Mutagenetix > Incidental Mutation

Incidental Mutation 'R7063:Vmn2r108'

548416

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r108

Ensembl Gene

ENSMUSG00000091805

Gene Name

vomeronasal 2, receptor 108

Synonyms

EG627805

MMRRC Submission

045159-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

R7063 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

20682635-20701498 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 20701410 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 30 (Y30C)

Ref Sequence

ENSEMBL: ENSMUSP00000130373 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167314]

AlphaFold

E9PYS0

Predicted Effect

probably damaging
Transcript: ENSMUST00000167314
AA Change: Y30C

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000130373
Gene: ENSMUSG00000091805
AA Change: Y30C

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	467	6e-33	PFAM
Pfam:NCD3G	510	563	9.2e-22	PFAM
Pfam:7tm_3	593	831	2.2e-51	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (43/43)

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arhgap35	A	G	7: 16,299,038 (GRCm39)	V9A	probably benign	Het
Btbd6	A	G	12: 112,941,132 (GRCm39)	Y148C	probably damaging	Het
Casr	T	C	16: 36,314,936 (GRCm39)	I968V	probably benign	Het
Celf1	T	C	2: 90,843,189 (GRCm39)		probably null	Het
Chst2	G	T	9: 95,287,621 (GRCm39)	R242S	probably benign	Het
Clca3a1	T	A	3: 144,460,967 (GRCm39)	D228V	probably damaging	Het
Cwf19l2	A	G	9: 3,430,532 (GRCm39)	Y288C	probably benign	Het
Cyp2r1	A	G	7: 114,152,184 (GRCm39)	S49P	probably damaging	Het
Dnah5	A	G	15: 28,233,394 (GRCm39)	E251G	probably benign	Het
Eepd1	A	G	9: 25,394,332 (GRCm39)	R199G	possibly damaging	Het
Fat1	C	T	8: 45,493,812 (GRCm39)	T3986I	probably benign	Het
Gbp4	G	A	5: 105,266,314 (GRCm39)	R576C	probably damaging	Het
Glp1r	A	G	17: 31,144,532 (GRCm39)	Y235C	probably damaging	Het
Gm6408	T	C	5: 146,420,594 (GRCm39)	I158T	probably benign	Het
Gpr89	C	G	3: 96,783,014 (GRCm39)	R312P	probably damaging	Het
Idh2	A	G	7: 79,745,432 (GRCm39)	V403A	probably damaging	Het
Lclat1	A	G	17: 73,546,986 (GRCm39)	E301G	possibly damaging	Het
Lgmn	A	G	12: 102,368,937 (GRCm39)	Y181H	probably damaging	Het
Lgr5	T	C	10: 115,292,639 (GRCm39)	Y417C	probably damaging	Het
Man1a	G	T	10: 53,906,840 (GRCm39)	N311K	probably damaging	Het
Nat10	G	A	2: 103,578,422 (GRCm39)	L228F	probably benign	Het
Or10d3	T	G	9: 39,461,411 (GRCm39)	Y252S	possibly damaging	Het
Or10v5	A	G	19: 11,805,548 (GRCm39)	F281L	probably damaging	Het
Or5b12b	A	G	19: 12,861,449 (GRCm39)	D68G	probably damaging	Het
Or5p55	C	A	7: 107,567,411 (GRCm39)	A269E	probably benign	Het
Pcmtd2	T	A	2: 181,496,776 (GRCm39)	Y130*	probably null	Het
Potefam3f	G	A	8: 20,479,013 (GRCm39)	C7Y		Het
Qrfprl	A	G	6: 65,418,387 (GRCm39)		probably benign	Het
Rapgef5	A	G	12: 117,652,864 (GRCm39)	D62G	possibly damaging	Het
Serpina3m	A	T	12: 104,357,726 (GRCm39)	I217L	probably benign	Het
Supt16	T	C	14: 52,409,505 (GRCm39)	R802G	possibly damaging	Het
Sypl2	A	T	3: 108,124,971 (GRCm39)	M130K	probably benign	Het
Tmtc2	A	T	10: 105,184,386 (GRCm39)	L503Q	probably damaging	Het
Ubald2	A	G	11: 116,325,443 (GRCm39)	Q60R	probably benign	Het
Vav1	C	T	17: 57,618,860 (GRCm39)	Q673*	probably null	Het
Vgll2	T	C	10: 51,904,072 (GRCm39)	S312P	probably benign	Het
Vmn1r191	C	T	13: 22,362,864 (GRCm39)	A297T	probably benign	Het
Vmn1r7	T	A	6: 57,001,418 (GRCm39)	I281F	possibly damaging	Het
Vmn2r16	A	G	5: 109,511,650 (GRCm39)	N619S	probably damaging	Het
Vstm5	A	G	9: 15,150,549 (GRCm39)		probably benign	Het
Zfp7	A	G	15: 76,775,919 (GRCm39)	I654V	possibly damaging	Het
Zmat2	A	G	18: 36,929,627 (GRCm39)	N129S	probably null	Het

