Incidental Mutation 'R7107:Zmym2'
ID 551277
Institutional Source Beutler Lab
Gene Symbol Zmym2
Ensembl Gene ENSMUSG00000021945
Gene Name zinc finger, MYM-type 2
Synonyms SCLL, RAMP, Zfp198, FIM, MYM
MMRRC Submission 045199-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.569) question?
Stock # R7107 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 57123986-57199815 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 57140169 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 3 (T3A)
Ref Sequence ENSEMBL: ENSMUSP00000022511 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022511] [ENSMUST00000223669]
AlphaFold Q9CU65
Predicted Effect probably benign
Transcript: ENSMUST00000022511
AA Change: T3A

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000022511
Gene: ENSMUSG00000021945
AA Change: T3A

DomainStartEndE-ValueType
TRASH 330 366 1.55e-5 SMART
TRASH 372 412 7.69e-1 SMART
TRASH 424 459 7.5e1 SMART
TRASH 466 505 6.53e-4 SMART
Pfam:zf-FCS 527 569 1.8e-9 PFAM
TRASH 583 619 4.79e1 SMART
TRASH 638 674 8.49e-3 SMART
TRASH 680 715 7.28e-2 SMART
TRASH 726 761 1.95e-2 SMART
TRASH 767 802 3.89e1 SMART
low complexity region 881 895 N/A INTRINSIC
low complexity region 904 917 N/A INTRINSIC
low complexity region 1087 1111 N/A INTRINSIC
Pfam:DUF3504 1191 1359 7.3e-66 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000223669
AA Change: T3A

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 99% (78/79)
MGI Phenotype FUNCTION: This gene encodes a protein that contains nine MYM-type zinc finger motifs. Expression of this gene may mediate the inhibition of hematopoietic cell development during ontogeny, and the encoded protein may also play a role in transforming growth factor-beta signaling as a Smad binding protein. [provided by RefSeq, Feb 2011]
PHENOTYPE: Mice homozygous for an ENU-induced mutation exhibit prenatal lethality. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b A G 11: 109,867,299 (GRCm39) L253S probably damaging Het
Adgrv1 T C 13: 81,726,261 (GRCm39) E588G probably benign Het
Ahcy G A 2: 154,910,893 (GRCm39) A25V probably damaging Het
Ank2 A C 3: 126,797,631 (GRCm39) L710R probably damaging Het
Ap1b1 A G 11: 4,989,558 (GRCm39) T824A probably benign Het
Arap2 T A 5: 62,763,551 (GRCm39) H1531L probably damaging Het
Atosb A T 4: 43,036,434 (GRCm39) V99E probably benign Het
B3gnt7 T C 1: 86,233,495 (GRCm39) L247P probably damaging Het
Bcl6b A G 11: 70,117,396 (GRCm39) C409R probably damaging Het
Bicdl1 T C 5: 115,808,229 (GRCm39) H301R probably benign Het
Casc3 T A 11: 98,718,413 (GRCm39) I491N possibly damaging Het
Ccdc92b T A 11: 74,520,887 (GRCm39) L63Q probably damaging Het
Cep250 A G 2: 155,837,314 (GRCm39) T2319A probably benign Het
Chd1 T C 17: 15,981,628 (GRCm39) S1356P probably damaging Het
Chd8 A G 14: 52,450,129 (GRCm39) S1542P probably benign Het
