|Institutional Source||Beutler Lab|
|Gene Name||Ly6/neurotoxin 1|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R7128 (G1)|
|Chromosomal Location||74747852-74753046 bp(-) (GRCm38)|
|Type of Mutation||nonsense|
|DNA Base Change (assembly)||G to A at 74751549 bp (GRCm38)|
|Amino Acid Change||Arginine to Stop codon at position 50 (R50*)|
|Ref Sequence||ENSEMBL: ENSMUSP00000023259 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000023259] [ENSMUST00000057932] [ENSMUST00000189128]|
AA Change: R50*
AA Change: R50*
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Ly-6/neurotoxin gene family, a group of lymphocyte antigens that attach to the cell surface by a glycosylphosphatidylinositol anchor and have a unique structure showing conserved 8-10 cysteine residues with a characteristic spacing pattern. Functional analysis indicates that this protein is not a ligand or neurotransmitter but has the capacity to enhance nicotinic acetylcholine receptor function in the presence of acetylcholine. This gene may also play a role in the pathogenesis of psoriasis vulgaris. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit increased sensitivity to nicotine, neurodegeneration, brain vacuoles amd improved cue-conditioned learning. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Lynx1||
(F):5'- CGTACACGGTTTCAAAGCAGC -3'
(R):5'- TTCTGGATGTCCTGATCTGGCC -3'
(F):5'- TTTCAAAGCAGCTGGGGACAC -3'
(R):5'- TGGCCGCCAGTGGAAGTG -3'