Incidental Mutation 'R7073:Or4k41'
ID 549005
Institutional Source Beutler Lab
Gene Symbol Or4k41
Ensembl Gene ENSMUSG00000095586
Gene Name olfactory receptor family 4 subfamily K member 41
Synonyms MOR248-15, GA_x6K02T2Q125-72500603-72501520, Olfr1287
MMRRC Submission 045169-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.125) question?
Stock # R7073 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 111279487-111280404 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 111279631 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 49 (I49F)
Ref Sequence ENSEMBL: ENSMUSP00000074850 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075390]
AlphaFold Q7TQY1
Predicted Effect probably benign
Transcript: ENSMUST00000075390
AA Change: I49F

PolyPhen 2 Score 0.225 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000074850
Gene: ENSMUSG00000095586
AA Change: I49F

DomainStartEndE-ValueType
Pfam:7tm_4 31 304 6.7e-48 PFAM
Pfam:7tm_1 41 287 9.5e-20 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 T G 13: 81,709,593 (GRCm39) E1133D probably damaging Het
Ankrd13b A T 11: 77,363,335 (GRCm39) D505E probably benign Het
Ano1 C T 7: 144,192,289 (GRCm39) E361K probably damaging Het
Arap3 T A 18: 38,107,495 (GRCm39) K1341* probably null Het
Arhgef17 A C 7: 100,579,198 (GRCm39) Y583* probably null Het
Ash1l G A 3: 88,892,647 (GRCm39) E1509K probably damaging Het
B430305J03Rik T G 3: 61,271,681 (GRCm39) R21S unknown Het
Bbof1 A G 12: 84,473,609 (GRCm39) E313G probably damaging Het
Catsperb C T 12: 101,475,497 (GRCm39) T347I probably benign Het
Ccdc24 G T 4: 117,729,201 (GRCm39) A92D probably damaging Het
Ccdc63 T C 5: 122,249,073 (GRCm39) T419A probably benign Het
Ccdc7a C T 8: 129,618,866 (GRCm39) V893I possibly damaging Het
Ccdc88b G T 19: 6,831,330 (GRCm39) D537E probably benign Het
Cd276 T C 9: 58,444,615 (GRCm39) S119G probably damaging Het
Cdkn3 T C 14: 47,004,647 (GRCm39) Y70H possibly damaging Het
Cdo1 G A 18: 46,861,266 (GRCm39) probably benign Het
Cdr2 A T 7: 120,581,247 (GRCm39) F10Y probably damaging Het
Cep290 A T 10: 100,374,865 (GRCm39) K1370N possibly damaging Het
Crb1 T A 1: 139,176,049 (GRCm39) I645F probably damaging Het
Cul7 T C 17: 46,969,657 (GRCm39) W975R probably damaging Het
Ddx39b A C 17: 35,471,826 (GRCm39) E324A probably benign Het
Diaph1 T G 18: 38,022,867 (GRCm39) probably null Het
Dnah2 G A 11: 69,321,318 (GRCm39) R3917* probably null Het
Dnph1 T A 17: 46,807,815 (GRCm39) L27Q probably damaging Het
Duox2 A G 2: 122,119,788 (GRCm39) F880S probably damaging Het
Ell2 C A 13: 75,910,006 (GRCm39) L119M probably damaging Het
Enpep A T 3: 129,106,319 (GRCm39) Y302* probably null Het
Ergic2 G T 6: 148,096,707 (GRCm39) H186Q probably damaging Het
Fam83b T C 9: 76,453,031 (GRCm39) D12G probably benign Het
Fbxw16 A T 9: 109,270,123 (GRCm39) V206D probably damaging Het
