Incidental Mutation 'R7111:Dnai3'
ID 551500
Institutional Source Beutler Lab
Gene Symbol Dnai3
Ensembl Gene ENSMUSG00000043020
Gene Name dynein axonemal intermediate chain 3
Synonyms 4931433A13Rik, Wdr63, Ida7, IC140
MMRRC Submission 045203-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.115) question?
Stock # R7111 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 145746281-145813855 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 145803028 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Methionine at position 54 (I54M)
Ref Sequence ENSEMBL: ENSMUSP00000124475 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000160285]
AlphaFold B2RY71
Predicted Effect probably damaging
Transcript: ENSMUST00000160285
AA Change: I54M

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000124475
Gene: ENSMUSG00000043020
AA Change: I54M

DomainStartEndE-ValueType
low complexity region 3 22 N/A INTRINSIC
low complexity region 26 35 N/A INTRINSIC
low complexity region 133 150 N/A INTRINSIC
low complexity region 165 180 N/A INTRINSIC
Blast:WD40 321 367 6e-19 BLAST
low complexity region 375 383 N/A INTRINSIC
WD40 390 429 6.34e-2 SMART
WD40 470 527 1.15e-4 SMART
low complexity region 536 553 N/A INTRINSIC
WD40 693 732 1.07e1 SMART
WD40 737 776 1.1e2 SMART
coiled coil region 867 902 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (54/54)
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ablim1 T G 19: 57,062,309 (GRCm39) N384T probably benign Het
Agap3 A G 5: 24,706,396 (GRCm39) Y843C probably damaging Het
Aldh9a1 T A 1: 167,182,021 (GRCm39) V118E probably benign Het
Arhgef26 T A 3: 62,252,689 (GRCm39) S414T possibly damaging Het
Armc9 T C 1: 86,087,717 (GRCm39) Y18H probably damaging Het
Bod1l A G 5: 41,970,463 (GRCm39) probably null Het
Casp1 A T 9: 5,299,816 (GRCm39) E96D probably benign Het
Ccdc171 A G 4: 83,611,998 (GRCm39) I898V probably benign Het
Cd79b T C 11: 106,205,365 (GRCm39) I42M possibly damaging Het
Cdca7 G A 2: 72,315,575 (GRCm39) R346H probably damaging Het
Cdh20 T C 1: 110,065,638 (GRCm39) S176P Het
Cdh23 T A 10: 60,222,823 (GRCm39) D1200V probably damaging Het
Cdkn1c T C 7: 143,014,326 (GRCm39) D40G possibly damaging Het
Ckap5 G A 2: 91,437,917 (GRCm39) R1666H probably damaging Het
Cxcl1 A G 5: 91,039,182 (GRCm39) T5A unknown Het
Dnah2 A C 11: 69,337,579 (GRCm39) probably null Het
Ephb3 A T 16: 21,037,577 (GRCm39) K500* probably null Het
Fam13c T A 10: 70,390,336 (GRCm39) H533Q probably benign Het
Fat4 T A 3: 39,064,682 (GRCm39) D4879E probably damaging Het
Grk6 G T 13: 55,606,733 (GRCm39) W511L probably damaging Het
Hivep3 G C 4: 119,952,431 (GRCm39) S249T possibly damaging Het
Iqch T A 9: 63,419,599 (GRCm39) Y496F possibly damaging Het
Itga2 T C 13: 115,037,066 (GRCm39) I21V unknown Het
Itpr2 A T 6: 146,226,554 (GRCm39) C1397S probably damaging Het
Krt86 A T 15: 101,374,498 (GRCm39) Y297F possibly damaging Het
Limch1 G T 5: 67,182,519 (GRCm39) probably null Het
Mfsd6 G T 1: 52,748,917 (GRCm39) probably null Het
Mx1 A G 16: 97,256,376 (GRCm39) V181A probably damaging Het
Nme8 G A 13: 19,859,817 (GRCm39) R268W probably benign Het
Ogfr GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG 2: 180,237,059 (GRCm39) probably benign Het
Or10p1 T A 10: 129,443,829 (GRCm39) I174F possibly damaging Het
Or5d36 G A 2: 87,901,000 (GRCm39) T242I probably damaging Het
Pappa2 T A 1: 158,784,096 (GRCm39) I305F probably benign Het
Pdlim3 A G 8: 46,370,539 (GRCm39) K232E probably damaging Het
Rcn1 T C 2: 105,219,359 (GRCm39) E278G probably damaging Het
Ros1 T C 10: 52,057,906 (GRCm39) D47G probably benign Het
Sema4c G A 1: 36,592,160 (GRCm39) T229M possibly damaging Het
Serpina3j T A 12: 104,283,792 (GRCm39) W297R probably damaging Het
Serpinb11 A G 1: 107,304,614 (GRCm39) E193G probably benign Het
Shank2 A G 7: 143,965,289 (GRCm39) I966V probably benign Het
Siglece T C 7: 43,309,327 (GRCm39) D77G probably damaging Het
Sqstm1 G T 11: 50,093,418 (GRCm39) Q327K probably benign Het
Stip1 C T 19: 6,999,178 (GRCm39) G467S possibly damaging Het
Styxl2 T C 1: 165,954,723 (GRCm39) E9G possibly damaging Het
Svep1 A T 4: 58,118,207 (GRCm39) D838E possibly damaging Het
Tacc2 G A 7: 130,330,618 (GRCm39) A191T probably benign Het
