Incidental Mutation 'R7131:Brwd1'
| ID |
552702 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Brwd1
|
| Ensembl Gene |
ENSMUSG00000022914 |
| Gene Name |
bromodomain and WD repeat domain containing 1 |
| Synonyms |
5330419I02Rik, Wdr9, G1-403-16, D530019K20Rik, repro5 |
| MMRRC Submission |
045216-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7131 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
16 |
| Chromosomal Location |
95793292-95883726 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 95867698 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Arginine
at position 149
(L149R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000023631
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023631]
[ENSMUST00000099502]
[ENSMUST00000113827]
|
| AlphaFold |
Q921C3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000023631
AA Change: L149R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000023631
Gene: ENSMUSG00000022914
AA Change: L149R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
|
WD40
|
175 |
214 |
1.3e-7 |
SMART |
|
WD40
|
217 |
256 |
2.26e-7 |
SMART |
|
WD40
|
259 |
302 |
1.83e-7 |
SMART |
|
WD40
|
311 |
352 |
3.82e1 |
SMART |
|
WD40
|
357 |
396 |
4.27e-8 |
SMART |
|
WD40
|
417 |
454 |
8.59e-1 |
SMART |
|
WD40
|
457 |
497 |
1.47e-6 |
SMART |
|
WD40
|
504 |
544 |
9.21e0 |
SMART |
|
low complexity region
|
660 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
753 |
767 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
868 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
927 |
N/A |
INTRINSIC |
|
BROMO
|
1156 |
1267 |
1.72e-6 |
SMART |
|
low complexity region
|
1277 |
1292 |
N/A |
INTRINSIC |
|
BROMO
|
1317 |
1422 |
2.65e-30 |
SMART |
|
low complexity region
|
1497 |
1513 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1558 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1574 |
1762 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
1764 |
1775 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1857 |
2050 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
2165 |
2174 |
N/A |
INTRINSIC |
|
low complexity region
|
2260 |
2270 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000099502
AA Change: L149R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000097101
Gene: ENSMUSG00000022914
AA Change: L149R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
|
WD40
|
175 |
214 |
1.3e-7 |
SMART |
|
WD40
|
217 |
256 |
2.26e-7 |
SMART |
|
WD40
|
259 |
302 |
1.83e-7 |
SMART |
|
WD40
|
311 |
352 |
3.82e1 |
SMART |
|
WD40
|
357 |
396 |
4.27e-8 |
SMART |
|
WD40
|
417 |
454 |
8.59e-1 |
SMART |
|
WD40
|
457 |
497 |
1.47e-6 |
SMART |
|
WD40
|
504 |
544 |
9.21e0 |
SMART |
|
low complexity region
|
660 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
753 |
767 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
868 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
927 |
N/A |
INTRINSIC |
|
BROMO
|
1156 |
1267 |
1.72e-6 |
SMART |
|
low complexity region
|
1277 |
1292 |
N/A |
INTRINSIC |
|
BROMO
|
1317 |
1422 |
2.65e-30 |
SMART |
|
low complexity region
|
1497 |
1513 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1558 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1574 |
1762 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
1764 |
1775 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1857 |
2050 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
