Incidental Mutation 'R7066:Zfp27'
ID |
548567 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zfp27
|
Ensembl Gene |
ENSMUSG00000062040 |
Gene Name |
zinc finger protein 27 |
Synonyms |
Zfp-27, mkr-4 |
MMRRC Submission |
045162-MU
|
Accession Numbers |
|
Essential gene? |
Possibly essential
(E-score: 0.602)
|
Stock # |
R7066 (G1)
|
Quality Score |
217.468 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
29592758-29605997 bp(-) (GRCm39) |
Type of Mutation |
small deletion (4 aa in frame mutation) |
DNA Base Change (assembly) |
AATCCGCTTGTGCA to AA
at 29594446 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000127677
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053521]
[ENSMUST00000159920]
[ENSMUST00000161904]
[ENSMUST00000162592]
[ENSMUST00000172448]
|
AlphaFold |
P10077 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000053521
|
SMART Domains |
Protein: ENSMUSP00000054012 Gene: ENSMUSG00000062040
Domain | Start | End | E-Value | Type |
KRAB
|
1 |
59 |
2.94e-12 |
SMART |
internal_repeat_2
|
108 |
195 |
4.1e-6 |
PROSPERO |
ZnF_C2H2
|
205 |
227 |
3.11e-2 |
SMART |
ZnF_C2H2
|
233 |
255 |
8.47e-4 |
SMART |
ZnF_C2H2
|
261 |
283 |
2.09e-3 |
SMART |
ZnF_C2H2
|
289 |
311 |
2.91e-2 |
SMART |
ZnF_C2H2
|
317 |
339 |
4.17e-3 |
SMART |
ZnF_C2H2
|
345 |
367 |
4.79e-3 |
SMART |
ZnF_C2H2
|
401 |
423 |
7.15e-2 |
SMART |
ZnF_C2H2
|
429 |
451 |
3.69e-4 |
SMART |
ZnF_C2H2
|
457 |
479 |
1.08e-1 |
SMART |
ZnF_C2H2
|
485 |
507 |
2.57e-3 |
SMART |
ZnF_C2H2
|
513 |
535 |
1.5e-4 |
SMART |
ZnF_C2H2
|
541 |
563 |
1.38e-3 |
SMART |
ZnF_C2H2
|
569 |
591 |
1.03e-2 |
SMART |
ZnF_C2H2
|
597 |
619 |
3.34e-2 |
SMART |
ZnF_C2H2
|
625 |
647 |
8.34e-3 |
SMART |
ZnF_C2H2
|
653 |
675 |
2.36e-2 |
SMART |
ZnF_C2H2
|
681 |
703 |
6.88e-4 |
SMART |
ZnF_C2H2
|
709 |
731 |
2.27e-4 |
SMART |
ZnF_C2H2
|
737 |
759 |
6.88e-4 |
SMART |
ZnF_C2H2
|
765 |
787 |
1.72e-4 |
SMART |
ZnF_C2H2
|
793 |
815 |
3.83e-2 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000159920
|
SMART Domains |
Protein: ENSMUSP00000125232 Gene: ENSMUSG00000062040
Domain | Start | End | E-Value | Type |
KRAB
|
1 |
59 |
2.94e-12 |
SMART |
internal_repeat_2
|
108 |
195 |
4.1e-6 |
PROSPERO |
ZnF_C2H2
|
205 |
227 |
3.11e-2 |
SMART |
ZnF_C2H2
|
233 |
255 |
8.47e-4 |
SMART |
ZnF_C2H2
|
261 |
283 |
2.09e-3 |
SMART |
ZnF_C2H2
|
289 |
311 |
2.91e-2 |
SMART |
