Mutagenetix > Incidental Mutation

Incidental Mutation 'R7069:Plxna2'

548721

Institutional Source

Beutler Lab

Gene Symbol

Plxna2

Ensembl Gene

ENSMUSG00000026640

Gene Name

plexin A2

Synonyms

2810428A13Rik, OCT, PlexA2, Plxn2

MMRRC Submission

045165-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R7069 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

194618218-194816869 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 194793904 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Lysine at position 1144 (T1144K)

Ref Sequence

ENSEMBL: ENSMUSP00000027952 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027952]

AlphaFold

P70207

PDB Structure

Plexin A2 / Semaphorin 6A complex [X-RAY DIFFRACTION]
Mouse Plexin A2 extracellular domain [X-RAY DIFFRACTION]
Mouse Plexin A2, extracellular domains 1-4 [X-RAY DIFFRACTION]
Plexin A2 in complex with Semaphorin 6A [X-RAY DIFFRACTION]
Complex of mouse Plexin A2 - Semaphorin 3A - Neuropilin-1 [X-RAY DIFFRACTION]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000027952
AA Change: T1144K

PolyPhen 2 Score 0.506 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000027952
Gene: ENSMUSG00000026640
AA Change: T1144K

Domain	Start	End	E-Value	Type
low complexity region	16	29	N/A	INTRINSIC
Sema	50	492	1.65e-132	SMART
PSI	510	560	8e-12	SMART
PSI	655	702	6.35e-6	SMART
PSI	803	856	1.24e-8	SMART
IPT	857	952	6.36e-21	SMART
IPT	953	1038	1.02e-24	SMART
IPT	1040	1140	1.48e-21	SMART
IPT	1142	1237	8.81e-6	SMART
transmembrane domain	1238	1260	N/A	INTRINSIC
Pfam:Plexin_cytopl	1311	1864	1.9e-261	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

