Mutagenetix > Incidental Mutation

Incidental Mutation 'R7083:Psg26'

549673

Institutional Source

Beutler Lab

Gene Symbol

Psg26

Ensembl Gene

ENSMUSG00000070799

Gene Name

pregnancy-specific beta-1-glycoprotein 26

Synonyms

EG574429, cea14

MMRRC Submission

045177-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

R7083 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

18208507-18218102 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 18213934 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Stop codon at position 243 (R243*)

Ref Sequence

ENSEMBL: ENSMUSP00000092392 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094798]

AlphaFold

Q4KL65

Predicted Effect

probably null
Transcript: ENSMUST00000094798
AA Change: R243*

SMART Domains

Protein: ENSMUSP00000092392
Gene: ENSMUSG00000070799
AA Change: R243*

Domain	Start	End	E-Value	Type
IG	40	141	4.93e-3	SMART
IG	160	261	2.39e-1	SMART
IG	280	379	6.07e-3	SMART
IGc2	397	461	5.48e-10	SMART

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam21	A	T	12: 81,607,015 (GRCm39)	M249K	possibly damaging	Het
Arhgef38	T	A	3: 132,838,197 (GRCm39)	Q613L	unknown	Het
Arpp21	A	G	9: 112,012,612 (GRCm39)	V70A	probably benign	Het
AW551984	T	C	9: 39,508,943 (GRCm39)	N327S	probably damaging	Het
Bnc1	T	C	7: 81,623,058 (GRCm39)	K723R	probably damaging	Het
Btbd7	A	G	12: 102,754,594 (GRCm39)	L724P	probably damaging	Het
Btnl10	G	T	11: 58,809,963 (GRCm39)	V35F	probably damaging	Het
Cd22	T	A	7: 30,567,473 (GRCm39)	T704S	probably damaging	Het
Cd4	T	G	6: 124,847,535 (GRCm39)	S210R	probably benign	Het
Cped1	A	G	6: 22,123,579 (GRCm39)	Q444R	probably benign	Het
Dusp26	A	G	8: 31,581,747 (GRCm39)		probably benign	Het
Dync1i1	C	T	6: 5,969,429 (GRCm39)	A418V	probably damaging	Het
Fibp	A	G	19: 5,513,659 (GRCm39)	D232G	probably damaging	Het
Frem2	T	A	3: 53,444,914 (GRCm39)	T2406S	probably damaging	Het
Gm40460	ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG	ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG	7: 141,794,450 (GRCm39)		probably benign	Het
Gpr39	T	A	1: 125,605,155 (GRCm39)	W28R	probably damaging	Het
Greb1	A	G	12: 16,773,315 (GRCm39)	V253A	probably benign	Het
Hexim1	T	G	11: 103,007,992 (GRCm39)	L82W	possibly damaging	Het
Hmga1	G	T	17: 27,779,945 (GRCm39)	R49L	possibly damaging	Het
Irag2	A	T	6: 145,115,509 (GRCm39)	N349I	probably damaging	Het
Itch	A	T	2: 155,052,364 (GRCm39)	N655Y	probably damaging	Het
Izumo2	A	G	7: 44,359,757 (GRCm39)	E129G	probably damaging	Het
Klk1b24	G	A	7: 43,841,225 (GRCm39)	C186Y	probably damaging	Het
Lnx1	G	A	5: 74,788,846 (GRCm39)	S31F	possibly damaging	Het
Lrrc37a	T	C	11: 103,394,166 (GRCm39)	I420V	probably benign	Het
Ltk	A	C	2: 119,582,555 (GRCm39)	C776G	probably damaging	Het
Mast4	A	C	13: 102,874,223 (GRCm39)	L1715R	probably damaging	Het
Med28	T	C	5: 45,680,878 (GRCm39)		probably null	Het
Naf1	GCCGCCGCCGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGA	GCCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGA	8: 67,313,138 (GRCm39)		probably benign	Het
Nckap1l	C	A	15: 103,390,551 (GRCm39)	T774K	probably damaging	Het
Nfkbiz	T	C	16: 55,638,663 (GRCm39)	K266E	possibly damaging	Het
Ntrk3	T	A	7: 77,900,587 (GRCm39)	D584V	probably damaging	Het
Or1o1	T	C	17: 37,717,063 (GRCm39)	V208A	probably benign	Het
Or2h15	T	A	17: 38,441,601 (GRCm39)	T161S	probably benign	Het
Or4c126	A	G	2: 89,824,201 (GRCm39)	I155V	probably benign	Het
Or4n4b	G	A	14: 50,536,736 (GRCm39)	T10I	possibly damaging	Het
Or5h25	T	C	16: 58,930,400 (GRCm39)	D191G	probably damaging	Het
Picalm	T	A	7: 89,825,976 (GRCm39)	I376K	probably benign	Het
Pkd1l3	GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA	GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA	8: 110,350,827 (GRCm39)		probably benign	Het
Prps1l3	A	T	12: 57,286,034 (GRCm39)	I275L	probably benign	Het
Ranbp2	A	G	10: 58,315,052 (GRCm39)	H1924R	probably damaging	Het
Rasef	T	C	4: 73,709,221 (GRCm39)	D4G	probably benign	Het
Rttn	T	C	18: 89,108,722 (GRCm39)	L1642P	probably damaging	Het
Shroom3	T	C	5: 93,112,384 (GRCm39)	L1915P	probably damaging	Het
Slc26a10	A	G	10: 127,013,037 (GRCm39)	V319A	probably damaging	Het
Slc4a10	A	G	2: 62,064,839 (GRCm39)	N231S	probably benign	Het
Sox18	T	C	2: 181,312,165 (GRCm39)	Q322R	possibly damaging	Het
Sting1	T	C	18: 35,867,703 (GRCm39)	H331R	probably damaging	Het
Syde1	G	T	10: 78,422,903 (GRCm39)	P490T	probably benign	Het
Syne2	A	G	12: 75,990,662 (GRCm39)	I1881M	probably damaging	Het
Taf1c	T	C	8: 120,327,407 (GRCm39)	D387G	probably damaging	Het
Tenm4	T	A	7: 96,544,556 (GRCm39)	Y2228N	probably damaging	Het
Tubgcp5	C	T	7: 55,450,443 (GRCm39)	Q185*	probably null	Het
Vmn2r44	T	A	7: 8,381,369 (GRCm39)	I175F	probably benign	Het
Zdhhc7	C	A	8: 120,812,166 (GRCm39)	C152F	probably damaging	Het
Zfp52	T	A	17: 21,780,392 (GRCm39)	M80K	possibly damaging	Het
Zfp612	T	C	8: 110,815,768 (GRCm39)	I325T	probably damaging	Het
Zmiz1	T	G	14: 25,652,372 (GRCm39)	F597V	probably damaging	Het