2165 |
2174 |
N/A |
INTRINSIC |
|
low complexity region
|
2260 |
2270 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113827
|
| SMART Domains |
Protein: ENSMUSP00000109458
Gene: ENSMUSG00000022914
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011]
PHENOTYPE: Homozygous males and females are infertile. Spermiogenesis is impaired; males have low epididymal sperm concentration with low motility and abnormal sperm head morphology. Female oocytes commonly contain vacuoles and have low developmental competence to 2-cell and blastocyst stages. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aadacl4fm4 |
A |
G |
4: 144,396,637 (GRCm39) |
V365A |
probably damaging |
Het |
| Abca13 |
A |
G |
11: 9,241,893 (GRCm39) |
N1252S |
probably benign |
Het |
| Abcc3 |
A |
T |
11: 94,255,857 (GRCm39) |
F543I |
probably damaging |
Het |
| Adam15 |
T |
A |
3: 89,254,287 (GRCm39) |
Q170L |
possibly damaging |
Het |
| Aldoc |
A |
G |
11: 78,215,282 (GRCm39) |
I19V |
possibly damaging |
Het |
| Aoc1l1 |
T |
A |
6: 48,953,306 (GRCm39) |
Y410* |
probably null |
Het |
| Atrip |
T |
C |
9: 108,889,488 (GRCm39) |
I711M |
probably benign |
Het |
| Capn9 |
A |
T |
8: 125,303,017 (GRCm39) |
D45V |
probably damaging |
Het |
| Card9 |
G |
A |
2: 26,248,847 (GRCm39) |
R101C |
probably damaging |
Het |
| Ccdc87 |
A |
G |
19: 4,891,785 (GRCm39) |
E759G |
probably damaging |
Het |
| Ccn1 |
T |
C |
3: 145,354,536 (GRCm39) |
D125G |
probably damaging |
Het |
| Cep250 |
T |
C |
2: 155,806,997 (GRCm39) |
M193T |
probably damaging |
Het |
| Cfap54 |
T |
C |
10: 92,656,966 (GRCm39) |
K3029E |
probably benign |
Het |
| Chrna9 |
G |
A |
5: 66,134,484 (GRCm39) |
G445D |
possibly damaging |
Het |
| Cluap1 |
C |
T |
16: 3,758,639 (GRCm39) |
S367L |
probably benign |
Het |
| Col5a1 |
A |
G |
2: 27,819,498 (GRCm39) |
D200G |
unknown |
Het |
| Crhr2 |
T |
C |
6: 55,069,112 (GRCm39) |
N388D |
|
Het |
| Cyp2b23 |
A |
G |
7: 26,380,838 (GRCm39) |
L129P |
probably benign |
Het |
| Dctd |
A |
G |
8: 48,565,075 (GRCm39) |
S67G |
probably benign |
Het |
| Dhtkd1 |
C |
G |
2: 5,908,881 (GRCm39) |
V738L |
probably benign |
Het |
| Dnah17 |
C |
T |
11: 117,970,484 (GRCm39) |
D2173N |
probably benign |
Het |
| Dnah7c |
G |
T |
1: 46,720,932 (GRCm39) |
A2819S |
probably benign |
Het |
| Dnai7 |
A |
T |
6: 145,123,132 (GRCm39) |
L578Q |
probably null |
Het |
| Dot1l |
A |
G |
10: 80,628,175 (GRCm39) |
H1071R |
unknown |
Het |
| Dync2h1 |
T |
A |
9: 7,075,786 (GRCm39) |
D3027V |
probably damaging |
Het |
| Efl1 |
A |
G |
7: 82,307,272 (GRCm39) |
Y56C |
probably damaging |
Het |
| Eif4e1b |
A |
T |
13: 54,931,913 (GRCm39) |
R29W |
probably null |
Het |
| Evc2 |
A |
G |
5: 37,567,602 (GRCm39) |
R860G |
probably damaging |
Het |
| Fbxl12 |
G |
A |
9: 20,555,679 (GRCm39) |
|
probably benign |
Het |
| Fibp |
T |
A |
19: 5,511,519 (GRCm39) |
I129N |
probably damaging |
Het |
| Folh1 |
G |
T |
7: 86,375,320 (GRCm39) |
H555Q |
probably damaging |
Het |
| Gcnt4 |
A |
T |
13: 97,083,027 (GRCm39) |
T108S |
probably damaging |
Het |
| H1f7 |
T |
A |
15: 98,154,250 (GRCm39) |
K300* |
probably null |
Het |
| Hecw2 |
A |
T |
1: 53,904,280 (GRCm39) |
V1156E |
probably damaging |
Het |
| Herc3 |
C |
G |
6: 58,864,409 (GRCm39) |
A681G |
probably damaging |
Het |
| Igkv13-84 |
T |
A |
6: 68,916,764 (GRCm39) |
C20* |
probably null |
Het |
| Iho1 |
A |
T |
9: 108,294,619 (GRCm39) |
D98E |
probably benign |