98% (86/88)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele show abnormal granule cell migration in the adult cerebellum and aberrant projection of mossy fibers in hippocampal slices. Mice homozygous for an ENU-induced allele are smaller and show granule cell migration defects and mild ataxia with incomplete penetrance. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 89 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2010300C02Rik	A	T	1: 37,631,901 (GRCm38)	F97Y	probably damaging	Het
4932415D10Rik	G	A	10: 82,289,943 (GRCm38)	T2411I	probably damaging	Het
Aasdh	T	A	5: 76,876,356 (GRCm38)	I991L	probably benign	Het
Actg2	C	A	6: 83,520,763 (GRCm38)	G96V	probably damaging	Het
Adh5	T	A	3: 138,451,051 (GRCm38)	L166*	probably null	Het
Akap13	A	G	7: 75,610,262 (GRCm38)	D75G	probably benign	Het
Ank2	T	C	3: 126,946,298 (GRCm38)		probably benign	Het
Arfgap1	T	A	2: 180,974,120 (GRCm38)	D197E	probably benign	Het
Aste1	T	C	9: 105,396,707 (GRCm38)		probably null	Het
Atp8b2	T	A	3: 89,954,571 (GRCm38)	N78I	probably damaging	Het
Btbd11	C	A	10: 85,387,656 (GRCm38)	R110S	unknown	Het
Cacna2d3	T	A	14: 28,969,303 (GRCm38)		probably benign	Het
Chrd	T	A	16: 20,739,433 (GRCm38)	W809R	probably damaging	Het
Col2a1	C	T	15: 97,998,588 (GRCm38)	G60D	unknown	Het
Coro7	T	A	16: 4,679,611 (GRCm38)	M1L	probably damaging	Het
Dhx40	T	C	11: 86,797,743 (GRCm38)	I285V	probably benign	Het
Dopey1	T	C	9: 86,550,169 (GRCm38)		probably null	Het
Enox1	A	T	14: 77,611,324 (GRCm38)	R358S	probably damaging	Het
Ep400	A	G	5: 110,668,124 (GRCm38)	V2724A	probably damaging	Het
Fam196b	T	A	11: 34,402,677 (GRCm38)	C240S	possibly damaging	Het
Fam221a	A	C	6: 49,378,498 (GRCm38)	Q178P	probably damaging	Het
Fcho1	A	C	8: 71,710,497 (GRCm38)		probably null	Het
Fndc1	A	T	17: 7,769,735 (GRCm38)	V1165D	unknown	Het
Gal3st2b	A	T	1: 93,940,619 (GRCm38)	N189Y	possibly damaging	Het
Ghr	T	A	15: 3,320,484 (GRCm38)	D404V	probably damaging	Het
Glis3	A	T	19: 28,531,519 (GRCm38)	V355D	probably damaging	Het
Gm15922	C	G	7: 3,737,320 (GRCm38)	A301P	probably damaging	Het
Gm21671	A	T	5: 25,949,844 (GRCm38)	S253T	possibly damaging	Het
Gpr12	A	C	5: 146,583,539 (GRCm38)	V32G	possibly damaging	Het
Gspt1	T	A	16: 11,222,661 (GRCm38)	L593F	probably damaging	Het
H2-Q7	A	T	17: 35,440,031 (GRCm38)	T153S	probably damaging	Het
Hars2	A	G	18: 36,787,956 (GRCm38)	I194V	probably damaging	Het
Hdac9	T	A	12: 34,429,549 (GRCm38)	T202S	possibly damaging	Het
Hoxd13	T	C	2: 74,669,024 (GRCm38)	Y239H	probably damaging	Het
Insm2	C	T	12: 55,599,836 (GRCm38)	Q122*	probably null	Het
Ip6k1	T	A	9: 108,045,452 (GRCm38)		probably null	Het
Ippk	T	C	13: 49,461,743 (GRCm38)	V534A	probably damaging	Het
Itch	T	G	2: 155,209,994 (GRCm38)	F611C	probably damaging	Het
Itga1	A	T	13: 114,968,240 (GRCm38)	N1083K	probably damaging	Het
Itgae	A	C	11: 73,116,143 (GRCm38)	D405A	probably damaging	Het
Kif18a	T	C	2: 109,295,002 (GRCm38)	S255P	probably damaging	Het
