Incidental Mutation 'R7094:Or51f23b'
ID 550355
Institutional Source Beutler Lab
Gene Symbol Or51f23b
Ensembl Gene ENSMUSG00000110008
Gene Name olfactory receptor family 51 subfamily F member 23B
Synonyms GA_x6K02T2PBJ9-5470572-5469628, Olfr560, MOR14-1
MMRRC Submission 045187-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.151) question?
Stock # R7094 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 102402190-102403134 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 102402305 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 277 (M277T)
Ref Sequence ENSEMBL: ENSMUSP00000148074 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060187] [ENSMUST00000168007] [ENSMUST00000210453] [ENSMUST00000232246]
AlphaFold A0A1B0GSU5
Predicted Effect probably benign
Transcript: ENSMUST00000060187
SMART Domains Protein: ENSMUSP00000058085
Gene: ENSMUSG00000043366

DomainStartEndE-ValueType
Pfam:7tm_4 30 309 1.9e-111 PFAM
Pfam:7TM_GPCR_Srsx 34 252 1.4e-8 PFAM
Pfam:7tm_1 40 291 2.3e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000168007
SMART Domains Protein: ENSMUSP00000133255
Gene: ENSMUSG00000043366

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 34 252 1.4e-8 PFAM
Pfam:7tm_1 40 291 1.4e-25 PFAM
Pfam:7tm_4 140 284 2.8e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000210453
AA Change: M277T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000232246
AA Change: M275T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 97% (59/61)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A T 11: 9,248,610 (GRCm39) I2786F probably damaging Het
Actl6a A T 3: 32,760,487 (GRCm39) probably benign Het
Actn2 A G 13: 12,324,543 (GRCm39) V100A probably damaging Het
Arfgef3 G T 10: 18,522,187 (GRCm39) A613E probably damaging Het
Atf6b G A 17: 34,872,790 (GRCm39) probably null Het
Bub1 T A 2: 127,663,681 (GRCm39) E240V probably null Het
C1ra G A 6: 124,494,684 (GRCm39) E316K probably benign Het
Ccdc141 C A 2: 76,871,797 (GRCm39) R829L possibly damaging Het
Ccdc85c GCCGCCGCCGCCAGCGCCCCCCGCCGCCGCCAGCGCC GCCGCCGCCGCCAGCGCC 12: 108,240,877 (GRCm39) probably null Het
Cd209g T C 8: 4,186,790 (GRCm39) F112L possibly damaging Het
Cebpe C T 14: 54,948,060 (GRCm39) R261H probably damaging Het
Cfap100 T C 6: 90,390,436 (GRCm39) E68G Het
Chd9 A G 8: 91,716,189 (GRCm39) N921S unknown Het
Chil6 T C 3: 106,311,486 (GRCm39) N98S probably damaging Het
Clip1 T C 5: 123,761,333 (GRCm39) K734E probably benign Het
Cracd C T 5: 77,006,879 (GRCm39) P1080L unknown Het
Cyp11b2 A G 15: 74,725,507 (GRCm39) F204S possibly damaging Het
Dnah5 A G 15: 28,453,482 (GRCm39) T4418A probably damaging Het
Dysf T C 6: 84,077,184 (GRCm39) V649A probably benign Het
Ergic3 G A 2: 155,858,683 (GRCm39) V270M possibly damaging Het
Eva1a C T 6: 82,069,024 (GRCm39) T117I probably damaging Het
Fat4 G A 3: 38,944,023 (GRCm39) G972D probably damaging Het
Gm14412 A T 2: 177,009,138 (GRCm39) N39K probably damaging Het
Gm5565 T C 5: 146,095,084 (GRCm39) T221A probably benign Het
Gnptab T G 10: 88,215,366 (GRCm39) V29G possibly damaging Het
Grem2 T C 1: 174,664,555 (GRCm39) Y98C probably damaging Het
