Incidental Mutation 'R7097:Olfr934'
ID 550568
Institutional Source Beutler Lab
Gene Symbol Olfr934
Ensembl Gene ENSMUSG00000057424
Gene Name olfactory receptor 934
Synonyms MOR224-6, GA_x6K02T2PVTD-32678895-32677963
MMRRC Submission 045189-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R7097 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 38981026-38988315 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 38982618 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 142 (M142K)
Ref Sequence ENSEMBL: ENSMUSP00000150864 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074211] [ENSMUST00000214324] [ENSMUST00000216238] [ENSMUST00000216823]
AlphaFold Q9EQ87
Predicted Effect probably benign
Transcript: ENSMUST00000074211
AA Change: M142K

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000073835
Gene: ENSMUSG00000057424
AA Change: M142K

DomainStartEndE-ValueType
Pfam:7tm_4 29 304 1.7e-48 PFAM
Pfam:7TM_GPCR_Srsx 33 222 7.2e-9 PFAM
Pfam:7tm_1 39 286 5.4e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214324
AA Change: M142K

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
Predicted Effect probably benign
Transcript: ENSMUST00000216238
Predicted Effect probably benign
Transcript: ENSMUST00000216823
AA Change: M142K

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 99% (75/76)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700010I14Rik A G 17: 9,005,220 (GRCm38) N435S probably damaging Het
Aip A T 19: 4,115,381 (GRCm38) V195E probably benign Het
Amer3 A T 1: 34,588,788 (GRCm38) I703F probably benign Het
Amfr T C 8: 94,012,009 (GRCm38) E7G probably benign Het
Angel1 A G 12: 86,726,384 (GRCm38) S4P probably damaging Het
Atp2c1 A G 9: 105,464,651 (GRCm38) I146T probably damaging Het
Atp6v0e A G 17: 26,695,416 (GRCm38) T72A probably benign Het
Bahcc1 T C 11: 120,272,646 (GRCm38) V590A possibly damaging Het
Bcl6 T C 16: 23,972,902 (GRCm38) D234G probably damaging Het
Bcl6 A G 16: 23,972,614 (GRCm38) V330A possibly damaging Het
Btaf1 C T 19: 36,949,102 (GRCm38) T58I probably damaging Het
Ccdc175 A T 12: 72,128,409 (GRCm38) probably null Het
Cdca4 C A 12: 112,821,569 (GRCm38) V180L probably benign Het
Ces1g C A 8: 93,317,037 (GRCm38) G425C possibly damaging Het
Chl1 T C 6: 103,706,448 (GRCm38) L745P probably damaging Het
Clec4g T A 8: 3,719,518 (GRCm38) T42S possibly damaging Het
Ctsg A C 14: 56,100,032 (GRCm38) I238S probably damaging Het
Cyb5rl A T 4: 107,087,316 (GRCm38) E41V unknown Het
Dcdc2a A G 13: 25,107,698 (GRCm38) E222G probably benign Het
Dnaaf1 G T 8: 119,596,799 (GRCm38) G509V possibly damaging Het
Dnah5 A G 15: 28,453,264 (GRCm38) I4394V probably benign Het
Dot1l T G 10: 80,790,726 (GRCm38) S1260R probably damaging Het
Dst T G 1: 34,169,260 (GRCm38) I1089S probably damaging Het
Eps8l3 A G 3: 107,884,485 (GRCm38) probably null Het
Fam135b A G 15: 71,622,068 (GRCm38) V4A possibly damaging Het
Fnip2 T C 3: 79,481,006 (GRCm38) E806G probably benign Het
Fryl T A 5: 73,073,908 (GRCm38) I1609F probably benign Het
Gdi1 G A X: 74,306,855 (GRCm38) R55H probably benign Het
Gm11639 A T 11: 105,008,961 (GRCm38) I4350F possibly damaging Het
Gsn A T 2: 35,295,049 (GRCm38) K339* probably null Het
Hecw2 T A 1: 53,865,124 (GRCm38) Y1155F possibly damaging Het
Kif20b T A 19: 34,974,492 (GRCm38) N1723K probably damaging Het
Kif2b T C 11: 91,576,824 (GRCm38) D211G probably benign Het
Lhfpl4 C T 6: 113,176,671 (GRCm38) V140I probably benign Het
Med16 C T 10: 79,903,343 (GRCm38) G203D probably damaging Het
Mrgpra3 T A 7: 47,589,641 (GRCm38) Y179F probably benign Het
Muc6 AGGCGCAGAAACCCTGGC AGGC 7: 141,634,450 (GRCm38) probably null Het
Myo18b A G 5: 112,874,405 (GRCm38) S374P unknown Het