Fhod1 A T 8: 106,063,771 (GRCm39) V278D unknown Het
Gba2 G C 4: 43,573,753 (GRCm39) Q180E probably damaging Het
Grhl3 G A 4: 135,300,723 (GRCm39) L5F probably benign Het
H2-T15 A T 17: 36,369,235 (GRCm39) C7S unknown Het
Ifit1bl1 C T 19: 34,576,667 (GRCm39) probably null Het
Ift57 A G 16: 49,584,230 (GRCm39) T413A probably benign Het
Itga2 A G 13: 114,996,149 (GRCm39) F714S probably damaging Het
Jmy A G 13: 93,577,841 (GRCm39) S776P probably benign Het
Kbtbd8 G A 6: 95,098,814 (GRCm39) A108T probably damaging Het
Kpna6 G A 4: 129,548,139 (GRCm39) A230V probably damaging Het
Lrfn1 C T 7: 28,159,397 (GRCm39) L439F possibly damaging Het
Lrrc1 T A 9: 77,375,847 (GRCm39) I147F probably benign Het
Lrrc7 C T 3: 157,832,884 (GRCm39) G1425R probably damaging Het
Madd T A 2: 90,992,854 (GRCm39) I1022F probably damaging Het
Map2k2 A T 10: 80,942,017 (GRCm39) T13S probably benign Het
Mdc1 G A 17: 36,164,960 (GRCm39) V1459I probably benign Het
Mdh1b G A 1: 63,760,719 (GRCm39) T114M probably damaging Het
Mfsd2a T C 4: 122,845,088 (GRCm39) I208V possibly damaging Het
Mmrn1 T A 6: 60,965,411 (GRCm39) D1147E probably damaging Het
Nbeal2 T A 9: 110,455,177 (GRCm39) I2574F probably damaging Het
Nr1d1 T G 11: 98,662,892 (GRCm39) S34R probably damaging Het
Nr3c1 A T 18: 39,619,449 (GRCm39) D279E probably benign Het
Nrde2 T C 12: 100,098,747 (GRCm39) D640G probably benign Het
Odf4 A G 11: 68,817,514 (GRCm39) L58P probably damaging Het
Or4p22 A T 2: 88,317,651 (GRCm39) I192F probably benign Het
Otud6b A C 4: 14,811,743 (GRCm39) M300R probably damaging Het
Pamr1 T A 2: 102,471,280 (GRCm39) D534E probably benign Het
Pcdh7 T A 5: 57,878,299 (GRCm39) V618E probably benign Het
Pcgf6 A C 19: 47,031,226 (GRCm39) N266K possibly damaging Het
Plcz1 A T 6: 139,968,849 (GRCm39) Y196* probably null Het
Plxna1 A T 6: 89,334,311 (GRCm39) L106Q probably damaging Het
Qrich2 G A 11: 116,337,701 (GRCm39) A184V probably damaging Het
Rimkla A G 4: 119,325,275 (GRCm39) L378S probably benign Het
Rufy1 G T 11: 50,295,290 (GRCm39) H472Q probably benign Het
Samd7 T A 3: 30,810,631 (GRCm39) M216K probably benign Het
Samd9l A T 6: 3,375,856 (GRCm39) Y468* probably null Het
Scn2a T G 2: 65,558,787 (GRCm39) L1194R probably benign Het
Sgo2a T A 1: 58,056,944 (GRCm39) S1043T possibly damaging Het
Slc6a17 G T 3: 107,378,755 (GRCm39) H642Q probably benign Het
Smox C T 2: 131,364,031 (GRCm39) A45V possibly damaging Het
St6galnac3 T A 3: 153,117,274 (GRCm39) T150S possibly damaging Het
Strip2 T A 6: 29,941,911 (GRCm39) I627N possibly damaging Het
Sv2c A T 13: 96,224,758 (GRCm39) C184S probably damaging Het
Tm7sf2 A T 19: 6,116,527 (GRCm39) probably null Het
Ttc28 T C 5: 111,371,282 (GRCm39) I608T possibly damaging Het
Vmn1r183 T G 7: 23,754,926 (GRCm39) L243R probably damaging Het
