Incidental Mutation 'R7092:Fasn'
| ID |
550309 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Fasn
|
| Ensembl Gene |
ENSMUSG00000025153 |
| Gene Name |
fatty acid synthase |
| Synonyms |
A630082H08Rik, FAS |
| MMRRC Submission |
045186-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7092 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
120696672-120715373 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 120710946 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glycine
at position 268
(V268G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000052872
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055655]
[ENSMUST00000205905]
[ENSMUST00000206589]
|
| AlphaFold |
P19096 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000055655
AA Change: V268G
PolyPhen 2
Score 0.562 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000052872
Gene: ENSMUSG00000025153
AA Change: V268G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ketoacyl-synt
|
1 |
239 |
6.8e-73 |
PFAM |
|
Pfam:Ketoacyl-synt_C
|
243 |
360 |
3.7e-38 |
PFAM |
|
Pfam:KAsynt_C_assoc
|
362 |
474 |
8.2e-46 |
PFAM |
|
Pfam:Acyl_transf_1
|
493 |
810 |
9.5e-115 |
PFAM |
|
Pfam:PS-DH
|
853 |
1169 |
9.9e-24 |
PFAM |
|
low complexity region
|
1175 |
1204 |
N/A |
INTRINSIC |
|
Pfam:Methyltransf_12
|
1238 |
1337 |
2e-9 |
PFAM |
|
PKS_ER
|
1532 |
1847 |
1.44e-147 |
SMART |
|
PKS_KR
|
1878 |
2059 |
2.33e-42 |
SMART |
|
Pfam:PP-binding
|
2119 |
2185 |
1.1e-10 |
PFAM |
|
Pfam:Thioesterase
|
2235 |
2494 |
1.6e-62 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205905
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206589
AA Change: V268G
PolyPhen 2
Score 0.192 (Sensitivity: 0.92; Specificity: 0.87)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
99% (88/89) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
PHENOTYPE: Targeted mutation of this locus has implicated its product in embryogenesis as all homozygotes and most heterozygotes die prior to birth. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 89 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930579F01Rik |
C |
T |
3: 137,889,506 (GRCm39) |
C37Y |
probably benign |
Het |
| A430005L14Rik |
T |
A |
4: 154,045,451 (GRCm39) |
|
probably null |
Het |
| Aadacl2fm3 |
T |
C |
3: 59,768,500 (GRCm39) |
F10S |
probably benign |
Het |
| Abca4 |
C |
G |
3: 121,932,218 (GRCm39) |
P1499A |
probably damaging |
Het |
| Adcy8 |
T |
C |
15: 64,743,619 (GRCm39) |
N330D |
possibly damaging |
Het |
| Arfgef1 |
A |
G |
1: 10,223,901 (GRCm39) |
Y1466H |
probably damaging |
Het |
| Asz1 |
A |
C |
6: 18,071,818 (GRCm39) |
|
probably null |
Het |
| Atad5 |
T |
A |
11: 80,011,546 (GRCm39) |
N1307K |
possibly damaging |
Het |
| B4galnt4 |
C |
A |
7: 140,648,549 (GRCm39) |
F688L |
probably damaging |
Het |
| Birc6 |
C |
T |
17: 74,953,740 (GRCm39) |
T3349I |
probably damaging |
Het |
| Ccp110 |
C |
A |
7: 118,334,494 (GRCm39) |
A989E |
probably benign |
Het |
| Ccser2 |
A |
G |
14: 36,662,612 (GRCm39) |
S191P |
probably benign |
Het |
| Cdca2 |
A |
G |
14: 67,944,800 (GRCm39) |
|
probably null |
Het |
| Cdcp1 |
T |
A |
9: 123,012,678 (GRCm39) |
T290S |
probably benign |
Het |
| Cep43 |
C |
T |
17: 8,391,802 (GRCm39) |
P161S |
probably benign |
Het |
| Clec2m |
T |
A |
6: 129,299,963 (GRCm39) |
T172S |
probably benign |
Het |
| Cnnm1 |
T |
C |
19: 43,430,387 (GRCm39) |
Y502H |
probably damaging |
Het |
| Cyba |
T |
G |
8: 123,154,437 (GRCm39) |
T29P |
probably damaging |
Het |
| Dcaf12 |
A |
T |
4: 41,301,366 (GRCm39) |
I190N |
probably damaging |
