Incidental Mutation 'R7090:Vmn2r99'
ID 550179
Institutional Source Beutler Lab
Gene Symbol Vmn2r99
Ensembl Gene ENSMUSG00000090304
Gene Name vomeronasal 2, receptor 99
Synonyms EG665376
MMRRC Submission 045184-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.131) question?
Stock # R7090 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 19361949-19401098 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 19393710 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Valine at position 564 (E564V)
Ref Sequence ENSEMBL: ENSMUSP00000135236 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000176107] [ENSMUST00000231989]
AlphaFold H3BK37
Predicted Effect possibly damaging
Transcript: ENSMUST00000176107
AA Change: E564V

PolyPhen 2 Score 0.828 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000135236
Gene: ENSMUSG00000090304
AA Change: E564V

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:ANF_receptor 81 448 5.7e-33 PFAM
Pfam:NCD3G 508 561 1.8e-21 PFAM
Pfam:7tm_3 593 829 4.6e-52 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000231989
AA Change: R606S
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (66/66)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Calm3 A T 7: 16,917,079 (GRCm38) Y139* probably null Het
Ccdc27 T C 4: 154,028,066 (GRCm38) N584S probably benign Het
Cdh24 C G 14: 54,639,507 (GRCm38) G13A probably damaging Het
Chd8 T C 14: 52,215,220 (GRCm38) K1281E probably damaging Het
Clasp1 G T 1: 118,482,086 (GRCm38) G4C probably benign Het
Cul9 G T 17: 46,500,839 (GRCm38) P2488T probably damaging Het
Daam2 A G 17: 49,482,945 (GRCm38) V428A probably damaging Het
Dcaf8 A G 1: 172,188,968 (GRCm38) S441G probably damaging Het
Dchs2 A G 3: 83,348,274 (GRCm38) T2426A probably benign Het
Dpys A G 15: 39,826,883 (GRCm38) V358A probably damaging Het
Efhd1 A G 1: 87,289,497 (GRCm38) D112G probably damaging Het
Exoc1 T C 5: 76,566,953 (GRCm38) S120P unknown Het
Fyco1 A G 9: 123,797,719 (GRCm38) L1309S probably damaging Het
Gm14403 A G 2: 177,509,321 (GRCm38) N111S possibly damaging Het
Gm5901 A G 7: 105,377,348 (GRCm38) T108A probably benign Het
Idh2 TCCCAGG T 7: 80,098,331 (GRCm38) probably benign Het
Itgb5 T G 16: 33,885,094 (GRCm38) D251E probably damaging Het
Kcnk15 T C 2: 163,858,717 (GRCm38) V292A probably benign Het
Kdm2a A T 19: 4,319,141 (GRCm38) Y1149N probably damaging Het
Kdm3a T C 6: 71,595,545 (GRCm38) T1011A possibly damaging Het
Krt35 A T 11: 100,095,672 (GRCm38) probably null Het
Lipn T A 19: 34,071,780 (GRCm38) D115E possibly damaging Het
Lpin3 T G 2: 160,896,752 (GRCm38) L208R probably damaging Het
Ltf C A 9: 111,025,980 (GRCm38) Q354K probably benign Het
Marf1 C A 16: 14,111,702 (GRCm38) C1680F possibly damaging Het
Mtss1l T A 8: 110,730,024 (GRCm38) V242E probably damaging Het
Myo7b T C 18: 31,998,712 (GRCm38) Y477C probably damaging Het
Nbn T A 4: 15,981,350 (GRCm38) S481T probably benign Het
Ncoa2 A G 1: 13,186,838 (GRCm38) Y146H probably damaging Het
Ntng1 A T 3: 109,935,180 (GRCm38) C92* probably null Het
Olfr1049 T A 2: 86,255,076 (GRCm38) N206Y probably damaging Het
Olfr1077-ps1 T C 2: 86,526,127 (GRCm38) I17V probably benign Het