Grik2 A T 10: 49,232,012 (GRCm39) I506N possibly damaging Het
Has2 T A 15: 56,545,017 (GRCm39) Y195F probably damaging Het
Kics2 A G 10: 121,576,098 (GRCm39) Y73C possibly damaging Het
Lars2 T C 9: 123,288,650 (GRCm39) L832P probably damaging Het
Lipo5 T A 19: 33,446,249 (GRCm39) E49D probably damaging Het
Macc1 T A 12: 119,414,126 (GRCm39) Y767* probably null Het
Map2 G T 1: 66,451,886 (GRCm39) E259* probably null Het
Mcm9 T C 10: 53,496,253 (GRCm39) D310G probably damaging Het
Mink1 C A 11: 70,500,901 (GRCm39) probably null Het
Mtrr T C 13: 68,727,803 (GRCm39) T48A possibly damaging Het
Nrsn1 A T 13: 25,437,724 (GRCm39) I68N possibly damaging Het
Or1ab2 A T 8: 72,863,347 (GRCm39) probably benign Het
Or4a71 A T 2: 89,357,902 (GRCm39) I284K probably damaging Het
Or5p60 G T 7: 107,723,840 (GRCm39) T210N probably benign Het
Or8k36-ps1 T C 2: 86,437,672 (GRCm39) N81S unknown Het
Pcdh17 A G 14: 84,684,835 (GRCm39) D434G probably damaging Het
Rnf213 T A 11: 119,328,430 (GRCm39) probably null Het
Selplg GTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCT GTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCT 5: 113,957,756 (GRCm39) probably benign Het
Sez6l2 A G 7: 126,552,096 (GRCm39) E121G probably damaging Het
Slc35e4 T C 11: 3,863,118 (GRCm39) S24G probably benign Het
Slc39a2 G T 14: 52,131,146 (GRCm39) probably benign Het
Slitrk5 C T 14: 111,918,268 (GRCm39) P631S probably benign Het
Taf2 A G 15: 54,923,482 (GRCm39) V265A probably benign Het
Tas2r106 T C 6: 131,655,542 (GRCm39) N103S probably benign Het
Tgm1 T C 14: 55,942,300 (GRCm39) T684A possibly damaging Het
Tgm7 C T 2: 120,929,489 (GRCm39) G262S probably damaging Het
Tpp2 T A 1: 44,008,148 (GRCm39) S451T probably damaging Het
Trim15 T C 17: 37,173,788 (GRCm39) Y240C probably benign Het
Trio A T 15: 27,891,534 (GRCm39) C465S unknown Het
Ttc22 G A 4: 106,493,104 (GRCm39) W250* probably null Het
Upb1 C A 10: 75,274,042 (GRCm39) F356L probably damaging Het
Vmn2r99 T A 17: 19,599,573 (GRCm39) M419K probably benign Het
Vstm2a G A 11: 16,207,990 (GRCm39) probably benign Het
Zfp820 T C 17: 22,038,246 (GRCm39) T361A probably benign Het
Other mutations in Or51f23b
AlleleSourceChrCoordTypePredicted EffectPPH Score
R7081:Or51f23b UTSW 7 102,402,395 (GRCm39) missense probably benign 0.18
R7605:Or51f23b UTSW 7 102,402,952 (GRCm39) missense probably benign 0.28
R7868:Or51f23b UTSW 7 102,402,812 (GRCm39) missense possibly damaging 0.95
R8209:Or51f23b UTSW 7 102,402,950 (GRCm39) missense probably benign 0.30
R8226:Or51f23b UTSW 7 102,402,950 (GRCm39) missense probably benign 0.30
R8242:Or51f23b UTSW 7 102,402,306 (GRCm39) missense probably benign 0.01
R9180:Or51f23b UTSW 7 102,402,734 (GRCm39) missense probably damaging 1.00
Z1176:Or51f23b UTSW 7 102,402,623 (GRCm39) missense possibly damaging 0.91
Z1176:Or51f23b UTSW 7 102,402,621 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CACCAGCTTAGAAGAAATGGTGTG -3'
(R):5'- TCTCATGCACAGACACCAGG -3'

Sequencing Primer
(F):5'- CGTCTCCTCATCTGTGAAGTAAAGG -3'
(R):5'- GGATTGACTGCCATGATCTCTACTG -3'
Posted On 2019-05-15