Incidental Mutation 'IGL00309:Zscan25'
ID5500
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zscan25
Ensembl Gene ENSMUSG00000070420
Gene Namezinc finger and SCAN domain containing 25
SynonymsZfp498, EG666311
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.197) question?
Stock #IGL00309
Quality Score
Status
Chromosome5
Chromosomal Location145280500-145291278 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 145283749 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 118 (E118G)
Ref Sequence ENSEMBL: ENSMUSP00000142367 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094116] [ENSMUST00000199563] [ENSMUST00000200246]
Predicted Effect probably damaging
Transcript: ENSMUST00000094116
AA Change: E118G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000091664
Gene: ENSMUSG00000070420
AA Change: E118G

DomainStartEndE-ValueType
SCAN 38 150 5.94e-53 SMART
Blast:KRAB 231 288 4e-31 BLAST
ZnF_C2H2 346 368 2.15e-5 SMART
ZnF_C2H2 374 396 5.06e-2 SMART
ZnF_C2H2 402 424 8.34e-3 SMART
ZnF_C2H2 430 452 3.39e-3 SMART
ZnF_C2H2 458 479 1.08e1 SMART
ZnF_C2H2 485 507 4.47e-3 SMART
ZnF_C2H2 513 536 5.59e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000199563
AA Change: E118G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000143449
Gene: ENSMUSG00000070420
AA Change: E118G

DomainStartEndE-ValueType
SCAN 38 150 2.1e-54 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000200246
AA Change: E118G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000142367
Gene: ENSMUSG00000070420
AA Change: E118G

DomainStartEndE-ValueType
SCAN 38 150 1.9e-55 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that bears some similarity to zinc finger proteins, which are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants have been identified, but the full-length nature for most of them has not been determined. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933430I17Rik T C 4: 62,532,666 probably benign Het
Abca9 T A 11: 110,160,516 D118V probably benign Het
Adgrb2 T A 4: 130,018,805 I1241N probably damaging Het
Arsb A G 13: 93,790,100 D126G probably benign Het
BB014433 G T 8: 15,042,510 N114K probably benign Het
Ccne2 T A 4: 11,199,322 V241E probably benign Het
Ccnjl A T 11: 43,583,196 K199N probably benign Het
Cyp2c55 A G 19: 39,011,746 T130A probably benign Het
Cyp2c70 A T 19: 40,156,826 N395K probably benign Het
Dst T C 1: 34,160,652 V67A probably damaging Het
Dysf G A 6: 84,108,099 R806H probably damaging Het
Extl3 G A 14: 65,076,989 P248L probably benign Het
Fcgbp A G 7: 28,085,130 D205G probably damaging Het
Gga1 G T 15: 78,883,355 V98L possibly damaging Het
Gpr6 C T 10: 41,070,816 A257T probably damaging Het
Mex3c C T 18: 73,589,889 T351M probably damaging Het
Olfr1019 A T 2: 85,841,362 V143D probably benign Het
Olfr1513 A G 14: 52,349,710 V112A probably benign Het
Olfr154 A T 2: 85,664,356 V26D probably benign Het
Olfr961 T A 9: 39,647,340 S205T probably benign Het
Prex1 A G 2: 166,609,823 Y412H probably damaging Het
Slc25a25 A T 2: 32,419,160 V75E probably benign Het
Sv2c A G 13: 96,048,429 C247R probably damaging Het
Trpm5 A T 7: 143,082,991 V403E probably benign Het
Wdr17 A G 8: 54,687,711 V202A probably damaging Het
Other mutations in Zscan25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02622:Zscan25 APN 5 145290702 missense probably damaging 1.00
IGL02881:Zscan25 APN 5 145290486 missense probably benign 0.25
PIT4445001:Zscan25 UTSW 5 145290612 missense probably damaging 1.00
R1713:Zscan25 UTSW 5 145283691 missense probably damaging 0.99
R1828:Zscan25 UTSW 5 145291048 missense possibly damaging 0.95
R2233:Zscan25 UTSW 5 145283692 missense probably damaging 1.00
R3882:Zscan25 UTSW 5 145291052 missense probably damaging 1.00
R4330:Zscan25 UTSW 5 145290551 missense probably damaging 0.99
R4527:Zscan25 UTSW 5 145283458 missense probably damaging 1.00
R4539:Zscan25 UTSW 5 145288391 missense probably benign 0.01
R4598:Zscan25 UTSW 5 145291005 missense probably benign 0.30
R4611:Zscan25 UTSW 5 145291116 missense probably damaging 1.00
R4662:Zscan25 UTSW 5 145286310 missense unknown
R6733:Zscan25 UTSW 5 145290913 unclassified probably null
R6751:Zscan25 UTSW 5 145290563 missense probably damaging 1.00
R7161:Zscan25 UTSW 5 145286441 missense probably benign 0.00
R7912:Zscan25 UTSW 5 145290511 missense probably benign 0.00
R7993:Zscan25 UTSW 5 145290511 missense probably benign 0.00
Posted On2012-04-20