Incidental Mutation 'R7101:Dhx37'
ID 550810
Institutional Source Beutler Lab
Gene Symbol Dhx37
Ensembl Gene ENSMUSG00000029480
Gene Name DEAH-box helicase 37
Synonyms LOC208144, LOC381671
MMRRC Submission 045193-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.456) question?
Stock # R7101 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 125490922-125511185 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 125502006 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 497 (Q497*)
Ref Sequence ENSEMBL: ENSMUSP00000131734 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169485]
AlphaFold Q6NZL1
Predicted Effect probably null
Transcript: ENSMUST00000169485
AA Change: Q497*
SMART Domains Protein: ENSMUSP00000131734
Gene: ENSMUSG00000029480
AA Change: Q497*

DomainStartEndE-ValueType
low complexity region 51 66 N/A INTRINSIC
low complexity region 156 173 N/A INTRINSIC
low complexity region 199 231 N/A INTRINSIC
DEXDc 246 438 3.55e-27 SMART
AAA 263 463 9.3e-3 SMART
HELICc 554 669 1.56e-14 SMART
Blast:DEXDc 678 717 1e-10 BLAST
HA2 729 852 3.32e-25 SMART
Pfam:OB_NTP_bind 886 1004 1.1e-25 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000198746
AA Change: Q131*
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a DEAD box protein. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam25 A G 8: 41,208,438 (GRCm39) D568G probably benign Het
Angpt1 T C 15: 42,386,965 (GRCm39) I130V probably benign Het
Ankrd11 G T 8: 123,622,194 (GRCm39) Q553K probably benign Het
Ankrd42 A T 7: 92,280,752 (GRCm39) H59Q possibly damaging Het
Ankrd52 C T 10: 128,218,249 (GRCm39) R318C probably damaging Het
Arrdc5 G A 17: 56,601,522 (GRCm39) T201M probably damaging Het
Atxn1l A G 8: 110,459,132 (GRCm39) S377P probably benign Het
Baz2a T C 10: 127,957,056 (GRCm39) F936S possibly damaging Het
Bicc1 T C 10: 70,766,483 (GRCm39) D913G probably damaging Het
Blnk T A 19: 40,961,082 (GRCm39) M21L probably benign Het
Cabin1 T C 10: 75,587,401 (GRCm39) H132R probably benign Het
Ccdc154 A G 17: 25,382,442 (GRCm39) H88R probably benign Het
Cfap20dc G T 14: 8,511,171 (GRCm38) S414R possibly damaging Het
Clic5 G T 17: 44,586,179 (GRCm39) A223S probably benign Het
Col28a1 T A 6: 8,014,795 (GRCm39) Y870F possibly damaging Het
Dnah11 T C 12: 118,031,880 (GRCm39) T1763A probably benign Het
Dnajc13 T C 9: 104,042,221 (GRCm39) R2005G possibly damaging Het
Dop1a G A 9: 86,389,722 (GRCm39) G541S probably benign Het
Drosha C T 15: 12,865,153 (GRCm39) T627M probably damaging Het
Ephb3 C T 16: 21,037,268 (GRCm39) H455Y possibly damaging Het
Eri1 A C 8: 35,949,777 (GRCm39) C127G probably damaging Het
Faf1 A T 4: 109,783,153 (GRCm39) E548D probably benign Het
Gm3285 C A 10: 77,698,194 (GRCm39) C114* probably null Het
Gm9736 C T 10: 77,587,167 (GRCm39) V8I unknown Het
Gnptab A T 10: 88,276,174 (GRCm39) M1154L probably benign Het
Grin1 G A 2: 25,186,647 (GRCm39) T770M probably damaging Het
Haus1 A G 18: 77,854,570 (GRCm39) S67P possibly damaging Het
Homer1 C A 13: 93,492,562 (GRCm39) Q184K probably benign Het
Hook2 A G 8: 85,723,680 (GRCm39) T401A probably benign Het
Il6st G A 13: 112,631,907 (GRCm39) probably null Het
Kcnh8 A T 17: 53,212,038 (GRCm39) D612V probably damaging Het
Ltbr C G 6: 125,289,763 (GRCm39) E144Q probably benign Het
Mcf2l G T 8: 13,063,579 (GRCm39) R961L possibly damaging Het
Muc6 AGGCGCAGAAACCCTGGC AGGC 7: 141,214,363 (GRCm39) probably null Het
Myo1b G T 1: 51,797,160 (GRCm39) Q961K probably benign Het
Myo1h C A 5: 114,480,258 (GRCm39) T531N Het
Ngly1 G A 14: 16,283,445 (GRCm38) R408Q probably damaging Het
Nup133 T C 8: 124,632,966 (GRCm39) E1055G possibly damaging Het
Nutm2 A G 13: 50,626,934 (GRCm39) K363R probably benign Het
Obox8 A T 7: 14,066,752 (GRCm39) Y97* probably null Het
Odc1 A G 12: 17,597,319 (GRCm39) D7G probably benign Het
Ogfod2 C T 5: 124,252,558 (GRCm39) T182I unknown Het
Or2t49 A G 11: 58,393,379 (GRCm39) M7T probably benign Het
Or4c111 A T 2: 88,844,324 (GRCm39) V28E possibly damaging Het
Or8b12b T C 9: 37,684,287 (GRCm39) S111P probably damaging Het
Or8b46 G A 9: 38,450,966 (GRCm39) M258I probably benign Het
