Incidental Mutation 'R7077:Prl3a1'
ID 549293
Institutional Source Beutler Lab
Gene Symbol Prl3a1
Ensembl Gene ENSMUSG00000038883
Gene Name prolactin family 3, subfamily a, member 1
Synonyms Prlpi, PLP-I, 1600016E11Rik, PLP-H, Plpi
MMRRC Submission 045172-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R7077 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 27443472-27460669 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 27460086 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 190 (N190I)
Ref Sequence ENSEMBL: ENSMUSP00000046522 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049463]
AlphaFold Q78Y73
Predicted Effect probably benign
Transcript: ENSMUST00000049463
AA Change: N190I

PolyPhen 2 Score 0.348 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000046522
Gene: ENSMUSG00000038883
AA Change: N190I

DomainStartEndE-ValueType
Pfam:Hormone_1 16 227 2.3e-59 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 98% (54/55)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam21 C T 12: 81,605,893 (GRCm39) C623Y probably damaging Het
Ago3 T C 4: 126,265,325 (GRCm39) K322R probably null Het
Ankrd17 T C 5: 90,433,723 (GRCm39) H682R possibly damaging Het
Aoah A G 13: 21,094,276 (GRCm39) D187G probably damaging Het
Arhgap17 T C 7: 122,879,231 (GRCm39) D840G unknown Het
AW551984 C T 9: 39,502,723 (GRCm39) V650I probably benign Het
Bok T A 1: 93,616,911 (GRCm39) Y86N probably damaging Het
Ccdc146 T A 5: 21,510,272 (GRCm39) N580I possibly damaging Het
Ccng2 T C 5: 93,417,199 (GRCm39) S72P possibly damaging Het
Cfap74 T G 4: 155,540,134 (GRCm39) I977S unknown Het
Cobl T C 11: 12,203,441 (GRCm39) N1087S probably benign Het
Cyp21a1 C A 17: 35,021,333 (GRCm39) R346L probably damaging Het
Eif4a1 A C 11: 69,561,490 (GRCm39) F52L probably damaging Het
Eif4ebp2 A C 10: 61,269,580 (GRCm39) I120S probably damaging Het
Enpp2 A C 15: 54,764,787 (GRCm39) D146E probably benign Het
Exosc9 T C 3: 36,607,205 (GRCm39) Y30H probably damaging Het
Fam117a G A 11: 95,268,498 (GRCm39) G300S probably benign Het
Focad C A 4: 88,328,914 (GRCm39) A1709E unknown Het
Fsd1 G A 17: 56,300,876 (GRCm39) R245H probably damaging Het
Fsip2 T C 2: 82,813,496 (GRCm39) F3272L probably benign Het
Gcnt2 G A 13: 41,013,896 (GRCm39) M22I probably benign Het
Gjd4 T C 18: 9,280,928 (GRCm39) E50G probably damaging Het
Gm10375 G T 14: 43,840,427 (GRCm39) T162K probably benign Het
Gm10837 C G 14: 122,728,142 (GRCm39) A6G unknown Het
Gm4924 T C 10: 82,215,057 (GRCm39) F952L unknown Het
Heatr1 T C 13: 12,433,045 (GRCm39) F1132L possibly damaging Het
Hnrnpu A G 1: 178,159,756 (GRCm39) Y442H unknown Het
Hp1bp3 C A 4: 137,966,929 (GRCm39) T408N probably damaging Het
Htra3 A G 5: 35,825,660 (GRCm39) V198A probably damaging Het
Katnal1 T C 5: 148,828,547 (GRCm39) T300A probably benign Het
Lipo5 G T 19: 33,445,170 (GRCm39) P133Q Het
Lrp1b A T 2: 41,660,858 (GRCm39) H197Q Het
Mdc1 C A 17: 36,156,839 (GRCm39) A82D probably damaging Het
Mstn A T 1: 53,103,408 (GRCm39) D248V probably benign Het
Myo1d C T 11: 80,565,460 (GRCm39) E426K probably damaging Het
Ola1 G A 2: 72,972,308 (GRCm39) T221I probably damaging Het
Or52z1 A G 7: 103,436,593 (GRCm39) I297T probably damaging Het
Or5t7 T C 2: 86,507,236 (GRCm39) Y147C possibly damaging Het
Or7e166 T A 9: 19,624,428 (GRCm39) S102T probably benign Het
Or8c20 T A 9: 38,261,266 (GRCm39) Y290N probably damaging Het
Phldb1 T C 9: 44,623,201 (GRCm39) T618A possibly damaging Het
Pkd1 T G 17: 24,810,093 (GRCm39) W3565G probably damaging Het
Ptk2 G A 15: 73,093,658 (GRCm39) P854S possibly damaging Het
Ptpn11 C T 5: 121,281,633 (GRCm39) R484Q probably benign Het
Rapgef4 T C 2: 72,071,820 (GRCm39) M900T probably damaging Het
Slc1a2 A T 2: 102,607,855 (GRCm39) D501V probably benign Het
Smarcd3 G T 5: 24,799,960 (GRCm39) A270D probably damaging Het
Srgap2 A G 1: 131,272,187 (GRCm39) M33T Het
Tle1 G C 4: 72,076,612 (GRCm39) P139A probably benign Het
Tmem161b C A 13: 84,370,537 (GRCm39) probably benign Het
Tsbp1 C A 17: 34,659,856 (GRCm39) T93N possibly damaging Het
Zfp658 T A 7: 43,223,413 (GRCm39) S563T probably benign Het
Zswim9 G A 7: 12,993,679 (GRCm39) R826C probably damaging Het
Other mutations in Prl3a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02216:Prl3a1 APN 13 27,454,127 (GRCm39) missense probably benign 0.13
IGL02648:Prl3a1 APN 13 27,454,218 (GRCm39) missense probably benign 0.00
R1405:Prl3a1 UTSW 13 27,459,051 (GRCm39) splice site probably null
R1405:Prl3a1 UTSW 13 27,459,051 (GRCm39) splice site probably null
R1596:Prl3a1 UTSW 13 27,443,600 (GRCm39) start gained probably benign
R1823:Prl3a1 UTSW 13 27,454,177 (GRCm39) missense probably damaging 0.99
R1952:Prl3a1 UTSW 13 27,454,136 (GRCm39) missense possibly damaging 0.91
R2059:Prl3a1 UTSW 13 27,454,127 (GRCm39) missense probably benign 0.13
R5843:Prl3a1 UTSW 13 27,454,093 (GRCm39) missense probably damaging 1.00
R6222:Prl3a1 UTSW 13 27,460,097 (GRCm39) missense probably benign 0.05
R6664:Prl3a1 UTSW 13 27,454,194 (GRCm39) nonsense probably null
R7846:Prl3a1 UTSW 13 27,456,442 (GRCm39) missense probably damaging 1.00
R9049:Prl3a1 UTSW 13 27,460,167 (GRCm39) missense probably damaging 1.00
R9616:Prl3a1 UTSW 13 27,459,118 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- TGACCTCTCACCTTCAAATATATGT -3'
(R):5'- AGAAATAAAGCATTGATGATCTGGAT -3'

Sequencing Primer
(F):5'- TGTGTACACATGCATACACACATGG -3'
(R):5'- TTGATGATCTGGATAACCAAGGACC -3'
Posted On 2019-05-15