Incidental Mutation 'R7086:Plxnc1'
ID 549903
Institutional Source Beutler Lab
Gene Symbol Plxnc1
Ensembl Gene ENSMUSG00000074785
Gene Name plexin C1
Synonyms 2510048K12Rik, vespr, CD232
MMRRC Submission 045180-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.472) question?
Stock # R7086 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 94626728-94780697 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 94667297 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 1126 (M1126V)
Ref Sequence ENSEMBL: ENSMUSP00000096939 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099337]
AlphaFold Q9QZC2
Predicted Effect probably benign
Transcript: ENSMUST00000099337
AA Change: M1126V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000096939
Gene: ENSMUSG00000074785
AA Change: M1126V

DomainStartEndE-ValueType
signal peptide 1 34 N/A INTRINSIC
Pfam:Sema 87 431 5.5e-10 PFAM
PSI 454 507 5.28e-12 SMART
PSI 590 634 1.07e-3 SMART
Pfam:TIG 665 752 3.7e-9 PFAM
IPT 755 847 5.14e-7 SMART
IPT 849 954 1.8e-2 SMART
low complexity region 978 997 N/A INTRINSIC
Pfam:Plexin_cytopl 1018 1541 1.4e-199 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 98% (60/61)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal neuron morphology and migration. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam30 A G 3: 98,068,635 (GRCm39) H28R probably damaging Het
Adgre4 T C 17: 56,127,649 (GRCm39) I563T probably benign Het
Ankub1 A T 3: 57,597,746 (GRCm39) C75S probably damaging Het
Antxrl G A 14: 33,787,873 (GRCm39) V299I probably benign Het
Arfgef2 T A 2: 166,718,536 (GRCm39) C1442S probably damaging Het
Atp13a3 T C 16: 30,169,881 (GRCm39) D399G possibly damaging Het
Cacna2d1 T A 5: 16,554,414 (GRCm39) Y666N probably damaging Het
Cenpo C T 12: 4,265,307 (GRCm39) E238K probably benign Het
Cfap91 A T 16: 38,127,219 (GRCm39) F512L possibly damaging Het
Chrng C A 1: 87,138,735 (GRCm39) R455S probably benign Het
Cimap1a A G 7: 140,429,402 (GRCm39) H151R probably benign Het
Cluh T A 11: 74,558,166 (GRCm39) H1155Q possibly damaging Het
Col16a1 G A 4: 129,946,773 (GRCm39) probably null Het
Cpne5 G A 17: 29,378,051 (GRCm39) P576L unknown Het
Crocc C A 4: 140,774,368 (GRCm39) V144L possibly damaging Het
Cubn A G 2: 13,324,669 (GRCm39) V2781A probably damaging Het
Cyp8b1 A G 9: 121,744,355 (GRCm39) F326L probably benign Het
Dclk1 G A 3: 55,395,333 (GRCm39) probably null Het
Dennd2b A G 7: 109,124,781 (GRCm39) I1083T probably damaging Het
Dnah7c A G 1: 46,789,285 (GRCm39) R3303G probably benign Het
Dnhd1 G T 7: 105,357,739 (GRCm39) R3191S probably benign Het
Fgfbp3 T G 19: 36,896,103 (GRCm39) S172R possibly damaging Het
Gpr158 G A 2: 21,831,386 (GRCm39) V829I probably benign Het
Gtse1 A G 15: 85,759,750 (GRCm39) D647G probably damaging Het
H2-Q7 T A 17: 35,658,461 (GRCm39) V33E probably damaging Het
