Incidental Mutation 'R7111:Vmn2r82'
| ID |
551524 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r82
|
| Ensembl Gene |
ENSMUSG00000091468 |
| Gene Name |
vomeronasal 2, receptor 82 |
| Synonyms |
EG624845 |
| MMRRC Submission |
045203-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.068)
|
| Stock # |
R7111 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
79192425-79232600 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 79214605 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 196
(T196I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000130114
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170596]
|
| AlphaFold |
G3UWA2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170596
AA Change: T196I
PolyPhen 2
Score 0.224 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000130114
Gene: ENSMUSG00000091468
AA Change: T196I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
79 |
474 |
6e-35 |
PFAM |
|
Pfam:NCD3G
|
517 |
570 |
9.3e-22 |
PFAM |
|
Pfam:7tm_3
|
603 |
838 |
6.5e-49 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
100% (54/54) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 54 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ablim1 |
T |
G |
19: 57,062,309 (GRCm39) |
N384T |
probably benign |
Het |
| Agap3 |
A |
G |
5: 24,706,396 (GRCm39) |
Y843C |
probably damaging |
Het |
| Aldh9a1 |
T |
A |
1: 167,182,021 (GRCm39) |
V118E |
probably benign |
Het |
| Arhgef26 |
T |
A |
3: 62,252,689 (GRCm39) |
S414T |
possibly damaging |
Het |
| Armc9 |
T |
C |
1: 86,087,717 (GRCm39) |
Y18H |
probably damaging |
Het |
| Bod1l |
A |
G |
5: 41,970,463 (GRCm39) |
|
probably null |
Het |
| Casp1 |
A |
T |
9: 5,299,816 (GRCm39) |
E96D |
probably benign |
Het |
| Ccdc171 |
A |
G |
4: 83,611,998 (GRCm39) |
I898V |
probably benign |
Het |
| Cd79b |
T |
C |
11: 106,205,365 (GRCm39) |
I42M |
possibly damaging |
Het |
| Cdca7 |
G |
A |
2: 72,315,575 (GRCm39) |
R346H |
probably damaging |
Het |
| Cdh20 |
T |
C |
1: 110,065,638 (GRCm39) |
S176P |
|
Het |
| Cdh23 |
T |
A |
10: 60,222,823 (GRCm39) |
D1200V |
probably damaging |
Het |
| Cdkn1c |
T |
C |
7: 143,014,326 (GRCm39) |
D40G |
possibly damaging |
Het |
| Ckap5 |
G |
A |
2: 91,437,917 (GRCm39) |
R1666H |
probably damaging |
Het |
| Cxcl1 |
A |
G |
5: 91,039,182 (GRCm39) |
T5A |
unknown |
Het |
| Dnah2 |
A |
C |
11: 69,337,579 (GRCm39) |
|
probably null |
Het |
| Dnai3 |
T |
C |
3: 145,803,028 (GRCm39) |
I54M |
probably damaging |
Het |
| Ephb3 |
A |
T |
16: 21,037,577 (GRCm39) |
K500* |
probably null |
Het |
| Fam13c |
T |
A |
10: 70,390,336 (GRCm39) |
H533Q |
probably benign |
Het |
| Fat4 |
T |
A |
3: 39,064,682 (GRCm39) |
D4879E |
probably damaging |
Het |
| Grk6 |
G |
T |
13: 55,606,733 (GRCm39) |
W511L |
probably damaging |
Het |
| Hivep3 |
G |
C |
4: 119,952,431 (GRCm39) |
S249T |
possibly damaging |
Het |
| Iqch |
T |
A |
9: 63,419,599 (GRCm39) |
Y496F |
possibly damaging |
Het |
| Itga2 |
T |
C |
13: 115,037,066 (GRCm39) |
I21V |
unknown |
Het |
| Itpr2 |
A |
T |
6: 146,226,554 (GRCm39) |
C1397S |
probably damaging |
Het |
| Krt86 |
A |
T |
15: 101,374,498 (GRCm39) |
Y297F |
possibly damaging |
Het |
| Limch1 |
G |
T |
5: 67,182,519 (GRCm39) |
|
probably null |
Het |
| Mfsd6 |
G |
T |
1: 52,748,917 (GRCm39) |
|
probably null |
Het |
| Mx1 |
A |
G |
16: 97,256,376 (GRCm39) |
V181A |
probably damaging |
Het |
| Nme8 |
G |
A |
13: 19,859,817 (GRCm39) |
R268W |
probably benign |
Het |
| Ogfr |
GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG |
GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG |
2: 180,237,059 (GRCm39) |
|
probably benign |
Het |
| Or10p1 |
T |
A |
10: 129,443,829 (GRCm39) |
I174F |
possibly damaging |
Het |
| Or5d36 |
G |
A |
2: 87,901,000 (GRCm39) |
T242I |
probably damaging |
Het |
| Pappa2 |
T |
A |
1: 158,784,096 (GRCm39) |
I305F |
probably benign |
Het |
| Pdlim3 |
A |
G |
8: 46,370,539 (GRCm39) |
K232E |
probably damaging |
Het |
| Rcn1 |
T |
C |
2: 105,219,359 (GRCm39) |
E278G |
probably damaging |
Het |
| Ros1 |
T |
C |
10: 52,057,906 (GRCm39) |
D47G |
probably benign |
Het |
| Sema4c |
G |
A |
1: 36,592,160 (GRCm39) |
T229M |
possibly damaging |
Het |
| Serpina3j |
T |
A |
