Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00430:Cyp3a25'

5498

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp3a25

Ensembl Gene

ENSMUSG00000029630

Gene Name

cytochrome P450, family 3, subfamily a, polypeptide 25

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.129) question?

Stock #

IGL00430

Quality Score

Status

Chromosome

Chromosomal Location

145977194-146009618 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 145993360 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 145 (M145K)

Ref Sequence

ENSEMBL: ENSMUSP00000065585 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000068317] [ENSMUST00000138870] [ENSMUST00000145062]

AlphaFold

O09158

Predicted Effect

probably damaging
Transcript: ENSMUST00000068317
AA Change: M145K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000065585
Gene: ENSMUSG00000029630
AA Change: M145K

Domain	Start	End	E-Value	Type
Pfam:p450	38	493	9.4e-129	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000138870

SMART Domains

Protein: ENSMUSP00000116077
Gene: ENSMUSG00000029630

Domain	Start	End	E-Value	Type
Pfam:p450	38	126	2e-13	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000145062

SMART Domains

Protein: ENSMUSP00000123615
Gene: ENSMUSG00000029630

Domain	Start	End	E-Value	Type
Pfam:p450	38	148	3.9e-21	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000153808

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc2	G	A	19: 43,784,202	S17N	probably benign	Het
Atp2a1	C	T	7: 126,447,216	W72*	probably null	Het
Baz2b	C	A	2: 59,912,795	A1611S	probably benign	Het
Cep290	A	T	10: 100,508,724	I475L	probably benign	Het
Cpsf4l	C	T	11: 113,709,218		probably benign	Het
Crispld2	A	T	8: 120,033,560	R408S	probably damaging	Het
Dexi	A	T	16: 10,542,445	D82E	probably benign	Het
Epyc	A	T	10: 97,681,147	K282N	probably benign	Het
Ercc6l2	G	T	13: 63,858,319	V588F	probably damaging	Het
Galnt14	C	T	17: 73,494,232	V532I	probably damaging	Het
Grk1	C	A	8: 13,413,128	Y383*	probably null	Het
Gtpbp1	G	T	15: 79,719,136	G609W	possibly damaging	Het
Hadha	C	T	5: 30,120,147	V682M	possibly damaging	Het
Igdcc3	A	C	9: 65,182,019	D499A	probably damaging	Het
Kcna10	T	G	3: 107,194,728	V225G	probably damaging	Het
Kcnh4	T	C	11: 100,757,654	T75A	possibly damaging	Het
Lama4	A	G	10: 39,045,704	E407G	possibly damaging	Het
Mrpl13	T	A	15: 55,540,201	K105N	probably damaging	Het
Pcdhb2	A	T	18: 37,296,463		probably null	Het
Pck2	C	T	14: 55,543,944	A209V	probably benign	Het
Plce1	A	G	19: 38,725,017	E1243G	probably damaging	Het
Plekhh2	A	T	17: 84,521,775	M25L	probably benign	Het
Rasef	G	A	4: 73,771,425	Q117*	probably null	Het
Rbm14	A	G	19: 4,811,426	V28A	probably damaging	Het
Rcan2	A	G	17: 43,836,384	T38A	probably benign	Het
Rin1	A	G	19: 5,051,376	N96S	probably benign	Het
Rrp12	A	G	19: 41,877,334		probably null	Het
Slco1a6	A	T	6: 142,101,651	C404*	probably null	Het
St6galnac3	T	C	3: 153,509,403	N38S	probably benign	Het
Top2b	T	A	14: 16,422,692	S1376R	probably benign	Het
Trip11	T	C	12: 101,886,147	I553V	probably benign	Het
Trip12	T	G	1: 84,763,861	H559P	probably damaging	Het
Uggt2	A	T	14: 119,026,429	L1063*	probably null	Het
Zmym6	T	A	4: 127,101,949	C269*	probably null	Het