Vmn1r68 T C 7: 10,261,778 (GRCm39) T107A probably benign Het
Vnn3 G A 10: 23,740,311 (GRCm39) G205R probably damaging Het
Zfp516 T A 18: 83,006,325 (GRCm39) probably null Het
Zpbp2 A G 11: 98,443,335 (GRCm39) D56G probably damaging Het
Other mutations in Or4k41
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01655:Or4k41 APN 2 111,280,234 (GRCm39) missense probably benign 0.13
IGL01748:Or4k41 APN 2 111,279,875 (GRCm39) missense probably damaging 1.00
IGL02264:Or4k41 APN 2 111,280,207 (GRCm39) missense probably benign 0.05
IGL02371:Or4k41 APN 2 111,280,354 (GRCm39) missense probably damaging 1.00
IGL02385:Or4k41 APN 2 111,279,695 (GRCm39) missense probably damaging 1.00
IGL02704:Or4k41 APN 2 111,279,492 (GRCm39) missense probably benign 0.00
R0368:Or4k41 UTSW 2 111,280,133 (GRCm39) missense probably benign 0.07
R1520:Or4k41 UTSW 2 111,279,619 (GRCm39) missense probably benign 0.00
R2036:Or4k41 UTSW 2 111,279,971 (GRCm39) missense possibly damaging 0.80
R2890:Or4k41 UTSW 2 111,279,634 (GRCm39) missense probably benign 0.12
R3757:Or4k41 UTSW 2 111,279,602 (GRCm39) missense possibly damaging 0.95
R3801:Or4k41 UTSW 2 111,279,910 (GRCm39) missense probably benign 0.07
R3958:Or4k41 UTSW 2 111,280,230 (GRCm39) missense possibly damaging 0.50
R4077:Or4k41 UTSW 2 111,279,848 (GRCm39) missense probably damaging 0.99
R4763:Or4k41 UTSW 2 111,280,023 (GRCm39) nonsense probably null
R4955:Or4k41 UTSW 2 111,279,950 (GRCm39) missense probably damaging 1.00
R4975:Or4k41 UTSW 2 111,280,028 (GRCm39) missense probably benign 0.16
R5046:Or4k41 UTSW 2 111,279,934 (GRCm39) missense probably benign 0.01
R5512:Or4k41 UTSW 2 111,280,099 (GRCm39) missense probably benign 0.00
R5708:Or4k41 UTSW 2 111,280,354 (GRCm39) missense probably damaging 1.00
R5771:Or4k41 UTSW 2 111,280,406 (GRCm39) splice site probably null
R5780:Or4k41 UTSW 2 111,280,178 (GRCm39) missense probably benign 0.03
R6981:Or4k41 UTSW 2 111,279,697 (GRCm39) missense probably benign 0.00
R7633:Or4k41 UTSW 2 111,279,967 (GRCm39) missense probably benign
R7963:Or4k41 UTSW 2 111,279,971 (GRCm39) missense possibly damaging 0.80
R8121:Or4k41 UTSW 2 111,279,505 (GRCm39) missense probably benign 0.20
R8889:Or4k41 UTSW 2 111,279,967 (GRCm39) missense probably benign
R8892:Or4k41 UTSW 2 111,279,967 (GRCm39) missense probably benign
R9036:Or4k41 UTSW 2 111,280,343 (GRCm39) missense probably damaging 1.00
RF037:Or4k41 UTSW 2 111,279,896 (GRCm39) missense not run
RF039:Or4k41 UTSW 2 111,279,896 (GRCm39) missense not run
Z1088:Or4k41 UTSW 2 111,279,802 (GRCm39) missense probably benign 0.02
Z1176:Or4k41 UTSW 2 111,280,129 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- TTCAACTCATTAGAACACCTTGTAG -3'
(R):5'- CACATACCGGTCATAGGCC -3'

Sequencing Primer
(F):5'- ACACCTTGTAGTAAATGGAAGAAAC -3'
(R):5'- CCGGTCATAGGCCATTGTTACAAG -3'
Posted On 2019-05-15