ZnF_C2H2
|
317 |
339 |
4.17e-3 |
SMART |
ZnF_C2H2
|
345 |
367 |
4.79e-3 |
SMART |
ZnF_C2H2
|
401 |
423 |
7.15e-2 |
SMART |
ZnF_C2H2
|
429 |
451 |
3.69e-4 |
SMART |
ZnF_C2H2
|
457 |
479 |
1.08e-1 |
SMART |
ZnF_C2H2
|
485 |
507 |
2.57e-3 |
SMART |
ZnF_C2H2
|
513 |
535 |
1.5e-4 |
SMART |
ZnF_C2H2
|
541 |
563 |
1.38e-3 |
SMART |
ZnF_C2H2
|
569 |
591 |
1.03e-2 |
SMART |
ZnF_C2H2
|
597 |
619 |
3.34e-2 |
SMART |
ZnF_C2H2
|
625 |
647 |
8.34e-3 |
SMART |
ZnF_C2H2
|
653 |
675 |
2.36e-2 |
SMART |
ZnF_C2H2
|
681 |
703 |
6.88e-4 |
SMART |
ZnF_C2H2
|
709 |
731 |
2.27e-4 |
SMART |
ZnF_C2H2
|
737 |
759 |
6.88e-4 |
SMART |
ZnF_C2H2
|
765 |
787 |
1.72e-4 |
SMART |
ZnF_C2H2
|
793 |
815 |
3.83e-2 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000161904
|
SMART Domains |
Protein: ENSMUSP00000124684 Gene: ENSMUSG00000062040
Domain | Start | End | E-Value | Type |
KRAB
|
1 |
59 |
2.94e-12 |
SMART |
internal_repeat_2
|
108 |
195 |
4.1e-6 |
PROSPERO |
ZnF_C2H2
|
205 |
227 |
3.11e-2 |
SMART |
ZnF_C2H2
|
233 |
255 |
8.47e-4 |
SMART |
ZnF_C2H2
|
261 |
283 |
2.09e-3 |
SMART |
ZnF_C2H2
|
289 |
311 |
2.91e-2 |
SMART |
ZnF_C2H2
|
317 |
339 |
4.17e-3 |
SMART |
ZnF_C2H2
|
345 |
367 |
4.79e-3 |
SMART |
ZnF_C2H2
|
401 |
423 |
7.15e-2 |
SMART |
ZnF_C2H2
|
429 |
451 |
3.69e-4 |
SMART |
ZnF_C2H2
|
457 |
479 |
1.08e-1 |
SMART |
ZnF_C2H2
|
485 |
507 |
2.57e-3 |
SMART |
ZnF_C2H2
|
513 |
535 |
1.5e-4 |
SMART |
ZnF_C2H2
|
541 |
563 |
1.38e-3 |
SMART |
ZnF_C2H2
|
569 |
591 |
1.03e-2 |
SMART |
ZnF_C2H2
|
597 |
619 |
3.34e-2 |
SMART |
ZnF_C2H2
|
625 |
647 |
8.34e-3 |
SMART |
ZnF_C2H2
|
653 |
675 |
2.36e-2 |
SMART |
ZnF_C2H2
|
681 |
703 |
6.88e-4 |
SMART |
ZnF_C2H2
|
709 |
731 |
2.27e-4 |
SMART |
ZnF_C2H2
|
737 |
759 |
6.88e-4 |
SMART |
ZnF_C2H2
|
765 |
787 |
1.72e-4 |
SMART |
ZnF_C2H2
|
793 |
815 |
3.83e-2 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000162592
|
SMART Domains |
Protein: ENSMUSP00000123953 Gene: ENSMUSG00000062040
Domain | Start | End | E-Value | Type |
KRAB
|
1 |
59 |
2.94e-12 |
SMART |
internal_repeat_2
|
108 |
195 |
4.1e-6 |
PROSPERO |
ZnF_C2H2
|
205 |
227 |
3.11e-2 |
SMART |
ZnF_C2H2
|
233 |
255 |
8.47e-4 |
SMART |
ZnF_C2H2
|
261 |
283 |
2.09e-3 |
SMART |
ZnF_C2H2
|
289 |
311 |
2.91e-2 |
SMART |
ZnF_C2H2
|
317 |
339 |
4.17e-3 |
SMART |
ZnF_C2H2
|
345 |
367 |
4.79e-3 |
SMART |
ZnF_C2H2
|
401 |
423 |
7.15e-2 |
SMART |
