Incidental Mutation 'R7067:Il1f5'
ID548604
Institutional Source Beutler Lab
Gene Symbol Il1f5
Ensembl Gene ENSMUSG00000026983
Gene Nameinterleukin 1 family, member 5 (delta)
SynonymsFIL1delta, IL-1H3, IL1HY1, IL1F5
MMRRC Submission
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R7067 (G1)
Quality Score225.009
Status Validated
Chromosome2
Chromosomal Location24276954-24283426 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to T at 24277529 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Stop codon at position 11 (R11*)
Ref Sequence ENSEMBL: ENSMUSP00000126028 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028360] [ENSMUST00000114490] [ENSMUST00000123053] [ENSMUST00000147885] [ENSMUST00000168941]
Predicted Effect probably null
Transcript: ENSMUST00000028360
AA Change: R11*
SMART Domains Protein: ENSMUSP00000028360
Gene: ENSMUSG00000026983
AA Change: R11*

DomainStartEndE-ValueType
IL1 5 153 7.96e-32 SMART
Predicted Effect probably null
Transcript: ENSMUST00000114490
AA Change: R11*
SMART Domains Protein: ENSMUSP00000110134
Gene: ENSMUSG00000026983
AA Change: R11*

DomainStartEndE-ValueType
IL1 5 153 7.96e-32 SMART
Predicted Effect probably null
Transcript: ENSMUST00000123053
AA Change: R11*
SMART Domains Protein: ENSMUSP00000116122
Gene: ENSMUSG00000026983
AA Change: R11*

DomainStartEndE-ValueType
PDB:1MD6|A 3 72 5e-45 PDB
Blast:IL1 5 72 1e-42 BLAST
SCOP:d1ilr1_ 10 71 1e-17 SMART
Predicted Effect probably null
Transcript: ENSMUST00000147885
AA Change: R11*
SMART Domains Protein: ENSMUSP00000141512
Gene: ENSMUSG00000026983
AA Change: R11*

DomainStartEndE-ValueType
PDB:1MD6|A 3 82 2e-52 PDB
Blast:IL1 5 82 3e-50 BLAST
SCOP:d1ilr1_ 10 82 2e-19 SMART
Predicted Effect probably null
Transcript: ENSMUST00000168941
AA Change: R11*
SMART Domains Protein: ENSMUSP00000126028
Gene: ENSMUSG00000026983
AA Change: R11*

