Incidental Mutation 'R7132:Kdm5b'
| ID |
552721 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kdm5b
|
| Ensembl Gene |
ENSMUSG00000042207 |
| Gene Name |
lysine (K)-specific demethylase 5B |
| Synonyms |
Jarid1b, Plu1, Rb-Bp2, 2210016I17Rik, 2010009J12Rik, PLU-1, D1Ertd202e |
| MMRRC Submission |
045217-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.268)
|
| Stock # |
R7132 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
134560171-134635285 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 134599106 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 322
(D322G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000038138
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047714]
[ENSMUST00000112198]
|
| AlphaFold |
Q80Y84 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000047714
AA Change: D322G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000038138
Gene: ENSMUSG00000042207
AA Change: D322G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
30 |
N/A |
INTRINSIC |
|
JmjN
|
31 |
72 |
2.87e-20 |
SMART |
|
ARID
|
94 |
183 |
7.39e-32 |
SMART |
|
BRIGHT
|
98 |
188 |
1.51e-35 |
SMART |
|
low complexity region
|
228 |
239 |
N/A |
INTRINSIC |
|
PHD
|
311 |
357 |
6.15e-14 |
SMART |
|
JmjC
|
453 |
619 |
2.33e-67 |
SMART |
|
Pfam:zf-C5HC2
|
692 |
744 |
2.2e-17 |
PFAM |
|
Pfam:PLU-1
|
757 |
1088 |
5.6e-92 |
PFAM |
|
low complexity region
|
1097 |
1109 |
N/A |
INTRINSIC |
|
PHD
|
1178 |
1222 |
6.2e-10 |
SMART |
|
low complexity region
|
1225 |
1236 |
N/A |
INTRINSIC |
|
low complexity region
|
1406 |
1417 |
N/A |
INTRINSIC |
|
low complexity region
|
1470 |
1484 |
N/A |
INTRINSIC |
|
PHD
|
1486 |
1536 |
1.18e-6 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112198
AA Change: D322G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000107817
Gene: ENSMUSG00000042207
AA Change: D322G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
30 |
N/A |
INTRINSIC |
|
JmjN
|
31 |
72 |
2.87e-20 |
SMART |
|
ARID
|
94 |
183 |
7.39e-32 |
SMART |
|
BRIGHT
|
98 |
188 |
1.51e-35 |
SMART |
|
low complexity region
|
228 |
239 |
N/A |
INTRINSIC |
|
PHD
|
311 |
357 |
6.15e-14 |
SMART |
|
JmjC
|
453 |
619 |
2.33e-67 |
SMART |
|
Pfam:zf-C5HC2
|
692 |
745 |
6.7e-21 |
PFAM |
|
Pfam:PLU-1
|
756 |
1088 |
6e-94 |
PFAM |
|
low complexity region
|
1097 |
1109 |
N/A |
INTRINSIC |
|
PHD
|
1178 |
1222 |
6.2e-10 |
SMART |
|
low complexity region
|
1225 |
1236 |
N/A |
INTRINSIC |
|
low complexity region
|
1406 |
1417 |
N/A |
INTRINSIC |
|
low complexity region
|
1470 |
1484 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Homozygous mutant mice display decreased body weight, decreased female fertility, lower uterine weight, and a delay in mammary development. Knockout of this gene has also been associated with embryonic lethality. [provided by RefSeq, Dec 2016]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit decreased body weight, background-sensitive premature mortality, decreased female fertility, delayed mammary gland development, decreased serum estradiol levels, and reduced mammary epithelial cell proliferation in early puberty. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 71 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ank3 |
C |
T |
10: 69,989,914 (GRCm38) |
A1471V |
|
Het |
| Ankrd12 |
C |
A |
17: 65,983,247 (GRCm38) |
M1730I |
probably benign |
Het |
| Ap2a2 |
T |
C |
7: 141,619,565 (GRCm38) |
Y462H |
probably benign |
Het |
| Ap5b1 |
T |
A |
19: 5,569,384 (GRCm38) |
Y277* |
probably null |
Het |
| App |
T |
C |