Het |
| Depp1 |
C |
A |
6: 116,628,749 (GRCm39) |
P31T |
probably damaging |
Het |
| Epha1 |
T |
C |
6: 42,341,179 (GRCm39) |
T512A |
probably benign |
Het |
| Fancg |
G |
A |
4: 43,004,831 (GRCm39) |
P454L |
probably benign |
Het |
| Fip1l1 |
T |
A |
5: 74,697,504 (GRCm39) |
L42Q |
probably damaging |
Het |
| Fjx1 |
A |
G |
2: 102,281,101 (GRCm39) |
L278P |
possibly damaging |
Het |
| Fsd1 |
G |
A |
17: 56,300,876 (GRCm39) |
R245H |
probably damaging |
Het |
| Fundc2b |
T |
A |
3: 40,856,809 (GRCm39) |
D22V |
possibly damaging |
Het |
| Gm1527 |
T |
A |
3: 28,968,696 (GRCm39) |
|
probably null |
Het |
| Gng3 |
T |
A |
19: 8,815,611 (GRCm39) |
M42L |
probably benign |
Het |
| Gsdmc2 |
T |
A |
15: 63,696,947 (GRCm39) |
Q408L |
probably damaging |
Het |
| Gtpbp3 |
T |
A |
8: 71,944,909 (GRCm39) |
I388K |
probably benign |
Het |
| Hmcn1 |
A |
T |
1: 150,479,997 (GRCm39) |
W4534R |
probably damaging |
Het |
| Inhca |
G |
A |
9: 103,158,242 (GRCm39) |
S106L |
possibly damaging |
Het |
| Ist1 |
A |
T |
8: 110,409,228 (GRCm39) |
|
probably null |
Het |
| Kifbp |
C |
A |
10: 62,414,079 (GRCm39) |
K26N |
probably damaging |
Het |
| Kyat3 |
T |
C |
3: 142,435,556 (GRCm39) |
I276T |
probably damaging |
Het |
| Lipm |
C |
T |
19: 34,098,758 (GRCm39) |
P411S |
possibly damaging |
Het |
| Lipo3 |
T |
C |
19: 33,591,092 (GRCm39) |
|
probably null |
Het |
| Lrrc9 |
C |
A |
12: 72,510,238 (GRCm39) |
Q446K |
possibly damaging |
Het |
| Mfsd4a |
G |
T |
1: 131,995,401 (GRCm39) |
T77N |
probably benign |
Het |
| Mmp1b |
T |
A |
9: 7,386,981 (GRCm39) |
D77V |
probably damaging |
Het |
| Mrgprb4 |
A |
G |
7: 47,847,984 (GRCm39) |
S315P |
probably benign |
Het |
| Mroh2b |
C |
A |
15: 4,964,160 (GRCm39) |
N887K |
possibly damaging |
Het |
| Mto1 |
A |
G |
9: 78,377,955 (GRCm39) |
K599R |
probably benign |
Het |
| Muc5ac |
T |
C |
7: 141,363,385 (GRCm39) |
|
probably benign |
Het |
| Muc5ac |
G |
C |
7: 141,363,424 (GRCm39) |
|
probably benign |
Het |
| Mylk2 |
A |
G |
2: 152,757,110 (GRCm39) |
N295S |
probably benign |
Het |
| Nr1i3 |
G |
A |
1: 171,041,747 (GRCm39) |
|
probably null |
Het |
| Nup107 |
T |
C |
10: 117,626,399 (GRCm39) |
K25E |
probably damaging |
Het |
| Odc1 |
G |
A |
12: 17,598,314 (GRCm39) |
V152I |
possibly damaging |
Het |
| Or13a20 |
G |
A |
7: 140,232,150 (GRCm39) |
G86D |
probably benign |
Het |
| Or1l4b |
T |
A |
2: 37,036,623 (GRCm39) |
M133K |
probably damaging |
Het |
| Or5m10b |
A |
T |
2: 85,698,951 (GRCm39) |
N5I |
probably damaging |
Het |
| Or7g16 |
G |
A |
9: 18,727,353 (GRCm39) |
P79L |
probably damaging |
Het |
| Pde1b |
G |
T |
15: 103,435,458 (GRCm39) |
V438L |
probably benign |
Het |
| Pde4b |
G |
A |
4: 102,459,048 (GRCm39) |
V523M |
probably damaging |
Het |
| Pdgfc |
C |
T |
3: 81,111,659 (GRCm39) |
P205S |
probably damaging |
Het |
| Per2 |
A |
G |
1: 91,349,153 (GRCm39) |
S1073P |
probably damaging |
Het |
| Plekhg5 |
C |
T |
4: 152,198,965 (GRCm39) |
T1051I |
probably damaging |
Het |
| Ppme1 |
A |
T |
7: 100,021,029 (GRCm39) |
M1K |
probably null |
Het |
| Prokr2 |
A |
T |
2: 132,223,236 (GRCm39) |
V102D |
possibly damaging |
Het |
| Ptk2 |
G |
A |
15: 73,093,658 (GRCm39) |
P854S |
possibly damaging |
Het |
| Ptprh |
C |
A |
7: 4,583,860 (GRCm39) |
|
probably null |
Het |
| Rbsn |
T |
C |
6: 92,166,607 (GRCm39) |
N679S |
probably damaging |
Het |
| Rce1 |
T |
C |
19: 4,673,118 (GRCm39) |
T303A |
probably damaging |
Het |
| Rnf123 |
C |
A |
9: 107,945,799 (GRCm39) |
R329L |
probably benign |
Het |
| Robo2 |
T |
A |
16: 73,753,531 (GRCm39) |
N782I |
