Mutagenetix > Incidental Mutation

Incidental Mutation 'R7078:Acaca'

549364

Institutional Source

Beutler Lab

Gene Symbol

Acaca

Ensembl Gene

ENSMUSG00000020532

Gene Name

acetyl-Coenzyme A carboxylase alpha

Synonyms

LOC327983, Acac, A530025K05Rik, acetyl-CoA carboxylase, Acc1

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R7078 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

84129672-84401651 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 84263312 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glutamine at position 953 (R953Q)

Ref Sequence

ENSEMBL: ENSMUSP00000020843 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000020843] [ENSMUST00000103201]

AlphaFold

Q5SWU9

Predicted Effect

possibly damaging
Transcript: ENSMUST00000020843
AA Change: R953Q

PolyPhen 2 Score 0.906 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000020843
Gene: ENSMUSG00000020532
AA Change: R953Q

Domain	Start	End	E-Value	Type
Pfam:CPSase_L_chain	116	236	4.7e-33	PFAM
Pfam:CPSase_L_D2	272	472	2.5e-55	PFAM
Pfam:ATP-grasp	280	443	4.3e-7	PFAM
Pfam:ATP-grasp_4	282	442	1.9e-11	PFAM
Pfam:Dala_Dala_lig_C	284	440	5.4e-7	PFAM
Biotin_carb_C	506	613	3.76e-24	SMART
low complexity region	708	725	N/A	INTRINSIC
Pfam:Biotin_lipoyl	751	817	9.8e-19	PFAM
Pfam:ACC_central	818	1568	2.1e-288	PFAM
Pfam:Carboxyl_trans	1668	2222	1.6e-185	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000103201
AA Change: R953Q

PolyPhen 2 Score 0.906 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000099490
Gene: ENSMUSG00000020532
AA Change: R953Q