Tnfrsf18 T A 4: 156,113,168 (GRCm39) W285R probably damaging Het
Tspan9 T C 6: 127,942,726 (GRCm39) D167G probably null Het
Uaca C T 9: 60,779,120 (GRCm39) T1169I probably benign Het
Umod G T 7: 119,076,369 (GRCm39) Y132* probably null Het
Vmn2r31 A G 7: 7,399,480 (GRCm39) F159S probably damaging Het
Vmn2r82 C T 10: 79,214,605 (GRCm39) T196I probably benign Het
Wrap53 A T 11: 69,453,305 (GRCm39) W379R probably damaging Het
Zfp866 A T 8: 70,219,221 (GRCm39) V133D probably benign Het
Other mutations in Dnai3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00093:Dnai3 APN 3 145,788,759 (GRCm39) missense probably benign
IGL00565:Dnai3 APN 3 145,750,674 (GRCm39) splice site probably benign
IGL01339:Dnai3 APN 3 145,748,591 (GRCm39) missense probably benign 0.14
IGL01952:Dnai3 APN 3 145,802,918 (GRCm39) missense probably damaging 0.96
IGL02663:Dnai3 APN 3 145,760,312 (GRCm39) missense possibly damaging 0.53
IGL02710:Dnai3 APN 3 145,753,903 (GRCm39) missense possibly damaging 0.96
P0041:Dnai3 UTSW 3 145,786,997 (GRCm39) missense possibly damaging 0.96
R0014:Dnai3 UTSW 3 145,787,178 (GRCm39) splice site probably null
R0014:Dnai3 UTSW 3 145,787,178 (GRCm39) splice site probably null
R0498:Dnai3 UTSW 3 145,787,119 (GRCm39) missense possibly damaging 0.54
R0589:Dnai3 UTSW 3 145,768,086 (GRCm39) missense probably benign 0.01
R1484:Dnai3 UTSW 3 145,802,996 (GRCm39) missense probably benign 0.02
R1537:Dnai3 UTSW 3 145,748,504 (GRCm39) missense probably damaging 0.98
R1611:Dnai3 UTSW 3 145,801,113 (GRCm39) missense probably damaging 1.00
R1743:Dnai3 UTSW 3 145,803,017 (GRCm39) missense possibly damaging 0.81
R1861:Dnai3 UTSW 3 145,788,801 (GRCm39) missense probably damaging 1.00
R1991:Dnai3 UTSW 3 145,769,235 (GRCm39) missense possibly damaging 0.82
R2185:Dnai3 UTSW 3 145,772,619 (GRCm39) missense possibly damaging 0.76
R4299:Dnai3 UTSW 3 145,774,561 (GRCm39) missense probably damaging 1.00
R4620:Dnai3 UTSW 3 145,748,564 (GRCm39) missense probably damaging 1.00
R4649:Dnai3 UTSW 3 145,753,922 (GRCm39) missense probably damaging 1.00
R4914:Dnai3 UTSW 3 145,772,582 (GRCm39) missense probably damaging 0.98
R4948:Dnai3 UTSW 3 145,788,820 (GRCm39) nonsense probably null
R5578:Dnai3 UTSW 3 145,802,983 (GRCm39) nonsense probably null
R6130:Dnai3 UTSW 3 145,748,559 (GRCm39) missense probably benign 0.25
R6162:Dnai3 UTSW 3 145,750,617 (GRCm39) missense probably damaging 1.00
R6291:Dnai3 UTSW 3 145,772,648 (GRCm39) missense probably benign 0.00
R6390:Dnai3 UTSW 3 145,801,143 (GRCm39) missense probably damaging 1.00
R6560:Dnai3 UTSW 3 145,801,161 (GRCm39) missense possibly damaging 0.79
R6893:Dnai3 UTSW 3 145,786,184 (GRCm39) missense probably damaging 1.00
R7090:Dnai3 UTSW 3 145,746,582 (GRCm39) missense possibly damaging 0.80
R7102:Dnai3 UTSW 3 145,761,459 (GRCm39) missense possibly damaging 0.49
R7260:Dnai3 UTSW 3 145,752,295 (GRCm39) missense probably benign 0.01
R7288:Dnai3 UTSW 3 145,787,007 (GRCm39) missense probably damaging 0.97
R7411:Dnai3 UTSW 3 145,802,900 (GRCm39) missense probably damaging 0.98
R7417:Dnai3 UTSW 3 145,798,835 (GRCm39) splice site probably null
R7466:Dnai3 UTSW 3 145,761,373 (GRCm39) missense probably benign 0.01
R7860:Dnai3 UTSW 3 145,772,675 (GRCm39) missense probably damaging 0.99
R7964:Dnai3 UTSW 3 145,774,531 (GRCm39) missense probably benign 0.09
R8013:Dnai3 UTSW 3 145,787,040 (GRCm39) missense probably damaging 1.00
R8059:Dnai3 UTSW 3 145,752,428 (GRCm39) missense possibly damaging 0.75
R8191:Dnai3 UTSW 3 145,800,066 (GRCm39) missense probably damaging 1.00
R8354:Dnai3 UTSW 3 145,802,982 (GRCm39) missense probably damaging 1.00
R8454:Dnai3 UTSW 3 145,802,982 (GRCm39) missense probably damaging 1.00
R8770:Dnai3 UTSW 3 145,752,298 (GRCm39) missense probably benign 0.01
R8967:Dnai3 UTSW 3 145,761,395 (GRCm39) missense possibly damaging 0.95
R9135:Dnai3 UTSW 3 145,772,589 (GRCm39) missense probably benign 0.39
R9310:Dnai3 UTSW 3 145,802,895 (GRCm39) critical splice donor site probably null
R9664:Dnai3 UTSW 3 145,748,594 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CTGGCAAGTCCCTGAGTTAG -3'
(R):5'- TCAGAAATCCACCTGCCTCTG -3'

Sequencing Primer
(F):5'- GGACTGAGAACAAACAGCTCACTTG -3'
(R):5'- GGATTAGAGGTGTGCGCCAC -3'
Posted On 2019-05-15