probably damaging |
Het |
| Ror2 |
A |
C |
13: 53,264,272 (GRCm39) |
V940G |
probably benign |
Het |
| Rpe65 |
C |
T |
3: 159,321,228 (GRCm39) |
R347C |
probably damaging |
Het |
| Rrp8 |
A |
T |
7: 105,383,316 (GRCm39) |
F317I |
probably damaging |
Het |
| Sidt1 |
A |
G |
16: 44,120,192 (GRCm39) |
V163A |
possibly damaging |
Het |
| Sin3b |
T |
C |
8: 73,474,498 (GRCm39) |
|
probably null |
Het |
| Slamf1 |
A |
G |
1: 171,604,757 (GRCm39) |
T176A |
probably benign |
Het |
| Slc12a4 |
G |
T |
8: 106,671,855 (GRCm39) |
A922D |
probably damaging |
Het |
| Slco1a5 |
T |
A |
6: 142,194,401 (GRCm39) |
Q414L |
probably benign |
Het |
| Snx11 |
C |
A |
11: 96,663,665 (GRCm39) |
R58L |
probably damaging |
Het |
| Sp9 |
A |
G |
2: 73,104,115 (GRCm39) |
D223G |
probably damaging |
Het |
| Sptbn1 |
T |
C |
11: 30,087,119 (GRCm39) |
I1107V |
possibly damaging |
Het |
| Stap2 |
T |
C |
17: 56,309,954 (GRCm39) |
R66G |
probably benign |
Het |
| Synrg |
T |
G |
11: 83,899,683 (GRCm39) |
F552V |
possibly damaging |
Het |
| Trim60 |
C |
T |
8: 65,453,700 (GRCm39) |
R183H |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,733,760 (GRCm39) |
D4505G |
unknown |
Het |
| Ubxn4 |
A |
G |
1: 128,179,959 (GRCm39) |
I34M |
probably benign |
Het |
| Vac14 |
T |
A |
8: 111,442,128 (GRCm39) |
M702K |
probably damaging |
Het |
| Vmn1r43 |
T |
C |
6: 89,846,885 (GRCm39) |
I200M |
probably benign |
Het |
| Vmn2r108 |
T |
A |
17: 20,701,338 (GRCm39) |
Y54F |
probably benign |
Het |
| Vps13b |
T |
C |
15: 35,640,780 (GRCm39) |
Y1382H |
probably damaging |
Het |
| Wdr72 |
T |
C |
9: 74,117,754 (GRCm39) |
I834T |
probably damaging |
Het |
| Zfp970 |
T |
A |
2: 177,167,085 (GRCm39) |
C220S |
probably damaging |
Het |
| Zkscan5 |
T |
G |
5: 145,156,899 (GRCm39) |
I467S |
probably benign |
Het |
|
| Other mutations in Fasn |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00468:Fasn
|
APN |
11 |
120,711,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01014:Fasn
|
APN |
11 |
120,708,055 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01131:Fasn
|
APN |
11 |
120,705,445 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01603:Fasn
|
APN |
11 |
120,706,891 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01606:Fasn
|
APN |
11 |
120,699,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01897:Fasn
|
APN |
11 |
120,698,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01899:Fasn
|
APN |
11 |
120,710,975 (GRCm39) |
splice site |
probably benign |
|
|
IGL01987:Fasn
|
APN |
11 |
120,708,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02103:Fasn
|
APN |
11 |
120,702,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02212:Fasn
|
APN |
11 |
120,698,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02294:Fasn
|
APN |
11 |
120,701,102 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02336:Fasn
|
APN |
11 |
120,704,562 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02417:Fasn
|
APN |
11 |
120,711,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02452:Fasn
|
APN |
11 |
120,699,006 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02559:Fasn
|
APN |
11 |
120,699,892 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL02724:Fasn
|
APN |
11 |
120,700,659 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02862:Fasn
|
APN |
11 |
120,709,805 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02947:Fasn
|
APN |
11 |
120,706,502 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03025:Fasn
|
APN |
11 |
120,708,974 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03131:Fasn
|
APN |