Domain	Start	End	E-Value	Type
Pfam:CPSase_L_chain	116	236	6.7e-29	PFAM
Pfam:ATP-grasp_4	239	442	2e-15	PFAM
Pfam:CPSase_L_D2	272	472	3.3e-55	PFAM
Pfam:Dala_Dala_lig_C	279	440	3e-7	PFAM
Pfam:ATP-grasp	281	442	1.1e-6	PFAM
Biotin_carb_C	506	613	3.76e-24	SMART
low complexity region	708	725	N/A	INTRINSIC
Pfam:Biotin_lipoyl	751	817	3.7e-18	PFAM
Pfam:ACC_central	818	1568	3.5e-253	PFAM
Pfam:Carboxyl_trans	1668	2222	2.7e-175	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice display embryonic lethality before embryo turning with growth arrest at the egg cylinder stage. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 91 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aldh1a1	A	T	19: 20,602,070 (GRCm38)	H20L	probably benign	Het
Ankrd52	T	A	10: 128,383,657 (GRCm38)	C487S	probably benign	Het
Ap1s3	T	C	1: 79,625,128 (GRCm38)	E54G	probably benign	Het
Arglu1	A	C	8: 8,667,361 (GRCm38)	M236R	probably benign	Het
Baz1b	T	A	5: 135,217,439 (GRCm38)	F581I	probably benign	Het
Bbox1	T	G	2: 110,292,539 (GRCm38)	D135A	probably benign	Het
Bcl2l14	T	A	6: 134,423,823 (GRCm38)	V69E	probably damaging	Het
Brinp3	C	T	1: 146,514,889 (GRCm38)	Q58*	probably null	Het
Ccnb1ip1	T	A	14: 50,792,267 (GRCm38)	K113*	probably null	Het
Cep128	T	C	12: 91,234,104 (GRCm38)	I830M	probably damaging	Het
Ces2f	C	T	8: 104,954,652 (GRCm38)	T541I	probably damaging	Het
Chsy3	C	A	18: 59,176,077 (GRCm38)	P134Q	possibly damaging	Het
Cobl	T	G	11: 12,378,271 (GRCm38)	T112P	probably damaging	Het
Cplane2	A	T	4: 141,219,848 (GRCm38)	Y180F	probably benign	Het
Dcc	T	A	18: 71,547,398 (GRCm38)	K589I	probably benign	Het
Depdc1b	T	A	13: 108,386,971 (GRCm38)	I460K	possibly damaging	Het
Dlst	T	C	12: 85,110,931 (GRCm38)	F12S	probably benign	Het
Dnah1	G	C	14: 31,297,110 (GRCm38)	F1342L	probably damaging	Het
Dtnb	A	G	12: 3,748,480 (GRCm38)	Q438R	possibly damaging	Het
Dusp4	C	A	8: 34,807,911 (GRCm38)	S61R	probably damaging	Het
E130308A19Rik	A	G	4: 59,737,688 (GRCm38)	Y433C	probably damaging	Het
Ebf2	T	C	14: 67,423,958 (GRCm38)	S512P	probably benign	Het
Elapor2	A	G	5: 9,410,709 (GRCm38)	N210S	probably benign	Het
Eya1	C	T	1: 14,231,412 (GRCm38)		probably null	Het
Fsd1	G	A	17: 55,993,876 (GRCm38)	R245H	probably damaging	Het
Fzr1	T	A	10: 81,368,629 (GRCm38)	D379V	probably damaging	Het
Gk2	T	A	5: 97,456,336 (GRCm38)	E214D	probably benign	Het
Gm10837	C	G	14: 122,490,730 (GRCm38)	A6G	unknown	Het
Gmnc	A	T	16: 26,960,522 (GRCm38)	V251E	probably benign	Het
Golga3	A	G	5: 110,193,087 (GRCm38)	Q549R	probably damaging	Het
Gsdmd	T	G	15: 75,864,355 (GRCm38)	V111G	probably damaging	Het
Gtf3c1	T	C	7: 125,645,742 (GRCm38)	T1707A	possibly damaging	Het
Gucy2c	C	T	6: 136,697,939 (GRCm38)	V1049M	probably benign	Het
Gucy2g	A	G	19: 55,241,151 (GRCm38)	V29A	probably damaging	Het
Hecw1	A	T	13: 14,434,459 (GRCm38)	M1K	probably null	Het
Hmcn1	T	C	1: 150,860,367 (GRCm38)	D117G	probably damaging	Het
Ifnab	T	A	4: 88,691,113 (GRCm38)	T39S	possibly damaging	Het
Lcorl	A	G	5: 45,747,224 (GRCm38)	Y171H	probably damaging	Het
Ly6g6c	C	T	17: 35,069,461 (GRCm38)	P103L	probably damaging	Het
Macf1	T	G	4: 123,432,143 (GRCm38)	E5189A	probably damaging	Het
