Incidental Mutation 'R7074:Vmn1r51'
ID 549097
Institutional Source Beutler Lab
Gene Symbol Vmn1r51
Ensembl Gene ENSMUSG00000062818
Gene Name vomeronasal 1 receptor 51
Synonyms VN12, V1ra1, V1r1
MMRRC Submission 045242-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7074 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 90099625-90107627 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 90106654 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 190 (D190V)
Ref Sequence ENSEMBL: ENSMUSP00000133870 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072859] [ENSMUST00000174204] [ENSMUST00000226542] [ENSMUST00000226977] [ENSMUST00000227109] [ENSMUST00000227766] [ENSMUST00000227876] [ENSMUST00000227911] [ENSMUST00000228880]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000072859
AA Change: D190V

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000072637
Gene: ENSMUSG00000062818
AA Change: D190V

DomainStartEndE-ValueType
transmembrane domain 41 63 N/A INTRINSIC
Pfam:V1R 64 328 1.5e-138 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000174204
AA Change: D190V

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000133870
Gene: ENSMUSG00000062818
AA Change: D190V

DomainStartEndE-ValueType
transmembrane domain 41 63 N/A INTRINSIC
Pfam:V1R 64 328 1.5e-138 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226542
AA Change: D190V

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Predicted Effect probably benign
Transcript: ENSMUST00000226977
AA Change: D190V

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Predicted Effect probably benign
Transcript: ENSMUST00000227109
AA Change: D190V

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Predicted Effect probably benign
Transcript: ENSMUST00000227766
AA Change: D190V

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Predicted Effect probably benign
Transcript: ENSMUST00000227876
AA Change: D190V

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Predicted Effect probably benign
Transcript: ENSMUST00000227911
AA Change: D190V

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Predicted Effect probably benign
Transcript: ENSMUST00000228880
AA Change: D190V

