Incidental Mutation 'R7123:Vmn2r104'
ID 552164
Institutional Source Beutler Lab
Gene Symbol Vmn2r104
Ensembl Gene ENSMUSG00000090315
Gene Name vomeronasal 2, receptor 104
Synonyms V2r7
MMRRC Submission 045211-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R7123 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 20249687-20268467 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 20261088 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 445 (D445G)
Ref Sequence ENSEMBL: ENSMUSP00000129895 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168050]
AlphaFold E9Q2J5
Predicted Effect probably benign
Transcript: ENSMUST00000168050
AA Change: D445G

PolyPhen 2 Score 0.117 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000129895
Gene: ENSMUSG00000090315
AA Change: D445G

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 85 457 4e-38 PFAM
Pfam:NCD3G 512 565 2.1e-20 PFAM
Pfam:7tm_3 598 833 1.7e-52 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 98% (52/53)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 A G 17: 24,484,949 (GRCm39) I1521T probably damaging Het
Adgrv1 A T 13: 81,740,693 (GRCm39) I145N probably damaging Het
Ago3 C A 4: 126,248,798 (GRCm39) probably null Het
Agrn A T 4: 156,257,297 (GRCm39) W1178R probably benign Het
Akap3 A T 6: 126,843,267 (GRCm39) I629L probably benign Het
Aknad1 T G 3: 108,682,560 (GRCm39) Y545* probably null Het
Anapc1 C A 2: 128,454,930 (GRCm39) V1925F probably damaging Het
Barhl1 C T 2: 28,799,943 (GRCm39) probably null Het
Cfap157 T C 2: 32,669,413 (GRCm39) E294G probably damaging Het
Cfd G A 10: 79,728,331 (GRCm39) G231S probably damaging Het
Csf2ra A G 19: 61,215,300 (GRCm39) V105A probably damaging Het
Dhtkd1 A T 2: 5,922,591 (GRCm39) W523R probably damaging Het
Disp1 C A 1: 182,869,030 (GRCm39) R1130L probably damaging Het
Dnajc22 A C 15: 98,999,085 (GRCm39) Y90S possibly damaging Het
Ebna1bp2 A G 4: 118,482,772 (GRCm39) K254E probably damaging Het
Gfpt1 A T 6: 87,033,168 (GRCm39) D131V probably damaging Het
Gm5460 A G 14: 33,763,982 (GRCm39) I21V unknown Het
H2-T9 A G 17: 36,438,686 (GRCm39) I235T possibly damaging Het
Htr1d C T 4: 136,169,664 (GRCm39) probably benign Het
Kndc1 G A 7: 139,516,749 (GRCm39) E1570K probably damaging Het
Kntc1 T C 5: 123,919,789 (GRCm39) Y887H probably damaging Het
Kti12 T C 4: 108,705,679 (GRCm39) S198P probably benign Het
Mcmdc2 A T 1: 10,010,643 (GRCm39) I604F unknown Het
Mmp8 A T 9: 7,563,196 (GRCm39) D253V probably damaging Het
Muc4 T C 16: 32,569,509 (GRCm39) S252P possibly damaging Het
Myo5c A G 9: 75,196,505 (GRCm39) K1317R probably benign Het
Ncoa7 T C 10: 30,530,435 (GRCm39) I749V probably benign Het
Nfrkb A G 9: 31,325,311 (GRCm39) probably null Het
Obscn T C 11: 58,904,477 (GRCm39) T7166A probably benign Het
Obsl1 A G 1: 75,466,313 (GRCm39) S1472P probably damaging Het
Or14j7 T A 17: 38,234,567 (GRCm39) L37M probably benign Het
Or1e20-ps1 T A 11: 73,324,536 (GRCm39) D172V unknown Het
Orc1 A C 4: 108,445,884 (GRCm39) M1L probably damaging Het
Pkd1 T A 17: 24,813,742 (GRCm39) S4069T possibly damaging Het
Pus1 T C 5: 110,921,798 (GRCm39) *442W probably null Het
Rgma A C 7: 73,059,139 (GRCm39) D97A probably damaging Het
Ryr1 T C 7: 28,746,279 (GRCm39) K3834E probably benign Het
Sars2 T C 7: 28,452,866 (GRCm39) V475A probably benign Het