Myoz1 A G 14: 20,649,409 (GRCm38) I287T possibly damaging Het
Ncoa6 T C 2: 155,438,063 (GRCm38) D11G probably benign Het
Nlrp9c A G 7: 26,385,621 (GRCm38) Y178H probably damaging Het
Nmur1 T C 1: 86,387,508 (GRCm38) T212A probably damaging Het
Oacyl A G 18: 65,720,252 (GRCm38) D143G probably benign Het
Obox5 A G 7: 15,758,807 (GRCm38) Y229C probably damaging Het
Olfr340 A G 2: 36,452,690 (GRCm38) Y35C probably damaging Het
Olfr347 G T 2: 36,734,424 (GRCm38) M34I probably benign Het
Olfr54 C A 11: 51,027,601 (GRCm38) L200I probably benign Het
Olfr891 A T 9: 38,180,336 (GRCm38) C162* probably null Het
Pcdhb17 A C 18: 37,486,513 (GRCm38) N452T probably benign Het
Pear1 T G 3: 87,751,445 (GRCm38) H901P probably benign Het
Pi16 A G 17: 29,326,339 (GRCm38) Y192C probably damaging Het
Pip5k1b T G 19: 24,358,060 (GRCm38) E362D probably damaging Het
Pla2g5 T C 4: 138,804,519 (GRCm38) D58G probably damaging Het
Pole T A 5: 110,325,102 (GRCm38) probably null Het
Prdm16 G T 4: 154,345,468 (GRCm38) T348K probably damaging Het
Prkdc T A 16: 15,689,343 (GRCm38) F896I probably damaging Het
Prmt7 T C 8: 106,235,100 (GRCm38) F215S unknown Het
Prss23 T A 7: 89,510,184 (GRCm38) T226S probably damaging Het
Ptpn14 G A 1: 189,863,398 (GRCm38) W739* probably null Het
Rfx5 G T 3: 94,956,539 (GRCm38) G135C probably damaging Het
Scmh1 A G 4: 120,525,055 (GRCm38) H573R probably benign Het
Serpina5 G T 12: 104,102,295 (GRCm38) probably null Het
Sh3rf2 G A 18: 42,104,162 (GRCm38) probably null Het
Slc38a2 T C 15: 96,693,301 (GRCm38) M229V probably damaging Het
Slc6a17 C G 3: 107,493,148 (GRCm38) G222R probably damaging Het
Sp110 C T 1: 85,579,685 (GRCm38) G367D possibly damaging Het
Srcap C A 7: 127,539,041 (GRCm38) L1128M probably damaging Het
Tmem189 C G 2: 167,661,478 (GRCm38) A7P probably benign Het
Tpra1 T A 6: 88,908,294 (GRCm38) I76N probably damaging Het
Trav6-4 A T 14: 53,454,592 (GRCm38) Y52F probably benign Het
Trp63 C A 16: 25,820,477 (GRCm38) H138Q probably damaging Het
Trub2 A G 2: 29,779,826 (GRCm38) V177A possibly damaging Het
Ugt2a2 T C 5: 87,460,396 (GRCm38) D528G possibly damaging Het
Wnk2 C A 13: 49,102,838 (GRCm38) R269L possibly damaging Het
Zc3h12c T A 9: 52,115,926 (GRCm38) Q731L possibly damaging Het
Other mutations in Olfr934
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02156:Olfr934 APN 9 38,982,546 (GRCm38) missense possibly damaging 0.71
R1061:Olfr934 UTSW 9 38,982,483 (GRCm38) missense probably damaging 1.00
R1604:Olfr934 UTSW 9 38,982,618 (GRCm38) missense probably benign 0.01
R1776:Olfr934 UTSW 9 38,982,894 (GRCm38) missense probably damaging 1.00
R3499:Olfr934 UTSW 9 38,982,465 (GRCm38) missense probably damaging 1.00
R3761:Olfr934 UTSW 9 38,982,366 (GRCm38) missense possibly damaging 0.94
R3876:Olfr934 UTSW 9 38,982,870 (GRCm38) missense probably damaging 1.00
R4191:Olfr934 UTSW 9 38,983,017 (GRCm38) missense probably benign 0.01
R4192:Olfr934 UTSW 9 38,983,017 (GRCm38) missense probably benign 0.01
R4333:Olfr934 UTSW 9 38,982,588 (GRCm38) missense possibly damaging 0.85
R4876:Olfr934 UTSW 9 38,982,626 (GRCm38) nonsense probably null
R5539:Olfr934 UTSW 9 38,982,277 (GRCm38) missense possibly damaging 0.85
R6916:Olfr934 UTSW 9 38,982,904 (GRCm38) missense probably benign 0.14
R7338:Olfr934 UTSW 9 38,982,520 (GRCm38) missense probably damaging 0.99
R8116:Olfr934 UTSW 9 38,982,873 (GRCm38) missense probably damaging 1.00
R9350:Olfr934 UTSW 9 38,982,785 (GRCm38) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- ACCCACCATCTCTAGGGTTG -3'
(R):5'- GGCTTCACACTCCCATGTAC -3'

Sequencing Primer
(F):5'- CCACCATCTCTAGGGTTGATGTG -3'
(R):5'- CTGTTCTACCTCTCAGGAAATAGCAG -3'
Posted On 2019-05-15