Incidental Mutation 'R7098:Adamts3'
| ID |
550629 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adamts3
|
| Ensembl Gene |
ENSMUSG00000043635 |
| Gene Name |
ADAM metallopeptidase with thrombospondin type 1 motif 3 |
| Synonyms |
1100001H14Rik, 6330442E02Rik |
| MMRRC Submission |
045190-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7098 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
89824946-90031193 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 90009354 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Aspartic acid
at position 103
(A103D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132219
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000061427]
[ENSMUST00000163159]
[ENSMUST00000198151]
|
| AlphaFold |
E9Q287 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000061427
AA Change: A103D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000058552
Gene: ENSMUSG00000043635
AA Change: A103D
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
42 |
201 |
5.1e-40 |
PFAM |
|
Pfam:Reprolysin_5
|
254 |
439 |
5.4e-15 |
PFAM |
|
Pfam:Reprolysin_4
|
256 |
454 |
1.9e-10 |
PFAM |
|
Pfam:Reprolysin
|
257 |
460 |
3.6e-22 |
PFAM |
|
Pfam:Reprolysin_2
|
274 |
451 |
7.7e-13 |
PFAM |
|
Pfam:Reprolysin_3
|
278 |
409 |
1.5e-12 |
PFAM |
|
TSP1
|
554 |
606 |
1.26e-15 |
SMART |
|
Pfam:ADAM_spacer1
|
713 |
827 |
3e-34 |
PFAM |
|
TSP1
|
848 |
905 |
4.35e-2 |
SMART |
|
TSP1
|
908 |
967 |
4.95e-2 |
SMART |
|
TSP1
|
969 |
1016 |
6.58e-5 |
SMART |
|
low complexity region
|
1114 |
1128 |
N/A |
INTRINSIC |
|
low complexity region
|
1157 |
1177 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000163159
AA Change: A103D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000132219
Gene: ENSMUSG00000043635
AA Change: A103D
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
43 |
201 |
1.5e-40 |
PFAM |
|
Pfam:Reprolysin_5
|
254 |
439 |
2.2e-15 |
PFAM |
|
Pfam:Reprolysin_4
|
256 |
454 |
7.7e-11 |
PFAM |
|
Pfam:Reprolysin
|
257 |
460 |
3.7e-21 |
PFAM |
|
Pfam:Reprolysin_2
|
274 |
451 |
4.3e-14 |
PFAM |
|
Pfam:Reprolysin_3
|
278 |
409 |
1.3e-12 |
PFAM |
|
TSP1
|
554 |
606 |
1.26e-15 |
SMART |
|
Pfam:ADAM_spacer1
|
713 |
828 |
3.6e-28 |
PFAM |
|
TSP1
|
849 |
906 |
4.35e-2 |
SMART |
|
TSP1
|
909 |
968 |
4.95e-2 |
SMART |
|
TSP1
|
970 |
1017 |
6.58e-5 |
SMART |
|
low complexity region
|
1115 |
1129 |
N/A |
INTRINSIC |
|
low complexity region
|
1158 |
1178 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000198151
AA Change: A103D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000142771
Gene: ENSMUSG00000043635
AA Change: A103D
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
42 |
174 |
2.3e-29 |
PFAM |
|
| Meta Mutation Damage Score |
0.8405 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
100% (78/78) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. [provided by RefSeq, Feb 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A430033K04Rik |
T |
A |
5: 138,644,784 (GRCm39) |
M223K |
probably benign |
Het |
| Abce1 |
T |
C |
8: 80,412,678 (GRCm39) |
T550A |
probably benign |
Het |
| Acoxl |
C |
T |
2: 127,696,835 (GRCm39) |
Q28* |
probably null |
Het |
| Adam8 |
T |
C |
7: 139,559,412 (GRCm39) |
K820R |
possibly damaging |
Het |
| Apba2 |
T |
A |
