Incidental Mutation 'R7063:Chst2'
ID 548401
Institutional Source Beutler Lab
Gene Symbol Chst2
Ensembl Gene ENSMUSG00000033350
Gene Name carbohydrate sulfotransferase 2
Synonyms C130041E03Rik, N-acetylglucosamine-6-O-sulfotransferase, Gn6st, GST-2
MMRRC Submission 045159-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # R7063 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 95282979-95289323 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 95287621 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Serine at position 242 (R242S)
Ref Sequence ENSEMBL: ENSMUSP00000040775 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036267]
AlphaFold Q80WV3
Predicted Effect probably benign
Transcript: ENSMUST00000036267
AA Change: R242S

PolyPhen 2 Score 0.276 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000040775
Gene: ENSMUSG00000033350
AA Change: R242S

DomainStartEndE-ValueType
low complexity region 6 45 N/A INTRINSIC
transmembrane domain 55 74 N/A INTRINSIC
low complexity region 88 114 N/A INTRINSIC
low complexity region 129 149 N/A INTRINSIC
Pfam:Sulfotransfer_1 164 507 7e-27 PFAM
Pfam:Sulfotransfer_3 165 446 6.6e-18 PFAM
Meta Mutation Damage Score 0.3386 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (43/43)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This locus encodes a sulfotransferase protein. The encoded enzyme catalyzes the sulfation of a nonreducing N-acetylglucosamine residue, and may play a role in biosynthesis of 6-sulfosialyl Lewis X antigen. [provided by RefSeq, Aug 2011]
PHENOTYPE: Mice homozygous for a knock-out allele display decreased lymphocyte binding to peripheral lymph node high endothelial venules, and significantly reduced lymphocyte homing to Peyer's patches, peripheral and mesenteric lymph nodes. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap35 A G 7: 16,299,038 (GRCm39) V9A probably benign Het
Btbd6 A G 12: 112,941,132 (GRCm39) Y148C probably damaging Het
Casr T C 16: 36,314,936 (GRCm39) I968V probably benign Het
Celf1 T C 2: 90,843,189 (GRCm39) probably null Het
Clca3a1 T A 3: 144,460,967 (GRCm39) D228V probably damaging Het
Cwf19l2 A G 9: 3,430,532 (GRCm39) Y288C probably benign Het
Cyp2r1 A G 7: 114,152,184 (GRCm39) S49P probably damaging Het
Dnah5 A G 15: 28,233,394 (GRCm39) E251G probably benign Het
Eepd1 A G 9: 25,394,332 (GRCm39) R199G possibly damaging Het
Fat1 C T 8: 45,493,812 (GRCm39) T3986I probably benign Het
Gbp4 G A 5: 105,266,314 (GRCm39) R576C probably damaging Het
Glp1r A G 17: 31,144,532 (GRCm39) Y235C probably damaging Het
Gm6408 T C 5: 146,420,594 (GRCm39) I158T probably benign Het
Gpr89 C G 3: 96,783,014 (GRCm39) R312P probably damaging Het
Idh2 A G 7: 79,745,432 (GRCm39) V403A probably damaging Het
Lclat1 A G 17: 73,546,986 (GRCm39) E301G possibly damaging Het
Lgmn A G 12: 102,368,937 (GRCm39) Y181H probably damaging Het
Lgr5 T C 10: 115,292,639 (GRCm39) Y417C probably damaging Het
Man1a G T 10: 53,906,840 (GRCm39) N311K probably damaging Het