Other mutations in Vmn2r108

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00903:Vmn2r108	APN	17	20,682,774 (GRCm39)	missense	probably damaging	0.98
IGL01143:Vmn2r108	APN	17	20,682,727 (GRCm39)	missense	possibly damaging	0.82
IGL01311:Vmn2r108	APN	17	20,682,939 (GRCm39)	nonsense	probably null
IGL01411:Vmn2r108	APN	17	20,691,282 (GRCm39)	missense	probably benign	0.01
IGL01414:Vmn2r108	APN	17	20,691,942 (GRCm39)	missense	probably benign	0.00
IGL01536:Vmn2r108	APN	17	20,683,543 (GRCm39)	missense	probably damaging	1.00
IGL01748:Vmn2r108	APN	17	20,683,476 (GRCm39)	missense	probably benign	0.03
IGL01769:Vmn2r108	APN	17	20,691,280 (GRCm39)	missense	probably benign	0.02
IGL02022:Vmn2r108	APN	17	20,691,987 (GRCm39)	missense	possibly damaging	0.77
IGL02041:Vmn2r108	APN	17	20,683,398 (GRCm39)	missense	probably damaging	1.00
IGL02049:Vmn2r108	APN	17	20,691,608 (GRCm39)	missense	probably benign	0.00
IGL02344:Vmn2r108	APN	17	20,689,405 (GRCm39)	missense	probably damaging	1.00
IGL02939:Vmn2r108	APN	17	20,691,545 (GRCm39)	missense	probably benign	0.05
IGL03202:Vmn2r108	APN	17	20,691,319 (GRCm39)	nonsense	probably null
PIT4498001:Vmn2r108	UTSW	17	20,683,279 (GRCm39)	missense	probably damaging	1.00
R0112:Vmn2r108	UTSW	17	20,691,897 (GRCm39)	missense	probably benign	0.07
R0505:Vmn2r108	UTSW	17	20,683,096 (GRCm39)	missense	possibly damaging	0.77
R0833:Vmn2r108	UTSW	17	20,691,721 (GRCm39)	missense	probably benign
R0836:Vmn2r108	UTSW	17	20,691,721 (GRCm39)	missense	probably benign
R0943:Vmn2r108	UTSW	17	20,691,397 (GRCm39)	nonsense	probably null
R1411:Vmn2r108	UTSW	17	20,683,107 (GRCm39)	missense	probably damaging	0.98
R1442:Vmn2r108	UTSW	17	20,692,623 (GRCm39)	nonsense	probably null
R1587:Vmn2r108	UTSW	17	20,692,383 (GRCm39)	missense	probably damaging	1.00
R1751:Vmn2r108	UTSW	17	20,682,786 (GRCm39)	missense	probably damaging	1.00
R1773:Vmn2r108	UTSW	17	20,689,335 (GRCm39)	missense	probably damaging	1.00
R2021:Vmn2r108	UTSW	17	20,691,252 (GRCm39)	missense	probably benign	0.00
R2159:Vmn2r108	UTSW	17	20,689,363 (GRCm39)	missense	probably benign	0.41
R2224:Vmn2r108	UTSW	17	20,701,295 (GRCm39)	nonsense	probably null
R2226:Vmn2r108	UTSW	17	20,701,295 (GRCm39)	nonsense	probably null
R2517:Vmn2r108	UTSW	17	20,692,577 (GRCm39)	missense	probably damaging	1.00
R3710:Vmn2r108	UTSW	17	20,682,932 (GRCm39)	missense	probably benign
R4470:Vmn2r108	UTSW	17	20,682,990 (GRCm39)	missense	probably damaging	1.00
R4686:Vmn2r108	UTSW	17	20,691,636 (GRCm39)	missense	probably damaging	0.99
R4729:Vmn2r108	UTSW	17	20,692,632 (GRCm39)	missense	probably damaging	0.99
R4799:Vmn2r108	UTSW	17	20,682,891 (GRCm39)	missense	probably damaging	1.00
R4993:Vmn2r108	UTSW	17	20,701,449 (GRCm39)	missense	probably benign	0.04
R5088:Vmn2r108	UTSW	17	20,690,454 (GRCm39)	missense	possibly damaging	0.46
R5213:Vmn2r108	UTSW	17	20,691,755 (GRCm39)	missense	probably benign	0.00