Klhl24	C	G	16: 20,107,481 (GRCm38)	T253R	probably benign	Het
Krt81	T	A	15: 101,460,728 (GRCm38)	T307S	possibly damaging	Het
Lbr	A	T	1: 181,828,789 (GRCm38)	W265R	probably damaging	Het
Lgals3bp	T	C	11: 118,393,173 (GRCm38)	T527A	probably benign	Het
Lzts1	A	C	8: 69,140,745 (GRCm38)	V70G	probably damaging	Het
Map3k6	C	T	4: 133,251,712 (GRCm38)	P1154S	probably benign	Het
Masp1	T	C	16: 23,452,455 (GRCm38)	D681G	probably benign	Het
Mdga2	T	C	12: 66,486,752 (GRCm38)	N948D	probably benign	Het
Mettl4	A	T	17: 94,733,633 (GRCm38)	F364L	probably damaging	Het
Mosmo	T	C	7: 120,677,832 (GRCm38)	I23T	probably benign	Het
Mtg1	G	A	7: 140,143,744 (GRCm38)	V96I	probably benign	Het
Myh11	T	A	16: 14,218,939 (GRCm38)	R966S	possibly damaging	Het
Ncapg2	A	G	12: 116,424,717 (GRCm38)		probably null	Het
Nid1	G	A	13: 13,508,768 (GRCm38)	V1144I	probably benign	Het
Olfr1250	T	C	2: 89,656,566 (GRCm38)	I292V	probably benign	Het
Olfr544	C	A	7: 102,484,772 (GRCm38)	C116F	possibly damaging	Het
Olfr622	A	T	7: 103,639,960 (GRCm38)	M60K	probably damaging	Het
Oscar	T	G	7: 3,611,239 (GRCm38)	Y167S	probably damaging	Het
Pa2g4	T	C	10: 128,560,690 (GRCm38)	T200A	probably benign	Het
Pcdh7	A	G	5: 57,719,784 (GRCm38)	D227G	probably benign	Het
Plce1	G	A	19: 38,758,940 (GRCm38)	G1702R	probably damaging	Het
Prl8a8	G	A	13: 27,511,467 (GRCm38)	T99I	probably benign	Het
Prr29	C	A	11: 106,376,259 (GRCm38)	H83Q	probably damaging	Het
Raly	T	A	2: 154,859,744 (GRCm38)	I108N	possibly damaging	Het
Ranbp9	A	T	13: 43,419,622 (GRCm38)	S475R	probably benign	Het
Rogdi	C	A	16: 5,013,498 (GRCm38)		probably benign	Het
Rorc	C	T	3: 94,372,907 (GRCm38)	Q6*	probably null	Het
Sacs	T	C	14: 61,212,496 (GRCm38)	L3997S	probably damaging	Het
Scn2a	A	T	2: 65,764,606 (GRCm38)	Y1933F	probably benign	Het
Sik3	T	C	9: 46,210,743 (GRCm38)	L898P	probably damaging	Het
Sipa1l1	A	G	12: 82,341,406 (GRCm38)	I135M	probably damaging	Het
Slc26a3	C	A	12: 31,450,935 (GRCm38)	Q224K	probably damaging	Het
Sobp	G	T	10: 43,021,440 (GRCm38)	N716K	probably benign	Het
Spata16	A	G	3: 26,927,334 (GRCm38)	D513G	probably damaging	Het
Stac	T	C	9: 111,572,326 (GRCm38)	R351G	possibly damaging	Het
Tecta	T	A	9: 42,394,941 (GRCm38)	T64S	probably benign	Het
Tert	G	A	13: 73,628,410 (GRCm38)	V427M	probably damaging	Het
Tex15	G	A	8: 33,570,720 (GRCm38)	M333I	probably benign	Het
Tmbim4	A	T	10: 120,220,759 (GRCm38)	Q72L	probably benign	Het
Trav9n-4	T	C	14: 53,294,799 (GRCm38)	S37P	probably benign	Het
Trpv5	A	T	6: 41,675,960 (GRCm38)	M93K	possibly damaging	Het
Ulk4	T	C	9: 121,266,517 (GRCm38)	T79A	probably benign	Het
Ulk4	T	C	9: 121,258,810 (GRCm38)	E272G	probably benign	Het
Upb1	A	G	10: 75,412,768 (GRCm38)	N41D	probably benign	Het
Wls	A	T	3: 159,934,329 (GRCm38)	Y532F	probably damaging	Het
Zdhhc5	G	A	2: 84,715,011 (GRCm38)		probably benign	Het
Zfp109	T	C	7: 24,229,360 (GRCm38)	D216G	probably benign	Het
Zfp473	G	A	7: 44,732,374 (GRCm38)	A845V	probably damaging	Het

