Incidental Mutation 'R0614:Zfp619'
ID 54945
Institutional Source Beutler Lab
Gene Symbol Zfp619
Ensembl Gene ENSMUSG00000068959
Gene Name zinc finger protein 619
Synonyms 3000002G13Rik
MMRRC Submission 038803-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R0614 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 39167190-39189844 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 39187099 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 1043 (M1043K)
Ref Sequence ENSEMBL: ENSMUSP00000103650 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108015]
AlphaFold G3X9T2
Predicted Effect possibly damaging
Transcript: ENSMUST00000108015
AA Change: M1043K

PolyPhen 2 Score 0.787 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000103650
Gene: ENSMUSG00000068959
AA Change: M1043K

DomainStartEndE-ValueType
KRAB 4 61 2.19e-20 SMART
ZnF_C2H2 218 240 2.91e-2 SMART
ZnF_C2H2 246 268 5.81e-2 SMART
ZnF_C2H2 274 296 3.16e-3 SMART
ZnF_C2H2 302 324 2.4e-3 SMART
ZnF_C2H2 330 352 2.95e-3 SMART
ZnF_C2H2 358 380 6.32e-3 SMART
ZnF_C2H2 386 408 8.47e-4 SMART
ZnF_C2H2 414 436 5.06e-2 SMART
ZnF_C2H2 442 464 1.58e-3 SMART
ZnF_C2H2 470 492 5.42e-2 SMART
ZnF_C2H2 526 548 2.09e-3 SMART
ZnF_C2H2 554 576 3.39e-3 SMART
ZnF_C2H2 582 604 1.56e-2 SMART
ZnF_C2H2 610 632 2.24e-3 SMART
ZnF_C2H2 638 660 4.72e-2 SMART
ZnF_C2H2 666 688 7.78e-3 SMART
ZnF_C2H2 694 716 5.9e-3 SMART
ZnF_C2H2 722 744 1.12e-3 SMART
ZnF_C2H2 748 770 6.42e-4 SMART
ZnF_C2H2 776 798 1.38e-3 SMART
ZnF_C2H2 804 826 9.44e-2 SMART
ZnF_C2H2 832 854 2.36e-2 SMART
ZnF_C2H2 860 882 8.94e-3 SMART
ZnF_C2H2 888 910 3.58e-2 SMART
ZnF_C2H2 916 938 6.42e-4 SMART
ZnF_C2H2 942 964 4.72e-2 SMART
ZnF_C2H2 970 992 2.3e-5 SMART
ZnF_C2H2 998 1020 8.34e-3 SMART
ZnF_C2H2 1026 1048 8.81e-2 SMART
ZnF_C2H2 1054 1076 1.69e-3 SMART
ZnF_C2H2 1082 1104 6.32e-3 SMART
ZnF_C2H2 1110 1132 1.47e-3 SMART
ZnF_C2H2 1138 1160 7.15e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191753
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.4%
  • 20x: 94.9%
Validation Efficiency 97% (61/63)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Zinc finger proteins (ZNFs), such as ZNF208, bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. A conserved protein motif, termed the Kruppel-associated box (KRAB) domain, mediates protein-protein interactions (Eichler et al., 1998 [PubMed 9724325]). See ZNF91 (MIM 603971) for further information on ZNFs.[supplied by OMIM, Aug 2009]
Allele List at MGI

All alleles(5) : Gene trapped(5)

Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik C T 13: 77,340,782 (GRCm39) T137I probably benign Het
3110082I17Rik C T 5: 139,349,786 (GRCm39) V88I possibly damaging Het
4930453N24Rik T A 16: 64,586,977 (GRCm39) Q249L probably damaging Het
Ap1g2 C T 14: 55,337,230 (GRCm39) V702I probably benign Het
Armcx5 G A X: 134,647,564 (GRCm39) E547K probably damaging Het
Asah2 C A 19: 31,994,128 (GRCm39) V406L probably damaging Het
Atp8b1 T C 18: 64,666,658 (GRCm39) probably benign Het
Axl C A 7: 25,473,588 (GRCm39) R346L probably benign Het
Baz1a G A 12: 54,988,304 (GRCm39) R282* probably null Het
Card14 A G 11: 119,213,653 (GRCm39) N200S probably benign Het
Cdt1 A G 8: 123,294,876 (GRCm39) T28A probably benign Het
Cep250 C T 2: 155,812,017 (GRCm39) Q438* probably null Het
Dapk1 C A 13: 60,865,946 (GRCm39) P181Q probably damaging Het
Dnah17 C T 11: 117,961,394 (GRCm39) probably benign Het
Dph7 T C 2: 24,858,968 (GRCm39) probably null Het
Edc4 A T 8: 106,616,028 (GRCm39) D801V possibly damaging Het
Eif4g2 A G 7: 110,676,430 (GRCm39) probably null Het
Eml2 T C 7: 18,936,516 (GRCm39) L531P probably damaging Het
Ephb2 T C 4: 136,400,676 (GRCm39) Y533C probably benign Het
Fcho1 C T 8: 72,165,204 (GRCm39) A418T probably benign Het
Fsip2 A G 2: 82,807,877 (GRCm39) K1399E probably benign Het
Hcls1 A G 16: 36,782,987 (GRCm39) D446G probably damaging Het
Hif1a T A 12: 73,992,405 (GRCm39) N787K probably damaging Het
Ints14 T C 9: 64,871,715 (GRCm39) S18P probably benign Het
Kalrn A T 16: 33,814,040 (GRCm39) probably benign Het
Llgl2 T A 11: 115,741,093 (GRCm39) D502E probably damaging Het
Lrwd1 A G 5: 136,152,354 (GRCm39) V570A probably damaging Het
Mga C G 2: 119,794,947 (GRCm39) P2877R probably damaging Het
Mvd T C 8: 123,163,292 (GRCm39) I313V probably benign Het
Myo15b C A 11: 115,773,739 (GRCm39) P270T probably damaging Het
Naip1 C A 13: 100,580,708 (GRCm39) V180L probably benign Het
Ofd1 T C X: 165,218,536 (GRCm39) probably benign Het
Or1j19 T A 2: 36,676,705 (GRCm39) L56H probably damaging Het
Or4c125 T A 2: 89,170,329 (GRCm39) I106F probably damaging Het
Or4d11 A T 19: 12,013,929 (GRCm39) M59K possibly damaging Het
Otogl G A 10: 107,634,216 (GRCm39) P1420S probably benign Het
Pakap C A 4: 57,856,720 (GRCm39) A926E probably benign Het
Pcnt C T 10: 76,256,150 (GRCm39) V697M probably damaging Het
Plekha7 A T 7: 115,753,880 (GRCm39) Y702* probably null Het
Plxnb3 A G X: 72,807,964 (GRCm39) probably benign Het
Ptgis A G 2: 167,048,802 (GRCm39) F405L probably damaging Het
Ptprk C T 10: 27,951,132 (GRCm39) P19L probably damaging Het
Ptprt A G 2: 161,654,040 (GRCm39) V530A possibly damaging Het
Rasgrp4 A T 7: 28,845,276 (GRCm39) Y299F probably damaging Het
Slc39a11 T A 11: 113,414,452 (GRCm39) probably null Het
Slc6a15 T A 10: 103,240,213 (GRCm39) L312* probably null Het
Slf1 T A 13: 77,197,233 (GRCm39) M794L probably benign Het
Sntg2 G A 12: 30,307,977 (GRCm39) T236I possibly damaging Het
Stau1 T C 2: 166,792,726 (GRCm39) Y413C probably damaging Het
Syne2 T G 12: 75,959,127 (GRCm39) probably null Het
Tas2r104 A T 6: 131,662,165 (GRCm39) N181K probably damaging Het
Tmem81 G A 1: 132,435,469 (GRCm39) V92I probably benign Het
Trap1 A G 16: 3,878,615 (GRCm39) probably benign Het
Trip12 T C 1: 84,735,482 (GRCm39) E905G probably damaging Het
Usp2 C T 9: 44,003,789 (GRCm39) R494* probably null Het
Vps13a G T 19: 16,630,058 (GRCm39) R2692S probably damaging Het
Zfhx3 T C 8: 109,675,171 (GRCm39) S2074P probably benign Het
Zfhx3 C G 8: 109,675,599 (GRCm39) Y2216* probably null Het
Zfp423 A G 8: 88,508,742 (GRCm39) F409S probably damaging Het
Zfp472 G A 17: 33,196,908 (GRCm39) E328K possibly damaging Het
