Incidental Mutation 'R7095:Jmjd1c'
| ID |
550435 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Jmjd1c
|
| Ensembl Gene |
ENSMUSG00000037876 |
| Gene Name |
jumonji domain containing 1C |
| Synonyms |
D630035I23Rik, TRIP8, 5430433L24Rik |
| MMRRC Submission |
045243-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.662)
|
| Stock # |
R7095 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
66932189-67092105 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 67055411 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glycine
at position 277
(V277G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134246
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000051446]
[ENSMUST00000173689]
[ENSMUST00000174317]
[ENSMUST00000174408]
|
| AlphaFold |
Q69ZK6 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000051446
AA Change: V564G
PolyPhen 2
Score 0.679 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000056227
Gene: ENSMUSG00000037876
AA Change: V564G
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
143 |
2236 |
N/A |
BLAST |
|
JmjC
|
2264 |
2488 |
3.29e-53 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173689
AA Change: V383G
PolyPhen 2
Score 0.390 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000133700
Gene: ENSMUSG00000037876
AA Change: V383G
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
1 |
2056 |
N/A |
BLAST |
|
JmjC
|
2084 |
2308 |
3.29e-53 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174317
AA Change: V277G
PolyPhen 2
Score 0.390 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000134246
Gene: ENSMUSG00000037876
AA Change: V277G
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
1 |
744 |
N/A |
BLAST |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000174408
AA Change: V564G
PolyPhen 2
Score 0.795 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000134551
Gene: ENSMUSG00000037876
AA Change: V564G
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
143 |
2237 |
N/A |
BLAST |
|
JmjC
|
2265 |
2489 |
3.29e-53 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
99% (71/72) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit an age-dependent male infertility phenotype, characterized by early loss of undifferentiated spermatogonia, and a progressive reduction in testis size/weight and male germ cells, partly due to increased male germ cell apoptosis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcf1 |
A |
G |
17: 36,268,403 (GRCm39) |
V809A |
possibly damaging |
Het |
| Adam32 |
T |
A |
8: 25,404,086 (GRCm39) |
D242V |
probably damaging |
Het |
| Adamts9 |
T |
A |
6: 92,864,672 (GRCm39) |
H763L |
probably benign |
Het |
| Aff1 |
A |
G |
5: 103,990,951 (GRCm39) |
D967G |
probably damaging |
Het |
| Anpep |
A |
T |
7: 79,491,950 (GRCm39) |
L17Q |
possibly damaging |
Het |
| Appbp2 |
G |
T |
11: 85,125,553 (GRCm39) |
S28* |
probably null |
Het |
| Bach1 |
G |
A |
16: 87,516,179 (GRCm39) |
R240Q |
probably benign |
Het |
| Bod1l |
A |
G |
5: 41,952,411 (GRCm39) |
|
probably null |
Het |
| Capn5 |
G |
A |
7: 97,775,038 (GRCm39) |
T534I |
probably benign |
Het |
| Cbx2 |
T |
C |
11: 118,918,885 (GRCm39) |
I150T |
probably damaging |
Het |
| Cdh11 |
A |
G |
8: 103,384,899 (GRCm39) |
V392A |
probably damaging |
Het |
| Cenpf |
A |
T |
1: 189,391,373 (GRCm39) |
C803S |
probably benign |
Het |
| Cep135 |
A |
G |
5: 76,741,905 (GRCm39) |
T114A |
probably benign |
Het |
| Chd2 |
A |
T |
7: 73,121,629 (GRCm39) |
D994E |
probably damaging |
Het |
| Chtf18 |