Other mutations in Plxna2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00227:Plxna2	APN	1	194,644,657 (GRCm38)	missense	probably damaging	1.00
IGL00332:Plxna2	APN	1	194,789,830 (GRCm38)	missense	probably damaging	0.98
IGL00392:Plxna2	APN	1	194,800,568 (GRCm38)	missense	probably damaging	1.00
IGL00432:Plxna2	APN	1	194,644,096 (GRCm38)	missense	probably benign	0.03
IGL00704:Plxna2	APN	1	194,751,461 (GRCm38)	missense	probably damaging	0.99
IGL00737:Plxna2	APN	1	194,746,239 (GRCm38)	splice site	probably benign
IGL01078:Plxna2	APN	1	194,786,693 (GRCm38)	unclassified	probably benign
IGL01354:Plxna2	APN	1	194,762,435 (GRCm38)	missense	probably benign	0.02
IGL01432:Plxna2	APN	1	194,644,318 (GRCm38)	missense	possibly damaging	0.58
IGL01459:Plxna2	APN	1	194,764,570 (GRCm38)	missense	probably benign	0.00
IGL01525:Plxna2	APN	1	194,712,311 (GRCm38)	missense	probably benign	0.00
IGL01656:Plxna2	APN	1	194,790,161 (GRCm38)	missense	possibly damaging	0.52
IGL01825:Plxna2	APN	1	194,788,902 (GRCm38)	missense	probably damaging	0.98
IGL01862:Plxna2	APN	1	194,643,950 (GRCm38)	missense	possibly damaging	0.87
IGL01899:Plxna2	APN	1	194,751,488 (GRCm38)	missense	probably damaging	1.00
IGL01996:Plxna2	APN	1	194,799,776 (GRCm38)	missense	probably damaging	0.99
IGL02123:Plxna2	APN	1	194,794,383 (GRCm38)	missense	probably damaging	1.00
IGL02226:Plxna2	APN	1	194,644,424 (GRCm38)	missense	probably damaging	1.00
IGL02227:Plxna2	APN	1	194,752,089 (GRCm38)	missense	probably damaging	1.00
IGL02415:Plxna2	APN	1	194,643,964 (GRCm38)	missense	probably damaging	1.00
IGL02440:Plxna2	APN	1	194,746,150 (GRCm38)	missense	probably benign	0.10
IGL02545:Plxna2	APN	1	194,786,690 (GRCm38)	unclassified	probably benign
IGL02553:Plxna2	APN	1	194,751,438 (GRCm38)	missense	probably benign	0.08
IGL02882:Plxna2	APN	1	194,762,570 (GRCm38)	missense	probably damaging	1.00
IGL02946:Plxna2	APN	1	194,749,309 (GRCm38)	splice site	probably benign
IGL03062:Plxna2	APN	1	194,762,550 (GRCm38)	missense	possibly damaging	0.72
IGL03095:Plxna2	APN	1	194,801,127 (GRCm38)	missense	probably damaging	1.00
IGL03293:Plxna2	APN	1	194,804,945 (GRCm38)	missense	probably damaging	0.99
G1Funyon:Plxna2	UTSW	1	194,790,175 (GRCm38)	missense	probably benign	0.01
PIT4514001:Plxna2	UTSW	1	194,794,937 (GRCm38)	missense	probably benign	0.00
R0024:Plxna2	UTSW	1	194,643,995 (GRCm38)	missense	possibly damaging	0.57
R0040:Plxna2	UTSW	1	194,643,896 (GRCm38)	missense	probably benign	0.13
R0040:Plxna2	UTSW	1	194,643,896 (GRCm38)	missense	probably benign	0.13
R0063:Plxna2	UTSW	1	194,644,939 (GRCm38)	missense	probably benign	0.00
R0063:Plxna2	UTSW	1	194,644,939 (GRCm38)	missense	probably benign	0.00
R0217:Plxna2	UTSW	1	194,644,598 (GRCm38)	missense	probably damaging	1.00
R0316:Plxna2	UTSW	1	194,644,150 (GRCm38)	missense	probably damaging	1.00
R0440:Plxna2	UTSW	1	194,644,404 (GRCm38)	nonsense	probably null
R0505:Plxna2	UTSW	1	194,644,348 (GRCm38)	missense	possibly damaging	0.93
R0568:Plxna2	UTSW	1	194,751,386 (GRCm38)	missense	probably benign	0.00
R0669:Plxna2	UTSW	1	194,788,837 (GRCm38)	missense	probably damaging	0.99
R0674:Plxna2	UTSW	1	194,649,475 (GRCm38)	missense	probably benign	0.00
R0885:Plxna2	UTSW	1	194,644,556 (GRCm38)	missense	probably benign
R0898:Plxna2	UTSW	1	194,797,024 (GRCm38)	missense	probably damaging	1.00
R0940:Plxna2	UTSW	1	194,800,555 (GRCm38)	missense	probably benign	0.01
R1061:Plxna2	UTSW	1	194,644,093 (GRCm38)	missense	probably damaging	1.00
R1067:Plxna2	UTSW	1	194,780,510 (GRCm38)	splice site	probably null
R1222:Plxna2	UTSW	1	194,800,649 (GRCm38)	missense	probably damaging	1.00
R1345:Plxna2	UTSW	1	194,644,486 (GRCm38)	missense	probably damaging	1.00
R1363:Plxna2	UTSW	1	194,804,939 (GRCm38)	nonsense	probably null
