Incidental Mutation 'R7075:Mettl25'
ID 549169
Institutional Source Beutler Lab
Gene Symbol Mettl25
Ensembl Gene ENSMUSG00000036009
Gene Name methyltransferase like 25
Synonyms BC067068
MMRRC Submission 045170-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.114) question?
Stock # R7075 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 105599050-105677241 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 105665785 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 147 (N147S)
Ref Sequence ENSEMBL: ENSMUSP00000038665 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046638] [ENSMUST00000176040] [ENSMUST00000176924]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000046638
AA Change: N147S

PolyPhen 2 Score 0.680 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000038665
Gene: ENSMUSG00000036009
AA Change: N147S

DomainStartEndE-ValueType
Pfam:Methyltransf_32 149 413 1.9e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000176040
Predicted Effect probably benign
Transcript: ENSMUST00000176924
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 95% (60/63)
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acyp1 A T 12: 85,325,782 (GRCm39) H72Q unknown Het
Afmid T A 11: 117,726,531 (GRCm39) D218E probably benign Het
Ankhd1 T C 18: 36,693,042 (GRCm39) V1A Het
Atf7ip T C 6: 136,573,513 (GRCm39) probably null Het
BC024139 C T 15: 76,008,599 (GRCm39) V326I probably benign Het
Bfsp1 T A 2: 143,690,885 (GRCm39) Q159L probably damaging Het
Cct2 A T 10: 116,897,370 (GRCm39) W125R unknown Het
Cnksr3 G T 10: 7,102,931 (GRCm39) T147K probably benign Het
Colq C G 14: 31,274,866 (GRCm39) G101R probably damaging Het
Dlg5 G T 14: 24,227,865 (GRCm39) T352K possibly damaging Het
Dusp9 TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG X: 72,684,217 (GRCm39) probably benign Het
Ebna1bp2 T C 4: 118,479,299 (GRCm39) V119A probably benign Het
Eif2ak4 C T 2: 118,251,291 (GRCm39) Q318* probably null Het
Eif2b1 G A 5: 124,709,314 (GRCm39) T286M probably damaging Het
Fam53b G T 7: 132,361,352 (GRCm39) D225E probably damaging Het
Fh1 A G 1: 175,435,421 (GRCm39) I354T probably benign Het
Fnbp1 T C 2: 30,948,926 (GRCm39) H206R probably benign Het
Gabrg3 A T 7: 56,973,444 (GRCm39) D74E probably damaging Het
Galnt18 A T 7: 111,155,595 (GRCm39) V246E possibly damaging Het
Glt6d1 T C 2: 25,685,292 (GRCm39) R44G probably benign Het
Gm17087 T C 17: 8,785,635 (GRCm39) M23V probably benign Het
Gpr160 A T 3: 30,950,926 (GRCm39) I333L possibly damaging Het
Hars1 T C 18: 36,905,408 (GRCm39) N142S possibly damaging Het
Hmgcll1 T C 9: 75,963,834 (GRCm39) V97A possibly damaging Het
Itih4 T G 14: 30,614,560 (GRCm39) V474G probably damaging Het
Itprid2 T A 2: 79,466,004 (GRCm39) S41T probably damaging Het
Keap1 C T 9: 21,142,552 (GRCm39) V568I probably benign Het
Kifc5b A G 17: 27,144,872 (GRCm39) M633V probably benign Het
Lsm4 A G 8: 71,130,435 (GRCm39) E18G probably damaging Het
Meox1 T A 11: 101,784,569 (GRCm39) Q88L probably damaging Het
Mphosph9 A C 5: 124,458,922 (GRCm39) W83G probably damaging Het
Or1j15 T C 2: 36,459,192 (GRCm39) I194T probably benign Het
Or5ak22 T C 2: 85,230,544 (GRCm39) D111G probably damaging Het
Or7e170 T A 9: 19,795,359 (GRCm39) M81L probably benign Het
Or8b4 T C 9: 37,830,370 (GRCm39) V139A probably benign Het
Or8h8 T G 2: 86,752,990 (GRCm39) K295N possibly damaging Het
Or9g4 T A 2: 85,505,168 (GRCm39) Y109F Het
Otogl G T 10: 107,614,790 (GRCm39) T1954K probably benign Het
Padi2 T C 4: 140,660,528 (GRCm39) V336A probably damaging Het
Phf21a C T 2: 92,190,724 (GRCm39) Q675* probably null Het
Ppip5k1 T C 2: 121,152,231 (GRCm39) E1092G probably damaging Het
Psg21 T C 7: 18,388,786 (GRCm39) N102S probably damaging Het
Ralgapa1 C A 12: 55,867,508 (GRCm39) Q15H possibly damaging Het
Rbm26 A T 14: 105,398,043 (GRCm39) D26E unknown Het
Rbp4 T C 19: 38,112,509 (GRCm39) Y152C probably damaging Het
Recql4 A G 15: 76,590,624 (GRCm39) V646A possibly damaging Het
Rnf220 A T 4: 117,143,079 (GRCm39) M63K probably benign Het
Selenok T C 14: 29,692,024 (GRCm39) S21P probably damaging Het