Mapkap1	A	G	2: 34,563,139 (GRCm38)	E348G	probably damaging	Het
Med25	G	T	7: 44,884,901 (GRCm38)	A280D	probably damaging	Het
Mep1b	C	A	18: 21,100,051 (GRCm38)	A703E	probably benign	Het
Morn5	T	A	2: 36,054,978 (GRCm38)	N71K	probably benign	Het
Mtmr10	T	A	7: 64,320,627 (GRCm38)	Y373N	possibly damaging	Het
Myo1d	C	T	11: 80,674,634 (GRCm38)	E426K	probably damaging	Het
Ncbp1	G	C	4: 46,155,756 (GRCm38)	V302L	probably benign	Het
Notch4	A	G	17: 34,582,546 (GRCm38)	T1123A	possibly damaging	Het
Nudt18	T	A	14: 70,579,012 (GRCm38)	M88K	possibly damaging	Het
Or12k8	A	G	2: 37,085,596 (GRCm38)	S51P	possibly damaging	Het
Or5b100-ps1	A	T	19: 13,016,733 (GRCm38)	D170V	possibly damaging	Het
Or6d12	T	A	6: 116,516,671 (GRCm38)	L298Q	probably damaging	Het
Or8g4	A	T	9: 39,750,491 (GRCm38)	Y35F	possibly damaging	Het
Pdcd6ip	T	C	9: 113,659,885 (GRCm38)	N694S	probably benign	Het
Pecam1	T	A	11: 106,688,947 (GRCm38)	T430S	probably benign	Het
Plaa	T	G	4: 94,574,051 (GRCm38)	T530P	probably benign	Het
Ppfia3	G	T	7: 45,360,595 (GRCm38)	Q95K	probably damaging	Het
Ppp4r2	T	C	6: 100,866,313 (GRCm38)	S331P	probably benign	Het
Prg4	T	C	1: 150,458,263 (GRCm38)	T117A	possibly damaging	Het
Prrc2b	A	T	2: 32,213,519 (GRCm38)	D1003V	probably benign	Het
Ptk2	G	A	15: 73,221,809 (GRCm38)	P854S	possibly damaging	Het
Rasef	T	C	4: 73,780,389 (GRCm38)	I12V	probably benign	Het
Robo2	T	G	16: 74,352,616 (GRCm38)	Y108S	probably damaging	Het
Rp1	T	A	1: 4,206,791 (GRCm38)	E762V	unknown	Het
Rsrc1	T	C	3: 66,994,654 (GRCm38)	S46P	unknown	Het
Rttn	A	T	18: 89,009,422 (GRCm38)	T554S	probably benign	Het
Sall3	C	T	18: 80,974,099 (GRCm38)	V205M	probably damaging	Het
Scn3a	C	A	2: 65,497,600 (GRCm38)	V849L	probably damaging	Het
Sec23a	A	G	12: 58,992,283 (GRCm38)	C277R	probably benign	Het
Sf3b3	C	T	8: 110,813,007 (GRCm38)	A1075T	possibly damaging	Het
Sfxn5	T	C	6: 85,332,384 (GRCm38)	D113G	unknown	Het
Slc22a22	C	T	15: 57,263,480 (GRCm38)	M64I	probably benign	Het
Slc5a11	C	T	7: 123,258,446 (GRCm38)	P253S	probably damaging	Het
Smarcd3	A	G	5: 24,593,069 (GRCm38)	F449S	probably damaging	Het
Sspo	C	T	6: 48,460,379 (GRCm38)	T1357M	probably damaging	Het
Styx	C	T	14: 45,372,416 (GRCm38)	T179I	probably benign	Het
Syt7	A	T	19: 10,435,599 (GRCm38)	T297S	probably benign	Het
Tbx19	T	A	1: 165,160,566 (GRCm38)		probably benign	Het
Tg	T	A	15: 66,673,543 (GRCm38)	V149E	probably damaging	Het
Tgfbr3l	T	A	8: 4,249,238 (GRCm38)	L35Q	probably damaging	Het
Tmem161b	C	A	13: 84,222,418 (GRCm38)		probably benign	Het
Tmem219	T	A	7: 126,891,803 (GRCm38)	T161S	probably damaging	Het
Tox2	T	A	2: 163,320,581 (GRCm38)	L68H		Het
Trim5	T	A	7: 104,278,474 (GRCm38)	D153V	possibly damaging	Het
Ttn	A	T	2: 76,751,809 (GRCm38)	N22913K	probably damaging	Het
Ttn	T	C	2: 76,750,307 (GRCm38)	Y23414C	probably damaging	Het
Ubr2	A	C	17: 46,955,853 (GRCm38)	M1124R	possibly damaging	Het
Vmn2r75	A	G	7: 86,166,360 (GRCm38)	S99P	probably damaging	Het
Wdr83	T	C	8: 85,076,051 (GRCm38)	D219G	probably damaging	Het
Wdr90	C	T	17: 25,849,649 (GRCm38)	V1285M	probably damaging	Het
Zmynd15	A	T	11: 70,460,755 (GRCm38)	L62F	probably damaging	Het