Olfr133 G A 17: 38,149,494 (GRCm38) G302D probably benign Het
Olfr286 C T 15: 98,227,202 (GRCm38) V150I probably benign Het
Os9 A T 10: 127,099,678 (GRCm38) S308T probably benign Het
Otx2 T A 14: 48,658,735 (GRCm38) T289S probably benign Het
Palm2 C T 4: 57,648,042 (GRCm38) A60V probably benign Het
Pigg A G 5: 108,336,512 (GRCm38) T675A possibly damaging Het
Pink1 C T 4: 138,315,601 (GRCm38) E461K probably damaging Het
Pip5k1a A G 3: 95,060,498 (GRCm38) S543P possibly damaging Het
Prkaa1 A G 15: 5,177,130 (GRCm38) T454A probably benign Het
Ptk2 G A 15: 73,221,809 (GRCm38) P854S possibly damaging Het
Rab31 C T 17: 65,698,017 (GRCm38) V83I possibly damaging Het
Rabggtb G T 3: 153,910,349 (GRCm38) D117E probably benign Het
Rbl1 T C 2: 157,152,900 (GRCm38) H951R probably benign Het
Sapcd2 A G 2: 25,376,079 (GRCm38) S314G probably benign Het
Sept4 T C 11: 87,584,438 (GRCm38) L164P probably damaging Het
Shroom1 A G 11: 53,465,933 (GRCm38) E541G probably damaging Het
Slc26a7 C A 4: 14,565,460 (GRCm38) G208* probably null Het
Smco2 A G 6: 146,871,213 (GRCm38) I304M probably damaging Het
Spg7 T C 8: 123,091,752 (GRCm38) probably null Het
Spocd1 T C 4: 129,953,898 (GRCm38) F552L Het
St6galnac2 T C 11: 116,677,635 (GRCm38) D334G probably damaging Het
Sub1 A G 15: 11,986,486 (GRCm38) S92P probably benign Het
Syne2 T C 12: 75,942,351 (GRCm38) F1829L probably benign Het
Tdrd1 T C 19: 56,851,401 (GRCm38) V631A probably benign Het
Tdrd9 T C 12: 111,992,470 (GRCm38) S113P probably benign Het
Tgfbrap1 A C 1: 43,071,565 (GRCm38) V260G probably damaging Het
Tyw3 G C 3: 154,593,789 (GRCm38) S94R probably benign Het
Urb2 T C 8: 124,030,599 (GRCm38) V1015A probably benign Het
Usp5 A G 6: 124,829,394 (GRCm38) M1T probably null Het
Utrn T C 10: 12,684,516 (GRCm38) D1343G possibly damaging Het
Vmn2r56 T C 7: 12,715,327 (GRCm38) Y328C probably damaging Het
Wdr63 C A 3: 146,040,827 (GRCm38) K881N possibly damaging Het
Zc3h8 T C 2: 128,935,321 (GRCm38) T133A possibly damaging Het
Other mutations in Vmn2r99
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00503:Vmn2r99 APN 17 19,378,854 (GRCm38) missense probably benign 0.01
IGL01113:Vmn2r99 APN 17 19,394,256 (GRCm38) missense probably benign 0.20
IGL01138:Vmn2r99 APN 17 19,382,623 (GRCm38) missense probably damaging 0.97
IGL01646:Vmn2r99 APN 17 19,393,658 (GRCm38) splice site probably benign
IGL01769:Vmn2r99 APN 17 19,380,115 (GRCm38) missense probably damaging 1.00
IGL02112:Vmn2r99 APN 17 19,380,232 (GRCm38) missense probably null 0.99
IGL02891:Vmn2r99 APN 17 19,378,690 (GRCm38) nonsense probably null
IGL03132:Vmn2r99 APN 17 19,378,223 (GRCm38) nonsense probably null
FR4548:Vmn2r99 UTSW 17 19,394,285 (GRCm38) missense probably damaging 0.97
FR4976:Vmn2r99 UTSW 17 19,394,285 (GRCm38) missense probably damaging 0.97
PIT4382001:Vmn2r99 UTSW 17 19,394,343 (GRCm38) missense probably damaging 1.00
R0196:Vmn2r99 UTSW 17 19,394,573 (GRCm38) missense probably benign 0.00
R0720:Vmn2r99 UTSW 17 19,379,043 (GRCm38) missense probably benign 0.00
R1501:Vmn2r99 UTSW 17 19,362,259 (GRCm38) missense possibly damaging 0.93
