Incidental Mutation 'R7069:Sipa1l1'
| ID |
548778 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Sipa1l1
|
| Ensembl Gene |
ENSMUSG00000042700 |
| Gene Name |
signal-induced proliferation-associated 1 like 1 |
| Synonyms |
Spar, 4931426N11Rik |
| MMRRC Submission |
045165-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7069 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
12 |
| Chromosomal Location |
82216138-82498560 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 82388180 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Methionine
at position 135
(I135M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000152681
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053969]
[ENSMUST00000166429]
[ENSMUST00000220963]
[ENSMUST00000222298]
[ENSMUST00000222714]
|
| AlphaFold |
Q8C0T5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000053969
AA Change: I135M
PolyPhen 2
Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000061014
Gene: ENSMUSG00000042700
AA Change: I135M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
92 |
129 |
N/A |
INTRINSIC |
|
low complexity region
|
362 |
377 |
N/A |
INTRINSIC |
|
low complexity region
|
430 |
449 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
628 |
810 |
8.9e-70 |
PFAM |
|
PDZ
|
962 |
1028 |
2.63e-9 |
SMART |
|
low complexity region
|
1149 |
1164 |
N/A |
INTRINSIC |
|
low complexity region
|
1255 |
1279 |
N/A |
INTRINSIC |
|
low complexity region
|
1315 |
1328 |
N/A |
INTRINSIC |
|
low complexity region
|
1432 |
1447 |
N/A |
INTRINSIC |
|
Pfam:SPAR_C
|
1483 |
1727 |
4.4e-86 |
PFAM |
|
low complexity region
|
1731 |
1746 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000166429
AA Change: I135M
PolyPhen 2
Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000131030
Gene: ENSMUSG00000042700
AA Change: I135M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
92 |
129 |
N/A |
INTRINSIC |
|
low complexity region
|
362 |
377 |
N/A |
INTRINSIC |
|
low complexity region
|
430 |
449 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
628 |
816 |
1.3e-64 |
PFAM |
|
PDZ
|
962 |
1028 |
1.3e-11 |
SMART |
|
low complexity region
|
1149 |
1164 |
N/A |
INTRINSIC |
|
low complexity region
|
1255 |
1279 |
N/A |
INTRINSIC |
|
low complexity region
|
1315 |
1328 |
N/A |
INTRINSIC |
|
low complexity region
|
1432 |
1447 |
N/A |
INTRINSIC |
|
Pfam:DUF3401
|
1483 |
1727 |
1.8e-91 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000220963
AA Change: I135M
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000222298
AA Change: I135M
PolyPhen 2
Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000222714
AA Change: I135M
PolyPhen 2
Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
|
| Meta Mutation Damage Score |
0.0787 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
98% (86/88) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 89 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aasdh |
T |
A |
5: 77,024,203 (GRCm39) |
I991L |
probably benign |
Het |
| Abtb3 |
C |
A |
10: 85,223,520 (GRCm39) |
R110S |
unknown |
Het |
| Actg2 |
C |
A |
6: 83,497,745 (GRCm39) |
G96V |
probably damaging |
Het |
| Adh5 |
T |
A |
3: 138,156,812 (GRCm39) |
L166* |
probably null |
Het |
| Akap13 |
A |
G |
7: 75,260,010 (GRCm39) |
D75G |
probably benign |
Het |
| Ank2 |
T |
C |
3: 126,739,947 (GRCm39) |
|
probably benign |
Het |
| Arfgap1 |
T |
A |
2: 180,615,913 (GRCm39) |
D197E |