16: 85,056,482 (GRCm38) |
D236G |
unknown |
Het |
| Arid2 |
A |
T |
15: 96,350,013 (GRCm38) |
K102I |
possibly damaging |
Het |
| Asl |
A |
G |
5: 130,014,702 (GRCm38) |
V211A |
possibly damaging |
Het |
| Card6 |
TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG |
TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG |
15: 5,098,691 (GRCm38) |
|
probably benign |
Het |
| Cbx2 |
A |
G |
11: 119,023,121 (GRCm38) |
S5G |
probably benign |
Het |
| Ccdc183 |
A |
G |
2: 25,616,530 (GRCm38) |
|
probably null |
Het |
| Cd72 |
T |
C |
4: 43,452,444 (GRCm38) |
Q183R |
possibly damaging |
Het |
| Cdh26 |
T |
A |
2: 178,486,762 (GRCm38) |
D702E |
possibly damaging |
Het |
| Cfap61 |
A |
T |
2: 146,109,950 (GRCm38) |
N784I |
probably damaging |
Het |
| Cgrrf1 |
G |
A |
14: 46,853,864 (GRCm38) |
V282M |
probably damaging |
Het |
| Cmtm1 |
CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT |
CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT |
8: 104,309,470 (GRCm38) |
|
probably benign |
Het |
| Cobll1 |
T |
G |
2: 65,133,768 (GRCm38) |
K170Q |
probably damaging |
Het |
| Copg2 |
A |
T |
6: 30,815,996 (GRCm38) |
V468D |
probably benign |
Het |
| Cracr2b |
C |
T |
7: 141,463,738 (GRCm38) |
A84V |
probably benign |
Het |
| Cyp2f2 |
A |
T |
7: 27,132,568 (GRCm38) |
D416V |
probably benign |
Het |
| Dcaf10 |
T |
C |
4: 45,342,391 (GRCm38) |
F75S |
probably benign |
Het |
| Eml3 |
G |
T |
19: 8,941,028 (GRCm38) |
A829S |
probably benign |
Het |
| Entpd3 |
A |
G |
9: 120,561,020 (GRCm38) |
T402A |
probably benign |
Het |
| Fer1l4 |
A |
T |
2: 156,045,626 (GRCm38) |
V550E |
probably damaging |
Het |
| Fgb |
G |
A |
3: 83,046,746 (GRCm38) |
R62* |
probably null |
Het |
| Fubp1 |
T |
A |
3: 152,232,024 (GRCm38) |
|
probably null |
Het |
| Gdf3 |
A |
C |
6: 122,606,324 (GRCm38) |
D361E |
probably damaging |
Het |
| Gm6685 |
A |
T |
11: 28,339,330 (GRCm38) |
I162N |
probably damaging |
Het |
| Hmx2 |
A |
G |
7: 131,555,916 (GRCm38) |
Y253C |
probably damaging |
Het |
| Ints2 |
G |
T |
11: 86,217,754 (GRCm38) |
N922K |
probably benign |
Het |
| Ipo7 |
C |
T |
7: 110,054,047 (GRCm38) |
L984F |
probably benign |
Het |
| Itgae |
A |
T |
11: 73,111,358 (GRCm38) |
Y96F |
possibly damaging |
Het |
| Kalrn |
A |
G |
16: 34,256,227 (GRCm38) |
V697A |
unknown |
Het |
| Kctd18 |
G |
A |
1: 57,967,578 (GRCm38) |
R38* |
probably null |
Het |
| Ldb3 |
A |
G |
14: 34,577,035 (GRCm38) |
Y211H |
probably benign |
Het |
| Limch1 |
T |
C |
5: 66,953,685 (GRCm38) |
F85S |
probably damaging |
Het |
| Lrrn4 |
A |
T |
2: 132,879,693 (GRCm38) |
L68* |
probably null |
Het |
| Lrwd1 |
A |
G |
5: 136,123,275 (GRCm38) |
V616A |
possibly damaging |
Het |
| Nars |
A |
G |
18: 64,507,770 (GRCm38) |
|
probably null |
Het |
| Nradd |
T |
C |
9: 110,622,261 (GRCm38) |
D13G |
probably benign |
Het |
| Oacyl |
A |
T |
18: 65,698,409 (GRCm38) |
N39I |
probably damaging |
Het |
| Olfr1499 |
T |
A |
19: 13,815,422 (GRCm38) |
Q56L |
probably benign |
Het |
| Onecut2 |
A |
T |
18: 64,340,912 (GRCm38) |
H178L |
possibly damaging |
Het |
| Pcdhga4 |
A |
C |
18: 37,687,377 (GRCm38) |
T660P |
probably damaging |
Het |
| Peg10 |
CCACATCAGGATCCACATCAGGATGCACATCAGCATCAGGATCCCCATCAGGATGCACATCAGGATCCACATCAGGATGCACATCAG |
CCACATCAGGATCCACATCAGGATGCACATCAG |
6: 4,756,398 (GRCm38) |
|
probably benign |
Het |
| Pitpnm3 |
T |
A |
11: 72,051,276 (GRCm38) |
I902F |
possibly damaging |
Het |
| Plod3 |
T |
C |
5: 136,995,117 (GRCm38) |
L180S |
|
Het |
| Prrc2c |
A |
T |
1: 162,681,281 (GRCm38) |
H2354Q |
possibly damaging |