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygotes and heterozygotes for a null mutation exhibit axons that fail to converge on multiple discrete glomeruli, but rather, appear widely distributed throughout the glomerular layer of the accessory olfactory bulb. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4 A T 4: 144,340,433 (GRCm39) I53L probably benign Het
Acss2 T C 2: 155,363,961 (GRCm39) L80P possibly damaging Het
Adam3 A T 8: 25,184,363 (GRCm39) F546I probably benign Het
Adtrp A T 13: 41,981,617 (GRCm39) probably null Het
Anapc1 G T 2: 128,520,194 (GRCm39) P208T probably damaging Het
Ankrd33 A G 15: 101,017,430 (GRCm39) K281R probably benign Het
Bcl11b A G 12: 107,955,766 (GRCm39) S128P probably benign Het
Ccdc57 T C 11: 120,794,200 (GRCm39) K265E possibly damaging Het
Cep72 A G 13: 74,199,699 (GRCm39) C244R probably benign Het
Cope A G 8: 70,765,537 (GRCm39) Q303R probably benign Het
Cpd T A 11: 76,704,420 (GRCm39) N398I probably damaging Het
Cplx1 C T 5: 108,696,393 (GRCm39) probably null Het
Dixdc1 T A 9: 50,601,214 (GRCm39) E344D possibly damaging Het
Dock7 A T 4: 98,833,445 (GRCm39) F1951I unknown Het
Ell2 C A 13: 75,910,006 (GRCm39) L119M probably damaging Het
Faap24 A T 7: 35,094,527 (GRCm39) I91K possibly damaging Het
Fubp3 T C 2: 31,485,306 (GRCm39) S107P probably damaging Het
Gas2l2 T A 11: 83,313,893 (GRCm39) Q473L probably benign Het
Ghr A T 15: 3,362,873 (GRCm39) Y200N probably damaging Het
Gm4950 G A 18: 51,998,521 (GRCm39) Q145* probably null Het
Gm826 C T 2: 160,153,810 (GRCm39) V78I unknown Het
Gnas G A 2: 174,126,842 (GRCm39) E126K probably damaging Het
Grip2 A T 6: 91,761,689 (GRCm39) V235E probably benign Het
Hmgcl A G 4: 135,681,178 (GRCm39) H88R probably benign Het
Htr7 A G 19: 36,034,283 (GRCm39) V124A probably damaging Het
Igf2r T A 17: 12,933,003 (GRCm39) I840F possibly damaging Het
Ints8 T C 4: 11,204,574 (GRCm39) I961V possibly damaging Het
Jmy A T 13: 93,590,439 (GRCm39) S555T probably benign Het
Klk1b27 G A 7: 43,705,977 (GRCm39) G227S probably damaging Het
Lao1 A C 4: 118,825,382 (GRCm39) T401P probably damaging Het
Lrwd1 C T 5: 136,152,511 (GRCm39) V547I probably benign Het
Mttp C A 3: 137,813,034 (GRCm39) R532L possibly damaging Het
Muc16 T C 9: 18,566,946 (GRCm39) T1858A unknown Het
Myo18a T A 11: 77,733,387 (GRCm39) D1409E probably benign Het
Ncor2 T A 5: 125,126,430 (GRCm39) R554* probably null Het
Or14j6 T A 17: 38,214,718 (GRCm39) Y94N possibly damaging Het
Or1e1b-ps1 A T 11: 73,845,975 (GRCm39) H153L probably benign Het
Or2b11 T C 11: 59,461,835 (GRCm39) T244A probably damaging Het
Or2l13b T A 16: 19,348,855 (GRCm39) I272F possibly damaging Het
Or52b1 A G 7: 104,978,475 (GRCm39) M308T probably benign Het
Prkar2b A G 12: 32,022,147 (GRCm39) Y213H probably damaging Het
Prkd3 T A 17: 79,282,236 (GRCm39) K306* probably null Het
Psd2 A G 18: 36,143,737 (GRCm39) E681G probably benign Het
Sel1l2 T A 2: 140,105,362 (GRCm39) N276I probably damaging Het
Smox C T 2: 131,364,031 (GRCm39) A45V possibly damaging Het
Smyd1 A G 6: 71,214,359 (GRCm39) V214A probably damaging Het
Spag5 T C 11: 78,195,868 (GRCm39) probably null Het
Trem3 C T 17: 48,556,909 (GRCm39) R127W probably damaging Het
Ttn G A 2: 76,748,425 (GRCm39) T4208I probably benign Het
Tubgcp6 A G 15: 89,004,839 (GRCm39) F260S probably damaging Het
Zc3h14 A G 12: 98,724,859 (GRCm39) I174V possibly damaging Het
Zfp423 G A 8: 88,509,060 (GRCm39) T428I probably benign Het
Zfp608 T A 18: 55,030,454 (GRCm39) N1162I possibly damaging Het
Zmym5 T C 14: 57,042,255 (GRCm39) M8V probably benign Het
Other mutations in Vmn1r51
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01411:Vmn1r51 APN 6 90,106,386 (GRCm39) missense probably benign 0.07
R3196:Vmn1r51 UTSW 6 90,106,498 (GRCm39) missense probably damaging 1.00
R5611:Vmn1r51 UTSW 6 90,106,692 (GRCm39) missense probably benign 0.04
R6402:Vmn1r51 UTSW 6 90,106,444 (GRCm39) missense probably benign 0.25
R6979:Vmn1r51 UTSW 6 90,106,186 (GRCm39) missense possibly damaging 0.61
R7035:Vmn1r51 UTSW 6 90,106,207 (GRCm39) missense probably benign 0.00
R7676:Vmn1r51 UTSW 6 90,106,437 (GRCm39) missense probably benign 0.37
R8900:Vmn1r51 UTSW 6 90,106,842 (GRCm39) missense probably damaging 1.00
R9468:Vmn1r51 UTSW 6 90,106,930 (GRCm39) missense probably damaging 1.00
R9672:Vmn1r51 UTSW 6 90,106,549 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- CAGAGTTTTGAGGGGTCTCTCC -3'
(R):5'- GGCTGATACCTTGCAGATGC -3'

Sequencing Primer
(F):5'- TACCACCAGCATGTTGAGTG -3'
(R):5'- ATACCTTGCAGATGCTGGGTC -3'
Posted On 2019-05-15