Hydin A G 8: 111,326,877 (GRCm39) T4739A possibly damaging Het
Kcnip1 G T 11: 33,584,629 (GRCm39) P175T probably damaging Het
Klhl10 T C 11: 100,347,768 (GRCm39) V608A probably benign Het
Klhl2 A G 8: 65,275,664 (GRCm39) Y80H probably damaging Het
Lnx2 A T 5: 146,956,988 (GRCm39) probably null Het
Lst1 G A 17: 35,404,262 (GRCm39) H59Y probably damaging Het
Mphosph8 G C 14: 56,905,980 (GRCm39) V58L possibly damaging Het
Mpnd C A 17: 56,316,457 (GRCm39) S45R possibly damaging Het
Myh8 A G 11: 67,183,453 (GRCm39) probably null Het
Or12j4 A G 7: 140,046,341 (GRCm39) T76A possibly damaging Het
Or4c52 A G 2: 89,845,594 (GRCm39) I107V probably benign Het
Phox2a A G 7: 101,467,718 (GRCm39) Y5C probably damaging Het
Pkdrej A G 15: 85,704,317 (GRCm39) S540P probably damaging Het
Plcb4 A G 2: 135,849,767 (GRCm39) M1133V probably benign Het
Ppm1l A G 3: 69,225,186 (GRCm39) Y96C probably damaging Het
Prpsap1 T C 11: 116,368,109 (GRCm39) T234A probably benign Het
R3hcc1l T C 19: 42,570,409 (GRCm39) V668A probably damaging Het
Rapgef2 A G 3: 78,993,353 (GRCm39) S712P probably benign Het
Rcc2 T C 4: 140,435,280 (GRCm39) C100R probably benign Het
Recql4 C A 15: 76,589,753 (GRCm39) G764V unknown Het
Rlbp1 A G 7: 79,029,813 (GRCm39) I140T possibly damaging Het
Samsn1 T C 16: 75,667,794 (GRCm39) T261A probably benign Het
Sgtb T C 13: 104,254,924 (GRCm39) S65P possibly damaging Het
Spag9 T C 11: 93,988,690 (GRCm39) V920A probably benign Het
Spata31 T A 13: 65,070,043 (GRCm39) S730R probably benign Het
Spta1 C T 1: 174,027,050 (GRCm39) A841V probably damaging Het
Tnfaip1 T C 11: 78,416,265 (GRCm39) S273G probably benign Het
Vezf1 T C 11: 87,969,364 (GRCm39) V371A probably benign Het
Vmn1r67 G A 7: 10,181,044 (GRCm39) V103I possibly damaging Het
Vmn2r87 G T 10: 130,333,178 (GRCm39) T24K probably benign Het
Wdr43 G A 17: 71,923,434 (GRCm39) G60D probably benign Het
Xkr4 G A 1: 3,287,185 (GRCm39) T335I probably damaging Het
Zdhhc23 A T 16: 43,791,873 (GRCm39) I300N probably damaging Het
Zfp729b T C 13: 67,741,056 (GRCm39) K403R probably damaging Het
Other mutations in Plxnc1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00843:Plxnc1 APN 10 94,683,411 (GRCm39) missense probably benign 0.25
IGL01285:Plxnc1 APN 10 94,635,230 (GRCm39) missense probably damaging 0.99
IGL01867:Plxnc1 APN 10 94,634,008 (GRCm39) missense possibly damaging 0.61
IGL01994:Plxnc1 APN 10 94,685,801 (GRCm39) missense probably damaging 1.00
IGL02083:Plxnc1 APN 10 94,758,587 (GRCm39) missense possibly damaging 0.61
IGL02250:Plxnc1 APN 10 94,706,893 (GRCm39) missense probably benign 0.00
IGL02429:Plxnc1 APN 10 94,718,453 (GRCm39) missense probably benign 0.00
IGL02752:Plxnc1 APN 10 94,630,542 (GRCm39) splice site probably null
IGL02973:Plxnc1 APN 10 94,646,546 (GRCm39) missense probably damaging 1.00
R0230:Plxnc1 UTSW 10 94,635,209 (GRCm39) missense probably benign 0.07