7: 64,386,696 (GRCm39) |
V441D |
probably damaging |
Het |
| Arap2 |
A |
G |
5: 62,833,293 (GRCm39) |
|
probably null |
Het |
| Arhgef10l |
T |
A |
4: 140,308,222 (GRCm39) |
M44L |
probably benign |
Het |
| Asb4 |
T |
C |
6: 5,398,499 (GRCm39) |
C155R |
probably damaging |
Het |
| Bpifb6 |
A |
T |
2: 153,748,810 (GRCm39) |
K269* |
probably null |
Het |
| Cc2d2a |
A |
T |
5: 43,840,481 (GRCm39) |
T161S |
probably benign |
Het |
| Ccdc15 |
T |
A |
9: 37,255,256 (GRCm39) |
Q98L |
probably damaging |
Het |
| Col19a1 |
A |
G |
1: 24,565,555 (GRCm39) |
S259P |
unknown |
Het |
| Col5a2 |
A |
T |
1: 45,419,227 (GRCm39) |
D1284E |
possibly damaging |
Het |
| Cyp2c70 |
T |
C |
19: 40,168,931 (GRCm39) |
T119A |
probably benign |
Het |
| Dennd6b |
C |
T |
15: 89,072,890 (GRCm39) |
C188Y |
probably damaging |
Het |
| Dhx8 |
T |
A |
11: 101,628,594 (GRCm39) |
|
probably null |
Het |
| Dhx9 |
T |
C |
1: 153,340,768 (GRCm39) |
K624R |
probably benign |
Het |
| Dpys |
C |
T |
15: 39,656,727 (GRCm39) |
V447M |
probably damaging |
Het |
| E130308A19Rik |
T |
C |
4: 59,753,004 (GRCm39) |
S706P |
possibly damaging |
Het |
| Esrrb |
A |
G |
12: 86,517,189 (GRCm39) |
D107G |
probably benign |
Het |
| Frmd4a |
T |
C |
2: 4,577,244 (GRCm39) |
S367P |
probably damaging |
Het |
| Garin2 |
G |
A |
12: 78,766,408 (GRCm39) |
|
probably null |
Het |
| Gdi1 |
G |
A |
X: 73,350,461 (GRCm39) |
R55H |
probably benign |
Het |
| Gm136 |
T |
C |
4: 34,746,628 (GRCm39) |
I128V |
probably benign |
Het |
| Gm6525 |
T |
A |
3: 84,082,309 (GRCm39) |
C77S |
possibly damaging |
Het |
| Grid2ip |
T |
C |
5: 143,343,346 (GRCm39) |
F14S |
probably damaging |
Het |
| Hdhd3 |
C |
T |
4: 62,418,152 (GRCm39) |
R8H |
probably damaging |
Het |
| Kdelr1 |
C |
A |
7: 45,523,480 (GRCm39) |
A69D |
possibly damaging |
Het |
| Krtap16-3 |
T |
A |
16: 88,759,560 (GRCm39) |
Y51F |
unknown |
Het |
| Lrrc40 |
T |
A |
3: 157,747,276 (GRCm39) |
N129K |
probably benign |
Het |
| Man1b1 |
T |
A |
2: 25,228,196 (GRCm39) |
D155E |
probably damaging |
Het |
| Mcm5 |
T |
C |
8: 75,847,529 (GRCm39) |
V442A |
probably damaging |
Het |
| Mfsd14a |
C |
T |
3: 116,435,361 (GRCm39) |
A235T |
probably benign |
Het |
| Mmp1a |
C |
A |
9: 7,475,938 (GRCm39) |
T401K |
probably benign |
Het |
| Mpig6b |
C |
T |
17: 35,283,320 (GRCm39) |
R196Q |
unknown |
Het |
| Mroh1 |
C |
T |
15: 76,292,657 (GRCm39) |
Q262* |
probably null |
Het |
| Msh3 |
A |
T |
13: 92,410,619 (GRCm39) |
D656E |
possibly damaging |
Het |
| Muc4 |
A |
T |
16: 32,577,465 (GRCm39) |
T252S |
|
Het |
| Myh15 |
C |
T |
16: 48,997,420 (GRCm39) |
A1746V |
possibly damaging |
Het |
| Myh8 |
C |
A |
11: 67,169,879 (GRCm39) |
T66K |
probably benign |
Het |
| Nemf |
A |
T |
12: 69,359,241 (GRCm39) |
Y999N |
probably damaging |
Het |
| Neurod1 |
T |
C |
2: 79,285,029 (GRCm39) |
N118S |
probably damaging |
Het |
| Nlrp1b |
T |
A |
11: 71,109,100 (GRCm39) |
I134L |
possibly damaging |
Het |
| Nsun7 |
A |
T |
5: 66,418,326 (GRCm39) |
I19F |
probably damaging |
Het |
| Ofcc1 |
A |
G |
13: 40,157,442 (GRCm39) |
|
probably null |
Het |
| P2rx7 |
A |
G |
5: 122,811,856 (GRCm39) |
E389G |
probably damaging |
Het |
| Pam |
C |
T |
1: 97,826,072 (GRCm39) |
R194H |
probably benign |
Het |
| Pcnt |
A |
G |
10: 76,220,673 (GRCm39) |
S2052P |