Nat10 G A 2: 103,578,422 (GRCm39) L228F probably benign Het
Or10d3 T G 9: 39,461,411 (GRCm39) Y252S possibly damaging Het
Or10v5 A G 19: 11,805,548 (GRCm39) F281L probably damaging Het
Or5b12b A G 19: 12,861,449 (GRCm39) D68G probably damaging Het
Or5p55 C A 7: 107,567,411 (GRCm39) A269E probably benign Het
Pcmtd2 T A 2: 181,496,776 (GRCm39) Y130* probably null Het
Potefam3f G A 8: 20,479,013 (GRCm39) C7Y Het
Qrfprl A G 6: 65,418,387 (GRCm39) probably benign Het
Rapgef5 A G 12: 117,652,864 (GRCm39) D62G possibly damaging Het
Serpina3m A T 12: 104,357,726 (GRCm39) I217L probably benign Het
Supt16 T C 14: 52,409,505 (GRCm39) R802G possibly damaging Het
Sypl2 A T 3: 108,124,971 (GRCm39) M130K probably benign Het
Tmtc2 A T 10: 105,184,386 (GRCm39) L503Q probably damaging Het
Ubald2 A G 11: 116,325,443 (GRCm39) Q60R probably benign Het
Vav1 C T 17: 57,618,860 (GRCm39) Q673* probably null Het
Vgll2 T C 10: 51,904,072 (GRCm39) S312P probably benign Het
Vmn1r191 C T 13: 22,362,864 (GRCm39) A297T probably benign Het
Vmn1r7 T A 6: 57,001,418 (GRCm39) I281F possibly damaging Het
Vmn2r108 T C 17: 20,701,410 (GRCm39) Y30C probably damaging Het
Vmn2r16 A G 5: 109,511,650 (GRCm39) N619S probably damaging Het
Vstm5 A G 9: 15,150,549 (GRCm39) probably benign Het
Zfp7 A G 15: 76,775,919 (GRCm39) I654V possibly damaging Het
Zmat2 A G 18: 36,929,627 (GRCm39) N129S probably null Het
Other mutations in Chst2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02403:Chst2 APN 9 95,287,285 (GRCm39) nonsense probably null
R1240:Chst2 UTSW 9 95,287,536 (GRCm39) missense possibly damaging 0.68
R1537:Chst2 UTSW 9 95,288,194 (GRCm39) missense probably benign 0.04
R1884:Chst2 UTSW 9 95,287,611 (GRCm39) missense probably damaging 1.00
R2355:Chst2 UTSW 9 95,288,148 (GRCm39) missense probably damaging 0.99
R4576:Chst2 UTSW 9 95,287,224 (GRCm39) missense probably damaging 0.99
R4818:Chst2 UTSW 9 95,287,417 (GRCm39) missense probably damaging 1.00
R4928:Chst2 UTSW 9 95,288,059 (GRCm39) missense probably benign 0.10
R5366:Chst2 UTSW 9 95,287,518 (GRCm39) missense probably damaging 1.00
R5703:Chst2 UTSW 9 95,286,985 (GRCm39) missense probably damaging 0.99
R5902:Chst2 UTSW 9 95,287,662 (GRCm39) missense probably damaging 1.00
R6339:Chst2 UTSW 9 95,287,803 (GRCm39) missense probably damaging 1.00
R6752:Chst2 UTSW 9 95,286,802 (GRCm39) nonsense probably null
R8061:Chst2 UTSW 9 95,287,224 (GRCm39) missense probably damaging 0.99
R9008:Chst2 UTSW 9 95,288,347 (GRCm39) start gained probably benign
R9204:Chst2 UTSW 9 95,287,155 (GRCm39) missense probably damaging 0.99
R9400:Chst2 UTSW 9 95,287,642 (GRCm39) missense probably benign 0.14
R9732:Chst2 UTSW 9 95,287,951 (GRCm39) missense probably benign 0.02
Z1177:Chst2 UTSW 9 95,286,894 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTGGATCTTTAAGCAGCGG -3'
(R):5'- CTTCAACCAGAACCCTGAGG -3'

Sequencing Primer
(F):5'- TTGATAACCAGCGTGCGGTAC -3'
(R):5'- GAGGTGTTCTTCCTCTATGAGCC -3'
Posted On 2019-05-13