Clec2m A G 6: 129,299,915 (GRCm39) C188R probably damaging Het
Cntnap4 A G 8: 113,542,120 (GRCm39) D751G probably damaging Het
Cpsf4l G A 11: 113,593,315 (GRCm39) R90C possibly damaging Het
Defa21 G A 8: 21,515,724 (GRCm39) A41T probably damaging Het
Dennd4a G T 9: 64,801,681 (GRCm39) L941F possibly damaging Het
Dnah12 G A 14: 26,500,869 (GRCm39) probably null Het
Dtx4 A T 19: 12,450,624 (GRCm39) C529* probably null Het
Entpd3 A G 9: 120,389,665 (GRCm39) Y317C probably damaging Het
Erp29 T A 5: 121,583,381 (GRCm39) I182F possibly damaging Het
Fam161a A G 11: 22,973,452 (GRCm39) R445G possibly damaging Het
Fam76a T A 4: 132,631,232 (GRCm39) M238L possibly damaging Het
Fn1 T C 1: 71,666,408 (GRCm39) Y875C probably damaging Het
Gnb2 A G 5: 137,528,444 (GRCm39) probably null Het
Hspg2 T C 4: 137,237,963 (GRCm39) S229P probably damaging Het
Ighv6-6 A G 12: 114,398,590 (GRCm39) S59P probably damaging Het
Itpkc C A 7: 26,927,702 (GRCm39) A71S probably benign Het
Kcnk10 G A 12: 98,485,002 (GRCm39) R45* probably null Het
Krcc1 A G 6: 71,261,198 (GRCm39) S77G probably benign Het
Lelp1 G A 3: 92,042,821 (GRCm39) T76I unknown Het
Lifr A T 15: 7,208,421 (GRCm39) I600F possibly damaging Het
Lrrk1 T A 7: 65,937,191 (GRCm39) D987V possibly damaging Het
Muc16 C T 9: 18,548,594 (GRCm39) D5900N probably benign Het
Muc6 AGGCGCAGAAACCCTGGC AGGC 7: 141,214,363 (GRCm39) probably null Het
Myo9a A G 9: 59,778,098 (GRCm39) I1285V probably benign Het
Ndel1 T C 11: 68,713,474 (GRCm39) D321G possibly damaging Het
Nlrp4b T C 7: 10,449,144 (GRCm39) V449A probably damaging Het
Or10q12 A G 19: 13,746,525 (GRCm39) E273G probably benign Het
Or2r11 T C 6: 42,437,488 (GRCm39) N155S possibly damaging Het
Or2y1c T A 11: 49,361,261 (GRCm39) Y94* probably null Het
Or51k1 A T 7: 103,661,489 (GRCm39) L140Q probably benign Het
Or5k3 A C 16: 58,969,279 (GRCm39) D22A probably benign Het
Osbpl1a G A 18: 12,974,310 (GRCm39) R459* probably null Het
Pabpc1l A C 2: 163,884,399 (GRCm39) T379P probably damaging Het
Pde2a A T 7: 101,071,175 (GRCm39) Q15L probably benign Het
Pdk1 A G 2: 71,726,085 (GRCm39) N331S probably benign Het
Pfdn1 A T 18: 36,584,519 (GRCm39) probably null Het
Pnliprp1 T A 19: 58,717,582 (GRCm39) L9H probably damaging Het
Prl7a2 A T 13: 27,843,076 (GRCm39) D242E possibly damaging Het
Prmt9 T A 8: 78,294,880 (GRCm39) I408N possibly damaging Het
Psme4 G A 11: 30,798,105 (GRCm39) R1366H probably benign Het
Pstpip1 A T 9: 56,035,934 (GRCm39) D393V probably damaging Het
Rab5b A G 10: 128,519,062 (GRCm39) probably null Het
Rap1gap2 G A 11: 74,283,945 (GRCm39) R618C probably damaging Het
Rin1 A G 19: 5,100,801 (GRCm39) probably benign Het
Sall3 G A 18: 81,016,969 (GRCm39) P320S probably benign Het
Sdk1 A G 5: 142,067,471 (GRCm39) T1124A probably damaging Het
Sirpb1c T A 3: 15,892,941 (GRCm39) T88S possibly damaging Het
Slc35f6 T A 5: 30,814,121 (GRCm39) I189N probably damaging Het