Het |
| Pth2r |
A |
G |
1: 65,322,066 (GRCm38) |
E58G |
probably benign |
Het |
| Rev1 |
G |
T |
1: 38,071,449 (GRCm38) |
D573E |
possibly damaging |
Het |
| Sec24a |
A |
T |
11: 51,715,136 (GRCm38) |
L696* |
probably null |
Het |
| Serpinb3c |
A |
G |
1: 107,276,951 (GRCm38) |
S22P |
probably damaging |
Het |
| St18 |
A |
T |
1: 6,859,127 (GRCm38) |
H81L |
|
Het |
| Stard9 |
A |
T |
2: 120,679,378 (GRCm38) |
K266* |
probably null |
Het |
| Stip1 |
C |
T |
19: 7,021,810 (GRCm38) |
G467S |
possibly damaging |
Het |
| Syne1 |
G |
A |
10: 5,243,180 (GRCm38) |
A3956V |
probably damaging |
Het |
| Tcp10a |
C |
T |
17: 7,344,952 (GRCm38) |
T381I |
probably benign |
Het |
| Tecpr2 |
T |
A |
12: 110,915,372 (GRCm38) |
V125D |
probably damaging |
Het |
| Tmc2 |
T |
C |
2: 130,232,409 (GRCm38) |
S341P |
possibly damaging |
Het |
| Tmem190 |
G |
A |
7: 4,784,225 (GRCm38) |
V143I |
probably benign |
Het |
| Trap1 |
A |
G |
16: 4,055,829 (GRCm38) |
Y288H |
probably benign |
Het |
| Trim39 |
T |
C |
17: 36,260,655 (GRCm38) |
T404A |
probably benign |
Het |
| Ttn |
G |
T |
2: 76,944,352 (GRCm38) |
N2161K |
unknown |
Het |
| Ttn |
T |
A |
2: 76,745,699 (GRCm38) |
K24950I |
probably damaging |
Het |
| Unc13b |
T |
C |
4: 43,215,757 (GRCm38) |
S19P |
probably benign |
Het |
| Uqcrc1 |
T |
A |
9: 108,949,468 (GRCm38) |
I471N |
probably damaging |
Het |
| Wbp11 |
T |
C |
6: 136,821,542 (GRCm38) |
T170A |
probably benign |
Het |
| Wnk4 |
A |
G |
11: 101,261,200 (GRCm38) |
I177V |
probably benign |
Het |
| Zfp455 |
C |
A |
13: 67,199,166 (GRCm38) |
P51T |
probably damaging |
Het |
| Zfp946 |
T |
C |
17: 22,454,663 (GRCm38) |
Y133H |
probably benign |
Het |
| Zfp955a |
A |
T |
17: 33,241,615 (GRCm38) |
Y514* |
probably null |
Het |
| Zzef1 |
T |
C |
11: 72,917,871 (GRCm38) |
|
probably null |
Het |
|
| Other mutations in Kdm5b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00230:Kdm5b
|
APN |
1 |
134,620,955 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01458:Kdm5b
|
APN |
1 |
134,621,986 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
IGL01567:Kdm5b
|
APN |
1 |
134,602,540 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01625:Kdm5b
|
APN |
1 |
134,617,968 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
IGL01970:Kdm5b
|
APN |
1 |
134,600,727 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02183:Kdm5b
|
APN |
1 |
134,624,931 (GRCm38) |
missense |
probably benign |
0.09 |
|
IGL02592:Kdm5b
|
APN |
1 |
134,624,853 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02695:Kdm5b
|
APN |
1 |
134,604,485 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL02697:Kdm5b
|
APN |
1 |
134,588,773 (GRCm38) |
splice site |
probably benign |
|
|
IGL03036:Kdm5b
|
APN |
1 |
134,608,937 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03056:Kdm5b
|
APN |
1 |
134,587,979 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03206:Kdm5b
|
APN |
1 |
134,627,317 (GRCm38) |
missense |
probably benign |
|
|
IGL03342:Kdm5b
|
APN |
1 |
134,602,576 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03388:Kdm5b
|
APN |
1 |
134,627,322 (GRCm38) |
missense |
probably benign |
|
|
amaryllis
|
UTSW |
1 |
134,609,061 (GRCm38) |
critical splice donor site |
probably null |
|
|
PIT4486001:Kdm5b
|
UTSW |
1 |
134,628,685 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0233:Kdm5b
|
UTSW |
1 |
134,604,634 (GRCm38) |
splice site |
probably benign |
|
|
R0334:Kdm5b
|
UTSW |
1 |
134,604,522 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0504:Kdm5b
|
UTSW |