12: 104,283,792 (GRCm39) |
W297R |
probably damaging |
Het |
| Serpinb11 |
A |
G |
1: 107,304,614 (GRCm39) |
E193G |
probably benign |
Het |
| Shank2 |
A |
G |
7: 143,965,289 (GRCm39) |
I966V |
probably benign |
Het |
| Siglece |
T |
C |
7: 43,309,327 (GRCm39) |
D77G |
probably damaging |
Het |
| Sqstm1 |
G |
T |
11: 50,093,418 (GRCm39) |
Q327K |
probably benign |
Het |
| Stip1 |
C |
T |
19: 6,999,178 (GRCm39) |
G467S |
possibly damaging |
Het |
| Styxl2 |
T |
C |
1: 165,954,723 (GRCm39) |
E9G |
possibly damaging |
Het |
| Svep1 |
A |
T |
4: 58,118,207 (GRCm39) |
D838E |
possibly damaging |
Het |
| Tacc2 |
G |
A |
7: 130,330,618 (GRCm39) |
A191T |
probably benign |
Het |
| Tnfrsf18 |
T |
A |
4: 156,113,168 (GRCm39) |
W285R |
probably damaging |
Het |
| Tspan9 |
T |
C |
6: 127,942,726 (GRCm39) |
D167G |
probably null |
Het |
| Uaca |
C |
T |
9: 60,779,120 (GRCm39) |
T1169I |
probably benign |
Het |
| Umod |
G |
T |
7: 119,076,369 (GRCm39) |
Y132* |
probably null |
Het |
| Vmn2r31 |
A |
G |
7: 7,399,480 (GRCm39) |
F159S |
probably damaging |
Het |
| Wrap53 |
A |
T |
11: 69,453,305 (GRCm39) |
W379R |
probably damaging |
Het |
| Zfp866 |
A |
T |
8: 70,219,221 (GRCm39) |
V133D |
probably benign |
Het |
|
| Other mutations in Vmn2r82 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01800:Vmn2r82
|
APN |
10 |
79,192,581 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01860:Vmn2r82
|
APN |
10 |
79,214,691 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01927:Vmn2r82
|
APN |
10 |
79,213,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01929:Vmn2r82
|
APN |
10 |
79,214,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02028:Vmn2r82
|
APN |
10 |
79,215,057 (GRCm39) |
missense |
probably benign |
|
|
IGL02112:Vmn2r82
|
APN |
10 |
79,231,833 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02632:Vmn2r82
|
APN |
10 |
79,192,542 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL02665:Vmn2r82
|
APN |
10 |
79,215,205 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02716:Vmn2r82
|
APN |
10 |
79,213,678 (GRCm39) |
missense |
probably benign |
0.20 |
|
IGL03030:Vmn2r82
|
APN |
10 |
79,217,149 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL03190:Vmn2r82
|
APN |
10 |
79,192,643 (GRCm39) |
splice site |
probably null |
|
|
IGL03349:Vmn2r82
|
APN |
10 |
79,213,703 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL03048:Vmn2r82
|
UTSW |
10 |
79,232,460 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0080:Vmn2r82
|
UTSW |
10 |
79,232,339 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0193:Vmn2r82
|
UTSW |
10 |
79,217,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0217:Vmn2r82
|
UTSW |
10 |
79,214,634 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0285:Vmn2r82
|
UTSW |
10 |
79,232,391 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1193:Vmn2r82
|
UTSW |
10 |
79,213,739 (GRCm39) |
nonsense |
probably null |
|
|
R1385:Vmn2r82
|
UTSW |
10 |
79,232,325 (GRCm39) |
nonsense |
probably null |
|
|
R1386:Vmn2r82
|
UTSW |
10 |
79,214,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1442:Vmn2r82
|
UTSW |
10 |
79,215,201 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1467:Vmn2r82
|
UTSW |
10 |
79,232,133 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1467:Vmn2r82
|
UTSW |
10 |
79,232,133 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1518:Vmn2r82
|
UTSW |
10 |
79,214,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1538:Vmn2r82
|
UTSW |
10 |
79,192,578 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1607:Vmn2r82
|
UTSW |
10 |
79,215,253 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R1812:Vmn2r82
|
UTSW |
10 |
79,215,046 (GRCm39) |
missense |
probably benign |
0.33 |
|
R1906:Vmn2r82
|
UTSW |
10 |
79,232,344 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1954:Vmn2r82
|
UTSW |
10 |
79,231,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1972:Vmn2r82
|
UTSW |
10 |
79,214,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2093:Vmn2r82
|
UTSW |
10 |
79,231,813 (GRCm39) |
missense |
probably benign |
0.30 |
|
R2156:Vmn2r82
|
UTSW |
10 |
79,214,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2202:Vmn2r82
|
UTSW |
10 |
79,192,519 (GRCm39) |
