Mutagenetix > Incidental Mutation

Incidental Mutation 'R7101:Vmn2r104'

550861

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r104

Ensembl Gene

ENSMUSG00000090315

Gene Name

vomeronasal 2, receptor 104

Synonyms

V2r7

MMRRC Submission

045193-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.097) question?

Stock #

R7101 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

20029425-20048205 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 20030096 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 638 (C638S)

Ref Sequence

ENSEMBL: ENSMUSP00000129895 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168050]

AlphaFold

E9Q2J5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000168050
AA Change: C638S

PolyPhen 2 Score 0.648 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000129895
Gene: ENSMUSG00000090315
AA Change: C638S

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	85	457	4e-38	PFAM
Pfam:NCD3G	512	565	2.1e-20	PFAM
Pfam:7tm_3	598	833	1.7e-52	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 71 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930452B06Rik	G	T	14: 8,511,171	S414R	possibly damaging	Het
Adam25	A	G	8: 40,755,401	D568G	probably benign	Het
Angpt1	T	C	15: 42,523,569	I130V	probably benign	Het
Ankrd11	G	T	8: 122,895,455	Q553K	probably benign	Het
Ankrd42	A	T	7: 92,631,544	H59Q	possibly damaging	Het
Ankrd52	C	T	10: 128,382,380	R318C	probably damaging	Het
Arrdc5	G	A	17: 56,294,522	T201M	probably damaging	Het
Atxn1l	A	G	8: 109,732,500	S377P	probably benign	Het
Baz2a	T	C	10: 128,121,187	F936S	possibly damaging	Het
Bicc1	T	C	10: 70,930,653	D913G	probably damaging	Het
Blnk	T	A	19: 40,972,638	M21L	probably benign	Het
Cabin1	T	C	10: 75,751,567	H132R	probably benign	Het
Ccdc154	A	G	17: 25,163,468	H88R	probably benign	Het
Clic5	G	T	17: 44,275,292	A223S	probably benign	Het
Col28a1	T	A	6: 8,014,795	Y870F	possibly damaging	Het
Dhx37	G	A	5: 125,424,942	Q497*	probably null	Het
Dnah11	T	C	12: 118,068,145	T1763A	probably benign	Het
Dnajc13	T	C	9: 104,165,022	R2005G	possibly damaging	Het
Dopey1	G	A	9: 86,507,669	G541S	probably benign	Het
Drosha	C	T	15: 12,865,067	T627M	probably damaging	Het
Ephb3	C	T	16: 21,218,518	H455Y	possibly damaging	Het
Eri1	A	C	8: 35,482,623	C127G	probably damaging	Het
Faf1	A	T	4: 109,925,956	E548D	probably benign	Het
Gm3285	C	A	10: 77,862,360	C114*	probably null	Het
Gm9736	C	T	10: 77,751,333	V8I	unknown	Het
Gnptab	A	T	10: 88,440,312	M1154L	probably benign	Het
Grin1	G	A	2: 25,296,635	T770M	probably damaging	Het
Haus1	A	G	18: 77,766,870	S67P	possibly damaging	Het
Homer1	C	A	13: 93,356,054	Q184K	probably benign	Het
Hook2	A	G	8: 84,997,051	T401A	probably benign	Het
Il6st	G	A	13: 112,495,373		probably null	Het
Kcnh8	A	T	17: 52,905,010	D612V	probably damaging	Het
Ltbr	C	G	6: 125,312,800	E144Q	probably benign	Het
Mcf2l	G	T	8: 13,013,579	R961L	possibly damaging	Het
Muc6	AGGCGCAGAAACCCTGGC	AGGC	7: 141,634,450		probably null	Het
Myo1b	G	T	1: 51,758,001	Q961K	probably benign	Het
Myo1h	C	A	5: 114,342,197	T531N		Het
Ngly1	G	A	14: 16,283,445	R408Q	probably damaging	Het
Nup133	T	C	8: 123,906,227	E1055G	possibly damaging	Het
Nutm2	A	G	13: 50,472,898	K363R	probably benign	Het
Obox8	A	T	7: 14,332,827	Y97*	probably null	Het
Odc1	A	G	12: 17,547,318	D7G	probably benign	Het
Ogfod2	C	T	5: 124,114,495	T182I	unknown	Het
Olfr1216	A	T	2: 89,013,980	V28E	possibly damaging	Het
Olfr331	A	G	11: 58,502,553	M7T	probably benign	Het
Olfr875	T	C	9: 37,772,991	S111P	probably damaging	Het
Olfr910	G	A	9: 38,539,670	M258I	probably benign	Het
Parp4	A	G	14: 56,589,973	D188G	probably benign	Het
Phactr2	T	C	10: 13,247,178	E400G	probably benign	Het
Phlpp1	G	A	1: 106,172,667	V222M	possibly damaging	Het
Ppp1r16b	T	C	2: 158,761,763	V536A	probably damaging	Het
Prex2	T	C	1: 11,153,609	V719A	possibly damaging	Het
Prpf8	C	T	11: 75,490,400	A242V	possibly damaging	Het
Prr14l	A	G	5: 32,829,427	L908P	probably damaging	Het
Prrc2b	A	G	2: 32,226,993	N2146D	possibly damaging	Het
Rtkn	T	C	6: 83,150,012	V333A	possibly damaging	Het
Samd8	T	C	14: 21,775,374	Y196H	probably benign	Het
Six5	A	G	7: 19,094,859	T75A	probably benign	Het
Slc35a4	T	A	18: 36,681,538	L42H	probably damaging	Het
Svs3a	A	T	2: 164,290,013	D168V	probably damaging	Het
Themis	T	A	10: 28,761,426	Y175*	probably null	Het
Tspan33	G	T	6: 29,716,784	R180L	probably benign	Het
Ttc28	C	T	5: 111,085,092	S145F	probably damaging	Het
Txn2	G	A	15: 77,926,678	T102I	unknown	Het
Usp34	T	A	11: 23,426,183	V1908E		Het
Vmn2r101	A	G	17: 19,589,088	I160V	probably null	Het
Wdfy4	C	T	14: 32,960,820	R3136Q		Het
Zan	C	A	5: 137,398,290	A4335S	unknown	Het
Zfp180	G	T	7: 24,104,533	V126F	probably benign	Het
Zfp429	T	A	13: 67,390,812	D171V	possibly damaging	Het
Zfp638	T	C	6: 83,954,726	I798T	probably benign	Het