ZnF_C2H2
|
429 |
451 |
3.69e-4 |
SMART |
ZnF_C2H2
|
457 |
479 |
1.08e-1 |
SMART |
ZnF_C2H2
|
485 |
507 |
2.57e-3 |
SMART |
ZnF_C2H2
|
513 |
535 |
1.5e-4 |
SMART |
ZnF_C2H2
|
541 |
563 |
1.38e-3 |
SMART |
ZnF_C2H2
|
569 |
591 |
1.03e-2 |
SMART |
ZnF_C2H2
|
597 |
619 |
3.34e-2 |
SMART |
ZnF_C2H2
|
625 |
647 |
8.34e-3 |
SMART |
ZnF_C2H2
|
653 |
675 |
2.36e-2 |
SMART |
ZnF_C2H2
|
681 |
703 |
6.88e-4 |
SMART |
ZnF_C2H2
|
709 |
731 |
2.27e-4 |
SMART |
ZnF_C2H2
|
737 |
759 |
6.88e-4 |
SMART |
ZnF_C2H2
|
765 |
787 |
1.72e-4 |
SMART |
ZnF_C2H2
|
793 |
815 |
3.83e-2 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000172448
|
SMART Domains |
Protein: ENSMUSP00000127677 Gene: ENSMUSG00000062040
Domain | Start | End | E-Value | Type |
KRAB
|
1 |
59 |
2.94e-12 |
SMART |
internal_repeat_2
|
108 |
195 |
4.1e-6 |
PROSPERO |
ZnF_C2H2
|
205 |
227 |
3.11e-2 |
SMART |
ZnF_C2H2
|
233 |
255 |
8.47e-4 |
SMART |
ZnF_C2H2
|
261 |
283 |
2.09e-3 |
SMART |
ZnF_C2H2
|
289 |
311 |
2.91e-2 |
SMART |
ZnF_C2H2
|
317 |
339 |
4.17e-3 |
SMART |
ZnF_C2H2
|
345 |
367 |
4.79e-3 |
SMART |
ZnF_C2H2
|
401 |
423 |
7.15e-2 |
SMART |
ZnF_C2H2
|
429 |
451 |
3.69e-4 |
SMART |
ZnF_C2H2
|
457 |
479 |
1.08e-1 |
SMART |
ZnF_C2H2
|
485 |
507 |
2.57e-3 |
SMART |
ZnF_C2H2
|
513 |
535 |
1.5e-4 |
SMART |
ZnF_C2H2
|
541 |
563 |
1.38e-3 |
SMART |
ZnF_C2H2
|
569 |
591 |
1.03e-2 |
SMART |
ZnF_C2H2
|
597 |
619 |
3.34e-2 |
SMART |
ZnF_C2H2
|
625 |
647 |
8.34e-3 |
SMART |
ZnF_C2H2
|
653 |
675 |
2.36e-2 |
SMART |
ZnF_C2H2
|
681 |
703 |
6.88e-4 |
SMART |
ZnF_C2H2
|
709 |
731 |
2.27e-4 |
SMART |
ZnF_C2H2
|
737 |
759 |
6.88e-4 |
SMART |
ZnF_C2H2
|
765 |
787 |
1.72e-4 |
SMART |
ZnF_C2H2
|
793 |
815 |
3.83e-2 |
SMART |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
Validation Efficiency |
98% (52/53) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 52 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
A1cf |
T |
C |
19: 31,904,514 (GRCm39) |
V175A |
probably damaging |
Het |
Adamts5 |
A |
T |
16: 85,659,652 (GRCm39) |
V880E |
probably damaging |
Het |
Adgrf1 |
T |
A |
17: 43,621,151 (GRCm39) |
F463I |
probably benign |
Het |
Ano1 |
T |
A |
7: 144,190,823 (GRCm39) |
E249D |
probably benign |
Het |
Aoc1 |
A |
G |
6: 48,885,553 (GRCm39) |
D686G |
probably damaging |
Het |
Cacna1d |
A |
T |
14: 30,074,935 (GRCm39) |
|
probably benign |
Het |
Cdc42ep4 |
