Mutagenetix > Incidental Mutations

Incidental Mutation 'R7068:Olfr206'

548708

Institutional Source

Beutler Lab

Gene Symbol

Olfr206

Ensembl Gene

ENSMUSG00000066257

Gene Name

olfactory receptor 206

Synonyms

MOR182-4, GA_x54KRFPKG5P-55560552-55559632

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

R7068 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

59344675-59349246 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 59345204 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 166 (T166A)

Ref Sequence

ENSEMBL: ENSMUSP00000146906 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000084791] [ENSMUST00000207927]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000084791
AA Change: T166A

PolyPhen 2 Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000081849
Gene: ENSMUSG00000066257
AA Change: T166A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	30	306	6.2e-48	PFAM
Pfam:7TM_GPCR_Srsx	34	295	2.6e-5	PFAM
Pfam:7tm_1	40	289	3.7e-20	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000207927
AA Change: T166A

PolyPhen 2 Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.9%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsm1	A	G	7: 119,622,580	H24R	probably benign	Het
Ago2	A	T	15: 73,146,450	F46L	probably damaging	Het
Amd1	A	G	10: 40,290,512	F123L	probably benign	Het
Arhgef10	T	C	8: 14,958,639	F546L	probably damaging	Het
Asic2	G	A	11: 81,152,255	H71Y	probably benign	Het
Asphd1	A	G	7: 126,948,678	V151A	probably benign	Het
Best3	T	C	10: 116,988,638	V3A	probably damaging	Het
C4b	A	G	17: 34,733,477	L1196P	probably damaging	Het
Cd22	A	G	7: 30,878,079	V3A	probably benign	Het
Cdkl3	T	C	11: 52,011,327		probably null	Het
Clcnka	A	T	4: 141,387,110	V631E	probably damaging	Het
Cmya5	A	G	13: 93,092,697	V1961A	possibly damaging	Het
Dnah14	A	G	1: 181,769,790	E3559G	probably benign	Het
Emsy	A	T	7: 98,610,761	D39E	probably benign	Het
Fam126a	A	G	5: 23,964,795	S519P	possibly damaging	Het
Fbxl16	G	T	17: 25,819,511	V477F	possibly damaging	Het
Flt1	A	T	5: 147,673,634	I393N	probably damaging	Het
Gabra4	A	T	5: 71,572,059	N433K	probably benign	Het
Gatad1	T	C	5: 3,643,540	R210G	probably benign	Het
Ghsr	T	A	3: 27,371,837	V14D	probably benign	Het
Glb1l	A	G	1: 75,202,737	Y183H	probably damaging	Het
Ighv3-4	T	C	12: 114,253,654	T106A	probably damaging	Het
Ik	T	G	18: 36,755,465	F439V	possibly damaging	Het
Itih5	T	C	2: 10,249,304	S789P	probably damaging	Het
Kcnj8	T	C	6: 142,566,239	D214G	probably damaging	Het
Kdm5a	C	A	6: 120,430,215	H1464N	probably benign	Het
Klb	A	T	5: 65,379,340	Y671F	probably damaging	Het
Kremen2	C	A	17: 23,741,885	R421L	possibly damaging	Het
Mroh9	T	A	1: 163,039,181	D662V	probably damaging	Het
Mtmr12	T	G	15: 12,257,670	M278R	probably null	Het
Ndufa8	T	C	2: 36,044,435	M44V	possibly damaging	Het
Nedd4l	A	T	18: 65,205,651	R695S	probably damaging	Het
Nuf2	G	A	1: 169,522,419	P97S	probably damaging	Het
Olfr1018	T	C	2: 85,823,052	V27A	probably benign	Het
Olfr310	A	C	7: 86,269,537	L84R	probably damaging	Het
P4ha2	A	G	11: 54,110,994	T33A	probably benign	Het
Parp1	A	G	1: 180,588,668	H544R	probably damaging	Het
Plec	A	G	15: 76,177,769	L2678P	probably damaging	Het
Rad1	T	A	15: 10,490,293	Y85*	probably null	Het
Sema6d	A	G	2: 124,657,821	I309V	probably benign	Het
Skint2	T	C	4: 112,624,351	V137A	probably damaging	Het
Slc23a3	T	C	1: 75,133,233	N130S	probably benign	Het
Slc35f1	T	C	10: 53,062,500	F176S	probably damaging	Het
Slc44a2	T	A	9: 21,320,848	Y10N	probably benign	Het
Smarcc1	A	G	9: 110,185,884	T506A	probably damaging	Het
Smchd1	A	T	17: 71,387,092	S1219R	probably benign	Het
Smco1	A	G	16: 32,274,111	N200S	probably benign	Het
Srcap	A	G	7: 127,541,943	T1571A	probably benign	Het
Strip2	C	T	6: 29,932,208	T459I	probably benign	Het
Tarbp1	C	T	8: 126,427,034	A1560T	probably damaging	Het
Tcl1b1	T	A	12: 105,159,693		probably benign	Het
Tdrd5	T	C	1: 156,284,271	E436G	probably damaging	Het
Trim31	T	A	17: 36,898,516	C55S	probably damaging	Het
Tsr1	G	T	11: 74,903,919	E467*	probably null	Het
Tulp4	T	A	17: 6,185,289	D178E	probably damaging	Het
Vmn1r30	A	G	6: 58,435,010	V279A	possibly damaging	Het
Vmn2r98	A	G	17: 19,065,313	R132G	probably benign	Het

Other mutations in Olfr206

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01372:Olfr206	APN	16	59345161	missense	probably damaging	0.97
IGL02106:Olfr206	APN	16	59345024	missense	probably benign	0.00
IGL02839:Olfr206	APN	16	59345390	missense	probably benign	0.01
IGL03010:Olfr206	APN	16	59344772	utr 3 prime	probably benign
R1163:Olfr206	UTSW	16	59345062	missense	probably damaging	0.99
R1507:Olfr206	UTSW	16	59345493	missense	probably damaging	1.00
R1670:Olfr206	UTSW	16	59345427	missense	possibly damaging	0.79
R2881:Olfr206	UTSW	16	59344852	missense	probably damaging	1.00
R2925:Olfr206	UTSW	16	59345343	nonsense	probably null
R4479:Olfr206	UTSW	16	59344867	missense	probably damaging	0.99
R4891:Olfr206	UTSW	16	59345471	missense	possibly damaging	0.87
R5085:Olfr206	UTSW	16	59345086	missense	probably damaging	0.99
R5099:Olfr206	UTSW	16	59344903	missense	probably benign	0.00
R5218:Olfr206	UTSW	16	59344907	missense	probably benign
R6019:Olfr206	UTSW	16	59345435	missense	possibly damaging	0.48
R6773:Olfr206	UTSW	16	59345216	missense	probably damaging	1.00
R7173:Olfr206	UTSW	16	59345147	missense	probably benign	0.00
R7192:Olfr206	UTSW	16	59345179	missense	probably benign	0.44
R7485:Olfr206	UTSW	16	59345324	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACTGCAGGTGAAGAAAGCTTTC -3'
(R):5'- CTACTGAAATTTTCCTTCTGGTAGCG -3'

Sequencing Primer
(F):5'- CAGGTGAAGAAAGCTTTCCTTCTGC -3'
(R):5'- CGATGGCCTATGACCGCTATGTAG -3'

Posted On

2019-05-13