Slc49a3 T A 5: 108,596,581 (GRCm39) probably null Het
Spata31d1e T A 13: 59,889,997 (GRCm39) R608* probably null Het
Spsb2 A T 6: 124,787,244 (GRCm39) Q226L probably benign Het
Stab2 T C 10: 86,741,456 (GRCm39) D1221G possibly damaging Het
Sugp1 G A 8: 70,522,800 (GRCm39) R500H probably benign Het
Syne1 A G 10: 5,082,078 (GRCm39) Y849H probably damaging Het
Tbck T A 3: 132,428,092 (GRCm39) I249N possibly damaging Het
Tdrd6 A C 17: 43,935,095 (GRCm39) F1984L probably benign Het
Tnxb T A 17: 34,890,314 (GRCm39) V219E unknown Het
Tpst1 T A 5: 130,143,344 (GRCm39) V294D probably damaging Het
Treml1 A G 17: 48,667,247 (GRCm39) Q44R probably damaging Het
Trrap G A 5: 144,733,945 (GRCm39) A933T probably benign Het
Vars2 A G 17: 35,969,142 (GRCm39) L853P probably damaging Het
Vmn1r10 A T 6: 57,090,615 (GRCm39) N69I possibly damaging Het
Vmn1r179 T A 7: 23,627,819 (GRCm39) Y3* probably null Het
Vmn2r38 T A 7: 9,093,728 (GRCm39) Y498F probably benign Het
Zc3h11a T C 1: 133,566,655 (GRCm39) T179A probably damaging Het
Other mutations in Zmym2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00516:Zmym2 APN 14 57,185,394 (GRCm39) splice site probably benign
IGL00587:Zmym2 APN 14 57,140,817 (GRCm39) missense possibly damaging 0.86
IGL00736:Zmym2 APN 14 57,140,668 (GRCm39) missense probably benign 0.01
IGL00753:Zmym2 APN 14 57,194,517 (GRCm39) nonsense probably null
IGL01608:Zmym2 APN 14 57,185,472 (GRCm39) missense possibly damaging 0.57
IGL01744:Zmym2 APN 14 57,184,029 (GRCm39) missense probably benign 0.24
IGL02150:Zmym2 APN 14 57,148,526 (GRCm39) splice site probably benign
IGL02186:Zmym2 APN 14 57,180,808 (GRCm39) missense probably benign 0.09
IGL02654:Zmym2 APN 14 57,148,772 (GRCm39) missense probably damaging 1.00
IGL02960:Zmym2 APN 14 57,175,870 (GRCm39) missense probably benign 0.09
IGL03104:Zmym2 APN 14 57,187,784 (GRCm39) missense possibly damaging 0.88
IGL03162:Zmym2 APN 14 57,151,500 (GRCm39) missense probably benign 0.24
IGL03356:Zmym2 APN 14 57,194,517 (GRCm39) nonsense probably null
IGL03412:Zmym2 APN 14 57,197,176 (GRCm39) nonsense probably null
R5038_Zmym2_756 UTSW 14 57,193,637 (GRCm39) missense possibly damaging 0.86
R0131:Zmym2 UTSW 14 57,180,715 (GRCm39) missense probably benign
R0131:Zmym2 UTSW 14 57,180,715 (GRCm39) missense probably benign
R0132:Zmym2 UTSW 14 57,180,715 (GRCm39) missense probably benign
R0270:Zmym2 UTSW 14 57,187,141 (GRCm39) splice site probably null
R0834:Zmym2 UTSW 14 57,194,420 (GRCm39) missense probably damaging 1.00
R1071:Zmym2 UTSW 14 57,197,278 (GRCm39) missense possibly damaging 0.93
R1386:Zmym2 UTSW 14 57,150,548 (GRCm39) missense probably damaging 1.00
R1442:Zmym2 UTSW 14 57,180,784 (GRCm39) missense probably damaging 0.99
R1472:Zmym2 UTSW 14 57,148,640 (GRCm39) missense probably benign 0.20
R1595:Zmym2 UTSW 14 57,158,187 (GRCm39) missense probably benign 0.25