11 |
120,701,550 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03157:Fasn
|
APN |
11 |
120,698,735 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL03182:Fasn
|
APN |
11 |
120,703,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03370:Fasn
|
APN |
11 |
120,703,621 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
BB007:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
BB017:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
R0019:Fasn
|
UTSW |
11 |
120,698,824 (GRCm39) |
splice site |
probably benign |
|
|
R0019:Fasn
|
UTSW |
11 |
120,698,824 (GRCm39) |
splice site |
probably benign |
|
|
R0243:Fasn
|
UTSW |
11 |
120,706,141 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0304:Fasn
|
UTSW |
11 |
120,710,762 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0389:Fasn
|
UTSW |
11 |
120,707,008 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0449:Fasn
|
UTSW |
11 |
120,701,894 (GRCm39) |
missense |
probably benign |
|
|
R0626:Fasn
|
UTSW |
11 |
120,702,751 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1037:Fasn
|
UTSW |
11 |
120,700,277 (GRCm39) |
missense |
probably benign |
|
|
R1061:Fasn
|
UTSW |
11 |
120,713,008 (GRCm39) |
splice site |
probably null |
|
|
R1109:Fasn
|
UTSW |
11 |
120,703,150 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1467:Fasn
|
UTSW |
11 |
120,701,866 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1467:Fasn
|
UTSW |
11 |
120,701,866 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1498:Fasn
|
UTSW |
11 |
120,706,245 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1552:Fasn
|
UTSW |
11 |
120,709,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1568:Fasn
|
UTSW |
11 |
120,704,075 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1624:Fasn
|
UTSW |
11 |
120,703,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1774:Fasn
|
UTSW |
11 |
120,707,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1826:Fasn
|
UTSW |
11 |
120,699,325 (GRCm39) |
splice site |
probably benign |
|
|
R1846:Fasn
|
UTSW |
11 |
120,704,133 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2298:Fasn
|
UTSW |
11 |
120,704,642 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2513:Fasn
|
UTSW |
11 |
120,705,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3001:Fasn
|
UTSW |
11 |
120,700,671 (GRCm39) |
missense |
probably benign |
|
|
R3002:Fasn
|
UTSW |
11 |
120,700,671 (GRCm39) |
missense |
probably benign |
|
|
R3154:Fasn
|
UTSW |
11 |
120,698,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3434:Fasn
|
UTSW |
11 |
120,713,599 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4794:Fasn
|
UTSW |
11 |
120,702,121 (GRCm39) |
missense |
probably benign |
0.36 |
|
R4840:Fasn
|
UTSW |
11 |
120,703,885 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4863:Fasn
|
UTSW |
11 |
120,699,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4876:Fasn
|
UTSW |
11 |
120,703,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4914:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4915:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4916:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4918:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4936:Fasn
|
UTSW |
11 |
120,706,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5025:Fasn
|
UTSW |
11 |
120,702,734 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5092:Fasn
|
UTSW |
11 |
120,705,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5120:Fasn
|
UTSW |
11 |
120,702,217 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5175:Fasn
|