probably benign |
Het |
| Pfkfb4 |
T |
A |
9: 108,828,222 (GRCm39) |
Y86N |
probably benign |
Het |
| Plcd3 |
T |
A |
11: 102,968,689 (GRCm39) |
D334V |
probably damaging |
Het |
| Ppard |
T |
C |
17: 28,517,787 (GRCm39) |
V285A |
possibly damaging |
Het |
| Prune2 |
A |
G |
19: 17,097,966 (GRCm39) |
S1157G |
probably benign |
Het |
| Psg21 |
A |
T |
7: 18,386,470 (GRCm39) |
L172H |
probably damaging |
Het |
| Psme4 |
C |
A |
11: 30,800,661 (GRCm39) |
T1417K |
probably damaging |
Het |
| Ptprc |
T |
C |
1: 138,027,423 (GRCm39) |
D336G |
probably benign |
Het |
| Ralgapa1 |
A |
T |
12: 55,837,095 (GRCm39) |
|
probably null |
Het |
| Rap1gap |
C |
A |
4: 137,443,393 (GRCm39) |
|
probably null |
Het |
| Scap |
T |
C |
9: 110,201,310 (GRCm39) |
S100P |
possibly damaging |
Het |
| Scpep1 |
T |
C |
11: 88,820,011 (GRCm39) |
I426V |
possibly damaging |
Het |
| Sdk1 |
T |
C |
5: 142,082,625 (GRCm39) |
I1341T |
probably damaging |
Het |
| Sfmbt2 |
T |
A |
2: 10,584,000 (GRCm39) |
Y786N |
probably benign |
Het |
| Sh3tc1 |
A |
T |
5: 35,859,358 (GRCm39) |
|
probably null |
Het |
| Slc5a5 |
T |
A |
8: 71,341,182 (GRCm39) |
I386F |
probably damaging |
Het |
| Smarca4 |
T |
G |
9: 21,546,116 (GRCm39) |
M98R |
probably benign |
Het |
| St18 |
G |
A |
1: 6,898,066 (GRCm39) |
D623N |
probably damaging |
Het |
| Sult2a1 |
A |
T |
7: 13,549,978 (GRCm39) |
|
probably null |
Het |
| Tgfb2 |
C |
T |
1: 186,362,834 (GRCm39) |
R330H |
probably damaging |
Het |
| Thoc3 |
A |
G |
13: 54,614,119 (GRCm39) |
I168T |
probably damaging |
Het |
| Tmem126a |
C |
T |
7: 90,100,062 (GRCm39) |
M160I |
possibly damaging |
Het |
| Tmem200b |
C |
T |
4: 131,649,704 (GRCm39) |
P208L |
probably benign |
Het |
| Tnrc6c |
T |
C |
11: 117,604,952 (GRCm39) |
V29A |
probably benign |
Het |
| Tsc1 |
C |
T |
2: 28,565,744 (GRCm39) |
S465F |
probably benign |
Het |
| Ttll5 |
A |
G |
12: 85,964,447 (GRCm39) |
|
probably null |
Het |
| Unc13d |
G |
T |
11: 115,954,552 (GRCm39) |
L1019I |
probably damaging |
Het |
| Vmn2r102 |
A |
T |
17: 19,914,670 (GRCm39) |
H745L |
probably damaging |
Het |
| Wars2 |
T |
G |
3: 99,123,957 (GRCm39) |
S273A |
probably damaging |
Het |
| Xrcc6 |
C |
A |
15: 81,919,955 (GRCm39) |
S498* |
probably null |
Het |
| Ybx1 |
A |
T |
4: 119,140,050 (GRCm39) |
N92K |
possibly damaging |
Het |
|
| Other mutations in Adamts3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00160:Adamts3
|
APN |
5 |
90,009,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00340:Adamts3
|
APN |
5 |
89,849,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00923:Adamts3
|
APN |
5 |
89,832,235 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01420:Adamts3
|
APN |
5 |
89,850,916 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
IGL01522:Adamts3
|
APN |
5 |
89,850,802 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL01676:Adamts3
|
APN |
5 |
90,029,402 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL01676:Adamts3
|
APN |
5 |
89,825,613 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01678:Adamts3
|
APN |
5 |
89,855,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01936:Adamts3
|
APN |
5 |
90,009,282 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01956:Adamts3
|
APN |
5 |
