Incidental Mutation 'R7071:Ifitm3'
ID 548906
Institutional Source Beutler Lab
Gene Symbol Ifitm3
Ensembl Gene ENSMUSG00000025492
Gene Name interferon induced transmembrane protein 3
Synonyms Fgls, 1110004C05Rik, IP15, mil-1, fragilis
MMRRC Submission 045167-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7071 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 140589503-140590657 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 140590437 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 41 (V41A)
Ref Sequence ENSEMBL: ENSMUSP00000026565 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026565]
AlphaFold Q9CQW9
Predicted Effect probably benign
Transcript: ENSMUST00000026565
AA Change: V41A

PolyPhen 2 Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000026565
Gene: ENSMUSG00000025492
AA Change: V41A

DomainStartEndE-ValueType
Pfam:CD225 47 130 7.6e-33 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 95% (41/43)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012]
PHENOTYPE: Mice homozygous for a reporter allele are viable and fertile with no detectable defects in embryogenesis or germ cell development but show increased susceptibility to respiratory syncytial virus and influenza A virus infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi3bp C T 16: 56,449,503 (GRCm39) Q854* probably null Het
Arl2bp G T 8: 95,393,794 (GRCm39) probably benign Het
Astl T C 2: 127,187,885 (GRCm39) M121T probably benign Het
Atrip T C 9: 108,896,082 (GRCm39) probably null Het
Camk1g A T 1: 193,042,117 (GRCm39) V44E probably benign Het
Cc2d2a A G 5: 43,866,455 (GRCm39) H804R probably benign Het
Cd300a T C 11: 114,792,099 (GRCm39) S314P probably damaging Het
Ceacam5 A T 7: 17,484,577 (GRCm39) I440L possibly damaging Het
Cfap61 T G 2: 145,843,832 (GRCm39) I306R probably benign Het
Cnot10 T C 9: 114,446,787 (GRCm39) probably null Het
Cntln T A 4: 85,018,622 (GRCm39) L76Q probably damaging Het
Cobl A G 11: 12,204,795 (GRCm39) C636R probably benign Het
Dnm3 A T 1: 161,847,412 (GRCm39) H148Q probably damaging Het
Dot1l T A 10: 80,628,079 (GRCm39) L1039Q probably benign Het
Faiml T A 9: 99,118,400 (GRCm39) M1L unknown Het
Fat1 T G 8: 45,442,145 (GRCm39) I1149S possibly damaging Het
Gatad1 T C 5: 3,693,540 (GRCm39) R210G probably benign Het
Gm11938 A T 11: 99,493,910 (GRCm39) C62S probably damaging Het
Gtf2i A G 5: 134,292,475 (GRCm39) L423S probably damaging Het
Hmcn1 A T 1: 150,479,853 (GRCm39) C4582S probably damaging Het
Ipo11 T A 13: 107,061,604 (GRCm39) S19C probably damaging Het
Khsrp C A 17: 57,332,386 (GRCm39) M268I possibly damaging Het
Lrp1b T G 2: 41,298,276 (GRCm39) D1036A Het
Mecom T G 3: 30,034,857 (GRCm39) H273P probably damaging Het
Mfn1 G A 3: 32,622,544 (GRCm39) V601I probably benign Het
Mrps5 T A 2: 127,442,772 (GRCm39) Y280* probably null Het
Myo18a A G 11: 77,714,653 (GRCm39) T811A probably damaging Het
Ndfip2 A C 14: 105,539,760 (GRCm39) N292H possibly damaging Het
Or2ak5 C A 11: 58,610,984 (GRCm39) V297F possibly damaging Het
Otog T A 7: 45,916,747 (GRCm39) C895S probably damaging Het
Pacs1 A T 19: 5,206,402 (GRCm39) I261N possibly damaging Het
Pira13 A G 7: 3,824,667 (GRCm39) S573P unknown Het
Ptprn A T 1: 75,237,263 (GRCm39) M113K possibly damaging Het
Rag1 T C 2: 101,473,807 (GRCm39) H445R probably damaging Het
Ranbp2 T G 10: 58,328,659 (GRCm39) F2853V probably damaging Het
Skint5 A T 4: 113,636,277 (GRCm39) F647Y unknown Het
Stt3b T C 9: 115,083,085 (GRCm39) Y449C probably damaging Het
Ythdc2 A G 18: 44,978,855 (GRCm39) D455G probably benign Het
Zfp451 A C 1: 33,815,825 (GRCm39) D708E possibly damaging Het
Zfp456 T C 13: 67,520,896 (GRCm39) E33G probably damaging Het
Zfp599 T C 9: 22,169,392 (GRCm39) T27A probably benign Het
Other mutations in Ifitm3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02039:Ifitm3 APN 7 140,590,563 (GRCm39) utr 5 prime probably benign
IGL02478:Ifitm3 APN 7 140,589,787 (GRCm39) missense possibly damaging 0.68
IGL02889:Ifitm3 APN 7 140,589,792 (GRCm39) missense probably damaging 1.00
I0000:Ifitm3 UTSW 7 140,590,441 (GRCm39) missense possibly damaging 0.85
R1069:Ifitm3 UTSW 7 140,589,813 (GRCm39) splice site probably benign
R4019:Ifitm3 UTSW 7 140,589,772 (GRCm39) missense possibly damaging 0.71
R4991:Ifitm3 UTSW 7 140,590,372 (GRCm39) missense probably damaging 1.00
R5288:Ifitm3 UTSW 7 140,590,554 (GRCm39) missense probably benign 0.00
R5385:Ifitm3 UTSW 7 140,590,554 (GRCm39) missense probably benign 0.00
R5386:Ifitm3 UTSW 7 140,590,554 (GRCm39) missense probably benign 0.00
R5543:Ifitm3 UTSW 7 140,589,730 (GRCm39) missense unknown
R7602:Ifitm3 UTSW 7 140,590,372 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TAGATGGAGCTTCAGGTTCACAC -3'
(R):5'- TCTGAGAAACCGAAACTGCCG -3'

Sequencing Primer
(F):5'- AGGTTCACACACACCTTTTTACAC -3'
(R):5'- ACTGCCGCAGAAAGGGC -3'
Posted On 2019-05-15