C |
A |
17: 25,941,652 (GRCm39) |
W584C |
probably damaging |
Het |
| Dclk2 |
C |
T |
3: 86,700,566 (GRCm39) |
R638H |
probably damaging |
Het |
| Dgkh |
C |
A |
14: 78,865,224 (GRCm39) |
M172I |
probably benign |
Het |
| Dpy19l2 |
T |
G |
9: 24,607,110 (GRCm39) |
H117P |
probably benign |
Het |
| Dzip3 |
A |
T |
16: 48,748,153 (GRCm39) |
N908K |
probably benign |
Het |
| Erc2 |
A |
T |
14: 27,620,550 (GRCm39) |
N393Y |
probably damaging |
Het |
| Fam118b |
T |
C |
9: 35,132,786 (GRCm39) |
E291G |
possibly damaging |
Het |
| Fam193a |
C |
T |
5: 34,615,378 (GRCm39) |
L816F |
probably damaging |
Het |
| Fat2 |
A |
G |
11: 55,202,157 (GRCm39) |
Y306H |
probably damaging |
Het |
| Fndc10 |
C |
T |
4: 155,779,574 (GRCm39) |
T206I |
probably damaging |
Het |
| Fzd1 |
GGGACTCCTCCACCTCCCTGGA |
GGGA |
5: 4,805,824 (GRCm39) |
|
probably benign |
Het |
| Gsk3a |
A |
T |
7: 24,933,279 (GRCm39) |
Y177N |
probably damaging |
Het |
| Haus5 |
T |
C |
7: 30,358,997 (GRCm39) |
T222A |
probably benign |
Het |
| Igfbp7 |
G |
T |
5: 77,549,337 (GRCm39) |
Q189K |
probably benign |
Het |
| Inppl1 |
A |
T |
7: 101,476,663 (GRCm39) |
Y771* |
probably null |
Het |
| Iqck |
A |
T |
7: 118,514,814 (GRCm39) |
Y234F |
probably damaging |
Het |
| Irs1 |
G |
T |
1: 82,267,819 (GRCm39) |
C132* |
probably null |
Het |
| Klhl22 |
G |
A |
16: 17,610,614 (GRCm39) |
V622M |
probably damaging |
Het |
| Kri1 |
C |
T |
9: 21,190,728 (GRCm39) |
E378K |
|
Het |
| Lilra6 |
C |
T |
7: 3,916,196 (GRCm39) |
G221D |
probably damaging |
Het |
| Mecom |
T |
C |
3: 30,035,103 (GRCm39) |
E191G |
probably damaging |
Het |
| Mgrn1 |
T |
A |
16: 4,745,528 (GRCm39) |
|
probably null |
Het |
| Mical1 |
C |
T |
10: 41,355,206 (GRCm39) |
|
probably null |
Het |
| Mlxipl |
T |
C |
5: 135,162,884 (GRCm39) |
Y711H |
possibly damaging |
Het |
| Mpl |
T |
A |
4: 118,301,260 (GRCm39) |
H535L |
|
Het |
| Mtarc1 |
A |
G |
1: 184,527,437 (GRCm39) |
L297P |
probably damaging |
Het |
| Mtfr2 |
C |
A |
10: 20,228,666 (GRCm39) |
H71N |
probably benign |
Het |
| Mtrf1 |
GCCTTC |
GC |
14: 79,660,931 (GRCm39) |
|
probably null |
Het |
| Myh15 |
A |
G |
16: 48,992,272 (GRCm39) |
Q1582R |
possibly damaging |
Het |
| Neb |
C |
T |
2: 52,067,635 (GRCm39) |
E6062K |
possibly damaging |
Het |
| Nlrp4c |
G |
A |
7: 6,063,792 (GRCm39) |
A67T |
probably damaging |
Het |
| Noc3l |
T |
A |
19: 38,800,789 (GRCm39) |
H231L |
probably benign |
Het |
| Odf1 |
T |
C |
15: 38,219,803 (GRCm39) |
Y44H |
possibly damaging |
Het |
| Or52e2 |
G |
A |
7: 102,804,537 (GRCm39) |
T139I |
probably damaging |
Het |
| Or52s1b |
C |
T |
7: 102,822,253 (GRCm39) |
R197H |
probably benign |
Het |
| Or5j3 |
C |
T |
2: 86,129,021 (GRCm39) |
P287L |
probably benign |
Het |
| Otol1 |
G |
T |
3: 69,926,027 (GRCm39) |
E67D |
probably benign |
Het |
| Otud7b |
A |
G |
3: 96,062,554 (GRCm39) |
S598G |
probably benign |
Het |
| Ppwd1 |
T |
A |
13: 104,342,134 (GRCm39) |
T607S |
probably benign |
Het |
| Prag1 |
A |
G |
8: 36,569,714 (GRCm39) |
N99S |
probably benign |
Het |
| Ralgds |
C |
A |
2: 28,439,320 (GRCm39) |
Q737K |
possibly damaging |
Het |
| Scyl2 |
T |
C |
10: 89,505,549 (GRCm39) |
H98R |
probably damaging |
Het |
| Secisbp2 |
A |
C |
13: 51,831,290 (GRCm39) |
Q575H |
probably benign |
Het |
| Slc9a5 |
A |
T |
8: 106,084,268 (GRCm39) |
H497L |
probably benign |
Het |
| Sufu |
T |
A |
19: 46,464,027 (GRCm39) |
V414E |
probably damaging |
Het |
| Tbc1d22b |
A |
T |
17: 29,818,843 (GRCm39) |
E399V |
probably damaging |
Het |
| Tcp10c |