Het |
| Iqca1l |
A |
G |
5: 24,753,954 (GRCm39) |
V435A |
possibly damaging |
Het |
| Ivd |
C |
A |
2: 118,700,255 (GRCm39) |
T94K |
probably damaging |
Het |
| Kank2 |
C |
T |
9: 21,705,975 (GRCm39) |
A348T |
probably benign |
Het |
| Kcnma1 |
T |
C |
14: 23,417,562 (GRCm39) |
Y889C |
probably damaging |
Het |
| Kif13b |
T |
C |
14: 65,010,517 (GRCm39) |
V1272A |
probably damaging |
Het |
| Kmt2d |
GCTGCTGCT |
GCTGCTGCTCCTGCTGCT |
15: 98,747,497 (GRCm39) |
|
probably benign |
Het |
| Kmt5b |
T |
A |
19: 3,865,412 (GRCm39) |
D825E |
probably benign |
Het |
| Krt39 |
C |
T |
11: 99,411,697 (GRCm39) |
A130T |
probably benign |
Het |
| Krtap4-9 |
C |
T |
11: 99,676,283 (GRCm39) |
T68I |
unknown |
Het |
| Lmbr1l |
A |
T |
15: 98,804,204 (GRCm39) |
V365E |
probably benign |
Het |
| Lonp1 |
C |
T |
17: 56,924,814 (GRCm39) |
R531Q |
probably damaging |
Het |
| Mecom |
T |
A |
3: 30,035,094 (GRCm39) |
H194L |
probably damaging |
Het |
| Mlx |
C |
T |
11: 100,980,068 (GRCm39) |
H188Y |
probably damaging |
Het |
| Mrps10 |
T |
C |
17: 47,685,940 (GRCm39) |
S77P |
probably damaging |
Het |
| Mst1 |
A |
G |
9: 107,962,130 (GRCm39) |
E716G |
probably null |
Het |
| Mttp |
C |
T |
3: 137,821,893 (GRCm39) |
V210I |
probably benign |
Het |
| Mug2 |
T |
C |
6: 122,052,206 (GRCm39) |
V988A |
probably damaging |
Het |
| Ndufb6 |
A |
G |
4: 40,279,336 (GRCm39) |
M1T |
probably null |
Het |
| Neurog1 |
A |
T |
13: 56,399,563 (GRCm39) |
N61K |
probably benign |
Het |
| Nlrp14 |
A |
G |
7: 106,784,021 (GRCm39) |
D581G |
possibly damaging |
Het |
| Nlrp4a |
C |
A |
7: 26,149,258 (GRCm39) |
N288K |
probably benign |
Het |
| Notch3 |
T |
A |
17: 32,363,191 (GRCm39) |
H1264L |
probably benign |
Het |
| Or1e25 |
A |
T |
11: 73,493,562 (GRCm39) |
D52V |
possibly damaging |
Het |
| Or1e34 |
A |
T |
11: 73,778,780 (GRCm39) |
C139* |
probably null |
Het |
| Or3a1c |
A |
G |
11: 74,046,606 (GRCm39) |
M209V |
probably benign |
Het |
| Patl2 |
A |
T |
2: 121,952,263 (GRCm39) |
|
probably null |
Het |
| Pfkfb4 |
A |
G |
9: 108,836,370 (GRCm39) |
T133A |
probably benign |
Het |
| Pla2g4f |
T |
C |
2: 120,135,035 (GRCm39) |
E471G |
probably null |
Het |
| Postn |
T |
C |
3: 54,270,056 (GRCm39) |
V45A |
probably damaging |
Het |
| Ppan |
T |
A |
9: 20,802,450 (GRCm39) |
V257E |
possibly damaging |
Het |
| Ptcra |
C |
G |
17: 47,074,522 (GRCm39) |
A7P |
probably damaging |
Het |
| Ptprd |
C |
T |
4: 75,984,577 (GRCm39) |
R523H |
probably damaging |
Het |
| Pycr3 |
A |
T |
15: 75,790,544 (GRCm39) |
I105N |
possibly damaging |
Het |
| Rfx1 |
C |
A |
8: 84,821,708 (GRCm39) |
Q815K |
probably damaging |
Het |
| Rfx3 |
T |
A |
19: 27,746,028 (GRCm39) |
K668* |
probably null |
Het |
| Ryr2 |
A |
T |
13: 11,655,213 (GRCm39) |
D3661E |
possibly damaging |
Het |
| Ryr2 |
A |
G |
13: 11,683,697 (GRCm39) |
|
probably null |
Het |
| Sec23ip |
T |
A |
7: 128,381,364 (GRCm39) |
S974T |
probably damaging |
Het |
| Semp2l2a |
A |
T |
8: 13,886,982 (GRCm39) |
W370R |
probably damaging |
Het |
| Setbp1 |
A |
G |
18: 79,130,175 (GRCm39) |
F19S |
probably benign |
Het |
| Setd1a |
AAGCAGCAGCAGCAGCAGCAG |
AAGCAGCAGCAGCAGCAG |
7: 127,395,590 (GRCm39) |
|
probably benign |
Het |
| Sh3pxd2b |
A |
G |
11: 32,372,072 (GRCm39) |
K413R |
probably damaging |
Het |
| Slc39a12 |
T |
C |
2: 14,454,614 (GRCm39) |
V544A |
probably damaging |
Het |
| Slc6a7 |
T |
C |
18: 61,135,274 (GRCm39) |
Y418C |
