Incidental Mutation 'R0595:Zfp428'
ID 55060
Institutional Source Beutler Lab
Gene Symbol Zfp428
Ensembl Gene ENSMUSG00000064264
Gene Name zinc finger protein 428
Synonyms 2410005H09Rik
MMRRC Submission 038785-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.165) question?
Stock # R0595 (G1)
Quality Score 166
Status Validated
Chromosome 7
Chromosomal Location 24206431-24215107 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 24214803 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 140 (S140T)
Ref Sequence ENSEMBL: ENSMUSP00000135750 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071361] [ENSMUST00000176880] [ENSMUST00000177205] [ENSMUST00000177228]
AlphaFold Q8C1M2
Predicted Effect probably benign
Transcript: ENSMUST00000071361
AA Change: S127T

PolyPhen 2 Score 0.085 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000071318
Gene: ENSMUSG00000064264
AA Change: S127T

DomainStartEndE-ValueType
low complexity region 15 45 N/A INTRINSIC
low complexity region 55 70 N/A INTRINSIC
low complexity region 120 134 N/A INTRINSIC
low complexity region 138 147 N/A INTRINSIC
ZnF_C2H2 149 171 2.67e-1 SMART
Predicted Effect unknown
Transcript: ENSMUST00000176880
AA Change: S140T
SMART Domains Protein: ENSMUSP00000135601
Gene: ENSMUSG00000064264
AA Change: S140T

DomainStartEndE-ValueType
low complexity region 38 58 N/A INTRINSIC
low complexity region 68 83 N/A INTRINSIC
low complexity region 133 147 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000177205
AA Change: S140T

PolyPhen 2 Score 0.271 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000135750
Gene: ENSMUSG00000064264
AA Change: S140T

DomainStartEndE-ValueType
low complexity region 38 58 N/A INTRINSIC
low complexity region 68 83 N/A INTRINSIC
low complexity region 133 147 N/A INTRINSIC
low complexity region 151 160 N/A INTRINSIC
ZnF_C2H2 162 184 2.67e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000177228
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.3%
  • 20x: 94.5%
Validation Efficiency 100% (50/50)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1a T A 5: 8,790,417 (GRCm39) D1093E probably damaging Het
Aldh2 G T 5: 121,711,563 (GRCm39) A276D probably damaging Het
Aldh2 C T 5: 121,711,564 (GRCm39) A276T probably damaging Het
Aldh7a1 C T 18: 56,679,965 (GRCm39) probably benign Het
Ano1 C T 7: 144,143,890 (GRCm39) R964H possibly damaging Het
Apob G A 12: 8,058,369 (GRCm39) V2251I probably benign Het
Atp6v1e1 A G 6: 120,778,091 (GRCm39) V148A probably benign Het
Bbs9 T A 9: 22,408,111 (GRCm39) H73Q probably benign Het
Brca1 A G 11: 101,415,713 (GRCm39) V807A probably benign Het
Cacna1b C T 2: 24,540,001 (GRCm39) probably benign Het
Cadps2 A T 6: 23,321,703 (GRCm39) probably null Het
Cep152 T C 2: 125,436,983 (GRCm39) Q519R probably damaging Het
Cep295 A C 9: 15,243,487 (GRCm39) Y1608* probably null Het
Cfap54 T C 10: 92,720,598 (GRCm39) I2619V unknown Het
Dnajb9 A G 12: 44,255,067 (GRCm39) V7A probably benign Het
Ep400 T C 5: 110,851,408 (GRCm39) K1358R unknown Het
Fbxw7 C A 3: 84,884,674 (GRCm39) probably null Het
Fsip2 T C 2: 82,777,296 (GRCm39) Y108H probably damaging Het
Ggt6 T A 11: 72,328,493 (GRCm39) L331Q probably damaging Het
Ifitm1 T A 7: 140,548,242 (GRCm39) I25N possibly damaging Het
Krt75 C T 15: 101,476,789 (GRCm39) E367K probably damaging Het
Lifr A G 15: 7,206,950 (GRCm39) Y487C probably damaging Het
Map3k6 G T 4: 132,968,574 (GRCm39) G59W probably damaging Het
Mme A G 3: 63,235,602 (GRCm39) T129A probably benign Het
Mmp10 G A 9: 7,508,199 (GRCm39) E442K probably benign Het
Myh13 T C 11: 67,235,672 (GRCm39) S646P probably benign Het
Nbea A T 3: 55,535,917 (GRCm39) I2889N probably benign Het
Nlrp4d T A 7: 10,114,972 (GRCm39) K581N probably benign Het
Nr3c2 C T 8: 77,636,233 (GRCm39) P445S possibly damaging Het
Or5p63 A T 7: 107,810,868 (GRCm39) N289K probably damaging Het
Pck1 T A 2: 172,998,822 (GRCm39) V360E probably damaging Het
Plekha7 T C 7: 115,744,203 (GRCm39) D766G probably damaging Het
Prag1 A G 8: 36,614,156 (GRCm39) N1236S probably damaging Het
Prkdc A C 16: 15,625,952 (GRCm39) Q3326P probably damaging Het
Prrc2b T C 2: 32,073,189 (GRCm39) M57T probably damaging Het
Rb1 A T 14: 73,511,120 (GRCm39) F330I probably damaging Het
Rufy4 A G 1: 74,180,089 (GRCm39) E448G possibly damaging Het
Scn10a T A 9: 119,495,129 (GRCm39) M371L probably benign Het
Sgta T C 10: 80,884,742 (GRCm39) D189G probably damaging Het
Spata31d1b A G 13: 59,864,091 (GRCm39) H413R probably benign Het
Stau2 T C 1: 16,510,674 (GRCm39) T95A probably damaging Het
Supt4a C T 11: 87,633,982 (GRCm39) probably null Het
Tanc2 A G 11: 105,605,003 (GRCm39) probably null Het
Tap2 T A 17: 34,431,328 (GRCm39) V422D probably damaging Het
Tas2r138 A G 6: 40,589,799 (GRCm39) L149P probably damaging Het
Tex15 T C 8: 34,062,645 (GRCm39) S692P probably damaging Het
Tgm2 C T 2: 157,984,962 (GRCm39) R48H probably damaging Het
Ticrr T A 7: 79,345,311 (GRCm39) F1725L possibly damaging Het
Tnpo2 T A 8: 85,778,670 (GRCm39) C672* probably null Het
Xkr9 A G 1: 13,771,008 (GRCm39) I175V probably benign Het
Other mutations in Zfp428
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01384:Zfp428 APN 7 24,210,167 (GRCm39) missense possibly damaging 0.65
FR4340:Zfp428 UTSW 7 24,214,506 (GRCm39) missense probably damaging 1.00
FR4342:Zfp428 UTSW 7 24,214,506 (GRCm39) missense probably damaging 1.00
R5070:Zfp428 UTSW 7 24,214,550 (GRCm39) missense probably damaging 1.00
R6768:Zfp428 UTSW 7 24,214,908 (GRCm39) missense probably damaging 1.00
R7246:Zfp428 UTSW 7 24,215,069 (GRCm39) splice site probably null
R9553:Zfp428 UTSW 7 24,214,866 (GRCm39) missense possibly damaging 0.66
Predicted Primers PCR Primer
(F):5'- ACTGATGACCCCGAATATGACCCTG -3'
(R):5'- AGCTCGAACATATGCGGAGCCAAC -3'

Sequencing Primer
(F):5'- CCGAATATGACCCTGGCTATAAGG -3'
(R):5'- tgcggagccaacatgtag -3'
Posted On 2013-07-11