Zfp940 T C 7: 29,545,671 (GRCm39) I79V probably benign Het
Other mutations in Zfp619
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02157:Zfp619 APN 7 39,184,288 (GRCm39) missense probably damaging 1.00
IGL02221:Zfp619 APN 7 39,186,334 (GRCm39) missense probably benign 0.00
IGL02625:Zfp619 APN 7 39,183,609 (GRCm39) splice site probably benign
3-1:Zfp619 UTSW 7 39,186,189 (GRCm39) missense probably damaging 1.00
R0035:Zfp619 UTSW 7 39,186,706 (GRCm39) missense probably damaging 1.00
R0035:Zfp619 UTSW 7 39,186,706 (GRCm39) missense probably damaging 1.00
R0113:Zfp619 UTSW 7 39,187,183 (GRCm39) missense probably benign 0.01
R0377:Zfp619 UTSW 7 39,186,221 (GRCm39) nonsense probably null
R0848:Zfp619 UTSW 7 39,185,983 (GRCm39) missense probably damaging 1.00
R1157:Zfp619 UTSW 7 39,186,282 (GRCm39) missense probably damaging 0.98
R2047:Zfp619 UTSW 7 39,187,062 (GRCm39) missense probably damaging 0.99
R2074:Zfp619 UTSW 7 39,184,185 (GRCm39) missense probably benign 0.00
R2419:Zfp619 UTSW 7 39,185,307 (GRCm39) missense possibly damaging 0.71
R2571:Zfp619 UTSW 7 39,186,595 (GRCm39) missense probably damaging 1.00
R2890:Zfp619 UTSW 7 39,184,393 (GRCm39) missense probably benign 0.00
R3814:Zfp619 UTSW 7 39,184,823 (GRCm39) missense probably benign 0.01
R4003:Zfp619 UTSW 7 39,186,730 (GRCm39) missense possibly damaging 0.91
R4059:Zfp619 UTSW 7 39,184,823 (GRCm39) missense probably benign 0.01
R4503:Zfp619 UTSW 7 39,186,280 (GRCm39) missense probably damaging 1.00
R4664:Zfp619 UTSW 7 39,183,559 (GRCm39) missense probably benign 0.00
R4696:Zfp619 UTSW 7 39,186,412 (GRCm39) missense probably benign 0.00
R4895:Zfp619 UTSW 7 39,187,396 (GRCm39) missense possibly damaging 0.68
R4975:Zfp619 UTSW 7 39,186,504 (GRCm39) missense possibly damaging 0.90
R4977:Zfp619 UTSW 7 39,186,811 (GRCm39) missense probably damaging 1.00
R5049:Zfp619 UTSW 7 39,184,938 (GRCm39) missense probably benign 0.02
R5240:Zfp619 UTSW 7 39,186,642 (GRCm39) missense possibly damaging 0.68
R5468:Zfp619 UTSW 7 39,185,152 (GRCm39) missense unknown
R5546:Zfp619 UTSW 7 39,184,577 (GRCm39) missense probably benign 0.01
R5572:Zfp619 UTSW 7 39,184,663 (GRCm39) missense probably benign 0.01
R6106:Zfp619 UTSW 7 39,184,558 (GRCm39) missense probably benign 0.01
R6329:Zfp619 UTSW 7 39,186,969 (GRCm39) missense probably damaging 1.00
R6354:Zfp619 UTSW 7 39,184,243 (GRCm39) missense probably benign 0.02
R6395:Zfp619 UTSW 7 39,186,454 (GRCm39) missense possibly damaging 0.91
R6490:Zfp619 UTSW 7 39,183,586 (GRCm39) missense probably benign 0.00
R6560:Zfp619 UTSW 7 39,186,954 (GRCm39) missense probably damaging 1.00
R6713:Zfp619 UTSW 7 39,187,322 (GRCm39) missense probably damaging 0.99
R7011:Zfp619 UTSW 7 39,187,186 (GRCm39) missense probably damaging 1.00
R7022:Zfp619 UTSW 7 39,184,387 (GRCm39) missense probably benign 0.00
R7046:Zfp619 UTSW 7 39,186,787 (GRCm39) missense possibly damaging 0.95
R7206:Zfp619 UTSW 7 39,184,824 (GRCm39) missense probably benign 0.00
R7780:Zfp619 UTSW 7 39,184,432 (GRCm39) missense possibly damaging 0.68
R7787:Zfp619 UTSW 7 39,186,226 (GRCm39) missense possibly damaging 0.91
R8001:Zfp619 UTSW 7 39,184,645 (GRCm39) missense probably benign 0.29
R8559:Zfp619 UTSW 7 39,186,559 (GRCm39) missense probably benign 0.31
R8775:Zfp619 UTSW 7 39,184,639 (GRCm39) missense possibly damaging 0.75
R8775-TAIL:Zfp619 UTSW 7 39,184,639 (GRCm39) missense possibly damaging 0.75
R9014:Zfp619 UTSW 7 39,187,246 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- AAAGTGCGGGTTACCTTCGAATTCA -3'
(R):5'- GCACAATTCAAGGGTTCCCCTCC -3'

Sequencing Primer
(F):5'- tgagtgtaagcagtgtggtaag -3'
(R):5'- gcatttacagagccttcccc -3'
Posted On 2013-07-11