probably damaging |
Het |
| Snx19 |
T |
G |
9: 30,339,189 (GRCm39) |
I109S |
probably damaging |
Het |
| Spart |
T |
C |
3: 55,029,220 (GRCm39) |
|
probably null |
Het |
| Sptbn2 |
A |
T |
19: 4,799,488 (GRCm39) |
Q2097L |
probably null |
Het |
| Syne1 |
T |
C |
10: 5,178,221 (GRCm39) |
K4751R |
probably damaging |
Het |
| Tigit |
C |
A |
16: 43,482,615 (GRCm39) |
G40C |
probably damaging |
Het |
| Tmem181a |
T |
A |
17: 6,348,247 (GRCm39) |
I264K |
probably damaging |
Het |
| Tom1 |
T |
A |
8: 75,783,877 (GRCm39) |
I287N |
possibly damaging |
Het |
| Top2a |
G |
A |
11: 98,895,008 (GRCm39) |
P864L |
possibly damaging |
Het |
| Trmt44 |
A |
T |
5: 35,728,410 (GRCm39) |
V290E |
probably damaging |
Het |
| Try4 |
T |
C |
6: 41,281,337 (GRCm39) |
I93T |
probably benign |
Het |
| Usp24 |
T |
A |
4: 106,239,500 (GRCm39) |
H1147Q |
possibly damaging |
Het |
| Uspl1 |
A |
T |
5: 149,130,745 (GRCm39) |
R109S |
probably benign |
Het |
| Vav3 |
T |
A |
3: 109,571,662 (GRCm39) |
F755I |
probably damaging |
Het |
| Vezt |
A |
T |
10: 93,806,409 (GRCm39) |
Y667* |
probably null |
Het |
| Vmn1r231 |
T |
A |
17: 21,110,140 (GRCm39) |
L258F |
possibly damaging |
Het |
| Zfp207 |
T |
C |
11: 80,286,354 (GRCm39) |
M489T |
unknown |
Het |
| Zfp462 |
A |
G |
4: 55,009,380 (GRCm39) |
T449A |
probably benign |
Het |
| Zfp956 |
C |
A |
6: 47,932,781 (GRCm39) |
Q19K |
probably benign |
Het |
| Zkscan8 |
A |
T |
13: 21,709,443 (GRCm39) |
W152R |
probably damaging |
Het |
|
| Other mutations in Brwd1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00690:Brwd1
|
APN |
16 |
95,818,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00974:Brwd1
|
APN |
16 |
95,844,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01014:Brwd1
|
APN |
16 |
95,817,373 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01447:Brwd1
|
APN |
16 |
95,848,579 (GRCm39) |
nonsense |
probably null |
|
|
IGL01459:Brwd1
|
APN |
16 |
95,848,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01631:Brwd1
|
APN |
16 |
95,847,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02184:Brwd1
|
APN |
16 |
95,815,029 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02264:Brwd1
|
APN |
16 |
95,820,656 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02679:Brwd1
|
APN |
16 |
95,804,023 (GRCm39) |
missense |
probably benign |
|
|
IGL02833:Brwd1
|
APN |
16 |
95,853,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02960:Brwd1
|
APN |
16 |
95,858,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03053:Brwd1
|
APN |
16 |
95,818,877 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL03074:Brwd1
|
APN |
16 |
95,813,050 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03135:Brwd1
|
APN |
16 |
95,822,458 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03168:Brwd1
|
APN |
16 |
95,818,877 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL03214:Brwd1
|
APN |
16 |
95,839,100 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL03328:Brwd1
|
APN |
16 |
95,803,925 (GRCm39) |
missense |
probably damaging |
0.99 |
|
bromide
|
UTSW |
16 |
95,866,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Embers
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Glowing
|
UTSW |
16 |
95,837,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Soporific
|
UTSW |
16 |
95,835,043 (GRCm39) |
nonsense |
probably null |
|
|
G1citation:Brwd1
|
UTSW |
16 |
95,842,474 (GRCm39) |
missense |
