Mutagenetix > Incidental Mutation

Incidental Mutation 'R7097:Olfr934'

550568

Institutional Source

Beutler Lab

Gene Symbol

Olfr934

Ensembl Gene

ENSMUSG00000057424

Gene Name

olfactory receptor 934

Synonyms

MOR224-6, GA_x6K02T2PVTD-32678895-32677963

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

R7097 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

38981026-38988315 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 38982618 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 142 (M142K)

Ref Sequence

ENSEMBL: ENSMUSP00000150864 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074211] [ENSMUST00000214324] [ENSMUST00000216238] [ENSMUST00000216823]

AlphaFold

Q9EQ87

Predicted Effect

probably benign
Transcript: ENSMUST00000074211
AA Change: M142K

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000073835
Gene: ENSMUSG00000057424
AA Change: M142K

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	304	1.7e-48	PFAM
Pfam:7TM_GPCR_Srsx	33	222	7.2e-9	PFAM
Pfam:7tm_1	39	286	5.4e-20	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214324
AA Change: M142K

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)

Predicted Effect

probably benign
Transcript: ENSMUST00000216238

Predicted Effect

probably benign
Transcript: ENSMUST00000216823
AA Change: M142K

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)

Meta Mutation Damage Score

0.0846

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

99% (75/76)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 75 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700010I14Rik	A	G	17: 9,005,220	N435S	probably damaging	Het
Aip	A	T	19: 4,115,381	V195E	probably benign	Het
Amer3	A	T	1: 34,588,788	I703F	probably benign	Het
Amfr	T	C	8: 94,012,009	E7G	probably benign	Het
Angel1	A	G	12: 86,726,384	S4P	probably damaging	Het
Atp2c1	A	G	9: 105,464,651	I146T	probably damaging	Het
Atp6v0e	A	G	17: 26,695,416	T72A	probably benign	Het
Bahcc1	T	C	11: 120,272,646	V590A	possibly damaging	Het
Bcl6	A	G	16: 23,972,614	V330A	possibly damaging	Het
Bcl6	T	C	16: 23,972,902	D234G	probably damaging	Het
Btaf1	C	T	19: 36,949,102	T58I	probably damaging	Het
Ccdc175	A	T	12: 72,128,409		probably null	Het
Cdca4	C	A	12: 112,821,569	V180L	probably benign	Het
Ces1g	C	A	8: 93,317,037	G425C	possibly damaging	Het
Chl1	T	C	6: 103,706,448	L745P	probably damaging	Het
Clec4g	T	A	8: 3,719,518	T42S	possibly damaging	Het
Ctsg	A	C	14: 56,100,032	I238S	probably damaging	Het
Cyb5rl	A	T	4: 107,087,316	E41V	unknown	Het
Dcdc2a	A	G	13: 25,107,698	E222G	probably benign	Het
Dnaaf1	G	T	8: 119,596,799	G509V	possibly damaging	Het
Dnah5	A	G	15: 28,453,264	I4394V	probably benign	Het
Dot1l	T	G	10: 80,790,726	S1260R	probably damaging	Het
Dst	T	G	1: 34,169,260	I1089S	probably damaging	Het
Eps8l3	A	G	3: 107,884,485		probably null	Het
Fam135b	A	G	15: 71,622,068	V4A	possibly damaging	Het
Fnip2	T	C	3: 79,481,006	E806G	probably benign	Het
Fryl	T	A	5: 73,073,908	I1609F	probably benign	Het
Gdi1	G	A	X: 74,306,855	R55H	probably benign	Het
Gm11639	A	T	11: 105,008,961	I4350F	possibly damaging	Het
Gsn	A	T	2: 35,295,049	K339*	probably null	Het
Hecw2	T	A	1: 53,865,124	Y1155F	possibly damaging	Het
Kif20b	T	A	19: 34,974,492	N1723K	probably damaging	Het
Kif2b	T	C	11: 91,576,824	D211G	probably benign	Het
Lhfpl4	C	T	6: 113,176,671	V140I	probably benign	Het
Med16	C	T	10: 79,903,343	G203D	probably damaging	Het
Mrgpra3	T	A	7: 47,589,641	Y179F	probably benign	Het
Muc6	AGGCGCAGAAACCCTGGC	AGGC	7: 141,634,450		probably null	Het
Myo18b	A	G	5: 112,874,405	S374P	unknown	Het
Myoz1	A	G	14: 20,649,409	I287T	possibly damaging	Het
Ncoa6	T	C	2: 155,438,063	D11G	probably benign	Het
Nlrp9c	A	G	7: 26,385,621	Y178H	probably damaging	Het
Nmur1	T	C	1: 86,387,508	T212A	probably damaging	Het
Oacyl	A	G	18: 65,720,252	D143G	probably benign	Het
Obox5	A	G	7: 15,758,807	Y229C	probably damaging	Het
Olfr340	A	G	2: 36,452,690	Y35C	probably damaging	Het
Olfr347	G	T	2: 36,734,424	M34I	probably benign	Het
Olfr54	C	A	11: 51,027,601	L200I	probably benign	Het
Olfr891	A	T	9: 38,180,336	C162*	probably null	Het
Pcdhb17	A	C	18: 37,486,513	N452T	probably benign	Het
Pear1	T	G	3: 87,751,445	H901P	probably benign	Het
Pi16	A	G	17: 29,326,339	Y192C	probably damaging	Het
Pip5k1b	T	G	19: 24,358,060	E362D	probably damaging	Het
Pla2g5	T	C	4: 138,804,519	D58G	probably damaging	Het
Pole	T	A	5: 110,325,102		probably null	Het
Prdm16	G	T	4: 154,345,468	T348K	probably damaging	Het
Prkdc	T	A	16: 15,689,343	F896I	probably damaging	Het
Prmt7	T	C	8: 106,235,100	F215S	unknown	Het
Prss23	T	A	7: 89,510,184	T226S	probably damaging	Het
Ptpn14	G	A	1: 189,863,398	W739*	probably null	Het
Rfx5	G	T	3: 94,956,539	G135C	probably damaging	Het
Scmh1	A	G	4: 120,525,055	H573R	probably benign	Het
Serpina5	G	T	12: 104,102,295		probably null	Het
Sh3rf2	G	A	18: 42,104,162		probably null	Het
Slc38a2	T	C	15: 96,693,301	M229V	probably damaging	Het
Slc6a17	C	G	3: 107,493,148	G222R	probably damaging	Het
Sp110	C	T	1: 85,579,685	G367D	possibly damaging	Het
Srcap	C	A	7: 127,539,041	L1128M	probably damaging	Het
Tmem189	C	G	2: 167,661,478	A7P	probably benign	Het
Tpra1	T	A	6: 88,908,294	I76N	probably damaging	Het
Trav6-4	A	T	14: 53,454,592	Y52F	probably benign	Het
Trp63	C	A	16: 25,820,477	H138Q	probably damaging	Het
Trub2	A	G	2: 29,779,826	V177A	possibly damaging	Het
Ugt2a2	T	C	5: 87,460,396	D528G	possibly damaging	Het
Wnk2	C	A	13: 49,102,838	R269L	possibly damaging	Het
Zc3h12c	T	A	9: 52,115,926	Q731L	possibly damaging	Het

