Incidental Mutation 'R7115:Tas2r131'
| ID |
551723 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tas2r131
|
| Ensembl Gene |
ENSMUSG00000057699 |
| Gene Name |
taste receptor, type 2, member 131 |
| Synonyms |
Tas2r31, mGR31, T2R31, mt2r61 |
| MMRRC Submission |
045206-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7115 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
132933875-132934807 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 132934567 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 81
(F81L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000080736
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000082085]
|
| AlphaFold |
Q7M708 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000082085
AA Change: F81L
PolyPhen 2
Score 0.067 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000080736
Gene: ENSMUSG00000057699
AA Change: F81L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
293 |
1.2e-66 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 36 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc1 |
T |
A |
16: 14,255,589 (GRCm39) |
I636N |
probably benign |
Het |
| Adam5 |
A |
G |
8: 25,271,712 (GRCm39) |
I565T |
possibly damaging |
Het |
| Amd2 |
C |
A |
10: 35,587,633 (GRCm39) |
|
probably benign |
Het |
| Ap5m1 |
T |
A |
14: 49,323,727 (GRCm39) |
Y472* |
probably null |
Het |
| Apcdd1 |
T |
C |
18: 63,070,024 (GRCm39) |
F97S |
probably damaging |
Het |
| Axdnd1 |
T |
C |
1: 156,208,446 (GRCm39) |
K267R |
|
Het |
| Carf |
G |
T |
1: 60,187,309 (GRCm39) |
L637F |
probably damaging |
Het |
| Ccdc103 |
A |
T |
11: 102,774,636 (GRCm39) |
S95C |
possibly damaging |
Het |
| Cfap20 |
T |
C |
8: 96,147,874 (GRCm39) |
I156V |
probably benign |
Het |
| Csn1s2a |
T |
C |
5: 87,929,664 (GRCm39) |
C96R |
probably benign |
Het |
| Cspg4b |
T |
G |
13: 113,457,310 (GRCm39) |
S1119A |
|
Het |
| Ctif |
CGGGGCACACTTTGCTCTTACCTCCCGGAGGCACGTGTAGATGGGGCACACTTTGCTCTTACCTCCCGGAGGCACGTGTAGATGGGGCACAC |
CGGGGCACACTTTGCTCTTACCTCCCGGAGGCACGTGTAGATGGGGCACAC |
18: 75,604,874 (GRCm39) |
|
probably benign |
Het |
| Dennd2a |
G |
A |
6: 39,483,645 (GRCm39) |
T405M |
probably damaging |
Het |
| Dennd5a |
A |
G |
7: 109,493,961 (GRCm39) |
Y1248H |
probably damaging |
Het |
| Dnah14 |
A |
T |
1: 181,547,710 (GRCm39) |
K2504N |
probably damaging |
Het |
| Dnajb2 |
G |
A |
1: 75,220,306 (GRCm39) |
G275D |
|
Het |
| Elf3 |
T |
G |
1: 135,184,856 (GRCm39) |
D110A |
probably damaging |
Het |
| Eomes |
A |
G |
9: 118,313,557 (GRCm39) |
N534S |
probably benign |
Het |
| Fry |
A |
T |
5: 150,309,532 (GRCm39) |
R659W |
probably damaging |
Het |
| Gm10428 |
G |
A |
11: 62,644,206 (GRCm39) |
C94Y |
unknown |
Het |
| Gm2696 |
T |
A |
10: 77,672,133 (GRCm39) |
C111S |
unknown |
Het |
| Gpt2 |
G |
A |
8: 86,244,681 (GRCm39) |
E325K |
probably benign |
Het |
| Lrp1b |
T |
A |
2: 40,888,247 (GRCm39) |
N2338Y |
|
Het |
| Map2k1 |
A |
G |
9: 64,119,888 (GRCm39) |
I139T |
probably damaging |
Het |
| Or10n7-ps1 |
T |
C |
9: 39,598,003 (GRCm39) |
Y79C |
probably benign |
Het |
| Or8g20 |
T |
C |
9: 39,395,944 (GRCm39) |
I202V |
probably benign |
Het |
| Pxylp1 |
G |
A |
9: 96,707,063 (GRCm39) |
T373I |
probably benign |
Het |
| Ranbp9 |
T |
C |
13: 43,560,147 (GRCm39) |
N484S |
probably benign |
Het |
| Rassf5 |
A |
G |
1: 131,108,986 (GRCm39) |
V293A |
probably benign |
Het |
| Ring1 |
A |
G |
17: 34,242,420 (GRCm39) |
I29T |
probably damaging |
Het |
| Scn1a |
G |
A |
2: 66,154,962 (GRCm39) |
Q666* |
probably null |
Het |
| Spice1 |
G |
A |
16: 44,199,638 (GRCm39) |
G697R |
probably benign |
Het |
| Tenm2 |
G |
A |
11: 36,054,644 (GRCm39) |
S572L |
probably damaging |
Het |
| Tfr2 |
A |
G |
5: 137,569,977 (GRCm39) |
T128A |
probably benign |
Het |
| Trim56 |
T |
A |
5: 137,142,514 (GRCm39) |
Q334L |
probably damaging |
Het |
| Vmn2r44 |
T |
A |
7: 8,370,527 (GRCm39) |
R840* |
probably null |
Het |
|
| Other mutations in Tas2r131 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00592:Tas2r131
|
APN |
6 |
132,934,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00795:Tas2r131
|
APN |
6 |
132,934,554 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01023:Tas2r131
|
APN |
6 |
132,934,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02439:Tas2r131
|
APN |
6 |
132,934,732 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0335:Tas2r131
|
UTSW |
6 |
132,934,792 (GRCm39) |
missense |
probably benign |
|
|
R0523:Tas2r131
|
UTSW |
6 |
132,934,414 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1056:Tas2r131
|
UTSW |
6 |
132,934,030 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1069:Tas2r131
|
UTSW |
6 |
132,934,788 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4073:Tas2r131
|
UTSW |
6 |
132,934,802 (GRCm39) |
nonsense |
probably null |
|
|
R4719:Tas2r131
|
UTSW |
6 |
132,933,936 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5002:Tas2r131
|
UTSW |
6 |
132,934,114 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5049:Tas2r131
|
UTSW |
6 |
132,934,540 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5635:Tas2r131
|
UTSW |
6 |
132,934,571 (GRCm39) |
missense |
probably benign |
0.27 |
|
R5905:Tas2r131
|
UTSW |
6 |
132,934,639 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6028:Tas2r131
|
UTSW |
6 |
132,934,639 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6229:Tas2r131
|
UTSW |
6 |
132,933,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7561:Tas2r131
|
UTSW |
6 |
132,933,921 (GRCm39) |
missense |
probably benign |
0.26 |
|
R7741:Tas2r131
|
UTSW |
6 |
132,934,438 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R7810:Tas2r131
|
UTSW |
6 |
132,934,705 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8878:Tas2r131
|
UTSW |
6 |
132,934,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9506:Tas2r131
|
UTSW |
6 |
132,934,024 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
X0025:Tas2r131
|
UTSW |
6 |
132,934,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Tas2r131
|
UTSW |
6 |
132,933,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCAAATAGGAAGTGTTTCAAGCAG -3'
(R):5'- GCTGGGAAATATGTTCATTGGAC -3'
Sequencing Primer
(F):5'- CTCCACTTAAACCAGAGGAA -3'
(R):5'- TCATTGGACTGGCAAACTGC -3'
|
| Posted On |
2019-05-15 |
Incidental Mutation