89,825,770 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02342:Adamts3
|
APN |
5 |
89,839,332 (GRCm39) |
splice site |
probably null |
|
|
IGL02415:Adamts3
|
APN |
5 |
89,854,506 (GRCm39) |
splice site |
probably null |
|
|
IGL03261:Adamts3
|
APN |
5 |
90,030,756 (GRCm39) |
utr 5 prime |
probably benign |
|
|
IGL03301:Adamts3
|
APN |
5 |
89,855,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0041:Adamts3
|
UTSW |
5 |
89,832,326 (GRCm39) |
missense |
probably benign |
|
|
R0079:Adamts3
|
UTSW |
5 |
89,840,912 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0096:Adamts3
|
UTSW |
5 |
89,849,576 (GRCm39) |
nonsense |
probably null |
|
|
R0096:Adamts3
|
UTSW |
5 |
89,849,576 (GRCm39) |
nonsense |
probably null |
|
|
R0477:Adamts3
|
UTSW |
5 |
89,832,366 (GRCm39) |
missense |
probably benign |
|
|
R0605:Adamts3
|
UTSW |
5 |
90,009,334 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R1036:Adamts3
|
UTSW |
5 |
89,843,952 (GRCm39) |
splice site |
probably benign |
|
|
R1462:Adamts3
|
UTSW |
5 |
90,009,208 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1462:Adamts3
|
UTSW |
5 |
90,009,208 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1621:Adamts3
|
UTSW |
5 |
89,869,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1799:Adamts3
|
UTSW |
5 |
89,923,280 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2163:Adamts3
|
UTSW |
5 |
89,856,577 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2412:Adamts3
|
UTSW |
5 |
89,849,630 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2420:Adamts3
|
UTSW |
5 |
89,831,034 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2421:Adamts3
|
UTSW |
5 |
89,831,034 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2422:Adamts3
|
UTSW |
5 |
89,831,034 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2921:Adamts3
|
UTSW |
5 |
90,009,393 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2922:Adamts3
|
UTSW |
5 |
90,009,393 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2923:Adamts3
|
UTSW |
5 |
90,009,393 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3402:Adamts3
|
UTSW |
5 |
89,849,592 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3431:Adamts3
|
UTSW |
5 |
89,855,312 (GRCm39) |
splice site |
probably benign |
|
|
R3432:Adamts3
|
UTSW |
5 |
89,855,312 (GRCm39) |
splice site |
probably benign |
|
|
R3813:Adamts3
|
UTSW |
5 |
89,825,785 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R3816:Adamts3
|
UTSW |
5 |
89,853,123 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3905:Adamts3
|
UTSW |
5 |
90,009,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3906:Adamts3
|
UTSW |
5 |
90,009,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3907:Adamts3
|
UTSW |
5 |
90,009,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3908:Adamts3
|
UTSW |
5 |
90,009,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4557:Adamts3
|
UTSW |
5 |
89,848,346 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4684:Adamts3
|
UTSW |
5 |
89,850,866 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4844:Adamts3
|
UTSW |
5 |
89,825,675 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4925:Adamts3
|
UTSW |
5 |
89,832,182 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5097:Adamts3
|
UTSW |
5 |
89,840,909 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5100:Adamts3