A |
G |
11: 113,620,044 (GRCm39) |
S116P |
probably damaging |
Het |
Ces2a |
T |
C |
8: 105,466,880 (GRCm39) |
V463A |
probably damaging |
Het |
Depdc5 |
A |
G |
5: 33,059,192 (GRCm39) |
D297G |
probably benign |
Het |
Fsip2 |
T |
A |
2: 82,821,235 (GRCm39) |
V5656E |
possibly damaging |
Het |
Gbp5 |
A |
G |
3: 142,213,490 (GRCm39) |
T469A |
probably benign |
Het |
Gm21663 |
C |
G |
5: 26,146,259 (GRCm39) |
|
probably null |
Het |
Iqch |
A |
G |
9: 63,432,027 (GRCm39) |
V456A |
probably benign |
Het |
Lpcat1 |
A |
C |
13: 73,659,500 (GRCm39) |
I373L |
probably benign |
Het |
Morc2b |
C |
T |
17: 33,355,610 (GRCm39) |
V721I |
probably benign |
Het |
Mrgprb1 |
C |
T |
7: 48,097,424 (GRCm39) |
V163M |
probably benign |
Het |
Mtfr2 |
A |
G |
10: 20,229,972 (GRCm39) |
I142V |
possibly damaging |
Het |
Muc16 |
A |
T |
9: 18,569,317 (GRCm39) |
S1067R |
unknown |
Het |
Myh14 |
T |
C |
7: 44,280,179 (GRCm39) |
S892G |
possibly damaging |
Het |
Mylk2 |
C |
T |
2: 152,753,588 (GRCm39) |
|
probably null |
Het |
Mzf1 |
A |
T |
7: 12,777,490 (GRCm39) |
V638E |
possibly damaging |
Het |
Ncoa1 |
C |
T |
12: 4,372,934 (GRCm39) |
V156I |
possibly damaging |
Het |
Nf1 |
A |
G |
11: 79,447,546 (GRCm39) |
E2450G |
probably damaging |
Het |
Or14j3 |
T |
A |
17: 37,901,034 (GRCm39) |
D70V |
probably damaging |
Het |
Or1e29 |
A |
G |
11: 73,668,018 (GRCm39) |
I45T |
probably damaging |
Het |
Or4a72 |
T |
C |
2: 89,406,047 (GRCm39) |
T8A |
probably damaging |
Het |
Or4f60 |
G |
A |
2: 111,902,541 (GRCm39) |
P129L |
probably damaging |
Het |
Or5t7 |
T |
A |
2: 86,507,570 (GRCm39) |
T36S |
possibly damaging |
Het |
Or6c88 |
T |
C |
10: 129,407,373 (GRCm39) |
L283S |
probably damaging |
Het |
Or8g54 |
A |
G |
9: 39,707,420 (GRCm39) |
I250V |
probably benign |
Het |
Or8k17 |
T |
C |
2: 86,067,002 (GRCm39) |
D52G |
probably damaging |
Het |
P4htm |
T |
G |
9: 108,474,162 (GRCm39) |
K125N |
probably damaging |
Het |
Patj |
A |
G |
4: 98,301,434 (GRCm39) |
T240A |
probably benign |
Het |
Pcolce2 |
T |
C |
9: 95,563,674 (GRCm39) |
V220A |
probably benign |
Het |
Pcyox1 |
A |
T |
6: 86,371,478 (GRCm39) |
I136N |
probably damaging |
Het |
Pde4b |
A |
G |
4: 102,460,003 (GRCm39) |
S395G |
probably benign |
Het |
Peg3 |
C |
A |
7: 6,711,856 (GRCm39) |
R1122L |
probably damaging |
Het |
Plekhm1 |
A |
G |
11: 103,261,814 (GRCm39) |
V922A |