R0265:Plxnc1 UTSW 10 94,648,991 (GRCm39) missense probably benign 0.14
R0271:Plxnc1 UTSW 10 94,673,780 (GRCm39) missense probably null 1.00
R0299:Plxnc1 UTSW 10 94,685,683 (GRCm39) critical splice donor site probably null
R0361:Plxnc1 UTSW 10 94,700,869 (GRCm39) missense probably damaging 1.00
R0441:Plxnc1 UTSW 10 94,632,344 (GRCm39) missense probably damaging 1.00
R0558:Plxnc1 UTSW 10 94,673,797 (GRCm39) missense probably damaging 1.00
R0617:Plxnc1 UTSW 10 94,635,230 (GRCm39) missense probably damaging 1.00
R0671:Plxnc1 UTSW 10 94,635,194 (GRCm39) missense possibly damaging 0.63
R0692:Plxnc1 UTSW 10 94,673,362 (GRCm39) critical splice donor site probably null
R0751:Plxnc1 UTSW 10 94,667,195 (GRCm39) splice site probably benign
R1184:Plxnc1 UTSW 10 94,667,195 (GRCm39) splice site probably benign
R1260:Plxnc1 UTSW 10 94,667,227 (GRCm39) missense probably damaging 0.99
R1680:Plxnc1 UTSW 10 94,677,413 (GRCm39) missense probably benign 0.14
R1746:Plxnc1 UTSW 10 94,680,041 (GRCm39) splice site probably null
R1750:Plxnc1 UTSW 10 94,635,359 (GRCm39) missense probably damaging 1.00
R1751:Plxnc1 UTSW 10 94,685,677 (GRCm39) unclassified probably benign
R1768:Plxnc1 UTSW 10 94,680,184 (GRCm39) missense probably benign 0.05
R1876:Plxnc1 UTSW 10 94,702,803 (GRCm39) missense possibly damaging 0.94
R2004:Plxnc1 UTSW 10 94,688,484 (GRCm39) missense probably damaging 0.98
R2031:Plxnc1 UTSW 10 94,779,529 (GRCm39) missense probably benign 0.26
R2184:Plxnc1 UTSW 10 94,780,131 (GRCm39) missense probably damaging 1.00
R2437:Plxnc1 UTSW 10 94,742,395 (GRCm39) missense probably benign 0.02
R2927:Plxnc1 UTSW 10 94,629,154 (GRCm39) critical splice acceptor site probably null
R3001:Plxnc1 UTSW 10 94,629,080 (GRCm39) missense probably damaging 0.98
R3002:Plxnc1 UTSW 10 94,629,080 (GRCm39) missense probably damaging 0.98
R3003:Plxnc1 UTSW 10 94,629,080 (GRCm39) missense probably damaging 0.98
R3441:Plxnc1 UTSW 10 94,706,872 (GRCm39) missense probably benign 0.00
R3849:Plxnc1 UTSW 10 94,630,294 (GRCm39) missense probably benign 0.01
R3884:Plxnc1 UTSW 10 94,746,549 (GRCm39) splice site probably null
R4004:Plxnc1 UTSW 10 94,630,459 (GRCm39) nonsense probably null
R4679:Plxnc1 UTSW 10 94,630,306 (GRCm39) missense probably damaging 1.00
R4730:Plxnc1 UTSW 10 94,703,330 (GRCm39) intron probably benign
R4937:Plxnc1 UTSW 10 94,677,335 (GRCm39) missense probably damaging 1.00
R5068:Plxnc1 UTSW 10 94,635,239 (GRCm39) missense possibly damaging 0.91
R5345:Plxnc1 UTSW 10 94,685,831 (GRCm39) missense probably benign 0.26
R5397:Plxnc1 UTSW 10 94,679,614 (GRCm39) missense probably benign 0.08
R5416:Plxnc1 UTSW 10 94,673,416 (GRCm39) missense probably damaging 1.00
R5485:Plxnc1 UTSW 10 94,758,604 (GRCm39) missense probably benign 0.00
R5543:Plxnc1 UTSW 10 94,700,636 (GRCm39) missense probably benign
R5826:Plxnc1 UTSW 10 94,635,335 (GRCm39) critical splice donor site probably null