probably benign |
Het |
| Aste1 |
T |
C |
9: 105,273,906 (GRCm39) |
|
probably null |
Het |
| Atp8b2 |
T |
A |
3: 89,861,878 (GRCm39) |
N78I |
probably damaging |
Het |
| Cacna2d3 |
T |
A |
14: 28,691,260 (GRCm39) |
|
probably benign |
Het |
| Chrd |
T |
A |
16: 20,558,183 (GRCm39) |
W809R |
probably damaging |
Het |
| Col2a1 |
C |
T |
15: 97,896,469 (GRCm39) |
G60D |
unknown |
Het |
| Coro7 |
T |
A |
16: 4,497,475 (GRCm39) |
M1L |
probably damaging |
Het |
| Cracdl |
A |
T |
1: 37,670,982 (GRCm39) |
F97Y |
probably damaging |
Het |
| Dhx40 |
T |
C |
11: 86,688,569 (GRCm39) |
I285V |
probably benign |
Het |
| Dop1a |
T |
C |
9: 86,432,222 (GRCm39) |
|
probably null |
Het |
| Enox1 |
A |
T |
14: 77,848,764 (GRCm39) |
R358S |
probably damaging |
Het |
| Ep400 |
A |
G |
5: 110,815,990 (GRCm39) |
V2724A |
probably damaging |
Het |
| Fam221a |
A |
C |
6: 49,355,432 (GRCm39) |
Q178P |
probably damaging |
Het |
| Fcho1 |
A |
C |
8: 72,163,141 (GRCm39) |
|
probably null |
Het |
| Fndc1 |
A |
T |
17: 7,988,567 (GRCm39) |
V1165D |
unknown |
Het |
| Gal3st2b |
A |
T |
1: 93,868,341 (GRCm39) |
N189Y |
possibly damaging |
Het |
| Ghr |
T |
A |
15: 3,349,966 (GRCm39) |
D404V |
probably damaging |
Het |
| Glis3 |
A |
T |
19: 28,508,919 (GRCm39) |
V355D |
probably damaging |
Het |
| Gpr12 |
A |
C |
5: 146,520,349 (GRCm39) |
V32G |
possibly damaging |
Het |
| Gspt1 |
T |
A |
16: 11,040,525 (GRCm39) |
L593F |
probably damaging |
Het |
| H2-Q7 |
A |
T |
17: 35,659,007 (GRCm39) |
T153S |
probably damaging |
Het |
| Hars2 |
A |
G |
18: 36,921,009 (GRCm39) |
I194V |
probably damaging |
Het |
| Hdac9 |
T |
A |
12: 34,479,548 (GRCm39) |
T202S |
possibly damaging |
Het |
| Hoxd13 |
T |
C |
2: 74,499,368 (GRCm39) |
Y239H |
probably damaging |
Het |
| Insm2 |
C |
T |
12: 55,646,621 (GRCm39) |
Q122* |
probably null |
Het |
| Insyn2b |
T |
A |
11: 34,352,677 (GRCm39) |
C240S |
possibly damaging |
Het |
| Ip6k1 |
T |
A |
9: 107,922,651 (GRCm39) |
|
probably null |
Het |
| Ippk |
T |
C |
13: 49,615,219 (GRCm39) |
V534A |
probably damaging |
Het |
| Itch |
T |
G |
2: 155,051,914 (GRCm39) |
F611C |
probably damaging |
Het |
| Itga1 |
A |
T |
13: 115,104,776 (GRCm39) |
N1083K |
probably damaging |
Het |
| Itgae |
A |
C |
11: 73,006,969 (GRCm39) |
D405A |
probably damaging |
Het |
| Kif18a |
T |
C |
2: 109,125,347 (GRCm39) |
S255P |
probably damaging |
Het |
| Klhl24 |
C |
G |
16: 19,926,231 (GRCm39) |
T253R |
probably benign |
Het |
| Krt81 |
T |
A |
15: 101,358,609 (GRCm39) |
T307S |
possibly damaging |
Het |
| Lbr |
A |
T |
1: 181,656,354 (GRCm39) |
W265R |
probably damaging |
Het |
| Lgals3bp |
T |
C |
11: 118,283,999 (GRCm39) |
T527A |
probably benign |
Het |
| Lzts1 |
A |
C |
8: 69,593,397 (GRCm39) |
V70G |
probably damaging |
Het |
| Map3k6 |
C |
T |
4: 132,979,023 (GRCm39) |
P1154S |
probably benign |
Het |
| Masp1 |
T |
C |
16: 23,271,205 (GRCm39) |
D681G |
probably benign |
Het |
| Mdga2 |
T |
C |
12: 66,533,526 (GRCm39) |
N948D |
probably benign |
Het |
| Mettl4 |
A |
T |
17: 95,041,061 (GRCm39) |
F364L |
probably damaging |
Het |
| Mosmo |
T |
C |
7: 120,277,055 (GRCm39) |
I23T |
probably benign |
Het |
| Mtg1 |
G |
A |
7: 139,723,657 (GRCm39) |
V96I |
probably benign |
Het |
| Myh11 |
T |
A |
16: 14,036,803 (GRCm39) |
R966S |
possibly damaging |
Het |
| Ncapg2 |
A |
G |
12: 116,388,337 (GRCm39) |
|
probably null |
Het |
| Nid1 |
G |
A |
13: 13,683,353 (GRCm39) |
V1144I |