possibly damaging |
Het |
Rad51c |
T |
C |
11: 87,293,502 (GRCm39) |
N118S |
possibly damaging |
Het |
Rb1cc1 |
T |
A |
1: 6,320,229 (GRCm39) |
V1216D |
possibly damaging |
Het |
Rictor |
C |
T |
15: 6,801,635 (GRCm39) |
S441L |
probably benign |
Het |
Rlf |
T |
C |
4: 121,005,984 (GRCm39) |
M999V |
probably benign |
Het |
Rsf1 |
GGCGGCGGC |
GGCGGCGGCCGCGGCGGC |
7: 97,229,125 (GRCm39) |
|
probably benign |
Het |
Samd7 |
G |
C |
3: 30,805,272 (GRCm39) |
K18N |
probably benign |
Het |
Sema5b |
A |
C |
16: 35,471,682 (GRCm39) |
D425A |
probably benign |
Het |
Siglecg |
A |
G |
7: 43,061,166 (GRCm39) |
E413G |
probably benign |
Het |
Tcaf1 |
A |
T |
6: 42,656,111 (GRCm39) |
N288K |
probably damaging |
Het |
Tdp1 |
A |
G |
12: 99,860,991 (GRCm39) |
D210G |
probably benign |
Het |
Umps |
A |
T |
16: 33,782,103 (GRCm39) |
L273* |
probably null |
Het |
Vcan |
A |
T |
13: 89,853,805 (GRCm39) |
V385D |
probably damaging |
Het |
Wdr59 |
T |
C |
8: 112,192,477 (GRCm39) |
T676A |
probably benign |
Het |
Zdbf2 |
A |
G |
1: 63,346,718 (GRCm39) |
H1699R |
probably benign |
Het |
|
Other mutations in Zfp27 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00972:Zfp27
|
APN |
7 |
29,594,383 (GRCm39) |
missense |
probably damaging |
0.97 |
IGL02490:Zfp27
|
APN |
7 |
29,594,360 (GRCm39) |
missense |
possibly damaging |
0.73 |
IGL02899:Zfp27
|
APN |
7 |
29,595,680 (GRCm39) |
missense |
possibly damaging |
0.91 |
R0179:Zfp27
|
UTSW |
7 |
29,595,850 (GRCm39) |
missense |
possibly damaging |
0.51 |
R0234:Zfp27
|
UTSW |
7 |
29,593,532 (GRCm39) |
missense |
possibly damaging |
0.73 |
R0234:Zfp27
|
UTSW |
7 |
29,593,532 (GRCm39) |
missense |
possibly damaging |
0.73 |
R0511:Zfp27
|
UTSW |
7 |
29,593,947 (GRCm39) |
missense |
probably damaging |
0.97 |
R1185:Zfp27
|
UTSW |
7 |
29,595,254 (GRCm39) |
missense |
possibly damaging |
0.92 |
R1185:Zfp27
|
UTSW |
7 |
29,595,254 (GRCm39) |
missense |
possibly damaging |
0.92 |
R1185:Zfp27
|
UTSW |
7 |
29,595,254 (GRCm39) |
missense |
possibly damaging |
0.92 |
R1294:Zfp27
|
UTSW |
7 |
29,595,737 (GRCm39) |
missense |
possibly damaging |
0.53 |
R1581:Zfp27
|
UTSW |
7 |
29,595,549 (GRCm39) |
missense |
possibly damaging |
0.53 |
R1763:Zfp27
|
UTSW |
7 |
29,594,801 (GRCm39) |
missense |
possibly damaging |
0.96 |
R2083:Zfp27
|
UTSW |
7 |
29,594,208 (GRCm39) |
missense |
probably benign |
