Mutagenetix > Incidental Mutation

Incidental Mutation 'R7129:Vmn1r9'

552515

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r9

Ensembl Gene

ENSMUSG00000091541

Gene Name

vomeronasal 1 receptor 9

Synonyms

V1rc30

MMRRC Submission

045214-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

R7129 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

57047880-57048930 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 57048611 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Proline at position 229 (T229P)

Ref Sequence

ENSEMBL: ENSMUSP00000125762 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171186] [ENSMUST00000227399] [ENSMUST00000228714]

AlphaFold

A2RST7

Predicted Effect

probably damaging
Transcript: ENSMUST00000171186
AA Change: T229P

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000125762
Gene: ENSMUSG00000091541
AA Change: T229P

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	1.1e-53	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000227399
AA Change: T229P

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

Predicted Effect

probably damaging
Transcript: ENSMUST00000228714
AA Change: T229P

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.0%

Validation Efficiency

98% (58/59)

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700030K09Rik	A	G	8: 73,209,199 (GRCm39)	E443G	probably damaging	Het
2700049A03Rik	A	G	12: 71,263,004 (GRCm39)		probably null	Het
3110082I17Rik	A	G	5: 139,349,738 (GRCm39)	Y104H	probably damaging	Het
Abcg4	T	C	9: 44,190,681 (GRCm39)	K282E	probably benign	Het
Adamts17	T	C	7: 66,770,758 (GRCm39)	S956P	probably damaging	Het
Adh1	T	C	3: 137,986,235 (GRCm39)	V74A	probably damaging	Het
Akt1	A	T	12: 112,626,083 (GRCm39)	M63K	probably benign	Het
Arfrp1	G	A	2: 181,001,344 (GRCm39)	R177*	probably null	Het
Arl11	A	G	14: 61,548,346 (GRCm39)	E52G	possibly damaging	Het
BC051019	T	C	7: 109,319,825 (GRCm39)	S10G		Het
Bfsp2	T	A	9: 103,357,118 (GRCm39)	E103V	probably damaging	Het
Bms1	G	T	6: 118,380,122 (GRCm39)	C728*	probably null	Het
Cachd1	T	G	4: 100,775,263 (GRCm39)	N159K	probably null	Het
Cd38	A	G	5: 44,067,651 (GRCm39)	N294S	probably benign	Het
Cfap54	T	C	10: 92,852,433 (GRCm39)	N891S	probably benign	Het
Chsy3	A	T	18: 59,543,370 (GRCm39)	H836L	probably damaging	Het
Cldn16	A	T	16: 26,301,388 (GRCm39)	D232V	probably damaging	Het
Dhx33	A	T	11: 70,884,689 (GRCm39)	I425N	probably damaging	Het
Dock4	A	G	12: 40,878,878 (GRCm39)	N1506D	probably damaging	Het
Dok7	T	C	5: 35,236,392 (GRCm39)	S227P	probably damaging	Het
Elf2	T	C	3: 51,168,432 (GRCm39)	R201G	probably damaging	Het
Elp1	T	C	4: 56,787,944 (GRCm39)	H329R	probably damaging	Het
Etaa1	T	C	11: 17,890,339 (GRCm39)	R841G	possibly damaging	Het
Exoc4	T	C	6: 33,948,934 (GRCm39)	Y926H	probably damaging	Het
Fras1	A	G	5: 96,929,143 (GRCm39)	H3849R	probably benign	Het
Hapln3	C	T	7: 78,771,572 (GRCm39)	G106R	probably damaging	Het
Hmcn1	A	C	1: 150,452,961 (GRCm39)		probably null	Het
Ifitm7	A	T	16: 13,801,600 (GRCm39)	I53N	possibly damaging	Het
Il6ra	T	C	3: 89,778,554 (GRCm39)	N433D	probably damaging	Het
Iqch	C	T	9: 63,329,191 (GRCm39)	V1048I	probably benign	Het
Kif20a	A	G	18: 34,765,588 (GRCm39)	T862A	probably benign	Het
Mcrs1	G	A	15: 99,146,609 (GRCm39)	L141F	probably damaging	Het
Nkx3-2	A	G	5: 41,919,017 (GRCm39)	S324P	probably damaging	Het
Nmi	A	T	2: 51,845,936 (GRCm39)		probably null	Het
Nufip1	A	G	14: 76,372,325 (GRCm39)	K480E	possibly damaging	Het
Oit3	T	A	10: 59,264,166 (GRCm39)	I323F	probably damaging	Het
Or2ag17	T	C	7: 106,389,690 (GRCm39)	K173E	probably benign	Het
Or5b98	A	T	19: 12,931,478 (GRCm39)	H175L	possibly damaging	Het
Pcdha11	A	G	18: 37,140,291 (GRCm39)	E640G	probably benign	Het
Phip	C	T	9: 82,759,353 (GRCm39)	V1366I	probably damaging	Het
Plin5	T	C	17: 56,422,174 (GRCm39)	M162V	probably null	Het
Podxl2	A	G	6: 88,820,487 (GRCm39)		probably null	Het
Ptprb	GAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACT	GAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACT	10: 116,119,582 (GRCm39)		probably benign	Het
Rab4a	A	T	8: 124,554,069 (GRCm39)	D40V	probably benign	Het
Scn7a	A	G	2: 66,530,537 (GRCm39)	F603L	probably benign	Het
Slfn5	A	T	11: 82,851,976 (GRCm39)	K701*	probably null	Het
Speer4f2	A	G	5: 17,582,446 (GRCm39)	D223G		Het
Stip1	C	T	19: 6,999,178 (GRCm39)	G467S	possibly damaging	Het
Tas2r117	A	T	6: 132,780,350 (GRCm39)	T163S	probably benign	Het
Tecta	T	C	9: 42,259,287 (GRCm39)	D1532G	probably damaging	Het
Tmem63a	T	C	1: 180,782,441 (GRCm39)	I146T	probably damaging	Het
Ttn	C	A	2: 76,646,515 (GRCm39)	G12844W	probably damaging	Het
Usp22	T	C	11: 61,053,775 (GRCm39)	I190V	probably damaging	Het
Usp24	T	C	4: 106,219,412 (GRCm39)	I536T	probably damaging	Het
Vmn1r23	A	G	6: 57,903,061 (GRCm39)	V239A	possibly damaging	Het
Zbtb21	AGCTGCTGCTGCTGCTGCTGCTGCTACTGCTGCTGCTGCTGC	AGCTGCTGCTGCTGCTGCTGCTACTGCTGCTGCTGCTGC	16: 97,752,887 (GRCm39)		probably benign	Het
Zbtb8a	G	C	4: 129,254,188 (GRCm39)	A102G	probably damaging	Het
Zfp51	T	C	17: 21,681,971 (GRCm39)	W57R	probably damaging	Het