missense |
probably benign |
|
|
R2442:Vmn2r82
|
UTSW |
10 |
79,221,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2444:Vmn2r82
|
UTSW |
10 |
79,213,702 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2857:Vmn2r82
|
UTSW |
10 |
79,217,090 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2858:Vmn2r82
|
UTSW |
10 |
79,217,090 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2884:Vmn2r82
|
UTSW |
10 |
79,232,082 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2886:Vmn2r82
|
UTSW |
10 |
79,232,082 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4369:Vmn2r82
|
UTSW |
10 |
79,231,914 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4445:Vmn2r82
|
UTSW |
10 |
79,214,874 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4589:Vmn2r82
|
UTSW |
10 |
79,192,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4703:Vmn2r82
|
UTSW |
10 |
79,214,641 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4908:Vmn2r82
|
UTSW |
10 |
79,214,589 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4937:Vmn2r82
|
UTSW |
10 |
79,215,010 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5199:Vmn2r82
|
UTSW |
10 |
79,231,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5391:Vmn2r82
|
UTSW |
10 |
79,192,491 (GRCm39) |
missense |
probably null |
0.01 |
|
R5601:Vmn2r82
|
UTSW |
10 |
79,232,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5635:Vmn2r82
|
UTSW |
10 |
79,214,652 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6065:Vmn2r82
|
UTSW |
10 |
79,221,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6074:Vmn2r82
|
UTSW |
10 |
79,232,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6340:Vmn2r82
|
UTSW |
10 |
79,231,727 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6474:Vmn2r82
|
UTSW |
10 |
79,214,871 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6995:Vmn2r82
|
UTSW |
10 |
79,232,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7212:Vmn2r82
|
UTSW |
10 |
79,215,268 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7335:Vmn2r82
|
UTSW |
10 |
79,214,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7353:Vmn2r82
|
UTSW |
10 |
79,232,452 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7354:Vmn2r82
|
UTSW |
10 |
79,192,464 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7362:Vmn2r82
|
UTSW |
10 |
79,232,451 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7378:Vmn2r82
|
UTSW |
10 |
79,232,276 (GRCm39) |
nonsense |
probably null |
|
|
R7430:Vmn2r82
|
UTSW |
10 |
79,217,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7509:Vmn2r82
|
UTSW |
10 |
79,231,842 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7874:Vmn2r82
|
UTSW |
10 |
79,232,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7943:Vmn2r82
|
UTSW |
10 |
79,232,079 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8158:Vmn2r82
|
UTSW |
10 |
79,213,636 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8324:Vmn2r82
|
UTSW |
10 |
79,214,727 (GRCm39) |
nonsense |
probably null |
|
|
R8340:Vmn2r82
|
UTSW |
10 |
79,217,036 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8787:Vmn2r82
|
UTSW |
10 |
79,213,894 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8929:Vmn2r82
|
UTSW |
10 |
79,232,541 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9018:Vmn2r82
|
UTSW |
10 |
79,232,539 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9399:Vmn2r82
|
UTSW |
10 |
79,214,768 (GRCm39) |
nonsense |
probably null |
|
|
R9517:Vmn2r82
|
UTSW |
10 |
79,213,641 (GRCm39) |
nonsense |
probably null |
|
|
R9587:Vmn2r82
|
UTSW |
10 |
79,214,936 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R9602:Vmn2r82
|
UTSW |
10 |
79,214,880 (GRCm39) |
missense |
probably benign |
0.07 |
|
Z1088:Vmn2r82
|
UTSW |
10 |
79,192,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Vmn2r82
|
UTSW |
10 |
79,232,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Vmn2r82
|
UTSW |
10 |
79,192,429 (GRCm39) |
missense |
probably benign |
0.03 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTACAAAGACAAAGACACATTGGG -3'
(R):5'- GCAAACGAAGTAGGGTTTCCC -3'
Sequencing Primer
(F):5'- AACTTGACCCAGGCTGGAGTTATC -3'
(R):5'- CCCCAGATATAATACTGTTTGCAC -3'
|
| Posted On |
2019-05-15 |
Incidental Mutation