Incidental Mutation 'R7125:Or1e31'
ID 552277
Institutional Source Beutler Lab
Gene Symbol Or1e31
Ensembl Gene ENSMUSG00000070382
Gene Name olfactory receptor family 1 subfamily E member 31
Synonyms MOR135-24, Olfr391, Olfr391-ps1, Olfr391-ps, GA_x6K02T2P1NL-3951666-3950698, MOR135-30_i
MMRRC Submission 045327-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.113) question?
Stock # R7125 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 73689579-73693810 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 73689990 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 198 (M198V)
Ref Sequence ENSEMBL: ENSMUSP00000151029 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000214485]
AlphaFold A0A0U1RNJ4
Predicted Effect probably benign
Transcript: ENSMUST00000214485
AA Change: M198V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 96% (48/50)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730455P16Rik A T 11: 80,255,751 (GRCm39) C296S probably damaging Het
Ago3 T C 4: 126,264,145 (GRCm39) I354V probably null Het
Aldh1l1 G A 6: 90,553,761 (GRCm39) probably null Het
Ankrd49 TAA TA 9: 14,693,836 (GRCm39) probably null Het
B3gnt7 A G 1: 86,233,099 (GRCm39) Y115C probably damaging Het
Cacna1h A T 17: 25,602,510 (GRCm39) M1506K probably damaging Het
Cars1 T C 7: 143,138,510 (GRCm39) T226A probably benign Het
Ccdc28b T A 4: 129,514,885 (GRCm39) T75S probably benign Het
Cdc42bpg A G 19: 6,372,321 (GRCm39) I1436V probably damaging Het
Cep152 A T 2: 125,408,593 (GRCm39) Y1320* probably null Het
Cntnap2 A T 6: 46,965,580 (GRCm39) Y797F probably benign Het
Coq8a T A 1: 179,996,366 (GRCm39) N490I probably damaging Het
Csmd2 T C 4: 128,389,955 (GRCm39) L2230P Het
Cyp4a14 A T 4: 115,348,358 (GRCm39) I373N probably damaging Het
Ddx1 A G 12: 13,293,864 (GRCm39) S86P probably benign Het
Dennd3 A T 15: 73,405,140 (GRCm39) I298F possibly damaging Het
Disp1 C A 1: 182,869,030 (GRCm39) R1130L probably damaging Het
Dnah2 T C 11: 69,327,008 (GRCm39) T3533A probably damaging Het
Fam53b T C 7: 132,373,357 (GRCm39) H27R probably damaging Het
Firrm T C 1: 163,789,631 (GRCm39) T635A probably benign Het
Fyb1 G A 15: 6,674,337 (GRCm39) E658K possibly damaging Het
Gapvd1 T C 2: 34,585,612 (GRCm39) S996G probably benign Het
Gm47959 G A 1: 82,978,503 (GRCm39) G57S unknown Het
Golgb1 T A 16: 36,738,325 (GRCm39) H2262Q possibly damaging Het
Gpam T C 19: 55,064,767 (GRCm39) T646A probably benign Het
Gpt2 G A 8: 86,244,681 (GRCm39) E325K probably benign Het
Hexd C T 11: 121,095,496 (GRCm39) probably benign Het
Micu2 A T 14: 58,209,238 (GRCm39) Y73* probably null Het
N4bp2l2 T C 5: 150,573,894 (GRCm39) probably null Het
Or11h7 T C 14: 50,891,041 (GRCm39) C116R possibly damaging Het
Or1m1 A T 9: 18,666,174 (GRCm39) Y252* probably null Het
Or51t4 T C 7: 102,598,386 (GRCm39) V238A probably damaging Het
Or5b112 A T 19: 13,319,103 (GRCm39) probably null Het
P3r3urf A G 4: 116,030,667 (GRCm39) M24V probably benign Het
Prkca A G 11: 107,874,848 (GRCm39) Y365H probably damaging Het
Ptpre C T 7: 135,255,744 (GRCm39) R155* probably null Het
Ryr2 T A 13: 11,684,873 (GRCm39) N3023Y probably damaging Het
S100a7a A G 3: 90,562,822 (GRCm39) D3G probably benign Het
Scn2a T C 2: 65,594,277 (GRCm39) F1709L probably damaging Het
Slc15a2 T C 16: 36,602,660 (GRCm39) E67G probably damaging Het
Slc25a22 A G 7: 141,011,655 (GRCm39) L195P probably damaging Het
Sp140 TTTTTTTTTTTTT TTTTTTTTTTTTTTTTTT 1: 85,572,290 (GRCm39) probably benign Het
Stim1 T A 7: 102,084,741 (GRCm39) H564Q possibly damaging Het
Sulf2 C T 2: 165,917,448 (GRCm39) W855* probably null Het
Tenm3 T C 8: 49,127,588 (GRCm39) N30S probably benign Het
Trim59 T C 3: 68,944,197 (GRCm39) D381G probably benign Het
Ttc21b T C 2: 66,066,670 (GRCm39) T328A probably benign Het
Ttc6 C G 12: 57,623,125 (GRCm39) Q175E probably benign Het
Vmn2r44 T C 7: 8,370,941 (GRCm39) I702V probably damaging Het
Zfp768 A T 7: 126,943,959 (GRCm39) F59L probably damaging Het
Other mutations in Or1e31
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2967:Or1e31 UTSW 11 73,689,933 (GRCm39) missense possibly damaging 0.95
R4782:Or1e31 UTSW 11 73,689,665 (GRCm39) missense probably benign 0.00
R5011:Or1e31 UTSW 11 73,690,473 (GRCm39) missense possibly damaging 0.56
R5984:Or1e31 UTSW 11 73,690,407 (GRCm39) missense possibly damaging 0.95
R6276:Or1e31 UTSW 11 73,690,229 (GRCm39) missense probably damaging 1.00
R6338:Or1e31 UTSW 11 73,690,145 (GRCm39) missense possibly damaging 0.93
R6835:Or1e31 UTSW 11 73,690,061 (GRCm39) missense possibly damaging 0.95
R6968:Or1e31 UTSW 11 73,690,205 (GRCm39) missense possibly damaging 0.86
R7258:Or1e31 UTSW 11 73,690,206 (GRCm39) missense probably damaging 0.98
R7272:Or1e31 UTSW 11 73,689,695 (GRCm39) missense probably damaging 1.00
R7665:Or1e31 UTSW 11 73,689,787 (GRCm39) missense probably benign 0.03
R8053:Or1e31 UTSW 11 73,689,822 (GRCm39) missense probably benign 0.22
R8314:Or1e31 UTSW 11 73,690,568 (GRCm39) missense noncoding transcript
R9089:Or1e31 UTSW 11 73,690,052 (GRCm39) missense probably damaging 1.00
R9328:Or1e31 UTSW 11 73,690,478 (GRCm39) missense probably damaging 1.00
R9788:Or1e31 UTSW 11 73,689,768 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2019-05-15