Other mutations in Acaca

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00544:Acaca	APN	11	84,278,917 (GRCm38)	missense	probably damaging	1.00
IGL01134:Acaca	APN	11	84,251,279 (GRCm38)	missense	probably benign	0.22
IGL01446:Acaca	APN	11	84,260,631 (GRCm38)	missense	probably damaging	1.00
IGL01591:Acaca	APN	11	84,243,320 (GRCm38)	missense	probably damaging	1.00
IGL01663:Acaca	APN	11	84,277,802 (GRCm38)	missense	possibly damaging	0.85
IGL01767:Acaca	APN	11	84,320,542 (GRCm38)	missense	probably benign	0.01
IGL02206:Acaca	APN	11	84,260,747 (GRCm38)	nonsense	probably null
IGL02335:Acaca	APN	11	84,214,258 (GRCm38)	missense	possibly damaging	0.84
IGL02477:Acaca	APN	11	84,307,168 (GRCm38)	splice site	probably benign
IGL02515:Acaca	APN	11	84,262,403 (GRCm38)	missense	probably benign
IGL02651:Acaca	APN	11	84,245,204 (GRCm38)	splice site	probably benign
IGL02805:Acaca	APN	11	84,223,133 (GRCm38)	splice site	probably benign
IGL03328:Acaca	APN	11	84,320,529 (GRCm38)	missense	probably benign	0.00
effervescence	UTSW	11	84,262,474 (GRCm38)	missense	probably benign	0.41
fizz	UTSW	11	84,245,856 (GRCm38)	missense	probably damaging	0.98
greenhouse	UTSW	11	84,338,356 (GRCm38)	missense	probably damaging	1.00
Serene	UTSW	11	84,311,409 (GRCm38)	splice site	probably null
Tranquil	UTSW	11	84,280,461 (GRCm38)	missense	probably damaging	1.00
vitamin	UTSW	11	84,280,435 (GRCm38)	missense	possibly damaging	0.78
ANU05:Acaca	UTSW	11	84,315,852 (GRCm38)	missense	probably damaging	1.00
R0385:Acaca	UTSW	11	84,231,748 (GRCm38)	missense	probably benign	0.01
R0518:Acaca	UTSW	11	84,290,286 (GRCm38)	critical splice acceptor site	probably null
R0536:Acaca	UTSW	11	84,280,516 (GRCm38)	splice site	probably benign
R0962:Acaca	UTSW	11	84,311,303 (GRCm38)	missense	probably damaging	1.00
R0968:Acaca	UTSW	11	84,239,033 (GRCm38)	nonsense	probably null
R1123:Acaca	UTSW	11	84,264,080 (GRCm38)	missense	probably benign	0.09
R1452:Acaca	UTSW	11	84,295,059 (GRCm38)	splice site	probably benign
R1478:Acaca	UTSW	11	84,372,627 (GRCm38)	missense	probably damaging	1.00
R1500:Acaca	UTSW	11	84,293,984 (GRCm38)	missense	probably benign	0.00
R1512:Acaca	UTSW	11	84,195,469 (GRCm38)	missense	probably benign	0.00
R1657:Acaca	UTSW	11	84,264,084 (GRCm38)	missense	probably benign	0.09
R1681:Acaca	UTSW	11	84,226,185 (GRCm38)	missense	probably damaging	1.00
R1682:Acaca	UTSW	11	84,392,217 (GRCm38)	missense	probably benign	0.23
R1688:Acaca	UTSW	11	84,238,896 (GRCm38)	missense	probably damaging	1.00
R1755:Acaca	UTSW	11	84,276,564 (GRCm38)	frame shift	probably null
R1775:Acaca	UTSW	11	84,300,422 (GRCm38)	missense	possibly damaging	0.56
R1793:Acaca	UTSW	11	84,338,393 (GRCm38)	missense	probably damaging	1.00
R1793:Acaca	UTSW	11	84,315,969 (GRCm38)	missense	probably damaging	0.98
R1855:Acaca	UTSW	11	84,371,554 (GRCm38)	missense	probably damaging	0.96
R1881:Acaca	UTSW	11	84,300,471 (GRCm38)	splice site	probably benign
R1881:Acaca	UTSW	11	84,270,387 (GRCm38)	nonsense	probably null
R1989:Acaca	UTSW	11	84,262,529 (GRCm38)	missense	probably damaging	0.98