probably benign |
0.42 |
|
PIT4243001:Brwd1
|
UTSW |
16 |
95,803,871 (GRCm39) |
nonsense |
probably null |
|
|
R0012:Brwd1
|
UTSW |
16 |
95,860,852 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0012:Brwd1
|
UTSW |
16 |
95,860,852 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0030:Brwd1
|
UTSW |
16 |
95,822,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0135:Brwd1
|
UTSW |
16 |
95,848,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0366:Brwd1
|
UTSW |
16 |
95,839,164 (GRCm39) |
nonsense |
probably null |
|
|
R0551:Brwd1
|
UTSW |
16 |
95,837,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0586:Brwd1
|
UTSW |
16 |
95,844,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0865:Brwd1
|
UTSW |
16 |
95,869,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1226:Brwd1
|
UTSW |
16 |
95,832,748 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1329:Brwd1
|
UTSW |
16 |
95,804,434 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1378:Brwd1
|
UTSW |
16 |
95,842,570 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1420:Brwd1
|
UTSW |
16 |
95,837,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1441:Brwd1
|
UTSW |
16 |
95,867,351 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1484:Brwd1
|
UTSW |
16 |
95,829,491 (GRCm39) |
splice site |
probably null |
|
|
R1624:Brwd1
|
UTSW |
16 |
95,809,344 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R1636:Brwd1
|
UTSW |
16 |
95,860,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1988:Brwd1
|
UTSW |
16 |
95,822,437 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1998:Brwd1
|
UTSW |
16 |
95,822,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2066:Brwd1
|
UTSW |
16 |
95,847,665 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2898:Brwd1
|
UTSW |
16 |
95,867,300 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2983:Brwd1
|
UTSW |
16 |
95,867,774 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3966:Brwd1
|
UTSW |
16 |
95,845,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4086:Brwd1
|
UTSW |
16 |
95,847,572 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4257:Brwd1
|
UTSW |
16 |
95,824,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4290:Brwd1
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4292:Brwd1
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4293:Brwd1
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4614:Brwd1
|
UTSW |
16 |
95,848,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Brwd1
|
UTSW |
16 |
95,804,518 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5025:Brwd1
|
UTSW |
16 |
95,855,172 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5155:Brwd1
|
UTSW |
16 |
95,803,993 (GRCm39) |
nonsense |
probably null |
|
|
R5229:Brwd1
|
UTSW |
16 |
95,803,409 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R5246:Brwd1
|
UTSW |
16 |
95,803,757 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5668:Brwd1
|
UTSW |
16 |
95,817,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5763:Brwd1
|
UTSW |
16 |
95,835,043 (GRCm39) |
nonsense |
probably null |
|
|
R5782:Brwd1
|
UTSW |
16 |
95,844,243 (GRCm39) |
nonsense |
probably null |
|
|
R5831:Brwd1
|
UTSW |
16 |
95,820,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5836:Brwd1
|
UTSW |
16 |
95,865,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5906:Brwd1
|
UTSW |
16 |
95,859,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5995:Brwd1