G |
A |
17: 13,576,196 (GRCm39) |
V59I |
probably benign |
Het |
| Tdpoz3 |
T |
C |
3: 93,734,368 (GRCm39) |
S348P |
probably benign |
Het |
| Tmem219 |
A |
T |
7: 126,490,928 (GRCm39) |
F176L |
probably damaging |
Het |
| Trav6-2 |
A |
G |
14: 52,905,291 (GRCm39) |
D104G |
probably damaging |
Het |
| Uba7 |
A |
G |
9: 107,860,538 (GRCm39) |
K927R |
probably benign |
Het |
| Vps54 |
T |
G |
11: 21,221,720 (GRCm39) |
D158E |
probably benign |
Het |
| Xpnpep1 |
C |
T |
19: 53,000,196 (GRCm39) |
|
probably null |
Het |
| Xpo7 |
G |
A |
14: 70,942,146 (GRCm39) |
R73W |
probably damaging |
Het |
| Zfp532 |
A |
T |
18: 65,815,969 (GRCm39) |
M781L |
probably benign |
Het |
| Zfp930 |
T |
A |
8: 69,681,193 (GRCm39) |
I295K |
probably benign |
Het |
|
| Other mutations in Jmjd1c |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01062:Jmjd1c
|
APN |
10 |
67,062,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01604:Jmjd1c
|
APN |
10 |
67,085,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01753:Jmjd1c
|
APN |
10 |
67,067,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02081:Jmjd1c
|
APN |
10 |
67,055,305 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02128:Jmjd1c
|
APN |
10 |
67,079,648 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02134:Jmjd1c
|
APN |
10 |
67,056,171 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02215:Jmjd1c
|
APN |
10 |
67,056,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02408:Jmjd1c
|
APN |
10 |
67,062,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02502:Jmjd1c
|
APN |
10 |
67,061,640 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02546:Jmjd1c
|
APN |
10 |
67,061,115 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02943:Jmjd1c
|
APN |
10 |
67,055,433 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03171:Jmjd1c
|
APN |
10 |
67,061,277 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL03261:Jmjd1c
|
APN |
10 |
67,067,849 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Accordion
|
UTSW |
10 |
67,069,193 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4378001:Jmjd1c
|
UTSW |
10 |
67,065,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0126:Jmjd1c
|
UTSW |
10 |
67,055,105 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0133:Jmjd1c
|
UTSW |
10 |
67,076,587 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0201:Jmjd1c
|
UTSW |
10 |
67,054,888 (GRCm39) |
missense |
unknown |
|
|
R0396:Jmjd1c
|
UTSW |
10 |
67,055,302 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R0401:Jmjd1c
|
UTSW |
10 |
67,056,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0452:Jmjd1c
|
UTSW |
10 |
67,091,261 (GRCm39) |
missense |
probably benign |
0.28 |
|
R0488:Jmjd1c
|
UTSW |
10 |
67,076,506 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0504:Jmjd1c
|
UTSW |
10 |
67,061,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0555:Jmjd1c
|
UTSW |
10 |
67,061,568 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0673:Jmjd1c
|
UTSW |
10 |
67,062,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0718:Jmjd1c
|
UTSW |
10 |
67,054,725 (GRCm39) |
splice site |
probably null |
|
|
R0755:Jmjd1c
|
UTSW |
10 |
66,932,378 (GRCm39) |
intron |
probably benign |
|
|
R1142:Jmjd1c
|
UTSW |
10 |
67,061,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1196:Jmjd1c
|
UTSW |
10 |
67,075,015 (GRCm39) |
splice site |
probably benign |
|
|
R1413:Jmjd1c
|
UTSW |
10 |
67,085,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1619:Jmjd1c
|
UTSW |
10 |