DomainStartEndE-ValueType
IL1 5 153 7.96e-32 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 98% (62/63)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a reporter allele are overtly normal with no apparent histopathological abnormalities or immune cell alterations. Mice homozygous for a knock-out allele exhibit increased sensitivity to IMQ-induced psoriasis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438H23Rik T A 16: 91,056,033 S72C probably damaging Het
9330182L06Rik G T 5: 9,266,295 A9S possibly damaging Het
Abca13 A G 11: 9,291,845 D1236G probably benign Het
Abcc6 T C 7: 46,018,690 N165D probably benign Het
Aebp1 A G 11: 5,866,431 probably null Het
Anapc4 A G 5: 52,862,235 T580A probably benign Het
Apob T C 12: 8,009,423 I2602T probably damaging Het
Arap2 A G 5: 62,654,044 probably null Het
Asap3 T A 4: 136,241,362 probably null Het
Bend4 A G 5: 67,400,268 Y402H probably damaging Het
Crtc2 A G 3: 90,260,182 N271S probably benign Het
Csf2rb2 A T 15: 78,292,494 W233R probably damaging Het
Ctgf A G 10: 24,596,975 Y261C probably benign Het
Cyp2u1 G A 3: 131,293,553 L460F probably damaging Het
Dnm3 A G 1: 162,320,971 L277P probably damaging Het
Efemp1 A T 11: 28,867,926 N135I probably damaging Het
Fsip2 T A 2: 82,980,734 S2466T possibly damaging Het
Gal3st2 C T 1: 93,874,725 A276V possibly damaging Het
Gm47985 A T 1: 151,183,490 D294V unknown Het
Golga1 A T 2: 39,047,719 D104E probably benign Het
Hnrnpr C T 4: 136,327,393 A219V probably damaging Het
Hsd3b7 T C 7: 127,800,716 probably null Het
Hspa8 T C 9: 40,804,625 I562T probably damaging Het
Htra4 C T 8: 25,033,701 V283M probably damaging Het
Iqcd A G 5: 120,605,147 T325A probably damaging Het
Kif23 A T 9: 61,924,989 M624K probably benign Het
Krt25 G T 11: 99,317,383 Q340K probably benign Het
Lamp3 T A 16: 19,699,663 N275Y probably damaging Het
Lpin2 A C 17: 71,244,858 K789T possibly damaging Het
Mroh2b T C 15: 4,900,504 I24T probably benign Het
Muc16 T A 9: 18,658,251 I991F unknown Het
Ntf5 T A 7: 45,415,624 L60Q probably damaging Het
Nuak1 A G 10: 84,440,294 S22P possibly damaging Het
Obox8 T C 7: 14,333,054 T22A possibly damaging Het
Olfr1053 T A 2: 86,314,567 T240S probably damaging Het
Pde8a T C 7: 81,317,326 V405A probably benign Het
Phc2 T C 4: 128,747,141 S147P probably benign Het
Pole G T 5: 110,334,218 G142V probably damaging Het
Poli G A 18: 70,509,417 Q508* probably null Het
Repin1 T A 6: 48,597,916 L537* probably null Het
Rictor C T 15: 6,772,154 S441L probably benign Het
Samd7 G C 3: 30,751,123 K18N probably benign Het
Slc30a2 T A 4: 134,344,218 probably null Het
Slit3 A G 11: 35,508,230 S141G probably benign Het
Spata5 C T 3: 37,431,698 Q190* probably null Het
Spon2 A G 5: 33,214,614 S283P probably damaging Het
Srgap3 A T 6: 112,757,305 probably benign Het
Syde2 A G 3: 145,988,264 D89G probably benign Het
Syne1 A G 10: 5,234,586 I4099T probably damaging Het
Syt5 T C 7: 4,543,076 D105G probably benign Het
Tlx3 C T 11: 33,203,204 G86S probably damaging Het
Trim24 A T 6: 37,957,840 probably null Het
Umodl1 G A 17: 30,982,272 V392I probably damaging Het
Unc80 C A 1: 66,646,572 T2285K possibly damaging Het
Vars G A 17: 35,011,479 V513I probably damaging Het
Vmn1r87 T A 7: 13,131,922 Q146L probably benign Het
Vmn2r62 T C 7: 42,764,878 I714V probably benign Het
Xbp1 T A 11: 5,524,275 S159T probably damaging Het
Xrn1 T A 9: 95,969,512 H194Q probably damaging Het
Zc3h4 A T 7: 16,429,051 K459* probably null Het
Zdhhc6 G A 19: 55,304,439 R292* probably null Het
Zfp383 T A 7: 29,908,646 M1K probably null Het
Zfp703 A G 8: 26,979,016 D236G probably damaging Het
Other mutations in Il1f5
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2004:Il1f5 UTSW 2 24281364 missense probably damaging 1.00
R2162:Il1f5 UTSW 2 24279680 missense probably damaging 0.98
R2190:Il1f5 UTSW 2 24280819 missense probably damaging 1.00
R3737:Il1f5 UTSW 2 24281203 missense probably damaging 1.00
R4740:Il1f5 UTSW 2 24277491 utr 5 prime probably benign
R4867:Il1f5 UTSW 2 24280835 missense probably damaging 1.00
R5908:Il1f5 UTSW 2 24277490 start gained probably benign
R6218:Il1f5 UTSW 2 24277490 start gained probably benign
R6347:Il1f5 UTSW 2 24279714 missense probably damaging 1.00
R6348:Il1f5 UTSW 2 24279714 missense probably damaging 1.00
R6407:Il1f5 UTSW 2 24281353 missense probably damaging 1.00
R7403:Il1f5 UTSW 2 24281202 missense probably damaging 1.00
R7477:Il1f5 UTSW 2 24279692 nonsense probably null
Predicted Primers PCR Primer
(F):5'- AGGGCAGATCTGATGGATGC -3'
(R):5'- AACCTGTGAGGATCCTGCTC -3'

Sequencing Primer
(F):5'- TTCCAGATCCAGAATCGCCTG -3'
(R):5'- CTGTGAGGATCCTGCTCAGTTC -3'
Posted On2019-05-13