Incidental Mutation 'R7063:Or10v5'
ID 548421
Institutional Source Beutler Lab
Gene Symbol Or10v5
Ensembl Gene ENSMUSG00000048292
Gene Name olfactory receptor family 10 subfamily V member 5
Synonyms MOR266-2, GA_x6K02T2RE5P-2172809-2171862, Olfr1417
MMRRC Submission 045159-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R7063 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 11805441-11806388 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 11805548 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 281 (F281L)
Ref Sequence ENSEMBL: ENSMUSP00000149141 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061235] [ENSMUST00000214887]
AlphaFold Q8VGJ6
Predicted Effect probably damaging
Transcript: ENSMUST00000061235
AA Change: F281L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000062542
Gene: ENSMUSG00000048292
AA Change: F281L

DomainStartEndE-ValueType
Pfam:7tm_4 31 309 3.3e-53 PFAM
Pfam:7tm_1 41 291 3.1e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214887
AA Change: F281L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (43/43)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap35 A G 7: 16,299,038 (GRCm39) V9A probably benign Het
Btbd6 A G 12: 112,941,132 (GRCm39) Y148C probably damaging Het
Casr T C 16: 36,314,936 (GRCm39) I968V probably benign Het
Celf1 T C 2: 90,843,189 (GRCm39) probably null Het
Chst2 G T 9: 95,287,621 (GRCm39) R242S probably benign Het
Clca3a1 T A 3: 144,460,967 (GRCm39) D228V probably damaging Het
Cwf19l2 A G 9: 3,430,532 (GRCm39) Y288C probably benign Het
Cyp2r1 A G 7: 114,152,184 (GRCm39) S49P probably damaging Het
Dnah5 A G 15: 28,233,394 (GRCm39) E251G probably benign Het
Eepd1 A G 9: 25,394,332 (GRCm39) R199G possibly damaging Het
Fat1 C T 8: 45,493,812 (GRCm39) T3986I probably benign Het
Gbp4 G A 5: 105,266,314 (GRCm39) R576C probably damaging Het
Glp1r A G 17: 31,144,532 (GRCm39) Y235C probably damaging Het
Gm6408 T C 5: 146,420,594 (GRCm39) I158T probably benign Het
Gpr89 C G 3: 96,783,014 (GRCm39) R312P probably damaging Het
Idh2 A G 7: 79,745,432 (GRCm39) V403A probably damaging Het
Lclat1 A G 17: 73,546,986 (GRCm39) E301G possibly damaging Het
Lgmn A G 12: 102,368,937 (GRCm39) Y181H probably damaging Het
Lgr5 T C 10: 115,292,639 (GRCm39) Y417C probably damaging Het
Man1a G T 10: 53,906,840 (GRCm39) N311K probably damaging Het
Nat10 G A 2: 103,578,422 (GRCm39) L228F probably benign Het
Or10d3 T G 9: 39,461,411 (GRCm39) Y252S possibly damaging Het
Or5b12b A G 19: 12,861,449 (GRCm39) D68G probably damaging Het
Or5p55 C A 7: 107,567,411 (GRCm39) A269E probably benign Het
Pcmtd2 T A 2: 181,496,776 (GRCm39) Y130* probably null Het
Potefam3f G A 8: 20,479,013 (GRCm39) C7Y Het
Qrfprl A G 6: 65,418,387 (GRCm39) probably benign Het
Rapgef5 A G 12: 117,652,864 (GRCm39) D62G possibly damaging Het
Serpina3m A T 12: 104,357,726 (GRCm39) I217L probably benign Het
Supt16 T C 14: 52,409,505 (GRCm39) R802G possibly damaging Het
Sypl2 A T 3: 108,124,971 (GRCm39) M130K probably benign Het
Tmtc2 A T 10: 105,184,386 (GRCm39) L503Q probably damaging Het
Ubald2 A G 11: 116,325,443 (GRCm39) Q60R probably benign Het
Vav1 C T 17: 57,618,860 (GRCm39) Q673* probably null Het
Vgll2 T C 10: 51,904,072 (GRCm39) S312P probably benign Het
Vmn1r191 C T 13: 22,362,864 (GRCm39) A297T probably benign Het
Vmn1r7 T A 6: 57,001,418 (GRCm39) I281F possibly damaging Het
Vmn2r108 T C 17: 20,701,410 (GRCm39) Y30C probably damaging Het
Vmn2r16 A G 5: 109,511,650 (GRCm39) N619S probably damaging Het
Vstm5 A G 9: 15,150,549 (GRCm39) probably benign Het
Zfp7 A G 15: 76,775,919 (GRCm39) I654V possibly damaging Het
Zmat2 A G 18: 36,929,627 (GRCm39) N129S probably null Het
Other mutations in Or10v5
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0530:Or10v5 UTSW 19 11,805,556 (GRCm39) missense probably benign 0.26
R1532:Or10v5 UTSW 19 11,805,983 (GRCm39) missense probably benign 0.00
R1730:Or10v5 UTSW 19 11,805,445 (GRCm39) missense probably benign 0.06
R2032:Or10v5 UTSW 19 11,805,664 (GRCm39) missense probably damaging 1.00
R2237:Or10v5 UTSW 19 11,805,814 (GRCm39) missense probably damaging 1.00
R2238:Or10v5 UTSW 19 11,805,814 (GRCm39) missense probably damaging 1.00
R2239:Or10v5 UTSW 19 11,805,814 (GRCm39) missense probably damaging 1.00
R4959:Or10v5 UTSW 19 11,806,300 (GRCm39) missense probably benign
R4973:Or10v5 UTSW 19 11,806,300 (GRCm39) missense probably benign
R5015:Or10v5 UTSW 19 11,805,482 (GRCm39) missense probably benign 0.00
R6799:Or10v5 UTSW 19 11,806,178 (GRCm39) missense possibly damaging 0.91
R6984:Or10v5 UTSW 19 11,805,668 (GRCm39) missense probably damaging 1.00
R7222:Or10v5 UTSW 19 11,806,021 (GRCm39) missense probably damaging 0.99
R8021:Or10v5 UTSW 19 11,806,256 (GRCm39) missense probably benign 0.39
R8748:Or10v5 UTSW 19 11,805,596 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCCATGTTGAAGAATGAGTACCC -3'
(R):5'- ATGCCATCCTGAAGATCCGC -3'

Sequencing Primer
(F):5'- CCACCATTGAATAGTAATGAGACTGG -3'
(R):5'- ATCCTGAAGATCCGCTCAGCTG -3'
Posted On 2019-05-13