R1432:Plxna2	UTSW	1	194,767,463 (GRCm38)	missense	probably benign	0.10
R1434:Plxna2	UTSW	1	194,751,540 (GRCm38)	splice site	probably benign
R1597:Plxna2	UTSW	1	194,749,306 (GRCm38)	splice site	probably benign
R1719:Plxna2	UTSW	1	194,644,370 (GRCm38)	missense	possibly damaging	0.93
R1778:Plxna2	UTSW	1	194,810,970 (GRCm38)	missense	probably benign	0.01
R1795:Plxna2	UTSW	1	194,806,303 (GRCm38)	missense	probably damaging	0.99
R1819:Plxna2	UTSW	1	194,790,186 (GRCm38)	missense	probably benign	0.03
R1926:Plxna2	UTSW	1	194,762,450 (GRCm38)	missense	probably benign	0.02
R1966:Plxna2	UTSW	1	194,644,700 (GRCm38)	missense	possibly damaging	0.91
R1987:Plxna2	UTSW	1	194,643,989 (GRCm38)	missense	probably damaging	1.00
R1988:Plxna2	UTSW	1	194,643,989 (GRCm38)	missense	probably damaging	1.00
R2034:Plxna2	UTSW	1	194,780,594 (GRCm38)	missense	probably benign	0.00
R2131:Plxna2	UTSW	1	194,644,750 (GRCm38)	missense	probably benign	0.01
R2171:Plxna2	UTSW	1	194,800,617 (GRCm38)	missense	probably damaging	1.00
R2217:Plxna2	UTSW	1	194,797,748 (GRCm38)	missense	probably damaging	1.00
R2311:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R2340:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R2342:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R2423:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R2424:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R2425:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R2842:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R2971:Plxna2	UTSW	1	194,797,731 (GRCm38)	missense	probably damaging	1.00
R3236:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R3731:Plxna2	UTSW	1	194,788,885 (GRCm38)	missense	probably benign	0.42
R3783:Plxna2	UTSW	1	194,807,521 (GRCm38)	missense	probably damaging	1.00
R3784:Plxna2	UTSW	1	194,644,617 (GRCm38)	missense	probably benign
R3787:Plxna2	UTSW	1	194,643,934 (GRCm38)	missense	probably benign	0.10
R3845:Plxna2	UTSW	1	194,793,790 (GRCm38)	missense	probably damaging	0.96
R3927:Plxna2	UTSW	1	194,746,157 (GRCm38)	missense	probably benign	0.02
R3930:Plxna2	UTSW	1	194,794,910 (GRCm38)	missense	probably benign	0.17
R3964:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R3980:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4067:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4120:Plxna2	UTSW	1	194,780,627 (GRCm38)	missense	probably damaging	1.00
R4231:Plxna2	UTSW	1	194,644,454 (GRCm38)	missense	probably damaging	1.00
R4257:Plxna2	UTSW	1	194,644,775 (GRCm38)	missense	probably damaging	1.00
R4396:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4397:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4418:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4444:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4446:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4482:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4487:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4489:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4571:Plxna2	UTSW	1	194,810,988 (GRCm38)	missense	possibly damaging	0.91
R4622:Plxna2	UTSW	1	194,812,150 (GRCm38)	missense	probably benign
R4623:Plxna2	UTSW	1	194,812,150 (GRCm38)	missense	probably benign
R4684:Plxna2	UTSW	1	194,762,594 (GRCm38)	missense	probably benign	0.42
R4688:Plxna2	UTSW	1	194,644,445 (GRCm38)	missense	probably damaging	1.00
R4855:Plxna2	UTSW	1	194,797,732 (GRCm38)	missense	probably benign	0.39
R4876:Plxna2	UTSW	1	194,643,775 (GRCm38)	missense	probably benign	0.02
R5161:Plxna2	UTSW	1	194,751,404 (GRCm38)	missense	probably benign
R5207:Plxna2	UTSW	1	194,788,899 (GRCm38)	missense	probably benign	0.19
R5479:Plxna2	UTSW	1	194,793,873 (GRCm38)	missense	probably benign