Other mutations in Vmn2r104

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Vmn2r104	APN	17	20038239	missense	probably damaging	0.98
IGL01098:Vmn2r104	APN	17	20048096	missense	probably benign	0.27
IGL01333:Vmn2r104	APN	17	20042793	missense	probably benign	0.17
IGL01527:Vmn2r104	APN	17	20042896	missense	possibly damaging	0.82
IGL01773:Vmn2r104	APN	17	20040668	missense	probably benign	0.10
IGL01939:Vmn2r104	APN	17	20029925	missense	probably damaging	0.99
IGL02121:Vmn2r104	APN	17	20041794	nonsense	probably null
IGL02305:Vmn2r104	APN	17	20042856	missense	probably benign	0.09
IGL02374:Vmn2r104	APN	17	20042786	missense	probably benign	0.34
IGL03260:Vmn2r104	APN	17	20042821	missense	probably benign	0.05
IGL03366:Vmn2r104	APN	17	20029604	missense	probably damaging	1.00
R0091:Vmn2r104	UTSW	17	20041813	missense	possibly damaging	0.79
R0125:Vmn2r104	UTSW	17	20029807	missense	probably damaging	0.98
R0257:Vmn2r104	UTSW	17	20029627	missense	probably damaging	1.00
R0381:Vmn2r104	UTSW	17	20048002	nonsense	probably null
R0709:Vmn2r104	UTSW	17	20042904	missense	probably damaging	1.00
R0786:Vmn2r104	UTSW	17	20042725	missense	probably benign
R1575:Vmn2r104	UTSW	17	20042215	missense	probably damaging	1.00
R1827:Vmn2r104	UTSW	17	20042235	missense	probably damaging	0.97
R1932:Vmn2r104	UTSW	17	20040769	missense	probably damaging	1.00
R1956:Vmn2r104	UTSW	17	20042051	missense	probably damaging	0.98
R2203:Vmn2r104	UTSW	17	20029821	missense	probably benign	0.05
R2205:Vmn2r104	UTSW	17	20029821	missense	probably benign	0.05
R2859:Vmn2r104	UTSW	17	20048193	missense	possibly damaging	0.82
R3701:Vmn2r104	UTSW	17	20029556	missense	probably damaging	1.00
R3834:Vmn2r104	UTSW	17	20029921	missense	probably benign	0.02
R4151:Vmn2r104	UTSW	17	20029885	missense	probably damaging	1.00
R4470:Vmn2r104	UTSW	17	20042241	missense	probably damaging	1.00
R4625:Vmn2r104	UTSW	17	20048181	missense	probably benign	0.00
R4754:Vmn2r104	UTSW	17	20040768	nonsense	probably null
R4911:Vmn2r104	UTSW	17	20030026	missense	probably benign	0.00
R5270:Vmn2r104	UTSW	17	20038266	missense	probably damaging	1.00
R5279:Vmn2r104	UTSW	17	20041884	missense	probably benign	0.07
R5311:Vmn2r104	UTSW	17	20029901	missense	probably damaging	1.00
R5370:Vmn2r104	UTSW	17	20030188	missense	probably damaging	0.97
R5461:Vmn2r104	UTSW	17	20030081	missense	probably damaging	1.00
R5683:Vmn2r104	UTSW	17	20040719	nonsense	probably null