0.06 |
R2217:Zfp27
|
UTSW |
7 |
29,595,536 (GRCm39) |
missense |
possibly damaging |
0.96 |
R2696:Zfp27
|
UTSW |
7 |
29,595,792 (GRCm39) |
missense |
possibly damaging |
0.85 |
R4084:Zfp27
|
UTSW |
7 |
29,594,792 (GRCm39) |
missense |
possibly damaging |
0.91 |
R4864:Zfp27
|
UTSW |
7 |
29,594,261 (GRCm39) |
missense |
probably damaging |
0.99 |
R6057:Zfp27
|
UTSW |
7 |
29,594,444 (GRCm39) |
missense |
possibly damaging |
0.83 |
R6063:Zfp27
|
UTSW |
7 |
29,593,727 (GRCm39) |
missense |
probably damaging |
0.97 |
R6553:Zfp27
|
UTSW |
7 |
29,595,818 (GRCm39) |
missense |
possibly damaging |
0.86 |
R6585:Zfp27
|
UTSW |
7 |
29,595,818 (GRCm39) |
missense |
possibly damaging |
0.86 |
R6800:Zfp27
|
UTSW |
7 |
29,593,860 (GRCm39) |
missense |
probably benign |
0.19 |
R7051:Zfp27
|
UTSW |
7 |
29,594,446 (GRCm39) |
small deletion |
probably benign |
|
R7052:Zfp27
|
UTSW |
7 |
29,594,446 (GRCm39) |
small deletion |
probably benign |
|
R7106:Zfp27
|
UTSW |
7 |
29,594,446 (GRCm39) |
small deletion |
probably benign |
|
R7432:Zfp27
|
UTSW |
7 |
29,594,784 (GRCm39) |
missense |
probably benign |
0.33 |
R7473:Zfp27
|
UTSW |
7 |
29,595,324 (GRCm39) |
missense |
possibly damaging |
0.71 |
R7670:Zfp27
|
UTSW |
7 |
29,594,221 (GRCm39) |
missense |
possibly damaging |
0.94 |
R7739:Zfp27
|
UTSW |
7 |
29,593,699 (GRCm39) |
missense |
possibly damaging |
0.93 |
R7817:Zfp27
|
UTSW |
7 |
29,595,815 (GRCm39) |
missense |
possibly damaging |
0.96 |
R8750:Zfp27
|
UTSW |
7 |
29,594,804 (GRCm39) |
missense |
possibly damaging |
0.53 |
R8819:Zfp27
|
UTSW |
7 |
29,594,013 (GRCm39) |
missense |
probably benign |
0.15 |
R8820:Zfp27
|
UTSW |
7 |
29,594,013 (GRCm39) |
missense |
probably benign |
0.15 |
R9189:Zfp27
|
UTSW |
7 |
29,595,359 (GRCm39) |
missense |
possibly damaging |
0.76 |
R9511:Zfp27
|
UTSW |
7 |
29,593,641 (GRCm39) |
missense |
possibly damaging |
0.71 |
R9705:Zfp27
|
UTSW |
7 |
29,595,342 (GRCm39) |
missense |
possibly damaging |
0.93 |
Z1177:Zfp27
|
UTSW |
7 |
29,595,657 (GRCm39) |
missense |
possibly damaging |
0.72 |
Z1177:Zfp27
|
UTSW |
7 |
29,594,586 (GRCm39) |
missense |
probably benign |
0.33 |
|
Predicted Primers |
PCR Primer
(F):5'- TTTCTGGGTAAAGGCTTTCCC -3'
(R):5'- ATCTCTCGACCGTGCGAAAC -3'
Sequencing Primer
(F):5'- GTGCTACACCCATATGGCTTC -3'
(R):5'- CAGGTCGGAGCTAATCATTCATCAG -3'
|
Posted On |
2019-05-13 |