|Institutional Source||Beutler Lab|
|Gene Name||chemokine (C-C motif) ligand 28|
|Is this an essential gene?||Not available|
|Stock #||R7096 (G1)|
|Chromosomal Location||119623819-119654359 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 119650893 bp|
|Amino Acid Change||Isoleucine to Valine at position 74 (I74V)|
|Ref Sequence||ENSEMBL: ENSMUSP00000096847 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000099241]|
|Predicted Effect||probably benign
AA Change: I74V
PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
AA Change: I74V
|Coding Region Coverage||
|Validation Efficiency||97% (68/70)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ccl28||
(F):5'- GGCTACTCACAAGTCACTAGTTC -3'
(R):5'- TTCTAACGAGAGGCTTCGTGC -3'
(F):5'- CACAGGCAGGATTTCTCTATGTAGC -3'
(R):5'- CGTGCCTGTGTGTTCCAC -3'