R5795:Vmn2r104	UTSW	17	20030110	missense	probably benign	0.02
R5795:Vmn2r104	UTSW	17	20030282	missense	possibly damaging	0.89
R5970:Vmn2r104	UTSW	17	20029471	missense	probably benign	0.01
R5983:Vmn2r104	UTSW	17	20041708	missense	probably damaging	1.00
R5992:Vmn2r104	UTSW	17	20029485	missense	probably damaging	1.00
R6066:Vmn2r104	UTSW	17	20038311	missense	possibly damaging	0.69
R6156:Vmn2r104	UTSW	17	20041647	missense	probably damaging	1.00
R6182:Vmn2r104	UTSW	17	20030245	missense	probably benign	0.16
R6245:Vmn2r104	UTSW	17	20041567	missense	possibly damaging	0.69
R6333:Vmn2r104	UTSW	17	20029586	missense	probably benign	0.30
R6573:Vmn2r104	UTSW	17	20042225	missense	probably damaging	1.00
R7123:Vmn2r104	UTSW	17	20040826	missense	probably benign	0.12
R7485:Vmn2r104	UTSW	17	20029475	missense	probably benign	0.01
R7514:Vmn2r104	UTSW	17	20029529	missense	probably damaging	1.00
R7634:Vmn2r104	UTSW	17	20041709	missense	possibly damaging	0.48
R7958:Vmn2r104	UTSW	17	20042726	missense	probably benign
R8031:Vmn2r104	UTSW	17	20042786	missense	probably benign	0.34
R8094:Vmn2r104	UTSW	17	20030221	missense	possibly damaging	0.77
R8191:Vmn2r104	UTSW	17	20030203	missense	possibly damaging	0.89
R8308:Vmn2r104	UTSW	17	20040778	missense	possibly damaging	0.55
R8691:Vmn2r104	UTSW	17	20041848	missense	probably damaging	0.98
R8795:Vmn2r104	UTSW	17	20042726	missense	probably benign
R8900:Vmn2r104	UTSW	17	20041662	missense	probably damaging	0.99
R8913:Vmn2r104	UTSW	17	20029706	missense	probably damaging	1.00
R9180:Vmn2r104	UTSW	17	20042825	missense	probably benign	0.00
R9199:Vmn2r104	UTSW	17	20041835	missense	probably damaging	0.99
R9282:Vmn2r104	UTSW	17	20040836	missense	probably damaging	1.00
R9303:Vmn2r104	UTSW	17	20048177	missense	possibly damaging	0.90
R9305:Vmn2r104	UTSW	17	20048177	missense	possibly damaging	0.90
R9322:Vmn2r104	UTSW	17	20042825	missense	probably benign	0.00
R9325:Vmn2r104	UTSW	17	20048171	missense	possibly damaging	0.95
R9414:Vmn2r104	UTSW	17	20029988	missense	probably damaging	0.99
R9785:Vmn2r104	UTSW	17	20048147	missense	probably benign
RF007:Vmn2r104	UTSW	17	20048040	missense	probably benign	0.36
Z1177:Vmn2r104	UTSW	17	20029789	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AGCTGGATCAGTGTGCAGATAG -3'
(R):5'- TGAGCTTTCTGGCCTATGAAGAC -3'

Sequencing Primer
(F):5'- AGGAATGATGTATCTTGGACCCC -3'
(R):5'- TGGCCTATGAAGACCCCTTG -3'

Posted On

2019-05-15