1 |
134,621,023 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0505:Kdm5b
|
UTSW |
1 |
134,602,571 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R0521:Kdm5b
|
UTSW |
1 |
134,618,033 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R1004:Kdm5b
|
UTSW |
1 |
134,588,904 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R1087:Kdm5b
|
UTSW |
1 |
134,600,637 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1126:Kdm5b
|
UTSW |
1 |
134,613,991 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R1221:Kdm5b
|
UTSW |
1 |
134,599,091 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1230:Kdm5b
|
UTSW |
1 |
134,613,254 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1345:Kdm5b
|
UTSW |
1 |
134,630,550 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R1482:Kdm5b
|
UTSW |
1 |
134,624,897 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1582:Kdm5b
|
UTSW |
1 |
134,624,853 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1653:Kdm5b
|
UTSW |
1 |
134,602,481 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1693:Kdm5b
|
UTSW |
1 |
134,597,576 (GRCm38) |
splice site |
probably benign |
|
|
R1721:Kdm5b
|
UTSW |
1 |
134,613,181 (GRCm38) |
splice site |
probably benign |
|
|
R1741:Kdm5b
|
UTSW |
1 |
134,618,017 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R1762:Kdm5b
|
UTSW |
1 |
134,604,467 (GRCm38) |
nonsense |
probably null |
|
|
R1820:Kdm5b
|
UTSW |
1 |
134,597,670 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R1872:Kdm5b
|
UTSW |
1 |
134,624,994 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1966:Kdm5b
|
UTSW |
1 |
134,613,873 (GRCm38) |
splice site |
probably null |
|
|
R2056:Kdm5b
|
UTSW |
1 |
134,613,214 (GRCm38) |
missense |
probably benign |
0.05 |
|
R2059:Kdm5b
|
UTSW |
1 |
134,613,214 (GRCm38) |
missense |
probably benign |
0.05 |
|
R2405:Kdm5b
|
UTSW |
1 |
134,609,016 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3417:Kdm5b
|
UTSW |
1 |
134,587,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3771:Kdm5b
|
UTSW |
1 |
134,613,345 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3783:Kdm5b
|
UTSW |
1 |
134,630,542 (GRCm38) |
missense |
probably benign |
|
|
R3803:Kdm5b
|
UTSW |
1 |
134,615,941 (GRCm38) |
missense |
probably benign |
0.07 |
|
R3980:Kdm5b
|
UTSW |
1 |
134,619,670 (GRCm38) |
missense |
probably benign |
0.11 |
|
R3983:Kdm5b
|
UTSW |
1 |
134,631,304 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R4013:Kdm5b
|
UTSW |
1 |
134,627,329 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R4162:Kdm5b
|
UTSW |
1 |
134,625,161 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4701:Kdm5b
|
UTSW |
1 |
134,606,012 (GRCm38) |
intron |
probably benign |
|
|
R4791:Kdm5b
|
UTSW |
1 |
134,630,800 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R4836:Kdm5b
|
UTSW |
1 |
134,593,315 (GRCm38) |
splice site |
probably null |
|
|
R4924:Kdm5b
|
UTSW |
1 |
134,631,351 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5135:Kdm5b
|
UTSW |
1 |
134,588,746 (GRCm38) |
intron |
probably benign |
|
|
R5248:Kdm5b
|
UTSW |
1 |
134,620,997 (GRCm38) |
missense |
probably benign |
0.11 |
|
R5290:Kdm5b
|
UTSW |
1 |
134,622,099 (GRCm38) |
splice site |
probably null |
|
|
R5358:Kdm5b
|
UTSW |
1 |
134,607,694 (GRCm38) |
nonsense |
probably null |
|
|
R5388:Kdm5b
|
UTSW |
1 |
134,608,897 (GRCm38) |
nonsense |
probably null |
|
|
R5396:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5397:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5398:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5399:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5529:Kdm5b