Other mutations in Vmn1r9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0551:Vmn1r9	UTSW	6	57,048,524 (GRCm39)	missense	probably benign	0.16
R1295:Vmn1r9	UTSW	6	57,048,522 (GRCm39)	missense	probably damaging	0.98
R1333:Vmn1r9	UTSW	6	57,048,615 (GRCm39)	missense	probably damaging	1.00
R1781:Vmn1r9	UTSW	6	57,048,300 (GRCm39)	missense	probably benign
R1840:Vmn1r9	UTSW	6	57,048,522 (GRCm39)	missense	probably damaging	0.98
R2960:Vmn1r9	UTSW	6	57,048,657 (GRCm39)	missense	possibly damaging	0.60
R4064:Vmn1r9	UTSW	6	57,048,306 (GRCm39)	missense	probably damaging	0.99
R4694:Vmn1r9	UTSW	6	57,048,314 (GRCm39)	missense	probably benign	0.01
R4884:Vmn1r9	UTSW	6	57,048,294 (GRCm39)	missense	possibly damaging	0.67
R6023:Vmn1r9	UTSW	6	57,048,239 (GRCm39)	missense	probably benign	0.19
R6031:Vmn1r9	UTSW	6	57,048,158 (GRCm39)	missense	probably benign	0.00
R6031:Vmn1r9	UTSW	6	57,048,158 (GRCm39)	missense	probably benign	0.00
R6761:Vmn1r9	UTSW	6	57,048,291 (GRCm39)	missense	probably benign	0.01
R7052:Vmn1r9	UTSW	6	57,048,396 (GRCm39)	missense	probably benign	0.44
R8037:Vmn1r9	UTSW	6	57,047,988 (GRCm39)	missense	probably benign	0.11
R8745:Vmn1r9	UTSW	6	57,048,767 (GRCm39)	missense	probably benign	0.39
R8930:Vmn1r9	UTSW	6	57,048,666 (GRCm39)	missense	probably damaging	1.00
R8932:Vmn1r9	UTSW	6	57,048,666 (GRCm39)	missense	probably damaging	1.00
R9053:Vmn1r9	UTSW	6	57,048,513 (GRCm39)	missense	probably benign
R9144:Vmn1r9	UTSW	6	57,048,788 (GRCm39)	missense	probably benign	0.44
R9167:Vmn1r9	UTSW	6	57,048,138 (GRCm39)	missense	probably benign	0.19
R9580:Vmn1r9	UTSW	6	57,048,812 (GRCm39)	missense	probably benign	0.03
R9642:Vmn1r9	UTSW	6	57,048,216 (GRCm39)	missense	probably damaging	1.00
RF009:Vmn1r9	UTSW	6	57,048,465 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- CAGGTCACTAAATCCTGCTCAC -3'
(R):5'- CTATTGATGCTTTGACTGCAGG -3'

Sequencing Primer
(F):5'- ACCCATGAACATTATTATCAGGGG -3'
(R):5'- CTTTGACTGCAGGTTTTTCAGC -3'

Posted On

2019-05-15