|
UTSW |
16 |
95,865,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6143:Brwd1
|
UTSW |
16 |
95,804,156 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6241:Brwd1
|
UTSW |
16 |
95,815,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6313:Brwd1
|
UTSW |
16 |
95,809,141 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6362:Brwd1
|
UTSW |
16 |
95,803,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6551:Brwd1
|
UTSW |
16 |
95,795,162 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6736:Brwd1
|
UTSW |
16 |
95,869,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6822:Brwd1
|
UTSW |
16 |
95,842,474 (GRCm39) |
missense |
probably benign |
0.42 |
|
R7080:Brwd1
|
UTSW |
16 |
95,810,730 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7208:Brwd1
|
UTSW |
16 |
95,837,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7322:Brwd1
|
UTSW |
16 |
95,867,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7483:Brwd1
|
UTSW |
16 |
95,857,373 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7615:Brwd1
|
UTSW |
16 |
95,835,039 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7621:Brwd1
|
UTSW |
16 |
95,866,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7665:Brwd1
|
UTSW |
16 |
95,842,543 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7697:Brwd1
|
UTSW |
16 |
95,847,601 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7740:Brwd1
|
UTSW |
16 |
95,828,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8120:Brwd1
|
UTSW |
16 |
95,820,649 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8187:Brwd1
|
UTSW |
16 |
95,803,934 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8359:Brwd1
|
UTSW |
16 |
95,817,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8480:Brwd1
|
UTSW |
16 |
95,848,630 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8511:Brwd1
|
UTSW |
16 |
95,859,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9046:Brwd1
|
UTSW |
16 |
95,829,402 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9074:Brwd1
|
UTSW |
16 |
95,824,610 (GRCm39) |
missense |
|
|
|
R9102:Brwd1
|
UTSW |
16 |
95,869,725 (GRCm39) |
missense |
probably benign |
0.43 |
|
R9115:Brwd1
|
UTSW |
16 |
95,848,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9130:Brwd1
|
UTSW |
16 |
95,866,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9200:Brwd1
|
UTSW |
16 |
95,839,154 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9246:Brwd1
|
UTSW |
16 |
95,804,016 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9407:Brwd1
|
UTSW |
16 |
95,803,693 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R9444:Brwd1
|
UTSW |
16 |
95,855,180 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9451:Brwd1
|
UTSW |
16 |
95,845,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9673:Brwd1
|
UTSW |
16 |
95,813,096 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9751:Brwd1
|
UTSW |
16 |
95,795,015 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9753:Brwd1
|
UTSW |
16 |
95,825,028 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0017:Brwd1
|
UTSW |
16 |
95,845,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0028:Brwd1
|
UTSW |
16 |
95,813,123 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCCGATTCTACTGTAGTGAC -3'
(R):5'- AATAAACCTCCCAGGCTTTTCTG -3'
Sequencing Primer
(F):5'- TAGTGACAGGGCCACTACG -3'
(R):5'- CCCAGGCTTTTCTGTTGTAAATTAG -3'
|
| Posted On |
2019-05-15 |
Incidental Mutation