R2147:Acaca	UTSW	11	84,276,536 (GRCm38)	missense	probably benign	0.03
R2215:Acaca	UTSW	11	84,363,793 (GRCm38)	missense	probably damaging	1.00
R2238:Acaca	UTSW	11	84,391,505 (GRCm38)	splice site	probably benign
R2252:Acaca	UTSW	11	84,371,532 (GRCm38)	missense	probably damaging	0.99
R2316:Acaca	UTSW	11	84,294,983 (GRCm38)	missense	possibly damaging	0.69
R2316:Acaca	UTSW	11	84,264,080 (GRCm38)	missense	probably benign	0.16
R2337:Acaca	UTSW	11	84,257,197 (GRCm38)	missense	possibly damaging	0.93
R2697:Acaca	UTSW	11	84,364,413 (GRCm38)	missense	probably damaging	1.00
R3551:Acaca	UTSW	11	84,261,624 (GRCm38)	missense	probably damaging	1.00
R3552:Acaca	UTSW	11	84,261,624 (GRCm38)	missense	probably damaging	1.00
R3748:Acaca	UTSW	11	84,311,409 (GRCm38)	splice site	probably null
R3844:Acaca	UTSW	11	84,364,413 (GRCm38)	missense	probably damaging	1.00
R3873:Acaca	UTSW	11	84,312,721 (GRCm38)	unclassified	probably benign
R4152:Acaca	UTSW	11	84,292,926 (GRCm38)	missense	possibly damaging	0.88
R4406:Acaca	UTSW	11	84,280,449 (GRCm38)	missense	probably benign	0.35
R4448:Acaca	UTSW	11	84,262,492 (GRCm38)	missense	probably damaging	1.00
R4642:Acaca	UTSW	11	84,280,461 (GRCm38)	missense	probably damaging	1.00
R4696:Acaca	UTSW	11	84,280,435 (GRCm38)	missense	possibly damaging	0.78
R4707:Acaca	UTSW	11	84,312,854 (GRCm38)	missense	probably damaging	0.96
R4710:Acaca	UTSW	11	84,392,337 (GRCm38)	missense	possibly damaging	0.84
R4775:Acaca	UTSW	11	84,243,339 (GRCm38)	missense	probably damaging	1.00
R4821:Acaca	UTSW	11	84,294,987 (GRCm38)	missense	possibly damaging	0.69
R4883:Acaca	UTSW	11	84,251,290 (GRCm38)	missense	probably benign	0.01
R4988:Acaca	UTSW	11	84,263,295 (GRCm38)	missense	probably damaging	1.00
R5034:Acaca	UTSW	11	84,245,264 (GRCm38)	missense	probably benign	0.00
R5255:Acaca	UTSW	11	84,311,307 (GRCm38)	missense	probably damaging	1.00
R5294:Acaca	UTSW	11	84,391,519 (GRCm38)	missense	probably benign	0.01
R5350:Acaca	UTSW	11	84,215,873 (GRCm38)	missense	probably damaging	0.99
R5437:Acaca	UTSW	11	84,346,820 (GRCm38)	splice site	probably null
R5664:Acaca	UTSW	11	84,243,384 (GRCm38)	missense	probably damaging	1.00
R5665:Acaca	UTSW	11	84,245,294 (GRCm38)	nonsense	probably null
R5959:Acaca	UTSW	11	84,215,966 (GRCm38)	missense	probably damaging	1.00
R6011:Acaca	UTSW	11	84,245,744 (GRCm38)	missense	probably benign	0.44
R6027:Acaca	UTSW	11	84,398,177 (GRCm38)	missense	probably benign
R6246:Acaca	UTSW	11	84,315,970 (GRCm38)	missense	probably benign	0.08
R6313:Acaca	UTSW	11	84,292,929 (GRCm38)	missense	probably benign	0.00
R6450:Acaca	UTSW	11	84,280,468 (GRCm38)	missense	probably damaging	0.98
R6623:Acaca	UTSW	11	84,371,499 (GRCm38)	critical splice acceptor site	probably null
R6736:Acaca	UTSW	11	84,238,838 (GRCm38)	missense	probably benign	0.05
R6752:Acaca	UTSW	11	84,195,483 (GRCm38)	missense	probably benign	0.44
R6807:Acaca	UTSW	11	84,391,530 (GRCm38)	missense	probably benign
R6826:Acaca	UTSW	11	84,195,536 (GRCm38)	missense	probably damaging	1.00
R7035:Acaca	UTSW	11	84,238,943 (GRCm38)	missense	probably damaging	1.00