probably benign |
Het |
| Or4a77 |
T |
C |
2: 89,486,910 (GRCm39) |
I292V |
probably benign |
Het |
| Or52a33 |
A |
T |
7: 103,289,167 (GRCm39) |
M60K |
probably damaging |
Het |
| Or55b4 |
C |
A |
7: 102,133,979 (GRCm39) |
C116F |
possibly damaging |
Het |
| Oscar |
T |
G |
7: 3,614,238 (GRCm39) |
Y167S |
probably damaging |
Het |
| Pa2g4 |
T |
C |
10: 128,396,559 (GRCm39) |
T200A |
probably benign |
Het |
| Pcdh7 |
A |
G |
5: 57,877,126 (GRCm39) |
D227G |
probably benign |
Het |
| Pira1 |
C |
G |
7: 3,740,319 (GRCm39) |
A301P |
probably damaging |
Het |
| Plce1 |
G |
A |
19: 38,747,384 (GRCm39) |
G1702R |
probably damaging |
Het |
| Plxna2 |
C |
A |
1: 194,476,212 (GRCm39) |
T1144K |
possibly damaging |
Het |
| Prl8a8 |
G |
A |
13: 27,695,450 (GRCm39) |
T99I |
probably benign |
Het |
| Prr29 |
C |
A |
11: 106,267,085 (GRCm39) |
H83Q |
probably damaging |
Het |
| Raly |
T |
A |
2: 154,701,664 (GRCm39) |
I108N |
possibly damaging |
Het |
| Ranbp9 |
A |
T |
13: 43,573,098 (GRCm39) |
S475R |
probably benign |
Het |
| Rogdi |
C |
A |
16: 4,831,362 (GRCm39) |
|
probably benign |
Het |
| Rorc |
C |
T |
3: 94,280,214 (GRCm39) |
Q6* |
probably null |
Het |
| Sacs |
T |
C |
14: 61,449,945 (GRCm39) |
L3997S |
probably damaging |
Het |
| Scn2a |
A |
T |
2: 65,594,950 (GRCm39) |
Y1933F |
probably benign |
Het |
| Sik3 |
T |
C |
9: 46,122,041 (GRCm39) |
L898P |
probably damaging |
Het |
| Slc26a3 |
C |
A |
12: 31,500,934 (GRCm39) |
Q224K |
probably damaging |
Het |
| Sobp |
G |
T |
10: 42,897,436 (GRCm39) |
N716K |
probably benign |
Het |
| Spata16 |
A |
G |
3: 26,981,483 (GRCm39) |
D513G |
probably damaging |
Het |
| Spata31h1 |
G |
A |
10: 82,125,777 (GRCm39) |
T2411I |
probably damaging |
Het |
| Speer4a3 |
A |
T |
5: 26,154,842 (GRCm39) |
S253T |
possibly damaging |
Het |
| Stac |
T |
C |
9: 111,401,394 (GRCm39) |
R351G |
possibly damaging |
Het |
| Tecta |
T |
A |
9: 42,306,237 (GRCm39) |
T64S |
probably benign |
Het |
| Tert |
G |
A |
13: 73,776,529 (GRCm39) |
V427M |
probably damaging |
Het |
| Tex15 |
G |
A |
8: 34,060,748 (GRCm39) |
M333I |
probably benign |
Het |
| Tmbim4 |
A |
T |
10: 120,056,664 (GRCm39) |
Q72L |
probably benign |
Het |
| Trav9n-4 |
T |
C |
14: 53,532,256 (GRCm39) |
S37P |
probably benign |
Het |
| Trpv5 |
A |
T |
6: 41,652,894 (GRCm39) |
M93K |
possibly damaging |
Het |
| Ulk4 |
T |
C |
9: 121,087,876 (GRCm39) |
E272G |
probably benign |
Het |
| Ulk4 |
T |
C |
9: 121,095,583 (GRCm39) |
T79A |
probably benign |
Het |
| Upb1 |
A |
G |
10: 75,248,602 (GRCm39) |
N41D |
probably benign |
Het |
| Wls |
A |
T |
3: 159,639,965 (GRCm39) |
Y532F |
probably damaging |
Het |
| Zdhhc5 |
G |
A |
2: 84,545,355 (GRCm39) |
|
probably benign |
Het |
| Zfp109 |
T |
C |
7: 23,928,785 (GRCm39) |
D216G |
probably benign |
Het |
| Zfp473 |
G |
A |
7: 44,381,798 (GRCm39) |
A845V |
probably damaging |
Het |
|
| Other mutations in Sipa1l1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01309:Sipa1l1
|
APN |
12 |
82,434,470 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01478:Sipa1l1
|
APN |
12 |
82,493,672 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01620:Sipa1l1
|
APN |
12 |
82,469,263 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02496:Sipa1l1
|
APN |
12 |
82,471,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02550:Sipa1l1
|
APN |
12 |
82,487,723 (GRCm39) |
nonsense |
probably null |
|
|
IGL02689:Sipa1l1
|
APN |
12 |