|
UTSW |
5 |
89,856,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5237:Adamts3
|
UTSW |
5 |
89,923,236 (GRCm39) |
missense |
probably benign |
|
|
R5265:Adamts3
|
UTSW |
5 |
90,009,411 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5322:Adamts3
|
UTSW |
5 |
89,855,159 (GRCm39) |
splice site |
probably null |
|
|
R5413:Adamts3
|
UTSW |
5 |
89,856,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5459:Adamts3
|
UTSW |
5 |
89,839,332 (GRCm39) |
splice site |
probably null |
|
|
R5738:Adamts3
|
UTSW |
5 |
89,856,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5979:Adamts3
|
UTSW |
5 |
90,009,528 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5992:Adamts3
|
UTSW |
5 |
89,839,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6364:Adamts3
|
UTSW |
5 |
89,869,673 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6572:Adamts3
|
UTSW |
5 |
90,009,468 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7172:Adamts3
|
UTSW |
5 |
90,030,860 (GRCm39) |
start gained |
probably benign |
|
|
R7263:Adamts3
|
UTSW |
5 |
89,825,601 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7401:Adamts3
|
UTSW |
5 |
89,855,309 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7599:Adamts3
|
UTSW |
5 |
90,009,256 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7829:Adamts3
|
UTSW |
5 |
90,009,349 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7835:Adamts3
|
UTSW |
5 |
89,848,299 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7892:Adamts3
|
UTSW |
5 |
90,009,288 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8021:Adamts3
|
UTSW |
5 |
89,831,043 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R8289:Adamts3
|
UTSW |
5 |
89,923,282 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8350:Adamts3
|
UTSW |
5 |
89,850,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8468:Adamts3
|
UTSW |
5 |
89,842,627 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8827:Adamts3
|
UTSW |
5 |
89,839,324 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8864:Adamts3
|
UTSW |
5 |
89,854,981 (GRCm39) |
intron |
probably benign |
|
|
R8906:Adamts3
|
UTSW |
5 |
89,825,575 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9000:Adamts3
|
UTSW |
5 |
89,854,570 (GRCm39) |
missense |
probably benign |
0.17 |
|
R9005:Adamts3
|
UTSW |
5 |
89,825,693 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9378:Adamts3
|
UTSW |
5 |
89,848,269 (GRCm39) |
nonsense |
probably null |
|
|
R9505:Adamts3
|
UTSW |
5 |
89,855,751 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9516:Adamts3
|
UTSW |
5 |
89,834,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0064:Adamts3
|
UTSW |
5 |
89,850,901 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
Z1088:Adamts3
|
UTSW |
5 |
89,832,308 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Adamts3
|
UTSW |
5 |
89,923,210 (GRCm39) |
missense |
not run |
|
|
Z1177:Adamts3
|
UTSW |
5 |
89,923,210 (GRCm39) |
missense |
not run |
|
|
Z1177:Adamts3
|
UTSW |
5 |
89,855,723 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CCCTTCCATGTTCATACAGGAAAGG -3'
(R):5'- TGGTGACACCAGTTAGCACG -3'
Sequencing Primer
(F):5'- GACCATCACAGTTGCTAATGGC -3'
(R):5'- CCAGTTAGCACGAATCTAAAAGG -3'
|
| Posted On |
2019-05-15 |
Incidental Mutation