67,055,654 (GRCm39) |
missense |
probably benign |
0.25 |
|
R1676:Jmjd1c
|
UTSW |
10 |
67,060,588 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1751:Jmjd1c
|
UTSW |
10 |
67,061,469 (GRCm39) |
missense |
probably benign |
|
|
R1950:Jmjd1c
|
UTSW |
10 |
67,075,701 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1968:Jmjd1c
|
UTSW |
10 |
67,061,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2049:Jmjd1c
|
UTSW |
10 |
66,993,777 (GRCm39) |
nonsense |
probably null |
|
|
R2061:Jmjd1c
|
UTSW |
10 |
67,054,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2202:Jmjd1c
|
UTSW |
10 |
67,075,242 (GRCm39) |
splice site |
probably null |
|
|
R2203:Jmjd1c
|
UTSW |
10 |
67,075,242 (GRCm39) |
splice site |
probably null |
|
|
R2256:Jmjd1c
|
UTSW |
10 |
67,061,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2312:Jmjd1c
|
UTSW |
10 |
67,074,629 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2349:Jmjd1c
|
UTSW |
10 |
67,091,279 (GRCm39) |
missense |
probably benign |
|
|
R2392:Jmjd1c
|
UTSW |
10 |
67,065,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3015:Jmjd1c
|
UTSW |
10 |
66,993,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3110:Jmjd1c
|
UTSW |
10 |
67,075,863 (GRCm39) |
splice site |
probably benign |
|
|
R4043:Jmjd1c
|
UTSW |
10 |
67,055,245 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4097:Jmjd1c
|
UTSW |
10 |
67,054,787 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4118:Jmjd1c
|
UTSW |
10 |
67,055,532 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4193:Jmjd1c
|
UTSW |
10 |
66,932,460 (GRCm39) |
intron |
probably benign |
|
|
R4352:Jmjd1c
|
UTSW |
10 |
67,080,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4577:Jmjd1c
|
UTSW |
10 |
67,085,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4630:Jmjd1c
|
UTSW |
10 |
66,993,753 (GRCm39) |
nonsense |
probably null |
|
|
R4717:Jmjd1c
|
UTSW |
10 |
66,993,830 (GRCm39) |
nonsense |
probably null |
|
|
R4741:Jmjd1c
|
UTSW |
10 |
67,060,718 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R4774:Jmjd1c
|
UTSW |
10 |
67,060,571 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R4836:Jmjd1c
|
UTSW |
10 |
67,069,225 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4914:Jmjd1c
|
UTSW |
10 |
67,054,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4939:Jmjd1c
|
UTSW |
10 |
67,081,916 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5211:Jmjd1c
|
UTSW |
10 |
67,067,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5215:Jmjd1c
|
UTSW |
10 |
67,076,480 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5514:Jmjd1c
|
UTSW |
10 |
67,053,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5530:Jmjd1c
|
UTSW |
10 |
67,085,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5624:Jmjd1c
|
UTSW |
10 |
67,069,193 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5640:Jmjd1c
|
UTSW |
10 |
67,061,857 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5654:Jmjd1c
|
UTSW |
10 |
67,065,785 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5742:Jmjd1c
|
UTSW |
10 |
67,056,112 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5764:Jmjd1c
|
UTSW |
10 |
67,062,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6118:Jmjd1c
|
UTSW |
10 |
67,075,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6163:Jmjd1c
|
UTSW |
10 |
67,083,827 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6256:Jmjd1c
|
UTSW |
10 |
67,056,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6266:Jmjd1c
|
UTSW |
10 |