UTSW |
11 |
120,707,195 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5183:Fasn
|
UTSW |
11 |
120,699,708 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5506:Fasn
|
UTSW |
11 |
120,700,336 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5557:Fasn
|
UTSW |
11 |
120,703,252 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5614:Fasn
|
UTSW |
11 |
120,704,154 (GRCm39) |
missense |
probably benign |
|
|
R5728:Fasn
|
UTSW |
11 |
120,704,339 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5838:Fasn
|
UTSW |
11 |
120,706,950 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5959:Fasn
|
UTSW |
11 |
120,699,390 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6029:Fasn
|
UTSW |
11 |
120,711,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6134:Fasn
|
UTSW |
11 |
120,713,012 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6335:Fasn
|
UTSW |
11 |
120,706,185 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6452:Fasn
|
UTSW |
11 |
120,706,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6627:Fasn
|
UTSW |
11 |
120,709,753 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6742:Fasn
|
UTSW |
11 |
120,701,279 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6767:Fasn
|
UTSW |
11 |
120,708,313 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R6927:Fasn
|
UTSW |
11 |
120,699,115 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6976:Fasn
|
UTSW |
11 |
120,710,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7157:Fasn
|
UTSW |
11 |
120,701,291 (GRCm39) |
nonsense |
probably null |
|
|
R7373:Fasn
|
UTSW |
11 |
120,704,802 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7575:Fasn
|
UTSW |
11 |
120,703,513 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7652:Fasn
|
UTSW |
11 |
120,707,154 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7670:Fasn
|
UTSW |
11 |
120,704,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7806:Fasn
|
UTSW |
11 |
120,700,821 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7930:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
R8007:Fasn
|
UTSW |
11 |
120,700,353 (GRCm39) |
missense |
probably benign |
|
|
R8012:Fasn
|
UTSW |
11 |
120,702,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8185:Fasn
|
UTSW |
11 |
120,702,969 (GRCm39) |
missense |
probably benign |
0.42 |
|
R8557:Fasn
|
UTSW |
11 |
120,706,610 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8711:Fasn
|
UTSW |
11 |
120,709,944 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8772:Fasn
|
UTSW |
11 |
120,711,362 (GRCm39) |
missense |
probably benign |
|
|
R8856:Fasn
|
UTSW |
11 |
120,708,979 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8875:Fasn
|
UTSW |
11 |
120,703,224 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9071:Fasn
|
UTSW |
11 |
120,708,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9153:Fasn
|
UTSW |
11 |
120,706,496 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9238:Fasn
|
UTSW |
11 |
120,705,871 (GRCm39) |
missense |
probably benign |
|
|
R9249:Fasn
|
UTSW |
11 |
120,703,915 (GRCm39) |
missense |
probably benign |
|
|
R9345:Fasn
|
UTSW |
11 |
120,706,735 (GRCm39) |
missense |
probably benign |
0.22 |
|
X0067:Fasn
|
UTSW |
11 |
120,707,129 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Fasn
|
UTSW |
11 |
120,706,297 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GGACCGAGTAATGCCATTCAG -3'
(R):5'- TCTATGCCACGATTCTGAATGCC -3'
Sequencing Primer
(F):5'- CGAGTAATGCCATTCAGTTCCTGG -3'
(R):5'- ACGATTCTGAATGCCGGCAC -3'
|
| Posted On |
2019-05-15 |
Incidental Mutation