Other mutations in Olfr934

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02156:Olfr934	APN	9	38982546	missense	possibly damaging	0.71
R1061:Olfr934	UTSW	9	38982483	missense	probably damaging	1.00
R1604:Olfr934	UTSW	9	38982618	missense	probably benign	0.01
R1776:Olfr934	UTSW	9	38982894	missense	probably damaging	1.00
R3499:Olfr934	UTSW	9	38982465	missense	probably damaging	1.00
R3761:Olfr934	UTSW	9	38982366	missense	possibly damaging	0.94
R3876:Olfr934	UTSW	9	38982870	missense	probably damaging	1.00
R4191:Olfr934	UTSW	9	38983017	missense	probably benign	0.01
R4192:Olfr934	UTSW	9	38983017	missense	probably benign	0.01
R4333:Olfr934	UTSW	9	38982588	missense	possibly damaging	0.85
R4876:Olfr934	UTSW	9	38982626	nonsense	probably null
R5539:Olfr934	UTSW	9	38982277	missense	possibly damaging	0.85
R6916:Olfr934	UTSW	9	38982904	missense	probably benign	0.14
R7338:Olfr934	UTSW	9	38982520	missense	probably damaging	0.99
R8116:Olfr934	UTSW	9	38982873	missense	probably damaging	1.00
R9350:Olfr934	UTSW	9	38982785	missense	probably benign	0.04

Predicted Primers

PCR Primer
(F):5'- ACCCACCATCTCTAGGGTTG -3'
(R):5'- GGCTTCACACTCCCATGTAC -3'

Sequencing Primer
(F):5'- CCACCATCTCTAGGGTTGATGTG -3'
(R):5'- CTGTTCTACCTCTCAGGAAATAGCAG -3'

Posted On

2019-05-15