900 (GRCm39) |
nonsense |
probably null |
|
|
R9046:Parp4
|
UTSW |
14 |
56,864,927 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9176:Parp4
|
UTSW |
14 |
56,873,274 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R9303:Parp4
|
UTSW |
14 |
56,852,224 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9303:Parp4
|
UTSW |
14 |
56,832,790 (GRCm39) |
frame shift |
probably null |
|
|
R9305:Parp4
|
UTSW |
14 |
56,852,224 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9305:Parp4
|
UTSW |
14 |
56,832,790 (GRCm39) |
frame shift |
probably null |
|
|
R9360:Parp4
|
UTSW |
14 |
56,878,775 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9430:Parp4
|
UTSW |
14 |
56,866,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9491:Parp4
|
UTSW |
14 |
56,832,828 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9729:Parp4
|
UTSW |
14 |
56,885,888 (GRCm39) |
missense |
unknown |
|
|
RF020:Parp4
|
UTSW |
14 |
56,884,806 (GRCm39) |
missense |
unknown |
|
|
Z1177:Parp4
|
UTSW |
14 |
56,829,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCAATGGGCCTTGGCTTTATAG -3'
(R):5'- TGTCTTAGGAGGATGAATAACTGTG -3'
Sequencing Primer
(F):5'- CGGTACTAGAAAGCTTACTTGTATGC -3'
(R):5'- GAAGTTGTAGGTGACTCAGCC -3'
|
| Posted On |
2019-05-13 |
Incidental Mutation