Parp4 A G 14: 56,827,430 (GRCm39) D188G probably benign Het
Phactr2 T C 10: 13,122,922 (GRCm39) E400G probably benign Het
Phlpp1 G A 1: 106,100,397 (GRCm39) V222M possibly damaging Het
Ppp1r16b T C 2: 158,603,683 (GRCm39) V536A probably damaging Het
Prex2 T C 1: 11,223,833 (GRCm39) V719A possibly damaging Het
Prpf8 C T 11: 75,381,226 (GRCm39) A242V possibly damaging Het
Prr14l A G 5: 32,986,771 (GRCm39) L908P probably damaging Het
Prrc2b A G 2: 32,117,005 (GRCm39) N2146D possibly damaging Het
Rtkn T C 6: 83,126,993 (GRCm39) V333A possibly damaging Het
Samd8 T C 14: 21,825,442 (GRCm39) Y196H probably benign Het
Six5 A G 7: 18,828,784 (GRCm39) T75A probably benign Het
Slc35a4 T A 18: 36,814,591 (GRCm39) L42H probably damaging Het
Svs3a A T 2: 164,131,933 (GRCm39) D168V probably damaging Het
Themis T A 10: 28,637,422 (GRCm39) Y175* probably null Het
Tspan33 G T 6: 29,716,783 (GRCm39) R180L probably benign Het
Ttc28 C T 5: 111,232,958 (GRCm39) S145F probably damaging Het
Txn2 G A 15: 77,810,878 (GRCm39) T102I unknown Het
Usp34 T A 11: 23,376,183 (GRCm39) V1908E Het
Vmn2r101 A G 17: 19,809,350 (GRCm39) I160V probably null Het
Vmn2r104 A T 17: 20,250,358 (GRCm39) C638S possibly damaging Het
Wdfy4 C T 14: 32,682,777 (GRCm39) R3136Q Het
Zan C A 5: 137,396,552 (GRCm39) A4335S unknown Het
Zfp180 G T 7: 23,803,958 (GRCm39) V126F probably benign Het
Zfp429 T A 13: 67,538,931 (GRCm39) D171V possibly damaging Het
Zfp638 T C 6: 83,931,708 (GRCm39) I798T probably benign Het
Other mutations in Dhx37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01123:Dhx37 APN 5 125,496,152 (GRCm39) missense possibly damaging 0.84
IGL02010:Dhx37 APN 5 125,495,777 (GRCm39) missense possibly damaging 0.58
IGL02412:Dhx37 APN 5 125,508,692 (GRCm39) missense probably damaging 0.98
IGL02484:Dhx37 APN 5 125,496,401 (GRCm39) missense possibly damaging 0.89
IGL02986:Dhx37 APN 5 125,496,379 (GRCm39) missense probably damaging 1.00
FR4304:Dhx37 UTSW 5 125,504,594 (GRCm39) unclassified probably benign
R0010:Dhx37 UTSW 5 125,508,680 (GRCm39) missense probably benign 0.02
R0019:Dhx37 UTSW 5 125,507,098 (GRCm39) missense probably benign 0.36
R0485:Dhx37 UTSW 5 125,499,295 (GRCm39) missense probably benign 0.00
R0959:Dhx37 UTSW 5 125,500,496 (GRCm39) missense probably benign
R1101:Dhx37 UTSW 5 125,492,216 (GRCm39) missense probably damaging 1.00
R1132:Dhx37 UTSW 5 125,498,103 (GRCm39) missense probably damaging 0.96
R1309:Dhx37 UTSW 5 125,494,502 (GRCm39) nonsense probably null
R1777:Dhx37 UTSW 5 125,506,995 (GRCm39) missense probably benign
R2001:Dhx37 UTSW 5 125,504,528 (GRCm39) missense probably damaging 1.00
R2116:Dhx37 UTSW 5 125,498,166 (GRCm39) missense probably damaging 0.98
R3826:Dhx37 UTSW 5 125,508,677 (GRCm39) missense probably benign 0.04
R3829:Dhx37 UTSW 5 125,508,677 (GRCm39) missense probably benign 0.04
R3830:Dhx37 UTSW 5 125,508,677 (GRCm39) missense probably benign 0.04
R4007:Dhx37 UTSW 5 125,501,995 (GRCm39) splice site probably benign
R5058:Dhx37 UTSW 5 125,499,295 (GRCm39) missense probably benign 0.00
R5158:Dhx37 UTSW 5 125,492,216 (GRCm39) missense probably damaging 1.00
R5436:Dhx37 UTSW 5 125,506,867 (GRCm39) missense probably benign
R5789:Dhx37 UTSW 5 125,498,103 (GRCm39) missense possibly damaging 0.55
R5834:Dhx37 UTSW 5 125,502,794 (GRCm39) missense probably damaging 1.00
R6066:Dhx37 UTSW 5 125,501,730 (GRCm39) missense probably benign 0.18
R6490:Dhx37 UTSW 5 125,496,196 (GRCm39) missense probably benign 0.00
R6967:Dhx37 UTSW 5 125,499,231 (GRCm39) missense probably benign 0.07
R8036:Dhx37 UTSW 5 125,501,739 (GRCm39) missense probably benign
R9177:Dhx37 UTSW 5 125,507,958 (GRCm39) missense probably benign 0.00
R9294:Dhx37 UTSW 5 125,499,736 (GRCm39) missense probably benign
Z1088:Dhx37 UTSW 5 125,493,655 (GRCm39) missense possibly damaging 0.72
Z1177:Dhx37 UTSW 5 125,502,536 (GRCm39) missense probably benign 0.01
Z1177:Dhx37 UTSW 5 125,502,044 (GRCm39) missense possibly damaging 0.81
Predicted Primers PCR Primer
(F):5'- TGGGAAAAGACTTCTGTAGCC -3'
(R):5'- TGGGTCCTAGCTCCTGAATGTC -3'

Sequencing Primer
(F):5'- GACTTCTGTAGCCAACGTAGG -3'
(R):5'- TGAATGTCCCAGGCCGTCAG -3'
Posted On 2019-05-15