Other mutations in Psg26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01010:Psg26	APN	7	18,212,255 (GRCm39)	missense	possibly damaging	0.83
IGL01383:Psg26	APN	7	18,214,179 (GRCm39)	missense	possibly damaging	0.90
IGL01453:Psg26	APN	7	18,213,999 (GRCm39)	missense	possibly damaging	0.91
IGL01603:Psg26	APN	7	18,209,028 (GRCm39)	missense	probably damaging	0.98
IGL02201:Psg26	APN	7	18,214,071 (GRCm39)	missense	probably benign	0.04
IGL02468:Psg26	APN	7	18,212,387 (GRCm39)	missense	probably damaging	0.96
IGL02648:Psg26	APN	7	18,216,691 (GRCm39)	missense	probably benign	0.05
IGL02812:Psg26	APN	7	18,209,080 (GRCm39)	missense	probably benign	0.00
R0226:Psg26	UTSW	7	18,217,883 (GRCm39)	missense	possibly damaging	0.81
R0352:Psg26	UTSW	7	18,209,181 (GRCm39)	missense	probably benign	0.00
R0369:Psg26	UTSW	7	18,216,481 (GRCm39)	nonsense	probably null
R0718:Psg26	UTSW	7	18,212,212 (GRCm39)	missense	probably benign	0.18
R0718:Psg26	UTSW	7	18,209,160 (GRCm39)	missense	probably benign	0.23
R1710:Psg26	UTSW	7	18,213,966 (GRCm39)	missense	probably damaging	0.99
R1899:Psg26	UTSW	7	18,212,350 (GRCm39)	missense	probably benign	0.01
R1958:Psg26	UTSW	7	18,212,264 (GRCm39)	missense	probably benign	0.04
R2102:Psg26	UTSW	7	18,209,067 (GRCm39)	missense	probably damaging	1.00
R3766:Psg26	UTSW	7	18,208,996 (GRCm39)	missense	probably benign
R4544:Psg26	UTSW	7	18,212,464 (GRCm39)	missense	probably damaging	1.00
R4977:Psg26	UTSW	7	18,209,235 (GRCm39)	missense	probably benign	0.11
R5000:Psg26	UTSW	7	18,214,057 (GRCm39)	missense	possibly damaging	0.95
R5376:Psg26	UTSW	7	18,214,030 (GRCm39)	missense	probably benign
R5416:Psg26	UTSW	7	18,216,525 (GRCm39)	missense	probably benign
R5435:Psg26	UTSW	7	18,212,398 (GRCm39)	missense	possibly damaging	0.60
R6000:Psg26	UTSW	7	18,216,617 (GRCm39)	nonsense	probably null
R6285:Psg26	UTSW	7	18,216,753 (GRCm39)	missense	probably benign
R7062:Psg26	UTSW	7	18,216,521 (GRCm39)	missense	probably damaging	1.00
R7513:Psg26	UTSW	7	18,209,225 (GRCm39)	missense	probably benign	0.03
R7817:Psg26	UTSW	7	18,216,572 (GRCm39)	missense	not run
R7857:Psg26	UTSW	7	18,212,215 (GRCm39)	missense	possibly damaging	0.71
R7905:Psg26	UTSW	7	18,209,242 (GRCm39)	missense	probably benign	0.00
R8047:Psg26	UTSW	7	18,212,474 (GRCm39)	missense	possibly damaging	0.50
R8789:Psg26	UTSW	7	18,216,494 (GRCm39)	missense	probably damaging	1.00
R8877:Psg26	UTSW	7	18,217,865 (GRCm39)	missense	probably benign	0.01
R9012:Psg26	UTSW	7	18,216,596 (GRCm39)	missense	probably benign	0.19
R9203:Psg26	UTSW	7	18,212,382 (GRCm39)	missense	probably damaging	0.98
R9327:Psg26	UTSW	7	18,216,480 (GRCm39)	missense	probably damaging	1.00
R9547:Psg26	UTSW	7	18,214,087 (GRCm39)	missense	probably benign	0.00
Z1177:Psg26	UTSW	7	18,214,216 (GRCm39)	missense	probably benign	0.02

Predicted Primers

PCR Primer
(F):5'- GAGTCTGACCCATGGGCATTTC -3'
(R):5'- CACTTTTCTGGTACAAAGGGCTG -3'

Sequencing Primer
(F):5'- GTGTTCTGCATACAGTGGTCAAACC -3'
(R):5'- GGTACAAAGGGCTGATTGTATTTAAC -3'

Posted On

2019-05-15