R7088:Acaca	UTSW	11	84,278,957 (GRCm38)	critical splice donor site	probably null
R7201:Acaca	UTSW	11	84,262,474 (GRCm38)	missense	probably benign	0.41
R7261:Acaca	UTSW	11	84,368,700 (GRCm38)	missense	probably damaging	1.00
R7399:Acaca	UTSW	11	84,260,679 (GRCm38)	missense	possibly damaging	0.89
R7421:Acaca	UTSW	11	84,363,736 (GRCm38)	missense	possibly damaging	0.64
R7443:Acaca	UTSW	11	84,315,793 (GRCm38)	missense	probably benign	0.02
R7453:Acaca	UTSW	11	84,245,310 (GRCm38)	missense	probably benign
R7471:Acaca	UTSW	11	84,277,782 (GRCm38)	splice site	probably null
R7519:Acaca	UTSW	11	84,245,856 (GRCm38)	missense	probably damaging	0.98
R7537:Acaca	UTSW	11	84,260,634 (GRCm38)	missense	probably damaging	1.00
R7574:Acaca	UTSW	11	84,261,588 (GRCm38)	missense	probably benign
R7633:Acaca	UTSW	11	84,372,639 (GRCm38)	missense	probably benign	0.26
R7643:Acaca	UTSW	11	84,338,356 (GRCm38)	missense	probably damaging	1.00
R7664:Acaca	UTSW	11	84,245,349 (GRCm38)	missense	probably damaging	1.00
R7675:Acaca	UTSW	11	84,315,916 (GRCm38)	missense	probably benign	0.04
R7676:Acaca	UTSW	11	84,294,987 (GRCm38)	missense	possibly damaging	0.69
R7729:Acaca	UTSW	11	84,371,513 (GRCm38)	missense	probably damaging	0.98
R7867:Acaca	UTSW	11	84,249,524 (GRCm38)	missense	possibly damaging	0.88
R7898:Acaca	UTSW	11	84,364,449 (GRCm38)	critical splice donor site	probably null
R7909:Acaca	UTSW	11	84,245,235 (GRCm38)	missense	possibly damaging	0.56
R7915:Acaca	UTSW	11	84,276,588 (GRCm38)	missense	probably benign
R7956:Acaca	UTSW	11	84,320,580 (GRCm38)	missense	probably damaging	0.98
R8000:Acaca	UTSW	11	84,392,231 (GRCm38)	missense	possibly damaging	0.88
R8038:Acaca	UTSW	11	84,215,904 (GRCm38)	missense	probably damaging	1.00
R8545:Acaca	UTSW	11	84,345,968 (GRCm38)	missense	probably damaging	1.00
R8722:Acaca	UTSW	11	84,338,457 (GRCm38)	missense	possibly damaging	0.85
R9005:Acaca	UTSW	11	84,371,584 (GRCm38)	missense	probably damaging	0.99
R9130:Acaca	UTSW	11	84,311,319 (GRCm38)	missense	probably damaging	1.00
R9397:Acaca	UTSW	11	84,368,725 (GRCm38)	missense	probably damaging	1.00
R9489:Acaca	UTSW	11	84,293,016 (GRCm38)	missense	probably benign	0.01
R9540:Acaca	UTSW	11	84,243,411 (GRCm38)	missense	probably damaging	1.00
R9593:Acaca	UTSW	11	84,380,513 (GRCm38)	nonsense	probably null
R9605:Acaca	UTSW	11	84,293,016 (GRCm38)	missense	probably benign	0.01
R9634:Acaca	UTSW	11	84,293,990 (GRCm38)	missense	probably benign	0.00
R9720:Acaca	UTSW	11	84,263,357 (GRCm38)	missense	probably damaging	1.00
RF014:Acaca	UTSW	11	84,231,724 (GRCm38)	missense	probably benign	0.01
X0027:Acaca	UTSW	11	84,292,895 (GRCm38)	missense	probably benign	0.01
X0060:Acaca	UTSW	11	84,264,104 (GRCm38)	missense	probably benign
X0067:Acaca	UTSW	11	84,368,737 (GRCm38)	nonsense	probably null
Z1176:Acaca	UTSW	11	84,260,720 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGTCAGACCCAGGGTTTGTC -3'
(R):5'- TTTGGGGCCATAATAACTGACAGAG -3'

Sequencing Primer
(F):5'- CCAGGGTTTGTCATGGTGTAACC -3'
(R):5'- GTGAGTTCAGTCACAGATCTAAGTAG -3'

Posted On

2019-05-15