R5289:Vmn2r108	UTSW	17	20,691,866 (GRCm39)	missense	probably damaging	1.00
R5290:Vmn2r108	UTSW	17	20,691,665 (GRCm39)	missense	probably benign	0.00
R5713:Vmn2r108	UTSW	17	20,691,290 (GRCm39)	missense	probably damaging	1.00
R5753:Vmn2r108	UTSW	17	20,683,179 (GRCm39)	missense	probably damaging	0.99
R5792:Vmn2r108	UTSW	17	20,683,398 (GRCm39)	missense	probably damaging	0.99
R5798:Vmn2r108	UTSW	17	20,692,545 (GRCm39)	missense	probably benign	0.39
R5897:Vmn2r108	UTSW	17	20,691,580 (GRCm39)	missense	probably benign	0.01
R6018:Vmn2r108	UTSW	17	20,683,268 (GRCm39)	missense	possibly damaging	0.83
R6093:Vmn2r108	UTSW	17	20,701,402 (GRCm39)	missense	probably benign	0.00
R6156:Vmn2r108	UTSW	17	20,692,447 (GRCm39)	missense	probably benign	0.03
R6199:Vmn2r108	UTSW	17	20,682,644 (GRCm39)	missense	probably benign	0.01
R6259:Vmn2r108	UTSW	17	20,683,371 (GRCm39)	missense	possibly damaging	0.95
R6309:Vmn2r108	UTSW	17	20,691,660 (GRCm39)	missense	probably damaging	0.98
R6324:Vmn2r108	UTSW	17	20,691,977 (GRCm39)	nonsense	probably null
R6364:Vmn2r108	UTSW	17	20,691,260 (GRCm39)	missense	probably benign	0.00
R6446:Vmn2r108	UTSW	17	20,692,609 (GRCm39)	nonsense	probably null
R6541:Vmn2r108	UTSW	17	20,701,480 (GRCm39)	missense	probably benign	0.02
R7025:Vmn2r108	UTSW	17	20,691,345 (GRCm39)	missense	possibly damaging	0.67
R7092:Vmn2r108	UTSW	17	20,701,338 (GRCm39)	missense	probably benign	0.10
R7096:Vmn2r108	UTSW	17	20,682,762 (GRCm39)	missense	probably damaging	1.00
R7203:Vmn2r108	UTSW	17	20,683,038 (GRCm39)	missense	probably benign	0.12
R7458:Vmn2r108	UTSW	17	20,692,532 (GRCm39)	missense	probably benign	0.17
R7619:Vmn2r108	UTSW	17	20,692,457 (GRCm39)	missense	probably benign	0.02
R7841:Vmn2r108	UTSW	17	20,690,305 (GRCm39)	critical splice donor site	probably null
R7944:Vmn2r108	UTSW	17	20,691,890 (GRCm39)	missense	probably damaging	0.99
R8048:Vmn2r108	UTSW	17	20,691,762 (GRCm39)	missense	probably benign	0.29
R8213:Vmn2r108	UTSW	17	20,690,350 (GRCm39)	missense	probably benign	0.03
R8218:Vmn2r108	UTSW	17	20,683,465 (GRCm39)	missense	probably damaging	1.00
R8507:Vmn2r108	UTSW	17	20,683,195 (GRCm39)	nonsense	probably null
R8708:Vmn2r108	UTSW	17	20,682,687 (GRCm39)	missense	probably damaging	0.98
R8845:Vmn2r108	UTSW	17	20,691,361 (GRCm39)	missense	probably benign	0.03
R9030:Vmn2r108	UTSW	17	20,690,312 (GRCm39)	missense	probably benign	0.01
R9226:Vmn2r108	UTSW	17	20,691,330 (GRCm39)	missense	probably benign
R9278:Vmn2r108	UTSW	17	20,692,561 (GRCm39)	missense	probably benign	0.11
X0022:Vmn2r108	UTSW	17	20,691,371 (GRCm39)	missense	probably damaging	1.00
Z1088:Vmn2r108	UTSW	17	20,691,375 (GRCm39)	missense	probably benign	0.01
Z1177:Vmn2r108	UTSW	17	20,691,219 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- ATTCAGACCTTATGGCCTAACC -3'
(R):5'- TGGAATGATTAGTGTGACCACC -3'

Sequencing Primer
(F):5'- TGGCCTAACCAGAATAGCTAATAAG -3'
(R):5'- AAGTTGAAAATATGCATGGTCACAG -3'

Posted On

2019-05-13