Mutagenetix > Incidental Mutations

Incidental Mutation 'R7101:Olfr331'

550843

Institutional Source

Beutler Lab

Gene Symbol

Olfr331

Ensembl Gene

ENSMUSG00000058807

Gene Name

olfactory receptor 331

Synonyms

GA_x6K02T2NKPP-912840-913784, MOR275-4

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

R7101 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

58501598-58502572 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 58502553 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Threonine at position 7 (M7T)

Ref Sequence

ENSEMBL: ENSMUSP00000080440 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081743] [ENSMUST00000170501]

Predicted Effect

probably benign
Transcript: ENSMUST00000081743
AA Change: M7T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000080440
Gene: ENSMUSG00000058807
AA Change: M7T

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	315	1e-42	PFAM
Pfam:7tm_1	45	299	1.8e-21	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000170501
AA Change: M1T

PolyPhen 2 Score 0.079 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000132693
Gene: ENSMUSG00000058807
AA Change: M1T

Domain	Start	End	E-Value	Type
low complexity region	23	37	N/A	INTRINSIC
Pfam:7tm_1	39	292	4.9e-28	PFAM
Pfam:7tm_4	141	285	3.6e-42	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.0%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Feb 2012]

Allele List at MGI

Other mutations in this stock

Total: 71 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930452B06Rik	G	T	14: 8,511,171	S414R	possibly damaging	Het
Adam25	A	G	8: 40,755,401	D568G	probably benign	Het
Angpt1	T	C	15: 42,523,569	I130V	probably benign	Het
Ankrd11	G	T	8: 122,895,455	Q553K	probably benign	Het
Ankrd42	A	T	7: 92,631,544	H59Q	possibly damaging	Het
Ankrd52	C	T	10: 128,382,380	R318C	probably damaging	Het
Arrdc5	G	A	17: 56,294,522	T201M	probably damaging	Het
Atxn1l	A	G	8: 109,732,500	S377P	probably benign	Het
Baz2a	T	C	10: 128,121,187	F936S	possibly damaging	Het
Bicc1	T	C	10: 70,930,653	D913G	probably damaging	Het
Blnk	T	A	19: 40,972,638	M21L	probably benign	Het
Cabin1	T	C	10: 75,751,567	H132R	probably benign	Het
Ccdc154	A	G	17: 25,163,468	H88R	probably benign	Het
Clic5	G	T	17: 44,275,292	A223S	probably benign	Het
Col28a1	T	A	6: 8,014,795	Y870F	possibly damaging	Het
Dhx37	G	A	5: 125,424,942	Q497*	probably null	Het
Dnah11	T	C	12: 118,068,145	T1763A	probably benign	Het
Dnajc13	T	C	9: 104,165,022	R2005G	possibly damaging	Het
Dopey1	G	A	9: 86,507,669	G541S	probably benign	Het
Drosha	C	T	15: 12,865,067	T627M	probably damaging	Het
Ephb3	C	T	16: 21,218,518	H455Y	possibly damaging	Het
Eri1	A	C	8: 35,482,623	C127G	probably damaging	Het
Faf1	A	T	4: 109,925,956	E548D	probably benign	Het
Gm3285	C	A	10: 77,862,360	C114*	probably null	Het
Gm9736	C	T	10: 77,751,333	V8I	unknown	Het
Gnptab	A	T	10: 88,440,312	M1154L	probably benign	Het
Grin1	G	A	2: 25,296,635	T770M	probably damaging	Het
Haus1	A	G	18: 77,766,870	S67P	possibly damaging	Het
Homer1	C	A	13: 93,356,054	Q184K	probably benign	Het
Hook2	A	G	8: 84,997,051	T401A	probably benign	Het
Il6st	G	A	13: 112,495,373		probably null	Het
Kcnh8	A	T	17: 52,905,010	D612V	probably damaging	Het
Ltbr	C	G	6: 125,312,800	E144Q	probably benign	Het
Mcf2l	G	T	8: 13,013,579	R961L	possibly damaging	Het
Muc6	AGGCGCAGAAACCCTGGC	AGGC	7: 141,634,450		probably null	Het
Myo1b	G	T	1: 51,758,001	Q961K	probably benign	Het
Myo1h	C	A	5: 114,342,197	T531N		Het
Ngly1	G	A	14: 16,283,445	R408Q	probably damaging	Het
Nup133	T	C	8: 123,906,227	E1055G	possibly damaging	Het
Nutm2	A	G	13: 50,472,898	K363R	probably benign	Het
Obox8	A	T	7: 14,332,827	Y97*	probably null	Het
Odc1	A	G	12: 17,547,318	D7G	probably benign	Het
Ogfod2	C	T	5: 124,114,495	T182I	unknown	Het
Olfr1216	A	T	2: 89,013,980	V28E	possibly damaging	Het
Olfr875	T	C	9: 37,772,991	S111P	probably damaging	Het
Olfr910	G	A	9: 38,539,670	M258I	probably benign	Het
Parp4	A	G	14: 56,589,973	D188G	probably benign	Het
Phactr2	T	C	10: 13,247,178	E400G	probably benign	Het
Phlpp1	G	A	1: 106,172,667	V222M	possibly damaging	Het
Ppp1r16b	T	C	2: 158,761,763	V536A	probably damaging	Het
Prex2	T	C	1: 11,153,609	V719A	possibly damaging	Het
Prpf8	C	T	11: 75,490,400	A242V	possibly damaging	Het
Prr14l	A	G	5: 32,829,427	L908P	probably damaging	Het
Prrc2b	A	G	2: 32,226,993	N2146D	possibly damaging	Het
Rtkn	T	C	6: 83,150,012	V333A	possibly damaging	Het
Samd8	T	C	14: 21,775,374	Y196H	probably benign	Het
Six5	A	G	7: 19,094,859	T75A	probably benign	Het
Slc35a4	T	A	18: 36,681,538	L42H	probably damaging	Het
Svs3a	A	T	2: 164,290,013	D168V	probably damaging	Het
Themis	T	A	10: 28,761,426	Y175*	probably null	Het
Tspan33	G	T	6: 29,716,784	R180L	probably benign	Het
Ttc28	C	T	5: 111,085,092	S145F	probably damaging	Het
Txn2	G	A	15: 77,926,678	T102I	unknown	Het
Usp34	T	A	11: 23,426,183	V1908E		Het
Vmn2r101	A	G	17: 19,589,088	I160V	probably null	Het
Vmn2r104	A	T	17: 20,030,096	C638S	possibly damaging	Het
Wdfy4	C	T	14: 32,960,820	R3136Q		Het
Zan	C	A	5: 137,398,290	A4335S	unknown	Het
Zfp180	G	T	7: 24,104,533	V126F	probably benign	Het
Zfp429	T	A	13: 67,390,812	D171V	possibly damaging	Het
Zfp638	T	C	6: 83,954,726	I798T	probably benign	Het