67,085,439 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6358:Jmjd1c
|
UTSW |
10 |
67,061,718 (GRCm39) |
missense |
probably benign |
|
|
R6430:Jmjd1c
|
UTSW |
10 |
67,059,939 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6455:Jmjd1c
|
UTSW |
10 |
67,061,795 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6887:Jmjd1c
|
UTSW |
10 |
67,025,599 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R6895:Jmjd1c
|
UTSW |
10 |
67,052,869 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7041:Jmjd1c
|
UTSW |
10 |
67,056,388 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7113:Jmjd1c
|
UTSW |
10 |
66,993,780 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7225:Jmjd1c
|
UTSW |
10 |
67,061,844 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7249:Jmjd1c
|
UTSW |
10 |
67,025,596 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7361:Jmjd1c
|
UTSW |
10 |
67,054,143 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7383:Jmjd1c
|
UTSW |
10 |
67,025,537 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7460:Jmjd1c
|
UTSW |
10 |
67,052,815 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7475:Jmjd1c
|
UTSW |
10 |
67,061,092 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7502:Jmjd1c
|
UTSW |
10 |
67,067,794 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7699:Jmjd1c
|
UTSW |
10 |
67,054,195 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7745:Jmjd1c
|
UTSW |
10 |
67,052,824 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7897:Jmjd1c
|
UTSW |
10 |
67,075,644 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7908:Jmjd1c
|
UTSW |
10 |
67,061,621 (GRCm39) |
missense |
probably benign |
|
|
R7911:Jmjd1c
|
UTSW |
10 |
67,067,774 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7967:Jmjd1c
|
UTSW |
10 |
67,085,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8058:Jmjd1c
|
UTSW |
10 |
67,090,274 (GRCm39) |
missense |
not run |
|
|
R8224:Jmjd1c
|
UTSW |
10 |
67,080,628 (GRCm39) |
missense |
noncoding transcript |
|
|
R8251:Jmjd1c
|
UTSW |
10 |
67,075,068 (GRCm39) |
missense |
noncoding transcript |
|
|
R8797:Jmjd1c
|
UTSW |
10 |
67,060,616 (GRCm39) |
missense |
probably benign |
|
|
R8833:Jmjd1c
|
UTSW |
10 |
67,054,162 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9262:Jmjd1c
|
UTSW |
10 |
67,083,793 (GRCm39) |
missense |
probably benign |
0.39 |
|
R9354:Jmjd1c
|
UTSW |
10 |
67,059,875 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9373:Jmjd1c
|
UTSW |
10 |
66,932,495 (GRCm39) |
intron |
probably benign |
|
|
R9477:Jmjd1c
|
UTSW |
10 |
66,993,734 (GRCm39) |
nonsense |
probably null |
|
|
R9519:Jmjd1c
|
UTSW |
10 |
66,993,798 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9701:Jmjd1c
|
UTSW |
10 |
67,060,745 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9802:Jmjd1c
|
UTSW |
10 |
67,060,745 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
RF011:Jmjd1c
|
UTSW |
10 |
67,055,978 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
Z1088:Jmjd1c
|
UTSW |
10 |
67,073,953 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Jmjd1c
|
UTSW |
10 |
67,073,953 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Jmjd1c
|
UTSW |
10 |
67,081,904 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1177:Jmjd1c
|
UTSW |
10 |
67,073,953 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGGAAAACCAACGCACAGTG -3'
(R):5'- TGCCTTCTGGGTATCTACTGAAG -3'
Sequencing Primer
(F):5'- TTACCAAAGGACAGGTTAGTGTC -3'
(R):5'- TTCTGGGTATCTACTGAAGTAGTTAG -3'
|
| Posted On |
2019-05-15 |
Incidental Mutation