82,487,594 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02706:Sipa1l1
|
APN |
12 |
82,444,207 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02995:Sipa1l1
|
APN |
12 |
82,404,105 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL03104:Sipa1l1
|
APN |
12 |
82,388,904 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03295:Sipa1l1
|
APN |
12 |
82,479,714 (GRCm39) |
missense |
probably damaging |
1.00 |
|
bullae
|
UTSW |
12 |
82,389,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
bullish
|
UTSW |
12 |
82,469,245 (GRCm39) |
nonsense |
probably null |
|
|
ebullient
|
UTSW |
12 |
82,388,446 (GRCm39) |
missense |
probably benign |
0.18 |
|
PIT4431001:Sipa1l1
|
UTSW |
12 |
82,443,290 (GRCm39) |
missense |
probably benign |
0.34 |
|
R0140:Sipa1l1
|
UTSW |
12 |
82,442,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0348:Sipa1l1
|
UTSW |
12 |
82,431,530 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0534:Sipa1l1
|
UTSW |
12 |
82,472,054 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0538:Sipa1l1
|
UTSW |
12 |
82,471,873 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0547:Sipa1l1
|
UTSW |
12 |
82,484,510 (GRCm39) |
missense |
probably benign |
|
|
R0980:Sipa1l1
|
UTSW |
12 |
82,388,994 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R1051:Sipa1l1
|
UTSW |
12 |
82,496,119 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R1244:Sipa1l1
|
UTSW |
12 |
82,472,190 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1473:Sipa1l1
|
UTSW |
12 |
82,387,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1508:Sipa1l1
|
UTSW |
12 |
82,487,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1563:Sipa1l1
|
UTSW |
12 |
82,387,935 (GRCm39) |
missense |
probably benign |
0.31 |
|
R1671:Sipa1l1
|
UTSW |
12 |
82,444,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1935:Sipa1l1
|
UTSW |
12 |
82,419,208 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1950:Sipa1l1
|
UTSW |
12 |
82,388,233 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2191:Sipa1l1
|
UTSW |
12 |
82,443,465 (GRCm39) |
nonsense |
probably null |
|
|
R2249:Sipa1l1
|
UTSW |
12 |
82,388,890 (GRCm39) |
missense |
probably benign |
|
|
R2909:Sipa1l1
|
UTSW |
12 |
82,404,105 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4012:Sipa1l1
|
UTSW |
12 |
82,388,556 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4154:Sipa1l1
|
UTSW |
12 |
82,471,988 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4382:Sipa1l1
|
UTSW |
12 |
82,493,596 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4448:Sipa1l1
|
UTSW |
12 |
82,388,524 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4651:Sipa1l1
|
UTSW |
12 |
82,469,245 (GRCm39) |
nonsense |
probably null |
|
|
R4652:Sipa1l1
|
UTSW |
12 |
82,469,245 (GRCm39) |
nonsense |
probably null |
|
|
R4751:Sipa1l1
|
UTSW |
12 |
82,387,968 (GRCm39) |
missense |
probably benign |
|
|
R4755:Sipa1l1
|
UTSW |
12 |
82,419,160 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R4888:Sipa1l1
|
UTSW |
12 |
82,389,107 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4912:Sipa1l1
|
UTSW |
12 |
82,443,452 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4937:Sipa1l1
|
UTSW |
12 |
82,388,103 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5068:Sipa1l1
|
UTSW |
12 |
82,484,601 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5113:Sipa1l1
|
UTSW |
12 |
82,487,682 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5114:Sipa1l1