Other mutations in Olfr331

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01124:Olfr331	APN	11	58502194	missense	possibly damaging	0.89
IGL02458:Olfr331	APN	11	58502247	missense	probably benign	0.20
IGL02971:Olfr331	APN	11	58502385	missense	probably damaging	1.00
IGL03346:Olfr331	APN	11	58501755	missense	possibly damaging	0.76
R0416:Olfr331	UTSW	11	58502396	missense	unknown
R1547:Olfr331	UTSW	11	58501825	missense	probably damaging	1.00
R1697:Olfr331	UTSW	11	58501676	missense	probably damaging	1.00
R1717:Olfr331	UTSW	11	58502059	missense	probably benign	0.09
R1721:Olfr331	UTSW	11	58501939	missense	probably damaging	1.00
R2194:Olfr331	UTSW	11	58501642	missense	probably damaging	0.97
R3606:Olfr331	UTSW	11	58502131	missense	possibly damaging	0.49
R4457:Olfr331	UTSW	11	58502118	missense	probably damaging	1.00
R4766:Olfr331	UTSW	11	58501668	missense	probably damaging	1.00
R4858:Olfr331	UTSW	11	58501909	missense	probably damaging	1.00
R5475:Olfr331	UTSW	11	58501605	missense	probably benign	0.10
R5822:Olfr331	UTSW	11	58501638	missense	possibly damaging	0.61
R6337:Olfr331	UTSW	11	58502012	nonsense	probably null
R6416:Olfr331	UTSW	11	58502340	missense	probably damaging	1.00
R7108:Olfr331	UTSW	11	58502554	missense	probably benign
RF035:Olfr331	UTSW	11	58502382	small deletion	probably benign

Predicted Primers

PCR Primer
(F):5'- CTTGGGCACAGTGACAGAAATG -3'
(R):5'- GACCAAGATGTGAATTCCAAGC -3'

Sequencing Primer
(F):5'- CAGTGACAGAAATGTACATCATGTCC -3'
(R):5'- GAGAACTTAGCACAGGCA -3'

Posted On

2019-05-15