R6007:Plxnc1 UTSW 10 94,629,152 (GRCm39) missense possibly damaging 0.88
R6018:Plxnc1 UTSW 10 94,779,710 (GRCm39) missense probably benign 0.21
R6052:Plxnc1 UTSW 10 94,779,635 (GRCm39) missense probably benign 0.13
R6291:Plxnc1 UTSW 10 94,669,504 (GRCm39) splice site probably null
R6653:Plxnc1 UTSW 10 94,779,738 (GRCm39) missense probably damaging 1.00
R6984:Plxnc1 UTSW 10 94,667,392 (GRCm39) missense probably damaging 1.00
R7401:Plxnc1 UTSW 10 94,706,867 (GRCm39) missense probably benign
R7727:Plxnc1 UTSW 10 94,779,971 (GRCm39) missense probably damaging 1.00
R7789:Plxnc1 UTSW 10 94,630,339 (GRCm39) missense probably damaging 1.00
R7803:Plxnc1 UTSW 10 94,779,377 (GRCm39) critical splice donor site probably null
R7809:Plxnc1 UTSW 10 94,630,302 (GRCm39) missense probably damaging 1.00
R7882:Plxnc1 UTSW 10 94,679,698 (GRCm39) missense probably benign
R8103:Plxnc1 UTSW 10 94,706,944 (GRCm39) missense probably benign
R8226:Plxnc1 UTSW 10 94,669,230 (GRCm39) missense possibly damaging 0.90
R8273:Plxnc1 UTSW 10 94,649,105 (GRCm39) missense probably benign 0.14
R8299:Plxnc1 UTSW 10 94,663,041 (GRCm39) missense probably benign 0.35
R8392:Plxnc1 UTSW 10 94,637,352 (GRCm39) missense possibly damaging 0.75
R8758:Plxnc1 UTSW 10 94,758,607 (GRCm39) missense possibly damaging 0.91
R8806:Plxnc1 UTSW 10 94,635,140 (GRCm39) missense probably damaging 1.00
R8882:Plxnc1 UTSW 10 94,677,428 (GRCm39) missense probably damaging 1.00
R8893:Plxnc1 UTSW 10 94,685,709 (GRCm39) missense probably benign 0.35
R8956:Plxnc1 UTSW 10 94,746,448 (GRCm39) missense probably benign 0.00
R9040:Plxnc1 UTSW 10 94,779,379 (GRCm39) nonsense probably null
R9102:Plxnc1 UTSW 10 94,663,107 (GRCm39) missense probably damaging 1.00
R9225:Plxnc1 UTSW 10 94,629,061 (GRCm39) missense probably damaging 1.00
R9324:Plxnc1 UTSW 10 94,780,685 (GRCm39) start gained probably benign
R9368:Plxnc1 UTSW 10 94,700,599 (GRCm39) nonsense probably null
R9375:Plxnc1 UTSW 10 94,649,093 (GRCm39) missense probably benign 0.20
R9430:Plxnc1 UTSW 10 94,758,544 (GRCm39) missense probably benign 0.01
R9460:Plxnc1 UTSW 10 94,700,895 (GRCm39) missense probably benign
R9498:Plxnc1 UTSW 10 94,649,004 (GRCm39) missense possibly damaging 0.48
RF003:Plxnc1 UTSW 10 94,630,306 (GRCm39) missense probably damaging 1.00
RF045:Plxnc1 UTSW 10 94,700,869 (GRCm39) missense probably damaging 1.00
RF046:Plxnc1 UTSW 10 94,700,869 (GRCm39) missense probably damaging 1.00
RF047:Plxnc1 UTSW 10 94,700,869 (GRCm39) missense probably damaging 1.00
X0024:Plxnc1 UTSW 10 94,700,577 (GRCm39) critical splice donor site probably null
Z1176:Plxnc1 UTSW 10 94,700,891 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- ATTAAACGCTGACTGCACAGAG -3'
(R):5'- CCCATTGCCAGCAAGATTTCAC -3'

Sequencing Primer
(F):5'- AGAGCATTCTGGACTTAGCTC -3'
(R):5'- TTTCACGGAAATCAGACAAGTCCTC -3'
Posted On 2019-05-15