Senp1 A G 15: 97,956,207 (GRCm39) V404A probably benign Het
Sh3yl1 A G 12: 30,990,165 (GRCm39) probably null Het
Snx32 A G 19: 5,547,018 (GRCm39) L275P probably damaging Het
Stat5a T C 11: 100,770,519 (GRCm39) V519A possibly damaging Het
Tbc1d10b A T 7: 126,802,410 (GRCm39) V388E possibly damaging Het
Tdrd6 A G 17: 43,936,065 (GRCm39) V1661A probably benign Het
Tmem63a T A 1: 180,788,714 (GRCm39) F350L probably damaging Het
Trio A T 15: 27,898,086 (GRCm39) I401K unknown Het
Ttn T C 2: 76,547,173 (GRCm39) E32291G probably damaging Het
Tubgcp5 G T 7: 55,479,155 (GRCm39) V1002L probably benign Het
Vav3 C T 3: 109,433,240 (GRCm39) T410I possibly damaging Het
Vmn1r1 A T 1: 181,985,597 (GRCm39) F23I probably benign Het
Vmn2r84 T A 10: 130,226,941 (GRCm39) Q299L probably damaging Het
Vmn2r85 T A 10: 130,258,557 (GRCm39) E499D probably benign Het
Other mutations in Mettl25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00310:Mettl25 APN 10 105,662,295 (GRCm39) missense probably benign
IGL00698:Mettl25 APN 10 105,629,201 (GRCm39) missense probably null 0.31
IGL00766:Mettl25 APN 10 105,615,443 (GRCm39) splice site probably benign
IGL01360:Mettl25 APN 10 105,659,058 (GRCm39) missense probably damaging 1.00
IGL01954:Mettl25 APN 10 105,659,068 (GRCm39) missense probably damaging 1.00
IGL02088:Mettl25 APN 10 105,659,111 (GRCm39) missense probably damaging 1.00
IGL02623:Mettl25 APN 10 105,662,185 (GRCm39) missense probably damaging 0.96
IGL03245:Mettl25 APN 10 105,662,358 (GRCm39) missense possibly damaging 0.86
IGL03134:Mettl25 UTSW 10 105,661,888 (GRCm39) nonsense probably null
R0238:Mettl25 UTSW 10 105,662,386 (GRCm39) missense probably damaging 1.00
R0238:Mettl25 UTSW 10 105,662,386 (GRCm39) missense probably damaging 1.00
R0239:Mettl25 UTSW 10 105,662,386 (GRCm39) missense probably damaging 1.00
R0239:Mettl25 UTSW 10 105,662,386 (GRCm39) missense probably damaging 1.00
R1297:Mettl25 UTSW 10 105,659,126 (GRCm39) missense probably benign 0.11
R1482:Mettl25 UTSW 10 105,662,451 (GRCm39) missense possibly damaging 0.61
R1526:Mettl25 UTSW 10 105,668,844 (GRCm39) missense possibly damaging 0.56
R1542:Mettl25 UTSW 10 105,661,981 (GRCm39) missense probably benign 0.04
R1589:Mettl25 UTSW 10 105,615,493 (GRCm39) missense probably damaging 1.00
R1901:Mettl25 UTSW 10 105,661,948 (GRCm39) missense probably damaging 0.96
R1902:Mettl25 UTSW 10 105,661,948 (GRCm39) missense probably damaging 0.96
R2016:Mettl25 UTSW 10 105,633,167 (GRCm39) missense probably benign 0.00
R2355:Mettl25 UTSW 10 105,599,316 (GRCm39) missense probably benign 0.00
R2920:Mettl25 UTSW 10 105,601,038 (GRCm39) splice site probably null
R3149:Mettl25 UTSW 10 105,662,214 (GRCm39) missense probably benign 0.00
R4547:Mettl25 UTSW 10 105,661,878 (GRCm39) missense probably damaging 1.00
R4646:Mettl25 UTSW 10 105,662,416 (GRCm39) missense probably damaging 1.00
R4652:Mettl25 UTSW 10 105,615,509 (GRCm39) nonsense probably null
R5020:Mettl25 UTSW 10 105,662,068 (GRCm39) missense possibly damaging 0.87
R5435:Mettl25 UTSW 10 105,615,447 (GRCm39) critical splice donor site probably null
R6947:Mettl25 UTSW 10 105,662,053 (GRCm39) missense probably benign 0.00
R7729:Mettl25 UTSW 10 105,601,871 (GRCm39) missense probably benign 0.03
R8074:Mettl25 UTSW 10 105,661,941 (GRCm39) missense probably benign 0.02
R8108:Mettl25 UTSW 10 105,659,040 (GRCm39) missense possibly damaging 0.53
R8415:Mettl25 UTSW 10 105,662,002 (GRCm39) missense probably benign 0.05
R8937:Mettl25 UTSW 10 105,601,122 (GRCm39) missense probably benign 0.17
R8949:Mettl25 UTSW 10 105,668,714 (GRCm39) missense probably benign 0.00
R9497:Mettl25 UTSW 10 105,677,090 (GRCm39) missense probably damaging 0.98
R9772:Mettl25 UTSW 10 105,633,127 (GRCm39) missense probably benign
RF009:Mettl25 UTSW 10 105,669,100 (GRCm39) intron probably benign
Z1176:Mettl25 UTSW 10 105,661,959 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- AGAACTGTGTGTAATCTCTTTGTTAAG -3'
(R):5'- CATGGAATGATTTTAGTAATCTGTGGA -3'

Sequencing Primer
(F):5'- TTGAGGAGAGGAGGATGCC -3'
(R):5'- AAGCTGTAAATTTCAGGTGA -3'
Posted On 2019-05-15