|
UTSW |
12 |
82,487,682 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5240:Sipa1l1
|
UTSW |
12 |
82,388,362 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6041:Sipa1l1
|
UTSW |
12 |
82,389,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6048:Sipa1l1
|
UTSW |
12 |
82,487,643 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6170:Sipa1l1
|
UTSW |
12 |
82,388,446 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6185:Sipa1l1
|
UTSW |
12 |
82,471,802 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6326:Sipa1l1
|
UTSW |
12 |
82,419,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6842:Sipa1l1
|
UTSW |
12 |
82,467,320 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7008:Sipa1l1
|
UTSW |
12 |
82,409,886 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7058:Sipa1l1
|
UTSW |
12 |
82,449,896 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7122:Sipa1l1
|
UTSW |
12 |
82,469,236 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R7310:Sipa1l1
|
UTSW |
12 |
82,419,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7469:Sipa1l1
|
UTSW |
12 |
82,467,438 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7718:Sipa1l1
|
UTSW |
12 |
82,389,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7787:Sipa1l1
|
UTSW |
12 |
82,496,762 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7844:Sipa1l1
|
UTSW |
12 |
82,444,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7893:Sipa1l1
|
UTSW |
12 |
82,388,342 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7953:Sipa1l1
|
UTSW |
12 |
82,496,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8043:Sipa1l1
|
UTSW |
12 |
82,496,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8099:Sipa1l1
|
UTSW |
12 |
82,480,600 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8135:Sipa1l1
|
UTSW |
12 |
82,388,075 (GRCm39) |
missense |
probably benign |
|
|
R8229:Sipa1l1
|
UTSW |
12 |
82,484,622 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8348:Sipa1l1
|
UTSW |
12 |
82,443,045 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8388:Sipa1l1
|
UTSW |
12 |
82,216,259 (GRCm39) |
unclassified |
probably benign |
|
|
R8693:Sipa1l1
|
UTSW |
12 |
82,216,517 (GRCm39) |
unclassified |
probably benign |
|
|
R8826:Sipa1l1
|
UTSW |
12 |
82,389,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8884:Sipa1l1
|
UTSW |
12 |
82,409,871 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8940:Sipa1l1
|
UTSW |
12 |
82,404,040 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8975:Sipa1l1
|
UTSW |
12 |
82,479,612 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9145:Sipa1l1
|
UTSW |
12 |
82,443,335 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9328:Sipa1l1
|
UTSW |
12 |
82,388,792 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R9455:Sipa1l1
|
UTSW |
12 |
82,434,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9486:Sipa1l1
|
UTSW |
12 |
82,404,139 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9631:Sipa1l1
|
UTSW |
12 |
82,387,776 (GRCm39) |
start codon destroyed |
probably null |
0.39 |
|
R9727:Sipa1l1
|
UTSW |
12 |
82,471,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9753:Sipa1l1
|
UTSW |
12 |
82,463,763 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAATAGCAGATTGGCCTCCG -3'
(R):5'- GTCGATTGAAGATGTGCTGC -3'
Sequencing Primer
(F):5'- CAGATTGGCCTCCGAGAAAG -3'
(R):5'- AATGATGGCCCCGACTTGTAG -3'
|
| Posted On |
2019-05-13 |
Incidental Mutation