Scamp2 A T 9: 57,494,385 (GRCm39) T253S probably benign Het
Skint9 C T 4: 112,248,174 (GRCm39) W190* probably null Het
Spata31d1e G A 13: 59,891,254 (GRCm39) Q189* probably null Het
Sv2b C T 7: 74,767,450 (GRCm39) V649I possibly damaging Het
Synpo2 A G 3: 122,906,835 (GRCm39) V827A probably benign Het
Tiparp A T 3: 65,460,948 (GRCm39) I646F probably damaging Het
Topaz1 G A 9: 122,577,480 (GRCm39) G130D probably damaging Het
Trio TACCTTGTTACTGAGCCCTTCTCACCTTCACAGACACCTTGTTACTGAGCCCTTCTCACCTTCACAGATACCTTGTTACTGAGCCCTTCTC TACCTTGTTACTGAGCCCTTCTCACCTTCACAGATACCTTGTTACTGAGCCCTTCTC 15: 27,742,399 (GRCm39) probably benign Het
Ttll7 C T 3: 146,619,051 (GRCm39) P319S possibly damaging Het
Umodl1 T A 17: 31,201,318 (GRCm39) F416I possibly damaging Het
Wnk2 A G 13: 49,235,462 (GRCm39) V651A possibly damaging Het
Zbtb21 C T 16: 97,751,112 (GRCm39) S1057N probably damaging Het
Zfp451 A T 1: 33,815,950 (GRCm39) C667S probably damaging Het
Other mutations in Vmn2r104
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00427:Vmn2r104 APN 17 20,258,501 (GRCm39) missense probably damaging 0.98
IGL01098:Vmn2r104 APN 17 20,268,358 (GRCm39) missense probably benign 0.27
IGL01333:Vmn2r104 APN 17 20,263,055 (GRCm39) missense probably benign 0.17
IGL01527:Vmn2r104 APN 17 20,263,158 (GRCm39) missense possibly damaging 0.82
IGL01773:Vmn2r104 APN 17 20,260,930 (GRCm39) missense probably benign 0.10
IGL01939:Vmn2r104 APN 17 20,250,187 (GRCm39) missense probably damaging 0.99
IGL02121:Vmn2r104 APN 17 20,262,056 (GRCm39) nonsense probably null
IGL02305:Vmn2r104 APN 17 20,263,118 (GRCm39) missense probably benign 0.09
IGL02374:Vmn2r104 APN 17 20,263,048 (GRCm39) missense probably benign 0.34
IGL03260:Vmn2r104 APN 17 20,263,083 (GRCm39) missense probably benign 0.05
IGL03366:Vmn2r104 APN 17 20,249,866 (GRCm39) missense probably damaging 1.00
R0091:Vmn2r104 UTSW 17 20,262,075 (GRCm39) missense possibly damaging 0.79
R0125:Vmn2r104 UTSW 17 20,250,069 (GRCm39) missense probably damaging 0.98
R0257:Vmn2r104 UTSW 17 20,249,889 (GRCm39) missense probably damaging 1.00
R0381:Vmn2r104 UTSW 17 20,268,264 (GRCm39) nonsense probably null
R0709:Vmn2r104 UTSW 17 20,263,166 (GRCm39) missense probably damaging 1.00
R0786:Vmn2r104 UTSW 17 20,262,987 (GRCm39) missense probably benign
R1575:Vmn2r104 UTSW 17 20,262,477 (GRCm39) missense probably damaging 1.00
R1827:Vmn2r104 UTSW 17 20,262,497 (GRCm39) missense probably damaging 0.97
R1932:Vmn2r104 UTSW 17 20,261,031 (GRCm39) missense probably damaging 1.00
R1956:Vmn2r104 UTSW 17 20,262,313 (GRCm39) missense probably damaging 0.98
R2203:Vmn2r104 UTSW 17 20,250,083 (GRCm39) missense probably benign 0.05
R2205:Vmn2r104 UTSW 17 20,250,083 (GRCm39) missense probably benign 0.05
R2859:Vmn2r104 UTSW 17 20,268,455 (GRCm39) missense possibly damaging 0.82
R3701:Vmn2r104 UTSW 17 20,249,818 (GRCm39) missense probably damaging 1.00
R3834:Vmn2r104 UTSW 17 20,250,183 (GRCm39) missense probably benign 0.02
R4151:Vmn2r104 UTSW 17 20,250,147 (GRCm39) missense probably damaging 1.00
R4470:Vmn2r104 UTSW 17 20,262,503 (GRCm39) missense probably damaging 1.00
R4625:Vmn2r104 UTSW 17 20,268,443 (GRCm39) missense probably benign 0.00
R4754:Vmn2r104 UTSW 17 20,261,030 (GRCm39) nonsense probably null