R5931:Plxna2	UTSW	1	194,810,870 (GRCm38)	missense	probably damaging	1.00
R6026:Plxna2	UTSW	1	194,799,814 (GRCm38)	missense	probably damaging	1.00
R6029:Plxna2	UTSW	1	194,799,575 (GRCm38)	missense	probably damaging	1.00
R6029:Plxna2	UTSW	1	194,794,427 (GRCm38)	missense	probably benign	0.00
R6059:Plxna2	UTSW	1	194,810,971 (GRCm38)	missense	possibly damaging	0.79
R6238:Plxna2	UTSW	1	194,790,196 (GRCm38)	missense	probably benign	0.01
R6322:Plxna2	UTSW	1	194,754,367 (GRCm38)	missense	possibly damaging	0.89
R6668:Plxna2	UTSW	1	194,810,088 (GRCm38)	missense	possibly damaging	0.68
R6709:Plxna2	UTSW	1	194,789,766 (GRCm38)	missense	probably benign	0.01
R6748:Plxna2	UTSW	1	194,794,182 (GRCm38)	splice site	probably null
R6838:Plxna2	UTSW	1	194,804,914 (GRCm38)	missense	possibly damaging	0.90
R6844:Plxna2	UTSW	1	194,793,828 (GRCm38)	missense	probably benign	0.08
R7122:Plxna2	UTSW	1	194,644,568 (GRCm38)	nonsense	probably null
R7145:Plxna2	UTSW	1	194,649,522 (GRCm38)	missense	probably benign	0.31
R7189:Plxna2	UTSW	1	194,801,058 (GRCm38)	missense	possibly damaging	0.58
R7207:Plxna2	UTSW	1	194,644,019 (GRCm38)	missense	probably damaging	1.00
R7232:Plxna2	UTSW	1	194,712,260 (GRCm38)	missense	probably damaging	1.00
R7234:Plxna2	UTSW	1	194,806,390 (GRCm38)	missense	probably damaging	0.96
R7246:Plxna2	UTSW	1	194,644,282 (GRCm38)	missense	possibly damaging	0.74
R7255:Plxna2	UTSW	1	194,752,103 (GRCm38)	missense	probably benign	0.03
R7283:Plxna2	UTSW	1	194,644,883 (GRCm38)	missense	probably damaging	0.99
R7288:Plxna2	UTSW	1	194,796,919 (GRCm38)	missense	probably damaging	1.00
R7361:Plxna2	UTSW	1	194,799,779 (GRCm38)	missense	probably damaging	1.00
R7424:Plxna2	UTSW	1	194,806,339 (GRCm38)	missense	probably damaging	0.98
R7501:Plxna2	UTSW	1	194,643,895 (GRCm38)	missense	possibly damaging	0.95
R7528:Plxna2	UTSW	1	194,812,156 (GRCm38)	missense	probably damaging	1.00
R7529:Plxna2	UTSW	1	194,643,871 (GRCm38)	missense	probably benign	0.25
R7532:Plxna2	UTSW	1	194,644,819 (GRCm38)	missense	probably benign	0.13
R7959:Plxna2	UTSW	1	194,810,962 (GRCm38)	missense	probably damaging	1.00
R7959:Plxna2	UTSW	1	194,793,864 (GRCm38)	frame shift	probably null
R7960:Plxna2	UTSW	1	194,793,864 (GRCm38)	frame shift	probably null
R8261:Plxna2	UTSW	1	194,749,416 (GRCm38)	missense	probably damaging	1.00
R8301:Plxna2	UTSW	1	194,790,175 (GRCm38)	missense	probably benign	0.01
R8463:Plxna2	UTSW	1	194,644,046 (GRCm38)	missense	probably damaging	1.00
R8519:Plxna2	UTSW	1	194,793,958 (GRCm38)	missense	probably damaging	1.00
R8836:Plxna2	UTSW	1	194,796,935 (GRCm38)	missense	possibly damaging	0.94
R9010:Plxna2	UTSW	1	194,788,909 (GRCm38)	missense	possibly damaging	0.95
R9034:Plxna2	UTSW	1	194,793,889 (GRCm38)	missense	probably damaging	1.00
R9254:Plxna2	UTSW	1	194,810,166 (GRCm38)	missense	probably damaging	1.00
R9274:Plxna2	UTSW	1	194,788,828 (GRCm38)	missense	probably damaging	1.00
R9379:Plxna2	UTSW	1	194,810,166 (GRCm38)	missense	probably damaging	1.00
R9385:Plxna2	UTSW	1	194,749,416 (GRCm38)	missense	possibly damaging	0.95
R9422:Plxna2	UTSW	1	194,644,422 (GRCm38)	missense	probably damaging	1.00
R9451:Plxna2	UTSW	1	194,644,384 (GRCm38)	missense	probably benign	0.05
R9484:Plxna2	UTSW	1	194,644,894 (GRCm38)	missense	probably damaging	1.00
X0027:Plxna2	UTSW	1	194,644,433 (GRCm38)	missense	probably damaging	1.00
Z1088:Plxna2	UTSW	1	194,764,539 (GRCm38)	missense	probably benign	0.06
Z1088:Plxna2	UTSW	1	194,644,441 (GRCm38)	missense	possibly damaging	0.56

Predicted Primers

PCR Primer
(F):5'- ACCAGGTGTTCAGGTTTGAATG -3'
(R):5'- GGGTACAACAAGACTCCTGTG -3'

Sequencing Primer
(F):5'- CCTTAGGTATGCACAGTGGTAAAC -3'
(R):5'- GTATTAGCATCTAGAGATCTGGCC -3'

Posted On

2019-05-13