R1519:Vmn2r99 UTSW 17 19,380,060 (GRCm38) missense probably benign 0.00
R1670:Vmn2r99 UTSW 17 19,362,252 (GRCm38) missense probably benign 0.37
R1682:Vmn2r99 UTSW 17 19,377,945 (GRCm38) missense probably damaging 0.97
R1873:Vmn2r99 UTSW 17 19,362,153 (GRCm38) missense probably benign 0.25
R1967:Vmn2r99 UTSW 17 19,378,815 (GRCm38) missense probably benign 0.01
R2101:Vmn2r99 UTSW 17 19,377,991 (GRCm38) missense probably damaging 1.00
R2474:Vmn2r99 UTSW 17 19,378,629 (GRCm38) missense probably benign 0.04
R2519:Vmn2r99 UTSW 17 19,378,708 (GRCm38) missense probably damaging 0.99
R3911:Vmn2r99 UTSW 17 19,394,373 (GRCm38) missense possibly damaging 0.92
R3947:Vmn2r99 UTSW 17 19,378,990 (GRCm38) missense probably benign 0.40
R3949:Vmn2r99 UTSW 17 19,378,990 (GRCm38) missense probably benign 0.40
R4016:Vmn2r99 UTSW 17 19,378,570 (GRCm38) missense possibly damaging 0.86
R4413:Vmn2r99 UTSW 17 19,379,260 (GRCm38) missense probably damaging 1.00
R4594:Vmn2r99 UTSW 17 19,393,662 (GRCm38) missense probably damaging 1.00
R4999:Vmn2r99 UTSW 17 19,362,135 (GRCm38) start codon destroyed probably null 0.96
R5206:Vmn2r99 UTSW 17 19,378,606 (GRCm38) missense probably benign 0.40
R5362:Vmn2r99 UTSW 17 19,379,339 (GRCm38) missense probably benign 0.00
R5377:Vmn2r99 UTSW 17 19,379,269 (GRCm38) missense probably damaging 1.00
R5455:Vmn2r99 UTSW 17 19,394,146 (GRCm38) nonsense probably null
R6021:Vmn2r99 UTSW 17 19,377,948 (GRCm38) missense probably damaging 1.00
R6059:Vmn2r99 UTSW 17 19,378,980 (GRCm38) missense probably benign 0.00
R6214:Vmn2r99 UTSW 17 19,382,558 (GRCm38) missense probably benign 0.19
R6215:Vmn2r99 UTSW 17 19,382,558 (GRCm38) missense probably benign 0.19
R6313:Vmn2r99 UTSW 17 19,382,605 (GRCm38) missense probably damaging 1.00
R6646:Vmn2r99 UTSW 17 19,380,031 (GRCm38) missense probably damaging 1.00
R6810:Vmn2r99 UTSW 17 19,380,034 (GRCm38) missense probably benign 0.20
R6885:Vmn2r99 UTSW 17 19,380,195 (GRCm38) missense possibly damaging 0.52
R6991:Vmn2r99 UTSW 17 19,378,110 (GRCm38) missense probably benign 0.03
R7060:Vmn2r99 UTSW 17 19,394,564 (GRCm38) nonsense probably null
R7094:Vmn2r99 UTSW 17 19,379,311 (GRCm38) missense probably benign 0.00
R7449:Vmn2r99 UTSW 17 19,379,145 (GRCm38) missense probably benign 0.01
R7789:Vmn2r99 UTSW 17 19,393,817 (GRCm38) missense possibly damaging 0.91
R8039:Vmn2r99 UTSW 17 19,380,040 (GRCm38) missense probably benign 0.00
R8493:Vmn2r99 UTSW 17 19,393,758 (GRCm38) missense probably benign 0.15
R8511:Vmn2r99 UTSW 17 19,394,181 (GRCm38) missense probably damaging 1.00
R8715:Vmn2r99 UTSW 17 19,393,660 (GRCm38) critical splice acceptor site probably benign
R9462:Vmn2r99 UTSW 17 19,378,126 (GRCm38) nonsense probably null
R9681:Vmn2r99 UTSW 17 19,378,627 (GRCm38) missense probably damaging 1.00
R9737:Vmn2r99 UTSW 17 19,362,301 (GRCm38) missense probably benign
Z1088:Vmn2r99 UTSW 17 19,379,301 (GRCm38) missense probably benign 0.18
Predicted Primers PCR Primer
(F):5'- AAGAACAAGGAGCAGTCTCTAACTC -3'
(R):5'- TAACTCAGAGCTCGATTATTTGCC -3'

Sequencing Primer
(F):5'- CCCTGCAGTTAGAGATGT -3'
(R):5'- CCTTAACAATAGGAGTGTCTCTGTGC -3'
Posted On 2019-05-15