R1598:Zmym2 UTSW 14 57,151,524 (GRCm39) missense probably damaging 1.00
R1598:Zmym2 UTSW 14 57,140,226 (GRCm39) missense possibly damaging 0.94
R1916:Zmym2 UTSW 14 57,197,299 (GRCm39) missense probably damaging 1.00
R2261:Zmym2 UTSW 14 57,165,719 (GRCm39) missense probably damaging 1.00
R2393:Zmym2 UTSW 14 57,158,180 (GRCm39) missense probably benign 0.17
R2866:Zmym2 UTSW 14 57,165,705 (GRCm39) missense probably damaging 1.00
R3727:Zmym2 UTSW 14 57,156,806 (GRCm39) splice site probably benign
R3847:Zmym2 UTSW 14 57,158,956 (GRCm39) splice site probably benign
R4043:Zmym2 UTSW 14 57,195,765 (GRCm39) splice site probably benign
R4074:Zmym2 UTSW 14 57,140,461 (GRCm39) missense probably damaging 0.99
R4343:Zmym2 UTSW 14 57,159,019 (GRCm39) missense probably damaging 0.99
R4420:Zmym2 UTSW 14 57,194,335 (GRCm39) missense probably damaging 0.98
R4645:Zmym2 UTSW 14 57,165,764 (GRCm39) missense probably damaging 1.00
R5015:Zmym2 UTSW 14 57,159,051 (GRCm39) missense probably damaging 1.00
R5038:Zmym2 UTSW 14 57,193,637 (GRCm39) missense possibly damaging 0.86
R5223:Zmym2 UTSW 14 57,183,971 (GRCm39) missense probably benign
R5364:Zmym2 UTSW 14 57,158,102 (GRCm39) missense possibly damaging 0.58
R5488:Zmym2 UTSW 14 57,193,712 (GRCm39) missense possibly damaging 0.56
R5489:Zmym2 UTSW 14 57,193,712 (GRCm39) missense possibly damaging 0.56
R5818:Zmym2 UTSW 14 57,183,986 (GRCm39) missense probably benign
R6160:Zmym2 UTSW 14 57,187,766 (GRCm39) missense probably damaging 1.00
R6437:Zmym2 UTSW 14 57,140,461 (GRCm39) missense probably damaging 1.00
R7153:Zmym2 UTSW 14 57,187,659 (GRCm39) missense probably benign 0.16
R7337:Zmym2 UTSW 14 57,181,557 (GRCm39) missense probably benign 0.04
R7535:Zmym2 UTSW 14 57,194,536 (GRCm39) missense probably damaging 1.00
R7730:Zmym2 UTSW 14 57,193,638 (GRCm39) missense possibly damaging 0.95
R7779:Zmym2 UTSW 14 57,165,740 (GRCm39) missense probably damaging 1.00
R7849:Zmym2 UTSW 14 57,184,020 (GRCm39) missense probably benign 0.03
R8219:Zmym2 UTSW 14 57,163,316 (GRCm39) missense probably benign 0.07
R8493:Zmym2 UTSW 14 57,151,606 (GRCm39) missense probably damaging 1.00
R8885:Zmym2 UTSW 14 57,185,329 (GRCm39) intron probably benign
R9162:Zmym2 UTSW 14 57,163,361 (GRCm39) missense probably benign 0.02
R9165:Zmym2 UTSW 14 57,185,464 (GRCm39) missense probably damaging 0.98
R9250:Zmym2 UTSW 14 57,148,732 (GRCm39) missense probably damaging 1.00
R9453:Zmym2 UTSW 14 57,180,770 (GRCm39) missense probably damaging 1.00
R9677:Zmym2 UTSW 14 57,187,115 (GRCm39) missense probably benign 0.01
Z1176:Zmym2 UTSW 14 57,150,456 (GRCm39) missense possibly damaging 0.94
Z1177:Zmym2 UTSW 14 57,151,419 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GATACCTGATGTGGACCCCTTG -3'
(R):5'- ATCAGCAACCAAAGGTGCAG -3'

Sequencing Primer
(F):5'- TTGGAGTTTCAGTTGACACTTAAC -3'
(R):5'- GTACAGGTTCAATAAAAACAACGTC -3'
Posted On 2019-05-15