Other mutations in Cyp3a25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00091:Cyp3a25	APN	5	146001463	nonsense	probably null
IGL00803:Cyp3a25	APN	5	146001443	splice site	probably benign
IGL00928:Cyp3a25	APN	5	145986954	missense	possibly damaging	0.94
IGL01557:Cyp3a25	APN	5	145984901	missense	probably damaging	1.00
IGL01997:Cyp3a25	APN	5	145994956	missense	possibly damaging	0.92
IGL02140:Cyp3a25	APN	5	146009463	splice site	probably benign
IGL02267:Cyp3a25	APN	5	145998552	missense	possibly damaging	0.48
IGL02272:Cyp3a25	APN	5	145993265	intron	probably benign
IGL02327:Cyp3a25	APN	5	145986921	missense	possibly damaging	0.50
IGL02411:Cyp3a25	APN	5	146001447	critical splice donor site	probably benign
IGL02504:Cyp3a25	APN	5	145993331	missense	probably benign	0.03
IGL02653:Cyp3a25	APN	5	146003110	missense	possibly damaging	0.95
R0378:Cyp3a25	UTSW	5	145986842	missense	probably damaging	1.00
R0403:Cyp3a25	UTSW	5	145998513	missense	probably damaging	1.00
R0685:Cyp3a25	UTSW	5	145998546	missense	probably damaging	1.00
R0725:Cyp3a25	UTSW	5	145994936	missense	probably damaging	1.00
R0798:Cyp3a25	UTSW	5	145991533	missense	probably damaging	0.98
R1061:Cyp3a25	UTSW	5	145986833	missense	probably benign
R1519:Cyp3a25	UTSW	5	146001447	critical splice donor site	probably null
R1628:Cyp3a25	UTSW	5	146001463	nonsense	probably null
R1822:Cyp3a25	UTSW	5	145984953	missense	probably damaging	1.00
R1824:Cyp3a25	UTSW	5	145984953	missense	probably damaging	1.00
R1864:Cyp3a25	UTSW	5	145994929	missense	probably damaging	0.98
R2062:Cyp3a25	UTSW	5	145986969	splice site	probably benign
R2401:Cyp3a25	UTSW	5	145986968	critical splice acceptor site	probably null
R2516:Cyp3a25	UTSW	5	146003027	splice site	probably null
R3080:Cyp3a25	UTSW	5	145998531	missense	probably benign	0.33
R3236:Cyp3a25	UTSW	5	146003128	splice site	probably benign
R3694:Cyp3a25	UTSW	5	145989976	splice site	probably null
R3730:Cyp3a25	UTSW	5	146003081	missense	probably damaging	1.00
R4112:Cyp3a25	UTSW	5	146003031	missense	probably benign	0.18
R4258:Cyp3a25	UTSW	5	145991438	missense	probably damaging	1.00
R4651:Cyp3a25	UTSW	5	145994891	missense	probably benign	0.01
R4788:Cyp3a25	UTSW	5	145985082	nonsense	probably null
R4899:Cyp3a25	UTSW	5	145977671	missense	possibly damaging	0.59
R4926:Cyp3a25	UTSW	5	145991456	missense	probably damaging	1.00
R4952:Cyp3a25	UTSW	5	145991524	missense	probably benign	0.01
R5270:Cyp3a25	UTSW	5	145981502	missense	probably benign	0.36
R5595:Cyp3a25	UTSW	5	145994863	critical splice donor site	probably null
R5659:Cyp3a25	UTSW	5	145991546	missense	possibly damaging	0.69
R5787:Cyp3a25	UTSW	5	145998503	missense	probably benign	0.14
R6307:Cyp3a25	UTSW	5	145994956	missense	possibly damaging	0.92
R6380:Cyp3a25	UTSW	5	145998547	missense	probably damaging	0.99
R7055:Cyp3a25	UTSW	5	145992991	missense	probably benign	0.00
R7140:Cyp3a25	UTSW	5	146003045	missense	probably benign
R7189:Cyp3a25	UTSW	5	146003060	missense	probably benign	0.37
R7201:Cyp3a25	UTSW	5	145991447	missense	probably benign	0.22
R7201:Cyp3a25	UTSW	5	146003058	missense	probably benign	0.00
R7332:Cyp3a25	UTSW	5	145993007	missense	probably damaging	1.00
R7404:Cyp3a25	UTSW	5	145986825	missense	probably damaging	1.00
R7548:Cyp3a25	UTSW	5	145986925	missense	probably damaging	0.98
R7607:Cyp3a25	UTSW	5	145984981	missense	possibly damaging	0.87
R8022:Cyp3a25	UTSW	5	145977668	missense	probably benign	0.33
R8266:Cyp3a25	UTSW	5	145992986	missense	probably damaging	1.00
R8894:Cyp3a25	UTSW	5	145994860	splice site	probably benign
R9249:Cyp3a25	UTSW	5	145991546	missense	possibly damaging	0.69
R9588:Cyp3a25	UTSW	5	145984889	missense	probably benign
R9691:Cyp3a25	UTSW	5	145994922	missense	probably benign	0.41
R9694:Cyp3a25	UTSW	5	145986875	nonsense	probably null

Posted On

2012-04-20