|Institutional Source||Beutler Lab|
|Gene Name||olfactomedin-like 3|
|Synonyms||2810002E22Rik, HNOEL-iso, mONT3, ONT3|
|Essential gene?||Non essential (E-score: 0.000)|
|Stock #||R7128 (G1)|
|Chromosomal Location||103722222-103738001 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 103737168 bp (GRCm38)|
|Amino Acid Change||Methionine to Valine at position 62 (M62V)|
|Ref Sequence||ENSEMBL: ENSMUSP00000029440 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000029440] [ENSMUST00000106852] [ENSMUST00000118317] [ENSMUST00000169286]|
|AlphaFold||no structure available at present|
AA Change: M62V
PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
AA Change: M62V
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the olfactomedin-like gene family which also includes genes encoding noelin, tiarin, myocilin, amassin, optimedin, photomedin, and latrophilin. The encoded protein is a secreted extracellular matrix glycoprotein with a C-terminal olfactomedin domain that facilitates protein-protein interactions, cell adhesion, and intercellular interactions. It serves as both a scaffold protein that recruits bone morphogenetic protein 1 to its substrate chordin, and as a vascular tissue remodeler with pro-angiogenic properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
PHENOTYPE: Mice homozygous for a disruption in this gene appear normal. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Olfml3||
(F):5'- GTGAGATCACTTACCCGTCACC -3'
(R):5'- TGACTAGTCTCCTCTGCTGTGG -3'
(F):5'- TGAGATCACTTACCCGTCACCATATC -3'
(R):5'- TGGGAGCATGGCTGAGC -3'