R4911:Vmn2r104 UTSW 17 20,250,288 (GRCm39) missense probably benign 0.00
R5270:Vmn2r104 UTSW 17 20,258,528 (GRCm39) missense probably damaging 1.00
R5279:Vmn2r104 UTSW 17 20,262,146 (GRCm39) missense probably benign 0.07
R5311:Vmn2r104 UTSW 17 20,250,163 (GRCm39) missense probably damaging 1.00
R5370:Vmn2r104 UTSW 17 20,250,450 (GRCm39) missense probably damaging 0.97
R5461:Vmn2r104 UTSW 17 20,250,343 (GRCm39) missense probably damaging 1.00
R5683:Vmn2r104 UTSW 17 20,260,981 (GRCm39) nonsense probably null
R5795:Vmn2r104 UTSW 17 20,250,544 (GRCm39) missense possibly damaging 0.89
R5795:Vmn2r104 UTSW 17 20,250,372 (GRCm39) missense probably benign 0.02
R5970:Vmn2r104 UTSW 17 20,249,733 (GRCm39) missense probably benign 0.01
R5983:Vmn2r104 UTSW 17 20,261,970 (GRCm39) missense probably damaging 1.00
R5992:Vmn2r104 UTSW 17 20,249,747 (GRCm39) missense probably damaging 1.00
R6066:Vmn2r104 UTSW 17 20,258,573 (GRCm39) missense possibly damaging 0.69
R6156:Vmn2r104 UTSW 17 20,261,909 (GRCm39) missense probably damaging 1.00
R6182:Vmn2r104 UTSW 17 20,250,507 (GRCm39) missense probably benign 0.16
R6245:Vmn2r104 UTSW 17 20,261,829 (GRCm39) missense possibly damaging 0.69
R6333:Vmn2r104 UTSW 17 20,249,848 (GRCm39) missense probably benign 0.30
R6573:Vmn2r104 UTSW 17 20,262,487 (GRCm39) missense probably damaging 1.00
R7101:Vmn2r104 UTSW 17 20,250,358 (GRCm39) missense possibly damaging 0.65
R7485:Vmn2r104 UTSW 17 20,249,737 (GRCm39) missense probably benign 0.01
R7514:Vmn2r104 UTSW 17 20,249,791 (GRCm39) missense probably damaging 1.00
R7634:Vmn2r104 UTSW 17 20,261,971 (GRCm39) missense possibly damaging 0.48
R7958:Vmn2r104 UTSW 17 20,262,988 (GRCm39) missense probably benign
R8031:Vmn2r104 UTSW 17 20,263,048 (GRCm39) missense probably benign 0.34
R8094:Vmn2r104 UTSW 17 20,250,483 (GRCm39) missense possibly damaging 0.77
R8191:Vmn2r104 UTSW 17 20,250,465 (GRCm39) missense possibly damaging 0.89
R8308:Vmn2r104 UTSW 17 20,261,040 (GRCm39) missense possibly damaging 0.55
R8691:Vmn2r104 UTSW 17 20,262,110 (GRCm39) missense probably damaging 0.98
R8795:Vmn2r104 UTSW 17 20,262,988 (GRCm39) missense probably benign
R8900:Vmn2r104 UTSW 17 20,261,924 (GRCm39) missense probably damaging 0.99
R8913:Vmn2r104 UTSW 17 20,249,968 (GRCm39) missense probably damaging 1.00
R9180:Vmn2r104 UTSW 17 20,263,087 (GRCm39) missense probably benign 0.00
R9199:Vmn2r104 UTSW 17 20,262,097 (GRCm39) missense probably damaging 0.99
R9282:Vmn2r104 UTSW 17 20,261,098 (GRCm39) missense probably damaging 1.00
R9303:Vmn2r104 UTSW 17 20,268,439 (GRCm39) missense possibly damaging 0.90
R9305:Vmn2r104 UTSW 17 20,268,439 (GRCm39) missense possibly damaging 0.90
R9322:Vmn2r104 UTSW 17 20,263,087 (GRCm39) missense probably benign 0.00
R9325:Vmn2r104 UTSW 17 20,268,433 (GRCm39) missense possibly damaging 0.95
R9414:Vmn2r104 UTSW 17 20,250,250 (GRCm39) missense probably damaging 0.99
R9785:Vmn2r104 UTSW 17 20,268,409 (GRCm39) missense probably benign
RF007:Vmn2r104 UTSW 17 20,268,302 (GRCm39) missense probably benign 0.36
Z1177:Vmn2r104 UTSW 17 20,250,051 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAAAAGCGAGTATACTAATGTTGCC -3'
(R):5'- TGAATACTCCGGTTTTCACTTAGTC -3'

Sequencing Primer
(F):5'- CTGGCCATTGAATTATCTGTTCAG -3'
(R):5'- CGGTTTTCACTTAGTCATCAATAATG -3'
Posted On 2019-05-15