|
UTSW |
1 |
134,588,003 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5540:Kdm5b
|
UTSW |
1 |
134,631,241 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5661:Kdm5b
|
UTSW |
1 |
134,599,073 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5663:Kdm5b
|
UTSW |
1 |
134,630,635 (GRCm38) |
missense |
probably benign |
|
|
R5822:Kdm5b
|
UTSW |
1 |
134,588,773 (GRCm38) |
splice site |
probably benign |
|
|
R6226:Kdm5b
|
UTSW |
1 |
134,608,878 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6368:Kdm5b
|
UTSW |
1 |
134,599,207 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6681:Kdm5b
|
UTSW |
1 |
134,613,269 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R6715:Kdm5b
|
UTSW |
1 |
134,609,061 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7202:Kdm5b
|
UTSW |
1 |
134,624,759 (GRCm38) |
missense |
probably benign |
|
|
R7258:Kdm5b
|
UTSW |
1 |
134,621,021 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7335:Kdm5b
|
UTSW |
1 |
134,560,439 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7420:Kdm5b
|
UTSW |
1 |
134,604,497 (GRCm38) |
missense |
probably benign |
0.14 |
|
R7426:Kdm5b
|
UTSW |
1 |
134,595,833 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7452:Kdm5b
|
UTSW |
1 |
134,624,948 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7595:Kdm5b
|
UTSW |
1 |
134,608,966 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7612:Kdm5b
|
UTSW |
1 |
134,624,918 (GRCm38) |
nonsense |
probably null |
|
|
R7704:Kdm5b
|
UTSW |
1 |
134,587,931 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7846:Kdm5b
|
UTSW |
1 |
134,617,840 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8115:Kdm5b
|
UTSW |
1 |
134,619,673 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R8146:Kdm5b
|
UTSW |
1 |
134,625,126 (GRCm38) |
missense |
probably benign |
0.05 |
|
R8160:Kdm5b
|
UTSW |
1 |
134,613,919 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8527:Kdm5b
|
UTSW |
1 |
134,605,774 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R8542:Kdm5b
|
UTSW |
1 |
134,605,774 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R8930:Kdm5b
|
UTSW |
1 |
134,616,272 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8932:Kdm5b
|
UTSW |
1 |
134,616,272 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8950:Kdm5b
|
UTSW |
1 |
134,613,926 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R9089:Kdm5b
|
UTSW |
1 |
134,607,768 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9109:Kdm5b
|
UTSW |
1 |
134,600,755 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9133:Kdm5b
|
UTSW |
1 |
134,602,585 (GRCm38) |
missense |
probably benign |
|
|
R9298:Kdm5b
|
UTSW |
1 |
134,600,755 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9423:Kdm5b
|
UTSW |
1 |
134,587,967 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R9630:Kdm5b
|
UTSW |
1 |
134,585,233 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9670:Kdm5b
|
UTSW |
1 |
134,630,502 (GRCm38) |
nonsense |
probably null |
|
|
X0063:Kdm5b
|
UTSW |
1 |
134,588,876 (GRCm38) |
missense |
probably benign |
0.07 |
|
Z1176:Kdm5b
|
UTSW |
1 |
134,625,035 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Kdm5b
|
UTSW |
1 |
134,595,798 (GRCm38) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGGTCTAAGGTCATCCTCCAC -3'
(R):5'- CCAAGCCTTGTTTTGTTCATGG -3'
Sequencing Primer
(F):5'- CTAAGCGATTAAGAGGCTACCTGCTC -3'
(R):5'- TTATCGATGAATCTAAAACCCACAGG -3'
|
| Posted On |
2019-05-15 |
Incidental Mutation